FR2404638A1 - Procede de preparation d'acide pseudomonique - Google Patents
Procede de preparation d'acide pseudomoniqueInfo
- Publication number
- FR2404638A1 FR2404638A1 FR7827765A FR7827765A FR2404638A1 FR 2404638 A1 FR2404638 A1 FR 2404638A1 FR 7827765 A FR7827765 A FR 7827765A FR 7827765 A FR7827765 A FR 7827765A FR 2404638 A1 FR2404638 A1 FR 2404638A1
- Authority
- FR
- France
- Prior art keywords
- pseudomonic acid
- organic solvent
- solution
- prepared
- constituents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- MINDHVHHQZYEEK-UHFFFAOYSA-N (E)-(2S,3R,4R,5S)-5-[(2S,3S,4S,5S)-2,3-epoxy-5-hydroxy-4-methylhexyl]tetrahydro-3,4-dihydroxy-(beta)-methyl-2H-pyran-2-crotonic acid ester with 9-hydroxynonanoic acid Natural products CC(O)C(C)C1OC1CC1C(O)C(O)C(CC(C)=CC(=O)OCCCCCCCCC(O)=O)OC1 MINDHVHHQZYEEK-UHFFFAOYSA-N 0.000 title abstract 4
- MINDHVHHQZYEEK-HBBNESRFSA-N mupirocin Chemical compound C[C@H](O)[C@H](C)[C@@H]1O[C@H]1C[C@@H]1[C@@H](O)[C@@H](O)[C@H](C\C(C)=C\C(=O)OCCCCCCCCC(O)=O)OC1 MINDHVHHQZYEEK-HBBNESRFSA-N 0.000 title abstract 4
- 229960003128 mupirocin Drugs 0.000 title abstract 4
- 229930194369 pseudomonic acid Natural products 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 abstract 3
- 239000000470 constituent Substances 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 abstract 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229940043265 methyl isobutyl ketone Drugs 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/162—Heterorings having oxygen atoms as the only ring heteroatoms, e.g. Lasalocid
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/38—Pseudomonas
- C12R2001/39—Pseudomonas fluorescens
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4067877 | 1977-09-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2404638A1 true FR2404638A1 (fr) | 1979-04-27 |
| FR2404638B1 FR2404638B1 (enExample) | 1982-04-16 |
Family
ID=10416087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7827765A Granted FR2404638A1 (fr) | 1977-09-30 | 1978-09-28 | Procede de preparation d'acide pseudomonique |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US4222942A (enExample) |
| JP (1) | JPS5459281A (enExample) |
| BE (1) | BE870855A (enExample) |
| CA (1) | CA1103264A (enExample) |
| CH (1) | CH642366A5 (enExample) |
| DE (1) | DE2842358A1 (enExample) |
| DK (1) | DK152126C (enExample) |
| ES (1) | ES473837A1 (enExample) |
| FR (1) | FR2404638A1 (enExample) |
| IE (1) | IE47386B1 (enExample) |
| IT (1) | IT1157197B (enExample) |
| NL (1) | NL7809859A (enExample) |
| NZ (1) | NZ188559A (enExample) |
| ZA (1) | ZA785515B (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60243010A (ja) * | 1984-05-17 | 1985-12-03 | Seiwa Kasei:Kk | 毛髪保護剤 |
| JPS60243011A (ja) * | 1984-05-17 | 1985-12-03 | Seiwa Kasei:Kk | パ−マネントウエ−ブ用第１剤 |
| GB9026873D0 (en) * | 1990-12-11 | 1991-01-30 | Beecham Group Plc | Novel compounds |
| US5594026A (en) * | 1990-12-11 | 1997-01-14 | Smithkline Beecham Group P.L.C. | Polymorphs of crystalline mupirocin |
| BR0009178A (pt) | 1999-02-03 | 2001-11-20 | Biogal Gyogyszergyar | Processo para o isolamento de ácidopseudomÈnico a partir de ácido pseudomÈnicocomplexo contendo fluido de cultura |
| EP1151131A4 (en) | 1999-02-03 | 2004-05-12 | Biogal Gyogyszergyar | PROCESS FOR THE PREPARATION OF A PSEUDOMONIC ACID ANTIBIOTIC USING A MICROBIOLOGICAL METHOD |
| PL374255A1 (en) * | 2001-06-21 | 2005-10-03 | Biogal Gyogyszergyar Rt | Metabolic controlled fermentation process for pseudomonic acid production |
| US7737177B2 (en) | 2001-12-28 | 2010-06-15 | TEVA Gyógyszergyár Zártkörüen Müködö Részvénytárasaság | Processes for preparing crystalline and amorphous mupirocin calcium |
| IL150907A (en) * | 2002-07-25 | 2007-07-04 | Stephan Cherkez | Process for the preparation of stable amorphous calcium pseudomonate |
| ES2339682T3 (es) * | 2004-06-01 | 2010-05-24 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Procedimiento para la preparacion de la forma amorfa de un farmaco. |
| DK1655242T3 (da) * | 2004-10-29 | 2007-11-05 | Ped Invest As | Sideböjende transportbånd |
| JP5101305B2 (ja) * | 2005-02-21 | 2012-12-19 | シンジェン バイオテック カンパニー リミテッド | ムピロシン精製法 |
| GB2441328A (en) | 2006-08-30 | 2008-03-05 | Alpharma Aps | A method for obtaining mupirocin calcium |
| CN104370896A (zh) * | 2013-11-29 | 2015-02-25 | 江苏汉邦科技有限公司 | 一种纯化假单孢菌素的方法 |
| TW202214611A (zh) | 2020-08-25 | 2022-04-16 | 大陸商杭州中美華東製藥有限公司 | 莫匹羅星的提取方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1395907A (en) * | 1971-06-12 | 1975-05-29 | Beecham Group Ltd | Antibiotics |
| JPS5270083A (en) * | 1975-12-04 | 1977-06-10 | Yoshitomi Pharmaceut Ind Ltd | Manufacture of an antibiotics, trans-pseudomonic acid |
| GB1565083A (en) * | 1976-02-20 | 1980-04-16 | Beecham Group Ltd | Pseudomonic acid amides |
-
1978
- 1978-09-27 CA CA312,240A patent/CA1103264A/en not_active Expired
- 1978-09-28 FR FR7827765A patent/FR2404638A1/fr active Granted
- 1978-09-28 ZA ZA00785515A patent/ZA785515B/xx unknown
- 1978-09-28 IT IT51285/78A patent/IT1157197B/it active
- 1978-09-28 BE BE190787A patent/BE870855A/xx not_active IP Right Cessation
- 1978-09-28 DE DE19782842358 patent/DE2842358A1/de active Granted
- 1978-09-29 DK DK433878A patent/DK152126C/da not_active IP Right Cessation
- 1978-09-29 US US05/946,873 patent/US4222942A/en not_active Expired - Lifetime
- 1978-09-29 ES ES473837A patent/ES473837A1/es not_active Expired
- 1978-09-29 CH CH1016178A patent/CH642366A5/de not_active IP Right Cessation
- 1978-09-29 IE IE1955/78A patent/IE47386B1/en not_active IP Right Cessation
- 1978-09-29 NL NL7809859A patent/NL7809859A/xx active Search and Examination
- 1978-09-30 JP JP12111878A patent/JPS5459281A/ja active Granted
- 1978-10-02 NZ NZ188559A patent/NZ188559A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2842358A1 (de) | 1979-04-05 |
| IE47386B1 (en) | 1984-03-07 |
| NL7809859A (nl) | 1979-04-03 |
| IT1157197B (it) | 1987-02-11 |
| BE870855A (fr) | 1979-03-28 |
| CA1103264A (en) | 1981-06-16 |
| FR2404638B1 (enExample) | 1982-04-16 |
| ZA785515B (en) | 1979-09-26 |
| CH642366A5 (de) | 1984-04-13 |
| DE2842358C2 (enExample) | 1989-05-24 |
| DK152126C (da) | 1988-06-20 |
| DK152126B (da) | 1988-02-01 |
| DK433878A (da) | 1979-03-31 |
| NZ188559A (en) | 1981-01-23 |
| AU531316B2 (en) | 1983-08-18 |
| IT7851285A0 (it) | 1978-09-28 |
| JPH032867B2 (enExample) | 1991-01-17 |
| ES473837A1 (es) | 1979-10-16 |
| JPS5459281A (en) | 1979-05-12 |
| AU4030478A (en) | 1980-04-03 |
| US4222942A (en) | 1980-09-16 |
| IE781955L (en) | 1979-03-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CC | Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990) |
Free format text: 92C0126, 920430 |
|
| CB | Supplementary protection certificate (spc) granted (law of 25 june 1990) |
Free format text: 92C0126, 780928 |
|
| CL | Concession to grant licences |