FR2384774B1 - - Google Patents

Info

Publication number
FR2384774B1
FR2384774B1 FR7808404A FR7808404A FR2384774B1 FR 2384774 B1 FR2384774 B1 FR 2384774B1 FR 7808404 A FR7808404 A FR 7808404A FR 7808404 A FR7808404 A FR 7808404A FR 2384774 B1 FR2384774 B1 FR 2384774B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7808404A
Other versions
FR2384774A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reckitt Benckiser Healthcare UK Ltd
Original Assignee
Reckitt and Colman Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reckitt and Colman Products Ltd filed Critical Reckitt and Colman Products Ltd
Publication of FR2384774A1 publication Critical patent/FR2384774A1/fr
Application granted granted Critical
Publication of FR2384774B1 publication Critical patent/FR2384774B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
FR7808404A 1977-03-23 1978-03-22 Nouveaux derives de la morphine et application a titre de medicament. Granted FR2384774A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB12325/77A GB1593191A (en) 1977-03-23 1977-03-23 Derivatives of morphine

Publications (2)

Publication Number Publication Date
FR2384774A1 FR2384774A1 (fr) 1978-10-20
FR2384774B1 true FR2384774B1 (fr) 1981-10-16

Family

ID=10002423

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7808404A Granted FR2384774A1 (fr) 1977-03-23 1978-03-22 Nouveaux derives de la morphine et application a titre de medicament.

Country Status (24)

Country Link
US (1) US4241066A (fr)
JP (1) JPS53119899A (fr)
AT (1) AT361139B (fr)
AU (1) AU519643B2 (fr)
BE (1) BE865183A (fr)
CA (1) CA1089456A (fr)
CH (1) CH629809A5 (fr)
CS (1) CS200542B2 (fr)
DD (1) DD133950A5 (fr)
DE (1) DE2812580A1 (fr)
DK (1) DK149858C (fr)
ES (1) ES468173A1 (fr)
FI (1) FI68236C (fr)
FR (1) FR2384774A1 (fr)
GB (1) GB1593191A (fr)
IE (1) IE46443B1 (fr)
IT (1) IT1105176B (fr)
LU (1) LU79294A1 (fr)
NL (1) NL7803083A (fr)
NZ (1) NZ186692A (fr)
PL (1) PL114723B1 (fr)
SE (1) SE436131B (fr)
SU (1) SU921467A3 (fr)
ZA (1) ZA781527B (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362870A (en) * 1980-01-16 1982-12-07 Regents Of The University Of Minnesota Selective opioid receptor alkylating agents
US4401672A (en) * 1981-10-13 1983-08-30 Regents Of The University Of Minnesota Non-addictive narcotic antitussive preparation
DE3381877D1 (de) * 1982-03-16 1990-10-18 Univ Rockefeller Verwendung von opium antagonisten zur herstellung von arzneimitteln zur behebung gastro-intestinaler stoerungen.
GB8711558D0 (en) * 1987-05-15 1987-06-17 Reckitt & Colmann Prod Ltd Derivative of codeine
EP0846694A1 (fr) 1992-01-23 1998-06-10 Toray Industries, Inc. Dérivés de morphinane et utilisation en médicine
IT1269826B (it) * 1994-05-24 1997-04-15 Paolo Minoia Uso di antagonisti degli oppiacei e di sali di calcio per la preparazione di medicamenti per il trattamento di forme patologiche endorfino-mediate
DK2368553T3 (en) 2003-04-08 2015-02-09 Progenics Pharm Inc Pharmaceutical preparation comprising methylnaltrexone
US20060063792A1 (en) * 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
CN101198612A (zh) 2005-06-16 2008-06-11 马林克罗特公司 通过1-卤代-蒂巴因或类似物制备14-羟基阿片类的合成路线
WO2007124114A2 (fr) * 2006-04-21 2007-11-01 Nektar Therapeutics Al, Corporation Réduction stéréosélective d'une morphinone
ES2493590T3 (es) 2007-03-29 2014-09-12 Wyeth Llc Antagonistas de receptores opioides periféricos y usos de los mismos
CA2682129A1 (fr) 2007-03-29 2008-10-09 Progenics Pharmaceuticals, Inc. Formes cristallines et leurs utilisations
WO2008121348A2 (fr) 2007-03-29 2008-10-09 Progenics Pharmaceuticals, Inc. Antagonistes de récepteurs opioïdes périphériques, et leurs utilisations
CA2713568C (fr) 2008-02-06 2016-09-20 Progenics Pharmaceuticals, Inc. Preparation et utilisation de (r),(r)-2,2'-bis-methylnaltrexone
AU2009300390B2 (en) 2008-09-30 2015-05-14 SpecGx LLC Processes for the production of buprenorphine with reduced impurity formation
AU2009300386B2 (en) 2008-09-30 2015-07-02 SpecGx LLC Processes for the alkylation of norbuprenorphine with reduced impurity formation
CA2676881C (fr) 2008-09-30 2017-04-25 Wyeth Antagonistes de recepteurs opioides peripheriques, et leurs utilisations
WO2015082932A1 (fr) 2013-12-05 2015-06-11 The University Of Bath Nouveaux composés opioïdes et leurs utilisations
CN110330500B (zh) * 2019-07-12 2021-11-23 宜昌人福药业有限责任公司 一种6β-羟基-7,8-二氢-吗啡衍生物的立体选择性合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3322771A (en) * 1967-05-30 Intermediates for preparing thebaine derivatives
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
IL26896A (en) * 1966-01-19 1970-11-30 Endo Lab 14 - Hydroxynormorphinins and 14 - Hydroxynormorphinones
BE788478A (fr) * 1971-09-08 1973-03-06 Bristol Myers Co Procede de preparation de composes analgesiques
US4017497A (en) * 1975-11-18 1977-04-12 Bristol-Myers Company Process for the preparation of 14-hydroxymorphinan derivatives
US4089855A (en) * 1976-04-23 1978-05-16 Cornell Research Foundation, Inc. Process for the stereoselective reduction of 6- and 8-keto morphine and morphinan derivatives with formamidinesulfinic acid and compounds obtained thereby

Also Published As

Publication number Publication date
CA1089456A (fr) 1980-11-11
AU3435778A (en) 1979-09-27
GB1593191A (en) 1981-07-15
SE7803328L (sv) 1978-09-24
BE865183A (fr) 1978-09-22
FI68236B (fi) 1985-04-30
DE2812580A1 (de) 1978-10-05
ZA781527B (en) 1979-04-25
CS200542B2 (en) 1980-09-15
ATA204278A (de) 1980-07-15
CH629809A5 (fr) 1982-05-14
IT1105176B (it) 1985-10-28
LU79294A1 (fr) 1979-10-29
IE46443B1 (en) 1983-06-15
US4241066A (en) 1980-12-23
FI68236C (fi) 1985-08-12
IT7848544A0 (it) 1978-03-22
ES468173A1 (es) 1979-09-16
SE436131B (sv) 1984-11-12
DK149858B (da) 1986-10-13
NZ186692A (en) 1980-02-21
IE780515L (en) 1978-09-23
JPH0112755B2 (fr) 1989-03-02
FR2384774A1 (fr) 1978-10-20
AU519643B2 (en) 1981-12-17
PL205498A1 (pl) 1979-04-09
JPS53119899A (en) 1978-10-19
SU921467A3 (ru) 1982-04-15
DK149858C (da) 1987-06-29
FI780882A (fi) 1978-09-24
DK130078A (da) 1978-09-24
PL114723B1 (en) 1981-02-28
DD133950A5 (de) 1979-01-31
NL7803083A (nl) 1978-09-26
AT361139B (de) 1981-02-25

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Legal Events

Date Code Title Description
ST Notification of lapse