FR2403345A1 - Procede d'obtention de l'acide 7- (d-mandelamido)-3- (1-methyl-1,2,3,4-tetrazol-5-yl) thiomethyl-3-cephem-4-carboxylique pur a partir de ses sels - Google Patents
Procede d'obtention de l'acide 7- (d-mandelamido)-3- (1-methyl-1,2,3,4-tetrazol-5-yl) thiomethyl-3-cephem-4-carboxylique pur a partir de ses selsInfo
- Publication number
- FR2403345A1 FR2403345A1 FR7826145A FR7826145A FR2403345A1 FR 2403345 A1 FR2403345 A1 FR 2403345A1 FR 7826145 A FR7826145 A FR 7826145A FR 7826145 A FR7826145 A FR 7826145A FR 2403345 A1 FR2403345 A1 FR 2403345A1
- Authority
- FR
- France
- Prior art keywords
- cefamandole
- salts
- mandelamido
- cephem
- thiomethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/12—Separation; Purification
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
L'invention concerne un procédé de préparation de céfamandole pur à partir de ses sels de métaux alcalins et d'ammonium. On fait passer une solution, tamponnée à un pH d'environ 3,5 à environ 4,5, d'un sel de métal alcalin ou d'ammonium de céfamandole dans un lit d'une résine adsorbante qui utilise pour l'adsorption des forces de van der Waals, puis on acidifie l'éluat à un pH d'environ 2,0 avec un acide minéral non oxydant et l'on obtient des cristaux purs de céfamandole que l'on peut séparer et sécher et que l'on peut transformer en céfamandole-sodium cristallin, forme qui est très utile pour préparer des compositions pharmaceutiques.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/834,633 US4115644A (en) | 1977-09-19 | 1977-09-19 | Process for preparing pure cefamandole from alkali metal and ammonium salts thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2403345A1 true FR2403345A1 (fr) | 1979-04-13 |
FR2403345B1 FR2403345B1 (fr) | 1982-09-10 |
Family
ID=25267406
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7826145A Granted FR2403345A1 (fr) | 1977-09-19 | 1978-09-12 | Procede d'obtention de l'acide 7- (d-mandelamido)-3- (1-methyl-1,2,3,4-tetrazol-5-yl) thiomethyl-3-cephem-4-carboxylique pur a partir de ses sels |
Country Status (8)
Country | Link |
---|---|
US (1) | US4115644A (fr) |
JP (1) | JPS5455594A (fr) |
CA (1) | CA1100945A (fr) |
DE (1) | DE2839670A1 (fr) |
ES (1) | ES473371A1 (fr) |
FR (1) | FR2403345A1 (fr) |
GB (1) | GB2004280B (fr) |
IE (1) | IE47441B1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101787039B (zh) * | 2010-01-26 | 2012-05-09 | 陶灵刚 | 一种高纯度的头孢美唑钠化合物 |
CN102093392B (zh) * | 2011-01-28 | 2013-04-24 | 海南灵康制药有限公司 | 一种头孢孟多酯钠的新制法 |
CN103044453B (zh) * | 2013-01-22 | 2014-07-30 | 湖北济生医药有限公司 | 头孢孟多酯钠化合物及其药物组合物 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3641021A (en) * | 1969-04-18 | 1972-02-08 | Lilly Co Eli | 3 7-(ring-substituted) cephalosporin compounds |
US3840531A (en) * | 1972-03-21 | 1974-10-08 | Lilly Co Eli | Process for preparing 7-(alpha-hydroxy-alpha-phenyl)acetamido-3-(1-methyl-1h-tetrazol-5-ylthiomethyl)-3-cephem-4-carboxylic acid and derivatives thereof |
BE824028A (fr) * | 1974-01-23 | 1975-06-30 | Procede pour la purification de cephalosporines comportant un groupe acide carboxylique libre | |
US4028355A (en) * | 1974-01-23 | 1977-06-07 | Smithkline Corporation | Cephalosporin purification process |
US3947415A (en) * | 1974-12-23 | 1976-03-30 | Eli Lilly And Company | Cefamandole derivatives |
US4029655A (en) * | 1975-04-11 | 1977-06-14 | Eli Lilly And Company | Method of preparing stable sterile crystalline cephalosporins for parenteral administration |
-
1977
- 1977-09-19 US US05/834,633 patent/US4115644A/en not_active Expired - Lifetime
-
1978
- 1978-09-12 CA CA311,083A patent/CA1100945A/fr not_active Expired
- 1978-09-12 FR FR7826145A patent/FR2403345A1/fr active Granted
- 1978-09-12 DE DE19782839670 patent/DE2839670A1/de not_active Withdrawn
- 1978-09-14 ES ES473371A patent/ES473371A1/es not_active Expired
- 1978-09-14 GB GB7836885A patent/GB2004280B/en not_active Expired
- 1978-09-18 IE IE1876/78A patent/IE47441B1/en unknown
- 1978-09-18 JP JP11506378A patent/JPS5455594A/ja active Granted
Also Published As
Publication number | Publication date |
---|---|
US4115644A (en) | 1978-09-19 |
GB2004280B (en) | 1982-03-10 |
IE781876L (en) | 1979-03-19 |
DE2839670A1 (de) | 1979-03-29 |
FR2403345B1 (fr) | 1982-09-10 |
ES473371A1 (es) | 1979-11-01 |
JPS5455594A (en) | 1979-05-02 |
JPS6312873B2 (fr) | 1988-03-23 |
GB2004280A (en) | 1979-03-28 |
IE47441B1 (en) | 1984-03-21 |
CA1100945A (fr) | 1981-05-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |