SU854274A3 - Способ получени фракции гва ковойСМОлы - Google Patents
Способ получени фракции гва ковойСМОлы Download PDFInfo
- Publication number
- SU854274A3 SU854274A3 SU782600100A SU2600100A SU854274A3 SU 854274 A3 SU854274 A3 SU 854274A3 SU 782600100 A SU782600100 A SU 782600100A SU 2600100 A SU2600100 A SU 2600100A SU 854274 A3 SU854274 A3 SU 854274A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- ratio
- acetone
- mixture
- guajacum
- producing
- Prior art date
Links
- 241000147041 Guaiacum officinale Species 0.000 title claims 3
- 229940091561 guaiac Drugs 0.000 title claims 3
- 238000000034 method Methods 0.000 title description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 10
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims description 9
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 9
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 241000190019 Guaiacum Species 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 2
- URLKBWYHVLBVBO-UHFFFAOYSA-N Para-Xylene Chemical group CC1=CC=C(C)C=C1 URLKBWYHVLBVBO-UHFFFAOYSA-N 0.000 claims 2
- 235000019439 ethyl acetate Nutrition 0.000 claims 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- 229960000583 acetic acid Drugs 0.000 claims 1
- 239000001569 carbon dioxide Substances 0.000 claims 1
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 1
- 239000003480 eluent Substances 0.000 claims 1
- 239000012362 glacial acetic acid Substances 0.000 claims 1
- 239000000741 silica gel Substances 0.000 claims 1
- 229910002027 silica gel Inorganic materials 0.000 claims 1
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract description 6
- 239000008280 blood Substances 0.000 abstract description 5
- 210000004369 blood Anatomy 0.000 abstract description 5
- 239000002253 acid Substances 0.000 abstract description 4
- 210000003608 fece Anatomy 0.000 abstract description 3
- 238000001514 detection method Methods 0.000 abstract description 2
- 102000003992 Peroxidases Human genes 0.000 abstract 1
- 230000008033 biological extinction Effects 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 108040007629 peroxidase activity proteins Proteins 0.000 abstract 1
- 239000003381 stabilizer Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000011347 resin Substances 0.000 description 9
- 229920005989 resin Polymers 0.000 description 9
- 238000004458 analytical method Methods 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 241000508269 Psidium Species 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 238000012505 colouration Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
- G01N33/725—Haemoglobin using peroxidative activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/904—Oxidation - reduction indicators
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Compounds Of Unknown Constitution (AREA)
Description
(54) СПОСОБ ПОЛУЧЕНИЯ ФРАКЦИИ ГВАЯКОВОЙ СМОЛЫ
Изобретение относитс к области органической химии, а именно к способу получени фракции гва ковой смо лы, примен емой в медицине в случае заболеваний органов пищеварени , при вод щих к по влению скрытой крови в стуле, обнаружение которой вл етс важным моментом при установлении пра вильного диагноза. Известна гва кова смола, котора добываетс из сердцевины тропического дерева Guajacum officinal is и. sanktum и примен етс дл определени скрытой крови в кале. Однако частое использование гва ковой смолы приводит к получению ошибочных результатов. Анализ осуществ л ют путем обработки взвеси кала перекисью водорода и спиртовым раствором гва ковой смолы. По вление гол бого окрашивани указывает на наличие скрытой крови. За по вление голу бого окрашивани ответственно два основных компонента смолы, а именно фурогва цин, а также гва конова кислота 1. Однако гва кова смола не всегда содержит имеющиес в ней компоненты в одном и том же соотношении , часто образуютс нестабильные компоненты, которые могут разлагатьс и, таким образом, снижать точность и воспроизводимость анали- за. В то же врем выделение и применение двух главных компонентов в индивидуальном виде затруднено, поскольку применение фурогва цина не дает стабильных результатов,о в выделение гва коновой кислоты возможно осуществить только с помощью тонкослойной хроматографии с очень низким выходом.. Цель изобретени заключаетс в разработке способа получени новой стабильной смеси компонентов гва ковой смолы - фракции гва ковой смолы, пригодной дл диагностики наличи крови в кале. Поставленна иель достигаетс способом получени фракции гва ковой смолы, заключающимс в том, что гва ковую смолу, выделенную из сердцевины тропического дерева Guajacum offtcinalls и Guajacum sanktum раствор ют в ацетоне, затем прибавл ют толуол, после чего полученную смесь фильтруют, фильтрат упаривают досуха и остаток раствор ют в смеси н-гептана и уксусного эфира в соотнойюнии 2:5 или в ацетоне и разде
Claims (1)
- Формула изобретенияСпособ получения фракции гваяковой смолы, отличающийся тем, что гваяковую смолу, выделенную 4Q из сердцевины тропического дерева Guajacum officinalis и Guajacum sanktum растворяют в ацетоне, затем прибавляют толуол, после чего полученную смесь фильтруют, фильтрат упаривают досуха и остаток растворяют в сМеси н-гептана и уксусно· го эфира в соотношении 2:5 или в ацетоне и разделяют на колонке с силикагелем в атмосфере углекислого газа при помощи элюента, в качестве которого используют смесь н-гептана и уксусного эфира в соотношении 2:5 или смесь ацетона и толуола в соотношении 1:5, при этом отбирают фракции с Rf 0,45 в смеси толуол, диоксан и ледяная уксусная кислота в соотношении 90:25:10, упаривают их досуха и полученный остаток перекристаллизовывают из п-ксилола.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2716061A DE2716061C2 (de) | 1977-04-09 | 1977-04-09 | Guajaconsäure A, Verfahren zu ihrer Herstellung und die Verwendung dieser Substanz als diagnostische Mittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU854274A3 true SU854274A3 (ru) | 1981-08-07 |
Family
ID=6006094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU782600100A SU854274A3 (ru) | 1977-04-09 | 1978-04-07 | Способ получени фракции гва ковойСМОлы |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US4219336A (ru) |
| JP (1) | JPS588400B2 (ru) |
| AR (1) | AR216788A1 (ru) |
| AT (1) | AT358743B (ru) |
| BE (1) | BE865700A (ru) |
| BR (1) | BR7802179A (ru) |
| CA (1) | CA1115724A (ru) |
| CH (1) | CH636625A5 (ru) |
| DD (1) | DD135768A5 (ru) |
| DE (1) | DE2716061C2 (ru) |
| FI (1) | FI781014A (ru) |
| FR (1) | FR2386556A1 (ru) |
| GB (1) | GB1571362A (ru) |
| HU (1) | HU180211B (ru) |
| IT (1) | IT1095395B (ru) |
| NL (1) | NL7803721A (ru) |
| SE (1) | SE7803890L (ru) |
| SU (1) | SU854274A3 (ru) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56117798A (en) * | 1980-02-21 | 1981-09-16 | Toyo Jozo Co Ltd | Kit for measuring lipoid peroxide |
| US4526869A (en) * | 1980-09-24 | 1985-07-02 | Regents Of The University Of Minnesota | Method for quantitatively determining the concentration of hemoglobin in a biological sample |
| US4956300A (en) * | 1982-01-05 | 1990-09-11 | Helena Laboratories Corporation | Aid for determining the presence of occult blood, method of making the aid, and method of using the aid |
| ZA829434B (en) * | 1982-01-05 | 1984-05-30 | Hematec Corp | Home diagnostic aid and method for determining the presence of occult blood for use by the general public |
| ZA831268B (en) * | 1982-04-30 | 1984-10-31 | Hematec Corp | Home diagnostic aid and method for determining the presence of occult blood for use by the general public |
| PH23572A (en) * | 1982-05-28 | 1989-09-11 | Smithkline Diagnostics Inc | Specimen test slide for occult blood testing |
| US4541987A (en) * | 1983-09-29 | 1985-09-17 | Helena Laboratories Corporation | Test pad for detecting occult blood |
| US4725553A (en) * | 1983-09-29 | 1988-02-16 | Helena Laboratories Corporation | Test composition for detecting occult blood |
| US5702913A (en) * | 1983-12-21 | 1997-12-30 | Helena Laboratories Corporation | Chromgen-reagent test system |
| US5273888A (en) * | 1984-01-16 | 1993-12-28 | Helena Laboratories Corporation | Chemical test kit and method for determining the presence of blood in a specimen and for verifying the effectiveness of the chemicals |
| US4676950A (en) * | 1984-02-03 | 1987-06-30 | Foster Research Corporation | Indicator and test device for detecting occult blood |
| US4615982A (en) * | 1984-12-11 | 1986-10-07 | Lawrence Paul J | Fecal occult blood test |
| US4818702A (en) * | 1986-06-02 | 1989-04-04 | Litmus Concepts, Inc. | Fecal occult blood test reagent |
| US5219554A (en) * | 1986-07-03 | 1993-06-15 | Advanced Magnetics, Inc. | Hydrated biodegradable superparamagnetic metal oxides |
| JPS63223096A (ja) * | 1987-03-11 | 1988-09-16 | 大日本印刷株式会社 | 精製グアヤク脂ならびにその製造方法 |
| JP2589079B2 (ja) * | 1987-03-11 | 1997-03-12 | 大日本印刷株式会社 | 精製グアャク脂の製造方法 |
| US5081040A (en) * | 1987-06-29 | 1992-01-14 | Helena Laboratories Corporation | Composition and kit for testing for occult blood in human and animal excretions, fluids, or tissue matrixes |
| JP2660558B2 (ja) * | 1988-08-17 | 1997-10-08 | 大日本印刷株式会社 | 精製グアヤク脂およびその製造法 |
| US5182191A (en) * | 1988-10-14 | 1993-01-26 | Pacific Biotech, Inc. | Occult blood sampling device and assay |
| US5217874A (en) * | 1989-04-04 | 1993-06-08 | Helena Laboratories Corporation | Fecal occult blood test product with positive and negative controls |
| US5196167A (en) * | 1989-04-04 | 1993-03-23 | Helena Laboratories Corporation | Fecal occult blood test product with positive and negative controls |
| US5629340A (en) * | 1993-01-11 | 1997-05-13 | Tsumura & Co. | Angiogenesis inhibitor and novel compound |
| US5447868A (en) | 1993-09-14 | 1995-09-05 | Propper Manufacturing Co. Inc. | Method, reagent and kit for the detection of fecal occult blood |
| US6309887B1 (en) * | 1998-01-27 | 2001-10-30 | Flexsite Diagnostics, Inc. | Filter paper treatment for improved diagnostic assays |
| US7109038B2 (en) * | 2002-06-13 | 2006-09-19 | The Johns Hopkins University | Occult blood detection in biological samples by laser desorption and matrix-assisted laser desorption/ionization mass spectrometry for biomedical applications |
| US7195878B2 (en) * | 2004-09-30 | 2007-03-27 | Cryo-Genomics | Device and method for fecal testing |
| US9091682B1 (en) | 2014-05-01 | 2015-07-28 | Steven M Hacker | Tissue specimen bottle with color indicator in lid verifying and confirming presence of human tissue or blood contained in specimen bottle |
| US11597961B2 (en) | 2019-04-22 | 2023-03-07 | Qualitic Biotechnology LLC | Rapid colorimetric diagnostic test for C. difficile |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2258673A (en) * | 1940-02-07 | 1941-10-14 | Nat Oil Prod Co | Process for treating fat-soluble vitamin-containing materials |
| US2345098A (en) * | 1941-07-26 | 1944-03-28 | Nat Oil Prod Co | Process of saponifying vitamin-containing fatty material |
| US2529446A (en) * | 1948-07-02 | 1950-11-07 | Swift & Co | Gum guaiac treatment |
| DK153334C (da) * | 1974-01-09 | 1988-11-14 | Shionogi & Co | Diagnostiske praeparater |
| JPS5263794A (en) * | 1975-11-21 | 1977-05-26 | Shionogi Seiyaku Kk | Test piece for latent blood |
| FI52256C (fi) * | 1975-12-08 | 1977-07-11 | Osmo Antero Suovaniemi | Laite näytteiden ottamista varten näytteiden kuljettamiseksi ja analys oimiseksi. |
-
1977
- 1977-04-09 DE DE2716061A patent/DE2716061C2/de not_active Expired
-
1978
- 1978-03-30 CA CA300,004A patent/CA1115724A/en not_active Expired
- 1978-03-31 US US05/892,359 patent/US4219336A/en not_active Expired - Lifetime
- 1978-04-03 FI FI781014A patent/FI781014A/fi not_active Application Discontinuation
- 1978-04-04 AR AR271683A patent/AR216788A1/es active
- 1978-04-05 CH CH367178A patent/CH636625A5/de not_active IP Right Cessation
- 1978-04-05 BE BE186572A patent/BE865700A/xx not_active IP Right Cessation
- 1978-04-05 GB GB13291/78A patent/GB1571362A/en not_active Expired
- 1978-04-06 SE SE7803890A patent/SE7803890L/xx unknown
- 1978-04-06 IT IT22063/78A patent/IT1095395B/it active
- 1978-04-06 DD DD78204637A patent/DD135768A5/xx unknown
- 1978-04-07 FR FR7810368A patent/FR2386556A1/fr active Granted
- 1978-04-07 BR BR7802179A patent/BR7802179A/pt unknown
- 1978-04-07 SU SU782600100A patent/SU854274A3/ru active
- 1978-04-07 AT AT248678A patent/AT358743B/de not_active IP Right Cessation
- 1978-04-07 NL NL7803721A patent/NL7803721A/xx not_active Application Discontinuation
- 1978-04-07 HU HU78BO1710A patent/HU180211B/hu unknown
- 1978-04-10 JP JP53042051A patent/JPS588400B2/ja not_active Expired
-
1980
- 1980-01-25 US US06/115,533 patent/US4297271A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2386556A1 (fr) | 1978-11-03 |
| BR7802179A (pt) | 1978-12-19 |
| JPS588400B2 (ja) | 1983-02-15 |
| JPS53127812A (en) | 1978-11-08 |
| AT358743B (de) | 1980-09-25 |
| FR2386556B1 (ru) | 1982-11-05 |
| NL7803721A (nl) | 1978-10-11 |
| IT7822063A0 (it) | 1978-04-06 |
| ATA248678A (de) | 1980-02-15 |
| SE7803890L (sv) | 1978-10-10 |
| AR216788A1 (es) | 1980-01-31 |
| US4297271A (en) | 1981-10-27 |
| BE865700A (fr) | 1978-10-05 |
| HU180211B (en) | 1983-02-28 |
| FI781014A (fi) | 1978-10-10 |
| GB1571362A (en) | 1980-07-16 |
| CA1115724A (en) | 1982-01-05 |
| IT1095395B (it) | 1985-08-10 |
| DD135768A5 (de) | 1979-05-23 |
| DE2716061C2 (de) | 1982-03-25 |
| US4219336A (en) | 1980-08-26 |
| DE2716061A1 (de) | 1978-10-19 |
| CH636625A5 (de) | 1983-06-15 |
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