FR2383189A1 - Reaction de deplacement du groupement acetoxy, et de ses derives, des cephalosporines par un agent nucleophile soufre - Google Patents
Reaction de deplacement du groupement acetoxy, et de ses derives, des cephalosporines par un agent nucleophile soufreInfo
- Publication number
- FR2383189A1 FR2383189A1 FR7806158A FR7806158A FR2383189A1 FR 2383189 A1 FR2383189 A1 FR 2383189A1 FR 7806158 A FR7806158 A FR 7806158A FR 7806158 A FR7806158 A FR 7806158A FR 2383189 A1 FR2383189 A1 FR 2383189A1
- Authority
- FR
- France
- Prior art keywords
- cephalosporins
- displacement
- derivatives
- reaction
- acetoxy group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 3
- 229940124587 cephalosporin Drugs 0.000 title abstract 3
- 238000006073 displacement reaction Methods 0.000 title abstract 2
- -1 ACETOXY GROUP Chemical group 0.000 title 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title 1
- HOKIDJSKDBPKTQ-GLXFQSAKSA-N cephalosporin C Chemical compound S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 title 1
- 238000006243 chemical reaction Methods 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 title 1
- 230000000269 nucleophilic effect Effects 0.000 title 1
- 229910052717 sulfur Inorganic materials 0.000 title 1
- 239000011593 sulfur Substances 0.000 title 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 2
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/36—Methylene radicals, substituted by sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77501877A | 1977-03-07 | 1977-03-07 | |
| US05/862,871 US4144391A (en) | 1977-03-07 | 1977-12-27 | Cephalosporin displacement reaction |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2383189A1 true FR2383189A1 (fr) | 1978-10-06 |
| FR2383189B1 FR2383189B1 (enrdf_load_stackoverflow) | 1981-06-26 |
Family
ID=27118982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7806158A Granted FR2383189A1 (fr) | 1977-03-07 | 1978-03-03 | Reaction de deplacement du groupement acetoxy, et de ses derives, des cephalosporines par un agent nucleophile soufre |
Country Status (30)
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5543043A (en) * | 1978-09-22 | 1980-03-26 | Sankyo Co Ltd | Preparation of 3-substituted thiomethylcephalosporin derivative |
| US4576937A (en) * | 1984-02-29 | 1986-03-18 | Smithkline Beckman Corporation | 7-D-Mandelamido-3(1-sulfomethyltetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid monosodium salt |
| GB8519606D0 (en) * | 1985-08-05 | 1985-09-11 | Fujisawa Pharmaceutical Co | 3 7-d substituted-3-cephem compounds |
| JP2503500B2 (ja) * | 1986-04-14 | 1996-06-05 | 萬有製薬株式会社 | 新規セフアロスポリン誘導体及びその製造法 |
| JPS62281881A (ja) * | 1986-09-08 | 1987-12-07 | Sankyo Co Ltd | ３−置換チオメチルセフアロスポリン誘導体の製法 |
| EP2539348A4 (en) * | 2010-02-26 | 2013-07-24 | Gary Igor Dmitrienko | CEPHALOSPORIN DERIVATIVES AS BETA LACTAMASE HEMMER AND COMPOSITIONS THEREFOR AND METHOD FOR THEIR USE |
| GB201818410D0 (en) * | 2018-11-12 | 2018-12-26 | Imperial Innovations Ltd | Compounds |
| WO2021041583A1 (en) * | 2019-08-29 | 2021-03-04 | The Regents Of The University Of California | Compounds to identify beta-lactamases, and methods of use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3641021A (en) * | 1969-04-18 | 1972-02-08 | Lilly Co Eli | 3 7-(ring-substituted) cephalosporin compounds |
| JPS5116436B1 (enrdf_load_stackoverflow) * | 1971-05-31 | 1976-05-24 | ||
| JPS5143785A (en) * | 1974-10-11 | 1976-04-14 | Yamanouchi Pharma Co Ltd | Shinsefuarosuhorinkanrenkagobutsuno goseiho |
| JPS612674B2 (enrdf_load_stackoverflow) * | 1974-06-20 | 1986-01-27 | Meiji Seika Co | |
| CA1100129A (en) * | 1974-08-02 | 1981-04-28 | William H.W. Lunn | Cephalosporin compounds |
| AU1303576A (en) * | 1975-04-21 | 1977-10-20 | Erba Carlo Spa | Cephalosporins |
-
1978
- 1978-03-02 NZ NZ186610A patent/NZ186610A/xx unknown
- 1978-03-02 GB GB8224/78A patent/GB1597036A/en not_active Expired
- 1978-03-02 CA CA298,070A patent/CA1083141A/en not_active Expired
- 1978-03-02 PT PT67732A patent/PT67732A/pt unknown
- 1978-03-02 CY CY1196A patent/CY1196A/xx unknown
- 1978-03-02 DE DE19782809058 patent/DE2809058A1/de active Granted
- 1978-03-02 AT AT0150778A patent/AT366696B/de not_active IP Right Cessation
- 1978-03-02 IL IL54181A patent/IL54181A/xx unknown
- 1978-03-03 FI FI780716A patent/FI69309C/fi not_active IP Right Cessation
- 1978-03-03 NL NL7802376A patent/NL190703C/xx not_active IP Right Cessation
- 1978-03-03 FR FR7806158A patent/FR2383189A1/fr active Granted
- 1978-03-03 GR GR55608A patent/GR68893B/el unknown
- 1978-03-03 AU AU33828/78A patent/AU515428B2/en not_active Expired
- 1978-03-03 CH CH236178A patent/CH637964A5/de not_active IP Right Cessation
- 1978-03-03 DK DK97378A patent/DK97378A/da not_active Application Discontinuation
- 1978-03-03 HU HU78EI784A patent/HU179967B/hu unknown
- 1978-03-03 PH PH20847A patent/PH14596A/en unknown
- 1978-03-06 MX MX786901U patent/MX5142E/es unknown
- 1978-03-06 IE IE453/78A patent/IE46437B1/en not_active IP Right Cessation
- 1978-03-06 YU YU00514/78A patent/YU51478A/xx unknown
- 1978-03-06 SE SE7802530A patent/SE437991B/sv not_active IP Right Cessation
- 1978-03-06 IT IT20912/78A patent/IT1093504B/it active
- 1978-03-07 PL PL1978205135A patent/PL122152B1/pl unknown
- 1978-03-07 JP JP2646878A patent/JPS53130689A/ja active Granted
- 1978-03-07 DD DD78204007A patent/DD137356A5/xx not_active IP Right Cessation
- 1978-03-07 CS CS781436A patent/CS205115B2/cs unknown
- 1978-03-07 BG BG038941A patent/BG31379A3/xx unknown
- 1978-03-07 EG EG149/78A patent/EG13454A/xx active
- 1978-03-07 ES ES467637A patent/ES467637A1/es not_active Expired
-
1983
- 1983-10-27 HK HK490/83A patent/HK49083A/en not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SE8401134D0 (sv) | Forfarande for framstellning av dihydro-cyklosporin d | |
| FR2383907A1 (fr) | Procede de preparation de derives de l'acide acetique et derives obtenus par ce procede | |
| ES507670A0 (es) | Un procedimiento de preparacion de derivados de 4-pregneno . | |
| FR2389629A1 (enrdf_load_stackoverflow) | ||
| ES8503686A1 (es) | Procedimiento de preparar derivados de penicilina. | |
| FR2398065A1 (enrdf_load_stackoverflow) | ||
| FR2383189A1 (fr) | Reaction de deplacement du groupement acetoxy, et de ses derives, des cephalosporines par un agent nucleophile soufre | |
| FR2376134A1 (fr) | Derives de 6-oxo-prostaglandines, leur procede de preparation et medicaments en contenant | |
| FR2433504A1 (fr) | Procede de preparation de derives du biphenyle | |
| BE864459A (fr) | Reaction de deplacement du groupement acetoxy, et de ses derives, des cephalosporines par un agent nucleophile soufre | |
| FR2386544A1 (fr) | Procede pour la preparation de derives d'imidazodiazepine | |
| FR2421901A1 (fr) | Procede de preparation de derives du lysergol | |
| FR2421914A1 (fr) | 3-acetoxy-9b-11b-epoxy-pregna-trienes et dienes et procede de preparation de 6a-halogeno-pregna-1,4-diene-3 ones et de 6a halogeno-pregna-4-ene-3-ones correspondants | |
| FR2381733A1 (fr) | Procede de preparation de m-bromo-a,a,a-trifluorotoluenes | |
| FR2386537A1 (fr) | Preparation de derives du furanne | |
| FR2361326A1 (fr) | Derives de cyclohexane utiles comme agents odoriferants | |
| FR2355848A1 (fr) | 7-(a-(2,3-dihydro-2-oxobenzimidazol-1-yl-carbonylamino) arylacetamido) cephalosporines | |
| SE7702130L (sv) | Forfarande for framstellning av n-(merkaptoacyl)-histidiner | |
| FR2400020A1 (fr) | Procede pour la preparation de furannones | |
| FR2383177A1 (fr) | Procede de preparation de derives de 2,1,3-thiadiazine-4-one-2,2-dioxyde | |
| FR2389631A1 (enrdf_load_stackoverflow) | ||
| FR2359133A1 (fr) | Procede de preparation de (vinyl 2,2-disubstitue)-g-butyrolactones | |
| FR2370038A1 (fr) | Derives de l'oxime de l'acide 4-(d-3-amino-3-carboxypropoxy) phenylglyoxylique, constituant la chaine laterale de l'antibiotique nocardicine | |
| FR2355031A1 (fr) | Procede de preparation de derives de pregnane | |
| FR2431497A1 (fr) | Nouveaux derives de l'acide clavulanique, utilisables comme medicament |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |