FR2405257A1 - Procede de preparation et de purification du facteur citrovorum par reduction de l'acide folique et nouveau produit ainsi obtenu - Google Patents

Procede de preparation et de purification du facteur citrovorum par reduction de l'acide folique et nouveau produit ainsi obtenu

Info

Publication number
FR2405257A1
FR2405257A1 FR7823483A FR7823483A FR2405257A1 FR 2405257 A1 FR2405257 A1 FR 2405257A1 FR 7823483 A FR7823483 A FR 7823483A FR 7823483 A FR7823483 A FR 7823483A FR 2405257 A1 FR2405257 A1 FR 2405257A1
Authority
FR
France
Prior art keywords
preparation
citrovorum factor
purification
folic acid
reduction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7823483A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Government
Original Assignee
US Government
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by US Government filed Critical US Government
Publication of FR2405257A1 publication Critical patent/FR2405257A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Préparation et purification du facteur citrovorum (acide 5-formyl-5,6,7,8-tétrahydrofolique). On prépare le facteur citrovorum réduisant l'acide folique par le borohydrure de sodium et en traitant une solution aqueuse d'acide tétrahydrofolique résultant par l'acide formique. La présente invention est particulièrement utile pour fournir un précédé de préparation du facteur citrovorum qui, utilisé avec le méthotréxate, sert au traitement de tumeurs.
FR7823483A 1977-08-22 1978-08-09 Procede de preparation et de purification du facteur citrovorum par reduction de l'acide folique et nouveau produit ainsi obtenu Withdrawn FR2405257A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/826,677 US4148999A (en) 1977-08-22 1977-08-22 Preparation and purification of citrovorum factor

Publications (1)

Publication Number Publication Date
FR2405257A1 true FR2405257A1 (fr) 1979-05-04

Family

ID=25247233

Family Applications (3)

Application Number Title Priority Date Filing Date
FR7823483A Withdrawn FR2405257A1 (fr) 1977-08-22 1978-08-09 Procede de preparation et de purification du facteur citrovorum par reduction de l'acide folique et nouveau produit ainsi obtenu
FR7900274A Withdrawn FR2405258A1 (fr) 1977-08-22 1979-01-05 Procede de preparation et de purification du facteur citrovorum par ouverture de noyau d'imidazoline et nouveau produit ainsi obtenu
FR7900275A Withdrawn FR2405259A1 (fr) 1977-08-22 1979-01-05 Procede de preparation et de purification du facteur citrovorum par precipitation des impuretes de ce facteur et nouveau produit ainsi obtenu

Family Applications After (2)

Application Number Title Priority Date Filing Date
FR7900274A Withdrawn FR2405258A1 (fr) 1977-08-22 1979-01-05 Procede de preparation et de purification du facteur citrovorum par ouverture de noyau d'imidazoline et nouveau produit ainsi obtenu
FR7900275A Withdrawn FR2405259A1 (fr) 1977-08-22 1979-01-05 Procede de preparation et de purification du facteur citrovorum par precipitation des impuretes de ce facteur et nouveau produit ainsi obtenu

Country Status (5)

Country Link
US (1) US4148999A (fr)
CA (1) CA1108134A (fr)
DE (1) DE2836599A1 (fr)
FR (3) FR2405257A1 (fr)
GB (3) GB2054597B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2474032A1 (fr) * 1980-01-21 1981-07-24 Wellcome Found Procede de preparation de leucovorine calcique

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1572137A (en) * 1977-02-22 1980-07-23 Bioresearch Sas Del Dr Livio C Stable compositions for therapeutic use based on d,1-5-methyltetrahydrofolic acid and its salts
US5223500A (en) * 1977-02-22 1993-06-29 Bioresearch S.P.A. Stable pharmaceutical composition of alkaline or alkaline earth 5-methyl tetrahydrofolate
US5124452A (en) * 1978-07-10 1992-06-23 Bioresearch S.P.A. Process for producing d,1-5-methyltetrahydrofolic acid and its salts
DE3002657A1 (de) * 1980-01-25 1981-07-30 The Wellcome Foundation Ltd., London Verfahren zur herstellung von calcium-leucovorin
JPS56110689A (en) * 1980-01-31 1981-09-01 Wellcome Found Manufacture of calcium leucovolin
JPS56145289A (en) * 1980-04-08 1981-11-11 Bisukonchiini Matsukusu Manufacture of 5-formyl-5,6,7,8-tetrahydrofolic acid
EP0189990A3 (fr) * 1985-01-29 1987-10-21 Dana Farber Cancer Institute Réduction et formylation en une étape de l'acide folique en homofolique
CH676981A5 (fr) * 1988-11-11 1991-03-28 Eprova Ag
FR2643081B1 (fr) * 1989-02-14 1991-06-07 Panmedica Sa Folates de magnesium, procede de preparation et compositions pharmaceutiques
ES2090075T3 (es) * 1989-12-11 1996-10-16 American Cyanamid Co Procedimiento para la preparacion de diastereoisomeros opticamente puros de compuestos de tetrahidrofolato.
FR2659330B1 (fr) * 1990-03-09 1994-02-11 Sapec Sa Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.
CH684270A5 (de) * 1991-10-04 1994-08-15 Sapec Fine Chemicals Verfahren zur Herstellung von Erdalkalimetallsalzen von (6R)-N(10)-Formyl-5,6,7,8-tetrahydrofolsäure.
US5198547A (en) * 1992-03-16 1993-03-30 South Alabama Medical Science Foundation, Usa Process for N5-formylating tetrahydropteridines
US5710271A (en) * 1994-06-08 1998-01-20 Dibra S.P.A. Process for the preparation and separation of diastereomeric salts of folinic acid
CH696717A5 (de) * 2004-02-20 2007-10-31 Cerbios Pharma Sa Konzentrierte, stabile Losung, insbesondere eine Injektionslosung oder Infusionslosung, welche nebst Wasser entweder (6S)-Natrium-Folinat oder (6S)-Kalium-Folinat entholt
CN110229155B (zh) * 2019-06-25 2022-01-18 重庆华邦胜凯制药有限公司 一种左亚叶酸钙杂质及杂质钙盐的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293541A (en) * 1969-03-18 1972-10-18 John Alexander Blair Folic acid derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2739966A (en) * 1950-03-31 1956-03-27 American Cyanamid Co N10formyldihydropteroylglutamic acid and process for preparing same
US2594271A (en) * 1950-08-05 1952-04-29 American Cyanamid Co Method of formylating tetrahydro pteroic acid and amino acid amides thereof
US2741608A (en) * 1951-03-08 1956-04-10 Research Corp 5-formyl-5,6,7,8-tetrahydropteroic acid and amides thereof and method of preparing same
US2737515A (en) * 1951-06-30 1956-03-06 American Cyanamid Co Salts of substituted tetrahydroformyl pteroyl amino acids
US2927113A (en) * 1957-10-14 1960-03-01 Lepetit Spa Leucovorin purification
CH496012A (de) * 1968-02-08 1970-09-15 Eprova Ag Verfahren zur Herstellung von Calcium-leucovorin
US3870719A (en) * 1972-06-16 1975-03-11 Us Health Synthesis of n-5-methyltetrahydrohomofolic acid and related reduced derivatives of homofolic acid

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1293541A (en) * 1969-03-18 1972-10-18 John Alexander Blair Folic acid derivatives

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/73 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2474032A1 (fr) * 1980-01-21 1981-07-24 Wellcome Found Procede de preparation de leucovorine calcique

Also Published As

Publication number Publication date
GB2054597A (en) 1981-02-18
GB2003869A (en) 1979-03-21
GB2054597B (en) 1982-07-14
US4148999A (en) 1979-04-10
FR2405259A1 (fr) 1979-05-04
CA1108134A (fr) 1981-09-01
GB2054596A (en) 1981-02-18
GB2003869B (en) 1982-06-30
DE2836599A1 (de) 1979-07-05
FR2405258A1 (fr) 1979-05-04
GB2054596B (en) 1982-07-14

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Legal Events

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