FR2362160A1 - Preparation de b-methyldigoxine par monoetherification de la digoxine en solution dans le dimethylformamide en presence d'alumine - Google Patents

Preparation de b-methyldigoxine par monoetherification de la digoxine en solution dans le dimethylformamide en presence d'alumine

Info

Publication number
FR2362160A1
FR2362160A1 FR7725232A FR7725232A FR2362160A1 FR 2362160 A1 FR2362160 A1 FR 2362160A1 FR 7725232 A FR7725232 A FR 7725232A FR 7725232 A FR7725232 A FR 7725232A FR 2362160 A1 FR2362160 A1 FR 2362160A1
Authority
FR
France
Prior art keywords
digoxin
dimethylformamide
alumina
solution
monoetherification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7725232A
Other languages
English (en)
Other versions
FR2362160B3 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lek Pharmaceuticals dd
Original Assignee
Lek Pharmaceuticals and Chemical Co dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceuticals and Chemical Co dd filed Critical Lek Pharmaceuticals and Chemical Co dd
Publication of FR2362160A1 publication Critical patent/FR2362160A1/fr
Application granted granted Critical
Publication of FR2362160B3 publication Critical patent/FR2362160B3/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
    • C07J19/005—Glycosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Procédé de préparation de beta -méthyidigoxine par monoéthérification sélective de la digoxine en solution dans la diméthylformamide en présence d'alumine. On conduit la réaction en atmosphère inerte au moyen d'esters méthyliques d'acides soufrés organiques ou minéraux comme agents de méthylation, en présence d'hydroxyde de strontium et d'un solvant inerte, à la température ambiante et, du produit brut de méthylation préalablement purifié, on isole la beta -méthyldigoxine pure par chromatographie sur colonne de SiO2 avec un mélange d'un hydrocarbure chloré et d'un alcanol inférieur. Application : obtention du produit recherché avec un rendement accru.
FR7725232A 1976-08-20 1977-08-18 Preparation de b-methyldigoxine par monoetherification de la digoxine en solution dans le dimethylformamide en presence d'alumine Granted FR2362160A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
YU2046/76A YU39367B (en) 1976-08-20 1976-08-20 Process for preparing beta-methyl-digoxine

Publications (2)

Publication Number Publication Date
FR2362160A1 true FR2362160A1 (fr) 1978-03-17
FR2362160B3 FR2362160B3 (fr) 1980-06-20

Family

ID=25556611

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7725232A Granted FR2362160A1 (fr) 1976-08-20 1977-08-18 Preparation de b-methyldigoxine par monoetherification de la digoxine en solution dans le dimethylformamide en presence d'alumine

Country Status (10)

Country Link
US (1) US4145528A (fr)
JP (1) JPS5331653A (fr)
AT (1) AT352910B (fr)
CS (1) CS202582B2 (fr)
DE (1) DE2734401B2 (fr)
FR (1) FR2362160A1 (fr)
GB (1) GB1545647A (fr)
PL (1) PL103874B1 (fr)
SU (1) SU665807A3 (fr)
YU (1) YU39367B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0093266A1 (fr) * 1982-04-30 1983-11-09 Chemie Linz Aktiengesellschaft Procédé de préparation de bêta-méthyldigoxine

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT384227B (de) * 1982-05-05 1987-10-12 Chemie Linz Ag Verfahren zur herstellung von beta-methyldigoxin
US4603196A (en) * 1983-04-27 1986-07-29 Chemie Linz Aktiengesellschaft Process for the preparation of β-methyldigoxin
JPS6249521U (fr) * 1985-09-13 1987-03-27

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1643665B1 (de) * 1967-09-20 1971-02-18 Boehringer Mannheim Gmbh Neue Digoxinaether und Verfahren zur Herstellung derselben
BE759912A (fr) * 1969-12-05 1971-06-04 Boehringer Mannheim Gmbh Procede perfectionne de preparation d'ethers monomethyliques dedigoxin
DE1962757C3 (de) * 1969-12-15 1979-11-15 Boehringer Mannheim Gmbh, 6800 Mannheim Evomonosid-Derivate, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittel
US3753974A (en) * 1969-12-19 1973-08-21 Boehringer Mannheim Gmbh Neriifolin derivatives
DE2122209A1 (de) * 1971-05-05 1972-11-23 Dr. Karl Thomae Gmbh, 7950 Biberach Neue durch einen Steroidrest substituierte Derivate des Acrylnitrils und Verfahren zu ihrer Herstellung
JPS5021475A (fr) * 1973-06-29 1975-03-07
JPS5028957A (fr) * 1973-07-16 1975-03-24

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0093266A1 (fr) * 1982-04-30 1983-11-09 Chemie Linz Aktiengesellschaft Procédé de préparation de bêta-méthyldigoxine

Also Published As

Publication number Publication date
GB1545647A (en) 1979-05-10
SU665807A3 (ru) 1979-05-30
PL103874B1 (pl) 1979-07-31
JPS5331653A (en) 1978-03-25
DE2734401A1 (de) 1978-02-23
PL200288A1 (pl) 1978-05-08
YU204676A (en) 1982-05-31
DE2734401B2 (de) 1978-10-26
ATA559477A (de) 1979-03-15
US4145528A (en) 1979-03-20
YU39367B (en) 1984-10-31
AT352910B (de) 1979-10-10
FR2362160B3 (fr) 1980-06-20
CS202582B2 (en) 1981-01-30

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