GB2007645A - Novel N-benzyl anthracyclines and pharmaceutical compositions containing them - Google Patents

Novel N-benzyl anthracyclines and pharmaceutical compositions containing them

Info

Publication number
GB2007645A
GB2007645A GB7839634A GB7839634A GB2007645A GB 2007645 A GB2007645 A GB 2007645A GB 7839634 A GB7839634 A GB 7839634A GB 7839634 A GB7839634 A GB 7839634A GB 2007645 A GB2007645 A GB 2007645A
Authority
GB
United Kingdom
Prior art keywords
pharmaceutical compositions
compositions containing
benzyl
novel
anthracyclines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7839634A
Other versions
GB2007645B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SRI International Inc
Original Assignee
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SRI International Inc, Stanford Research Institute filed Critical SRI International Inc
Publication of GB2007645A publication Critical patent/GB2007645A/en
Application granted granted Critical
Publication of GB2007645B publication Critical patent/GB2007645B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention provides novel N- benzyl derivatives of adriamycin and daunomycin having anti-cancer activity and being compounds of the formula <IMAGE> where R = -COCH3, -CHOHCH3, -COCH2OH or -CHOHCH2OH and X = NHCH2Ph or -N(CH2Ph)2, and their pharmaceutically acceptable acid addition salts. Also included are pharmaceutical compositions containing these derivatives and salts as the active ingredient. The compounds are made by reductive N-benzylation of the free amines.
GB7839634A 1977-10-17 1978-10-06 Benzyl anthracyclines and pharmaceutical compositions containing them Expired GB2007645B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84278777A 1977-10-17 1977-10-17

Publications (2)

Publication Number Publication Date
GB2007645A true GB2007645A (en) 1979-05-23
GB2007645B GB2007645B (en) 1982-05-12

Family

ID=25288238

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7839634A Expired GB2007645B (en) 1977-10-17 1978-10-06 Benzyl anthracyclines and pharmaceutical compositions containing them

Country Status (6)

Country Link
JP (1) JPS5470255A (en)
CA (1) CA1111028A (en)
DE (1) DE2844993A1 (en)
FR (1) FR2405957A1 (en)
GB (1) GB2007645B (en)
IT (1) IT1109281B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124318A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.R.L. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL124284B1 (en) * 1979-10-17 1983-01-31 Politechnika Gdanska Process for preparing n-glycosyl derivatives of antibiotics from anthracyclines group
GB8426672D0 (en) * 1984-10-22 1984-11-28 Erba Farmitalia Pharmaceutical compositions
US5977082A (en) * 1985-08-02 1999-11-02 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
GB8519452D0 (en) * 1985-08-02 1985-09-11 Erba Farmitalia Injectable solutions
ES2082023T3 (en) * 1986-12-05 1996-03-16 Pharmacia Spa INJECTABLE SOLUTIONS READY FOR USE CONTAINING AN ANTI-TUMORAL AGENT OF THE ANTHRACICLINE GLUCOSIDE TYPE.
SE0401066D0 (en) * 2004-04-22 2004-04-22 Stefan Sjoeberg Chemical Derivatives

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5124317A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.P.A. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US5124318A (en) * 1985-08-02 1992-06-23 Farmitalia Carlo Erba S.R.L. Injectable ready-to-use solutions containing an antitumor anthracycline glycoside
US6107285A (en) * 1985-08-02 2000-08-22 Pharmacia & Upjohn Company Injectable ready-to-use solutions containing an antitumor anthracycline glycoside

Also Published As

Publication number Publication date
JPS5470255A (en) 1979-06-05
GB2007645B (en) 1982-05-12
CA1111028A (en) 1981-10-20
DE2844993A1 (en) 1979-04-19
FR2405957A1 (en) 1979-05-11
FR2405957B1 (en) 1981-03-20
JPS6320839B2 (en) 1988-04-30
IT7851494A0 (en) 1978-10-13
IT1109281B (en) 1985-12-16

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19941006