IE780453L - Preparation of cephalosporin derivatives. - Google Patents

Preparation of cephalosporin derivatives.

Info

Publication number
IE780453L
IE780453L IE780453A IE45378A IE780453L IE 780453 L IE780453 L IE 780453L IE 780453 A IE780453 A IE 780453A IE 45378 A IE45378 A IE 45378A IE 780453 L IE780453 L IE 780453L
Authority
IE
Ireland
Prior art keywords
preparation
group
cephalosporins
cephalosporin derivatives
compounds
Prior art date
Application number
IE780453A
Other versions
IE46437B1 (en
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/862,871 external-priority patent/US4144391A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of IE780453L publication Critical patent/IE780453L/en
Publication of IE46437B1 publication Critical patent/IE46437B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

3-(Thiomethyl)cephalosporins of the formula <IMAGE> in which the substituents are defined in Claim 1 are prepared by a novel process. These compounds are obtained by replacing, in a corresponding cephalosporanic acid which has an acyloxy group in the 3-position, this group by the group -SR<13> by reaction with a sulphur nucleophile in an organic solvent under virtually anhydrous conditions. The compounds obtained can be used for the control of infections in warm-blooded animals (mammals) or as an intermediate for the preparation of other cephalosporins. [GB1597036A]
IE453/78A 1977-03-07 1978-03-06 Cephalosporin synthesis IE46437B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77501877A 1977-03-07 1977-03-07
US05/862,871 US4144391A (en) 1977-03-07 1977-12-27 Cephalosporin displacement reaction

Publications (2)

Publication Number Publication Date
IE780453L true IE780453L (en) 1978-09-07
IE46437B1 IE46437B1 (en) 1983-06-15

Family

ID=27118982

Family Applications (1)

Application Number Title Priority Date Filing Date
IE453/78A IE46437B1 (en) 1977-03-07 1978-03-06 Cephalosporin synthesis

Country Status (30)

Country Link
JP (1) JPS53130689A (en)
AT (1) AT366696B (en)
AU (1) AU515428B2 (en)
BG (1) BG31379A3 (en)
CA (1) CA1083141A (en)
CH (1) CH637964A5 (en)
CS (1) CS205115B2 (en)
CY (1) CY1196A (en)
DD (1) DD137356A5 (en)
DE (1) DE2809058A1 (en)
DK (1) DK97378A (en)
EG (1) EG13454A (en)
ES (1) ES467637A1 (en)
FI (1) FI69309C (en)
FR (1) FR2383189A1 (en)
GB (1) GB1597036A (en)
GR (1) GR68893B (en)
HK (1) HK49083A (en)
HU (1) HU179967B (en)
IE (1) IE46437B1 (en)
IL (1) IL54181A (en)
IT (1) IT1093504B (en)
MX (1) MX5142E (en)
NL (1) NL190703C (en)
NZ (1) NZ186610A (en)
PH (1) PH14596A (en)
PL (1) PL122152B1 (en)
PT (1) PT67732A (en)
SE (1) SE437991B (en)
YU (1) YU51478A (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5543043A (en) * 1978-09-22 1980-03-26 Sankyo Co Ltd Preparation of 3-substituted thiomethylcephalosporin derivative
US4576937A (en) * 1984-02-29 1986-03-18 Smithkline Beckman Corporation 7-D-Mandelamido-3(1-sulfomethyltetrazol-5-yl)thiomethyl-3-cephem-4-carboxylic acid monosodium salt
GB8519606D0 (en) * 1985-08-05 1985-09-11 Fujisawa Pharmaceutical Co 3 7-d substituted-3-cephem compounds
JP2503500B2 (en) * 1986-04-14 1996-06-05 萬有製薬株式会社 Novel cefalosporin derivative and method for producing the same
JPS62281881A (en) * 1986-09-08 1987-12-07 Sankyo Co Ltd Production of 3-substituted thiomethylcephalosporin derivative
US20120329770A1 (en) * 2010-02-26 2012-12-27 Gary Igor Dmitrienko Cephalosporin derivatives useful as beta-lactamase inhibitors and compositions and methods of use thereof
GB201818410D0 (en) * 2018-11-12 2018-12-26 Imperial Innovations Ltd Compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3641021A (en) * 1969-04-18 1972-02-08 Lilly Co Eli 3 7-(ring-substituted) cephalosporin compounds
JPS5116436B1 (en) * 1971-05-31 1976-05-24
JPS5143785A (en) * 1974-10-11 1976-04-14 Yamanouchi Pharma Co Ltd Shinsefuarosuhorinkanrenkagobutsuno goseiho
JPS612674B2 (en) * 1974-06-20 1986-01-27 Meiji Seika Co
CA1100129A (en) * 1974-08-02 1981-04-28 William H.W. Lunn Cephalosporin compounds
AU1303576A (en) * 1975-04-21 1977-10-20 Erba Carlo Spa Cephalosporins

Also Published As

Publication number Publication date
CS205115B2 (en) 1981-04-30
JPS53130689A (en) 1978-11-14
FI69309B (en) 1985-09-30
DD137356A5 (en) 1979-08-29
FI69309C (en) 1986-01-10
DE2809058A1 (en) 1978-09-14
IT1093504B (en) 1985-07-19
EG13454A (en) 1981-12-31
PH14596A (en) 1981-10-02
CH637964A5 (en) 1983-08-31
IE46437B1 (en) 1983-06-15
AU3382878A (en) 1979-09-06
ATA150778A (en) 1981-09-15
HU179967B (en) 1983-01-28
ES467637A1 (en) 1980-04-01
AT366696B (en) 1982-04-26
DK97378A (en) 1978-09-08
CA1083141A (en) 1980-08-05
JPH025758B2 (en) 1990-02-05
GB1597036A (en) 1981-09-03
SE7802530L (en) 1978-09-08
IL54181A0 (en) 1978-06-15
NL7802376A (en) 1978-09-11
IL54181A (en) 1981-03-31
PT67732A (en) 1978-04-01
NZ186610A (en) 1979-11-01
FI780716A (en) 1978-09-08
PL122152B1 (en) 1982-06-30
CY1196A (en) 1983-12-31
NL190703C (en) 1994-07-01
SE437991B (en) 1985-03-25
FR2383189B1 (en) 1981-06-26
PL205135A1 (en) 1979-06-04
MX5142E (en) 1983-03-30
DE2809058C2 (en) 1989-02-09
NL190703B (en) 1994-02-01
IT7820912A0 (en) 1978-03-06
GR68893B (en) 1982-03-15
AU515428B2 (en) 1981-04-02
BG31379A3 (en) 1981-12-15
HK49083A (en) 1983-11-04
FR2383189A1 (en) 1978-10-06
YU51478A (en) 1982-10-31

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Legal Events

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MK9A Patent expired