FR2394541A1 - Nouveaux hexahydro-1-hydroxy-9-hydroxymethyl-6h-dibenzo-(b,d)pyranes substitues en position 3, leur procede de preparation et composition pharmaceutique les contenant - Google Patents

Nouveaux hexahydro-1-hydroxy-9-hydroxymethyl-6h-dibenzo-(b,d)pyranes substitues en position 3, leur procede de preparation et composition pharmaceutique les contenant

Info

Publication number
FR2394541A1
FR2394541A1 FR7818138A FR7818138A FR2394541A1 FR 2394541 A1 FR2394541 A1 FR 2394541A1 FR 7818138 A FR7818138 A FR 7818138A FR 7818138 A FR7818138 A FR 7818138A FR 2394541 A1 FR2394541 A1 FR 2394541A1
Authority
FR
France
Prior art keywords
hydroxymethyl
hydroxy
substituted
pyranes
dibenzo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7818138A
Other languages
English (en)
Other versions
FR2394541B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of FR2394541A1 publication Critical patent/FR2394541A1/fr
Application granted granted Critical
Publication of FR2394541B1 publication Critical patent/FR2394541B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

L'invention concerne de nouveaux hexahydro-1-hydroxy-9- hydroxyméthyl-6H-dibenzoØb,dõpyranes substitués en position 3, ainsi que des composés intermédiaires permettant de les obtenir. Elle a également trait à la préparation de ces composés par un procédé d'hydroboration suivi d'oxydation. Les nouveaux composés de l'invention sont doués de propriétés analgésiques.
FR7818138A 1977-06-17 1978-06-16 Nouveaux hexahydro-1-hydroxy-9-hydroxymethyl-6h-dibenzo-(b,d)pyranes substitues en position 3, leur procede de preparation et composition pharmaceutique les contenant Granted FR2394541A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US05/807,439 US4133819A (en) 1977-06-17 1977-06-17 Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents
US06/024,783 US4232018A (en) 1977-06-17 1979-03-29 Hexahydro-1-hydroxy-9-hydroxymethyl-3-substituted-6H-dibenzo[b,d]pyrans as analgesic agents

Publications (2)

Publication Number Publication Date
FR2394541A1 true FR2394541A1 (fr) 1979-01-12
FR2394541B1 FR2394541B1 (fr) 1980-10-24

Family

ID=26698861

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7818138A Granted FR2394541A1 (fr) 1977-06-17 1978-06-16 Nouveaux hexahydro-1-hydroxy-9-hydroxymethyl-6h-dibenzo-(b,d)pyranes substitues en position 3, leur procede de preparation et composition pharmaceutique les contenant

Country Status (8)

Country Link
US (2) US4133819A (fr)
JP (2) JPS549274A (fr)
BE (1) BE868173A (fr)
DE (1) DE2826849A1 (fr)
FR (1) FR2394541A1 (fr)
GB (2) GB2004553B (fr)
LU (1) LU79824A1 (fr)
NL (1) NL7806509A (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0765160A1 (fr) * 1994-02-07 1997-04-02 RAMOT UNIVERSITY, AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD. Derives de dexanabinol et leur emploi en tant que compositions pharmaceutiques neuroprotectrices

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4243674A (en) * 1978-06-12 1981-01-06 Pfizer Inc. 9-Hydroxydibenzo[b,d]pyrans and intermediates therefore
US4327028A (en) * 1978-08-17 1982-04-27 Calcol, Inc. Composition of matter
US4454144A (en) * 1982-06-21 1984-06-12 Pfizer Inc. Substituted dibenzo[b,d]pyran analgesics
JPS6086601U (ja) * 1983-11-21 1985-06-14 株式会社トキメック パイロツト形シヨツクレス切換弁
IL80411A (en) * 1986-10-24 1991-08-16 Raphael Mechoulam Preparation of dibenzopyranol derivatives and pharmaceutical compositions containing them
JPH0192519U (fr) * 1987-12-11 1989-06-16
US5284867A (en) * 1989-11-07 1994-02-08 Yissum Research Development Company Of The Hebrew University In Jerusalem NMDA-blocking pharmaceutical compositions
IL92238A (en) * 1989-11-07 1995-07-31 Yissum Res Dev Co ADMN blocking product containing tetrahydrocannabinol history, several new tetrahydrocannabinol histories and process for their preparation
US6096740A (en) * 1990-11-06 2000-08-01 Ramot University Authority For Applied Research And Industrial Development Ltd. Dexanabinol derivatives and their use as neuroprotective pharmaceutical compositions
IL101927A0 (en) * 1992-05-19 1992-12-30 Yissum Res Dev Co Probe for cannabinoid receptors
US8449908B2 (en) * 2000-12-22 2013-05-28 Alltranz, Llc Transdermal delivery of cannabidiol
DE60234057D1 (de) 2001-07-25 2009-11-26 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
GB2394894B (en) * 2002-11-04 2005-08-31 G W Pharma Ltd New use for pharmaceutical composition
CN103259027A (zh) 2005-04-28 2013-08-21 普罗透斯数字保健公司 药物信息系统
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
DK2176208T3 (en) * 2007-07-30 2015-04-27 Zynerba Pharmaceuticals Inc Prodrugs of cannabidiol, compositions containing prodrugs of cannabidiol and methods of use thereof
US20090247619A1 (en) * 2008-03-06 2009-10-01 University Of Kentucky Cannabinoid-Containing Compositions and Methods for Their Use
PT2398500T (pt) 2009-02-20 2019-06-14 2 Bbb Medicines B V Sistema de entrega de medicamentos à base de glutationas
TWI556839B (zh) 2009-05-06 2016-11-11 研究室護膚股份有限公司 包含活性劑－磷酸鈣粒子複合物之皮膚遞送組成物及其使用方法
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
EP3654942A1 (fr) 2017-07-20 2020-05-27 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Compositions de film pharmaceutique pour l'administration de composés lipophiles dans et/ou à travers la peau
EP3681474A1 (fr) 2017-09-11 2020-07-22 Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. Compositions et procédés pour l'administration nasale de médicaments en direction du cerveau et en vue d'un effet systémique
CA3116187A1 (fr) 2017-11-29 2019-06-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Compositions de cannabinoides et methodes
US20220008354A1 (en) 2018-11-04 2022-01-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Orally administrable cannabinoids-containing compositions and methods

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2081512A1 (fr) * 1970-02-13 1971-12-03 Little Inc Arthur

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3507885A (en) * 1966-03-25 1970-04-21 Hoffmann La Roche 3-alkyl-6h-dibenzo(b,d)pyrans
CH558792A (de) * 1971-10-14 1975-02-14 Petrzilka Theodor Verfahren zur herstellung von tetrahydrodibenzopyranen.
US3927036A (en) * 1972-05-25 1975-12-16 Abbott Lab Basic carbonates and carbamates of benzopyrans
US3901926A (en) * 1973-04-02 1975-08-26 Abbott Lab Alkylphenyl benzopyrans
US4049653A (en) * 1973-04-05 1977-09-20 Abbott Laboratories Heterocyclic esters of alkylphenyl benzopyrans
US3968125A (en) * 1973-11-05 1976-07-06 Eli Lilly And Company Dihydroxyhexahydrodibenzo[b,d]pyrans
GB1522057A (en) * 1975-11-03 1978-08-23 Pfizer 9-hydroxydibenzo(b,d)pyrans and intermediates therefor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2081512A1 (fr) * 1970-02-13 1971-12-03 Little Inc Arthur

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
NV6013/73 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0765160A1 (fr) * 1994-02-07 1997-04-02 RAMOT UNIVERSITY, AUTHORITY FOR APPLIED RESEARCH & INDUSTRIAL DEVELOPMENT LTD. Derives de dexanabinol et leur emploi en tant que compositions pharmaceutiques neuroprotectrices
EP0765160A4 (fr) * 1994-02-07 1997-04-09

Also Published As

Publication number Publication date
GB2000131A (en) 1979-01-04
DE2826849A1 (de) 1978-12-21
NL7806509A (nl) 1978-12-19
FR2394541B1 (fr) 1980-10-24
GB2004553A (en) 1979-04-04
JPS5513270A (en) 1980-01-30
US4133819A (en) 1979-01-09
GB2004553B (en) 1982-01-06
GB2000131B (en) 1982-01-13
US4232018A (en) 1980-11-04
JPS549274A (en) 1979-01-24
LU79824A1 (fr) 1980-01-22
BE868173A (fr) 1978-12-18

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