FR2392027A1 - Nouveaux acides morpholine-carboxyliques, leur synthese et medicament les contenant - Google Patents

Nouveaux acides morpholine-carboxyliques, leur synthese et medicament les contenant

Info

Publication number
FR2392027A1
FR2392027A1 FR7825241A FR7825241A FR2392027A1 FR 2392027 A1 FR2392027 A1 FR 2392027A1 FR 7825241 A FR7825241 A FR 7825241A FR 7825241 A FR7825241 A FR 7825241A FR 2392027 A1 FR2392027 A1 FR 2392027A1
Authority
FR
France
Prior art keywords
carboxylic acids
synthesis
products containing
medicinal products
new morpholine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7825241A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of FR2392027A1 publication Critical patent/FR2392027A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

L'invention concerne de nouveaux acides DELTA **2,3-1,4-morpho-lino-2-carboxyliques à noyau de beta -lactame condensé en 1,6 et portant un substituant cis par rapport à l'atome c-5 en position 7 du système de noyaux condensés. Elle concerne également la synthèse totale stéréosélective de ces composés. Ces composés de l'invention ont de puissants agents antibactériens.
FR7825241A 1975-07-23 1978-08-31 Nouveaux acides morpholine-carboxyliques, leur synthese et medicament les contenant Withdrawn FR2392027A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/598,461 US4013648A (en) 1975-07-23 1975-07-23 Δ2,3 -0-2-Isocephem-4-carboxylic acid and derivatives as antibacterial agents

Publications (1)

Publication Number Publication Date
FR2392027A1 true FR2392027A1 (fr) 1978-12-22

Family

ID=24395629

Family Applications (2)

Application Number Title Priority Date Filing Date
FR7622435A Granted FR2318637A1 (fr) 1975-07-23 1976-07-22 Nouveaux acides morpholine-carboxyliques, leur synthese et medicament les contenant
FR7825241A Withdrawn FR2392027A1 (fr) 1975-07-23 1978-08-31 Nouveaux acides morpholine-carboxyliques, leur synthese et medicament les contenant

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FR7622435A Granted FR2318637A1 (fr) 1975-07-23 1976-07-22 Nouveaux acides morpholine-carboxyliques, leur synthese et medicament les contenant

Country Status (6)

Country Link
US (4) US4013648A (fr)
JP (1) JPS5214798A (fr)
CA (2) CA1095908A (fr)
DE (1) DE2633193A1 (fr)
FR (2) FR2318637A1 (fr)
GB (1) GB1540769A (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2283686A1 (fr) * 1974-09-03 1976-04-02 Bristol Myers Co Nouveaux composes heterocycliques et compositions pharmaceutiques les contenant
EP0048167A2 (fr) * 1980-09-17 1982-03-24 Eli Lilly And Company Bis-tétrazoleméthyl thiols et leur préparation
EP0503604A2 (fr) * 1991-03-11 1992-09-16 Otsuka Kagaku Kabushiki Kaisha Dérivés d'allényl-bêta-lactame et leur procédé de préparation

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4226866A (en) * 1972-11-06 1980-10-07 Merck & Co., Inc. Novel antibiotic analogues of cephalosporins
US4011216A (en) * 1975-04-11 1977-03-08 Bristol-Myers Company Δ2,3-0-2-Isocephem-4-carboxylic acid and derivatives thereof as antibacterial agents
US4171439A (en) * 1975-04-11 1979-10-16 Bristol-Myers Company Antibacterial analogs of isocephalosporins
US4108992A (en) * 1975-05-10 1978-08-22 Beecham Group Limited Cephalosporin analogues and compositions
US4171438A (en) * 1975-07-23 1979-10-16 Bristol-Myers Company 0-2-Isocephem-4-carboxylic acid derivatives as antibacterial agents
CA1085392A (fr) * 1976-03-25 1980-09-09 Masayuki Narisada Arylmalonamido-1-oxadethiacephalosporines
US4089956A (en) * 1976-09-08 1978-05-16 Smithkline Corporation 7-Acylamino-8-oxo-3-oxa-1-azabicyclo[4.2.0]octane-2-carboxylic acid derivatives and bactericidal compositions and use thereof
US4187375A (en) * 1976-09-08 1980-02-05 Smithkline Corporation Process for preparing oxazine ring compounds
US4203902A (en) * 1978-04-21 1980-05-20 Merck & Co., Inc. Process for preparing 6- and 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids
JPH02111750A (ja) * 1978-09-12 1990-04-24 Fujisawa Pharmaceut Co Ltd 酪酸誘導体
JPS5690088A (en) * 1979-11-02 1981-07-21 Meiji Seika Kaisha Ltd Novel cephalosporin analog compound
US4347355A (en) * 1980-02-21 1982-08-31 Abbott Laboratories Inhibitors of transpeptidase
WO1982001875A1 (fr) * 1980-12-01 1982-06-10 Lab Abbott Inhibiteurs de transpeptidase
US4820817A (en) * 1984-09-10 1989-04-11 Merck & Co., Inc. Process for preparing 3-substituted-6-substituted-7-oxo-1-azabicycl(3.2.0)-hept-2-ene-2-carboxylic acid
DE3687870T2 (de) * 1985-09-09 1993-08-19 Otsuka Pharma Co Ltd 2-oxa-isocephemverbindungen, sie enthaltende zusammensetzungen und verfahren zu deren herstellung.
KR960002856B1 (ko) * 1987-03-09 1996-02-27 오쓰까 세이야꾸 가부시끼가이샤 2-옥사-이소세펨 화합물, 이를 함유하는 조성물 및 이의 제조방법
DK582788A (da) * 1987-10-22 1989-04-23 Otsuka Pharma Co Ltd 2-oxa-isocephemforbindelser, midler der indeholder dem og fremgangsmaader til fremstilling af dem
JP3775820B2 (ja) * 1995-03-10 2006-05-17 大塚化学ホールディングス株式会社 ハロゲン化β−ラクタム化合物の製造法
US6527979B2 (en) * 1999-08-27 2003-03-04 Corazon Technologies, Inc. Catheter systems and methods for their use in the treatment of calcified vascular occlusions
AU5101699A (en) * 1998-07-15 2000-02-07 Corazon Technologies, Inc. Methods and devices for reducing the mineral content of vascular calcified lesions
US6290689B1 (en) * 1999-10-22 2001-09-18 Corazón Technologies, Inc. Catheter devices and methods for their use in the treatment of calcified vascular occlusions
CA2403533C (fr) * 2000-03-20 2014-12-30 Corazon Technologies, Inc. Procedes et systemes destines a ameliorer la circulation fluidique au travers d'un site vasculaire obstrue

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1914366A1 (de) * 1969-03-21 1970-10-01 Bayer Ag Arzneimittel auf Basis neuer,heterocyclischer Verbindungen
CH541576A (de) * 1970-11-03 1973-09-15 Ciba Geigy Ag Verfahren zur Herstellung thiaheterocyclischer Verbindungen
DE2219601A1 (de) 1971-04-27 1972-11-16 Astra Läkemedel AB, Södertälje (Schweden) beta-Lactame und Verfahren zu deren Herstellung
NL178005C (nl) * 1972-11-06 1986-01-02 Merck & Co Inc Werkwijze voor het bereiden van een farmaceutisch preparaat met antibacteriele werking, alsmede werkwijze ter bereiding van een cefalosporine-antibioticum.
US4012383A (en) * 1975-01-02 1977-03-15 Bristol-Myers Company Δ2,3 -1,4-morpholine-2-carboxylic acids and derivatives thereof useful in preparation of antibacteria agents
US4011216A (en) * 1975-04-11 1977-03-08 Bristol-Myers Company Δ2,3-0-2-Isocephem-4-carboxylic acid and derivatives thereof as antibacterial agents

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2283686A1 (fr) * 1974-09-03 1976-04-02 Bristol Myers Co Nouveaux composes heterocycliques et compositions pharmaceutiques les contenant
EP0048167A2 (fr) * 1980-09-17 1982-03-24 Eli Lilly And Company Bis-tétrazoleméthyl thiols et leur préparation
EP0048167A3 (fr) * 1980-09-17 1982-06-16 Eli Lilly And Company Bis-tétrazoleméthyl thiols et leur préparation
EP0503604A2 (fr) * 1991-03-11 1992-09-16 Otsuka Kagaku Kabushiki Kaisha Dérivés d'allényl-bêta-lactame et leur procédé de préparation
EP0503604A3 (en) * 1991-03-11 1992-12-02 Otsuka Kagaku Kabushiki Kaisha Allenyl beta-lactam compounds and process for preparing same

Also Published As

Publication number Publication date
US4065622A (en) 1977-12-27
FR2318637B1 (fr) 1979-03-02
JPS5214798A (en) 1977-02-03
US4068066A (en) 1978-01-10
CA1108136A (fr) 1981-09-01
US4013648A (en) 1977-03-22
FR2318637A1 (fr) 1977-02-18
CA1095908A (fr) 1981-02-17
GB1540769A (en) 1979-02-14
US4118566A (en) 1978-10-03
DE2633193A1 (de) 1977-02-10

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Legal Events

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