FR2398051A1 - Nouveau fragment du glucagon et ses derives - Google Patents
Nouveau fragment du glucagon et ses derivesInfo
- Publication number
- FR2398051A1 FR2398051A1 FR7821686A FR7821686A FR2398051A1 FR 2398051 A1 FR2398051 A1 FR 2398051A1 FR 7821686 A FR7821686 A FR 7821686A FR 7821686 A FR7821686 A FR 7821686A FR 2398051 A1 FR2398051 A1 FR 2398051A1
- Authority
- FR
- France
- Prior art keywords
- glucagon
- new
- derivatives
- new fragment
- gln
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000051325 Glucagon Human genes 0.000 title abstract 4
- 108060003199 Glucagon Proteins 0.000 title abstract 4
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title abstract 4
- 229960004666 glucagon Drugs 0.000 title abstract 4
- 239000012634 fragment Substances 0.000 title abstract 3
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 abstract 1
- 108010068380 arginylarginine Proteins 0.000 abstract 1
- 235000015278 beef Nutrition 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8855677A JPS5424868A (en) | 1977-07-22 | 1977-07-22 | Novel glucagon fragment |
| JP11424277A JPS5446776A (en) | 1977-09-21 | 1977-09-21 | Novel peptide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2398051A1 true FR2398051A1 (fr) | 1979-02-16 |
| FR2398051B1 FR2398051B1 (OSRAM) | 1983-09-16 |
Family
ID=26429925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7821686A Granted FR2398051A1 (fr) | 1977-07-22 | 1978-07-21 | Nouveau fragment du glucagon et ses derives |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4206199A (OSRAM) |
| DE (2) | DE2858718C2 (OSRAM) |
| FR (1) | FR2398051A1 (OSRAM) |
| GB (1) | GB2002387B (OSRAM) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2467841A1 (fr) * | 1979-10-16 | 1981-04-30 | Toyo Jozo Kk | Fragment de glucagon et son application a la preparation d'un anticorps specifique |
| FR2602679A1 (fr) * | 1986-08-14 | 1988-02-19 | Inst Nat Sante Rech Med | Nouvelles compositions pharmaceutiques renfermant comme principe actif regulateur du mouvement des ions calcium un fragment du glucagon, et preparation d'un tel fragment |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5539702A (en) * | 1978-08-30 | 1980-03-19 | Takeda Chem Ind Ltd | Method of measuring enzyme immunity of pancreas glucagon |
| JPS56163456A (en) * | 1980-05-21 | 1981-12-16 | Otsuka Pharmaceut Co Ltd | Preparation of antigen |
| US4423034A (en) * | 1980-10-16 | 1983-12-27 | Toyo Jozo Kabushiki Kaisha | Process for the preparation of antibodies |
| US5693741A (en) | 1988-03-15 | 1997-12-02 | The Boeing Company | Liquid molding compounds |
| US4430326A (en) | 1981-12-22 | 1984-02-07 | University Patents, Inc. | Method of diminishing glucose levels resulting from endogenous glucagon |
| GB2160312B (en) * | 1984-04-13 | 1987-09-16 | South African Inventions | Adjuvant for immunisation |
| US5089390A (en) * | 1987-09-04 | 1992-02-18 | Syntex (U.S.A.) Inc. | 2-methyl-4-hexene- and 2-methyl-4-heptene-1,2-diol derivatives |
| SI1180121T1 (en) * | 1999-05-17 | 2004-04-30 | Conjuchem, Inc. | Long lasting insulinotropic peptides |
| US7601691B2 (en) | 1999-05-17 | 2009-10-13 | Conjuchem Biotechnologies Inc. | Anti-obesity agents |
| US6887470B1 (en) | 1999-09-10 | 2005-05-03 | Conjuchem, Inc. | Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components |
| US20040266673A1 (en) * | 2002-07-31 | 2004-12-30 | Peter Bakis | Long lasting natriuretic peptide derivatives |
| AU2003292685A1 (en) * | 2003-01-10 | 2004-08-10 | Niigata Tlo Corporation | Vector for gene therapy and method of quantifying target protein in mammal or cultured cells with the administration of the vector for gene theraphy |
| CA2564031A1 (en) * | 2004-04-23 | 2005-11-03 | Conjuchem Biotechnologies Inc. | Method for the purification of albumin conjugates |
| US8039432B2 (en) * | 2005-11-09 | 2011-10-18 | Conjuchem, Llc | Method of treatment of diabetes and/or obesity with reduced nausea side effect |
| EP1976876A4 (en) * | 2005-12-22 | 2010-01-13 | Conjuchem Biotechnologies Inc | PROCESS FOR PRODUCING PREFORMED ALBUMIN CONJUGATES AND THERAPEUTIC AGENT |
| US20090099074A1 (en) * | 2007-01-10 | 2009-04-16 | Conjuchem Biotechnologies Inc. | Modulating food intake |
| BR112017005110A2 (pt) | 2014-09-16 | 2018-01-23 | Regeneron Pharma | anticorpo monoclonal isolado ou fragmento de ligação ao antígeno do mesmo, molécula isolada de ácido nucleico, composição farmacêutica, e, método para diminuir níveis de glicose no sangue ou para tratar uma condição ou doença. |
| JP7173962B2 (ja) | 2016-08-30 | 2022-11-16 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | グルカゴン受容体シグナル伝達の干渉による重度のインスリン抵抗性の処置方法 |
| US20190248888A1 (en) | 2016-10-20 | 2019-08-15 | Regeneron Pharmaceuticals, Inc. | Methods of lowering blood glucose levels |
| CA3071387A1 (en) | 2017-08-22 | 2019-02-28 | Regeneron Pharmaceuticals, Inc. | Methods of treating urea cycle disorders by interfering with glucagon receptor signaling |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1232040A (OSRAM) * | 1967-08-19 | 1971-05-19 | ||
| US3979506A (en) * | 1974-10-11 | 1976-09-07 | Pierce Chemical Company | Radioactive compounds for labeling proteins |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1643345C3 (de) * | 1967-08-19 | 1975-09-25 | Hoechst Ag, 6000 Frankfurt | Glucagonderivat und Verfahren zur Herstellung von Glucagon |
-
1978
- 1978-07-14 US US05/924,553 patent/US4206199A/en not_active Expired - Lifetime
- 1978-07-21 DE DE2858718A patent/DE2858718C2/de not_active Expired
- 1978-07-21 FR FR7821686A patent/FR2398051A1/fr active Granted
- 1978-07-21 GB GB7830677A patent/GB2002387B/en not_active Expired
- 1978-07-21 DE DE19782832090 patent/DE2832090A1/de active Granted
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1232040A (OSRAM) * | 1967-08-19 | 1971-05-19 | ||
| US3979506A (en) * | 1974-10-11 | 1976-09-07 | Pierce Chemical Company | Radioactive compounds for labeling proteins |
Non-Patent Citations (1)
| Title |
|---|
| EXBK/67 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2467841A1 (fr) * | 1979-10-16 | 1981-04-30 | Toyo Jozo Kk | Fragment de glucagon et son application a la preparation d'un anticorps specifique |
| FR2602679A1 (fr) * | 1986-08-14 | 1988-02-19 | Inst Nat Sante Rech Med | Nouvelles compositions pharmaceutiques renfermant comme principe actif regulateur du mouvement des ions calcium un fragment du glucagon, et preparation d'un tel fragment |
| WO1988001174A1 (fr) * | 1986-08-14 | 1988-02-25 | Institut National De La Sante Et De La Recherche M | Un fragment de glucagon regulateur du mouvement des ions calcium |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2832090A1 (de) | 1979-02-08 |
| US4206199A (en) | 1980-06-03 |
| DE2858718C2 (OSRAM) | 1989-07-06 |
| GB2002387A (en) | 1979-02-21 |
| DE2832090C2 (OSRAM) | 1989-07-20 |
| FR2398051B1 (OSRAM) | 1983-09-16 |
| GB2002387B (en) | 1982-02-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |