FR2362156A1 - Substances contenant un allergene - Google Patents

Substances contenant un allergene

Info

Publication number
FR2362156A1
FR2362156A1 FR7725051A FR7725051A FR2362156A1 FR 2362156 A1 FR2362156 A1 FR 2362156A1 FR 7725051 A FR7725051 A FR 7725051A FR 7725051 A FR7725051 A FR 7725051A FR 2362156 A1 FR2362156 A1 FR 2362156A1
Authority
FR
France
Prior art keywords
substances
allergen
substances containing
immunogenic
reagins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7725051A
Other languages
English (en)
Other versions
FR2362156B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Health AB
Original Assignee
Pharmacia AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia AB filed Critical Pharmacia AB
Publication of FR2362156A1 publication Critical patent/FR2362156A1/fr
Application granted granted Critical
Publication of FR2362156B1 publication Critical patent/FR2362156B1/fr
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A61K39/36—Allergens from pollen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/805—Drug, bio-affecting and body treating compositions involving IgE or IgD
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des substances contenant des allergènes. Ces substances sont des conjugués covalents de molecules d'allergène et de polymères non immunogènes solubles dans l'eau dont le degre de conjugaison est tel qu'ils soient rendus tolérogènes et pratiquement non allergisants et non immunogènes. Les substances de l'invention sont utiles comme médicaments pour la suppression immunospécifique des allergies courantes des mammifères, y compris l'homme, dans lesquelles interviennent les réagines de la catégorie IgE.
FR7725051A 1976-08-17 1977-08-16 Substances contenant un allergene Granted FR2362156A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB34114/76A GB1578348A (en) 1976-08-17 1976-08-17 Products and a method for the therapeutic suppression of reaginic antibodies responsible for common allergic

Publications (2)

Publication Number Publication Date
FR2362156A1 true FR2362156A1 (fr) 1978-03-17
FR2362156B1 FR2362156B1 (fr) 1981-07-24

Family

ID=10361546

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7725051A Granted FR2362156A1 (fr) 1976-08-17 1977-08-16 Substances contenant un allergene

Country Status (14)

Country Link
US (1) US4261973A (fr)
JP (1) JPS5324033A (fr)
AT (1) AT359637B (fr)
AU (1) AU520366B2 (fr)
BE (1) BE857869A (fr)
CA (1) CA1091153A (fr)
CH (1) CH641681A5 (fr)
DE (1) DE2736223A1 (fr)
DK (1) DK158359C (fr)
FR (1) FR2362156A1 (fr)
GB (1) GB1578348A (fr)
NL (1) NL7709025A (fr)
NO (1) NO148281C (fr)
SE (1) SE448147B (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2382458A1 (fr) * 1976-10-12 1978-09-29 Research Corp Complexe antigene proteine pour bloquer les reactions allergiques
WO1995012413A1 (fr) * 1993-11-03 1995-05-11 O'brien, Caroline, Jane Regulation et suppression cellulaires
WO1998059064A1 (fr) * 1997-06-20 1998-12-30 Boehringer Ingelheim International Gmbh Complexes pour le transport d'acide nucleique dans des cellules eucaryotes superieures

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EP0038154B1 (fr) * 1980-04-15 1983-09-21 Beecham Group Plc Allergènes modifiés à l'aide de polysarcosines
EP0077158A1 (fr) * 1981-10-09 1983-04-20 Beecham Group Plc Allergènes modifiés
US4609546A (en) * 1982-06-24 1986-09-02 Japan Chemical Research Co., Ltd. Long-acting composition
US5370871A (en) * 1983-01-24 1994-12-06 The Johns Hopkins University Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry
US6022544A (en) 1983-01-24 2000-02-08 The John Hopkins University Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry
US5126131A (en) * 1983-01-24 1992-06-30 The Johns Hopkins University Therapeutic suppression of specific immune responses by administration of antigen-competitive conjugates.
US5447722A (en) * 1983-12-12 1995-09-05 University Of Manitoba Method for the suppression of an immune response with antigen-MPEG conjugates in nonsensitized individuals
US4880635B1 (en) * 1984-08-08 1996-07-02 Liposome Company Dehydrated liposomes
US5206344A (en) * 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
US4766106A (en) * 1985-06-26 1988-08-23 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
JP2514950B2 (ja) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
US5037969A (en) * 1986-07-03 1991-08-06 Takeda Chemical Industries, Ltd. Glycosyl derivatives and use thereof
US4894226A (en) * 1986-11-14 1990-01-16 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polyproline conjugation
SE458339B (sv) * 1987-05-25 1989-03-20 Pharmacia Ab Testremsa foer att paavisa kontaktallergi
US5116612A (en) * 1987-06-23 1992-05-26 Allergy Immuno Technologies, Inc. Immunotherapy agents for treatment of IgE mediated allergies
US6093699A (en) * 1987-07-09 2000-07-25 The University Of Manitoba Method for gene therapy involving suppression of an immune response
US4847325A (en) * 1988-01-20 1989-07-11 Cetus Corporation Conjugation of polymer to colony stimulating factor-1
US5510418A (en) * 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
US5162430A (en) * 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5306500A (en) * 1988-11-21 1994-04-26 Collagen Corporation Method of augmenting tissue with collagen-polymer conjugates
US5565519A (en) * 1988-11-21 1996-10-15 Collagen Corporation Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
US4990336A (en) * 1989-02-08 1991-02-05 Biosearch, Inc. Sustained release dosage form
US5166322A (en) * 1989-04-21 1992-11-24 Genetics Institute Cysteine added variants of interleukin-3 and chemical modifications thereof
US5358710A (en) * 1989-12-01 1994-10-25 Alec Sehon Method for the suppression of an immune response
US5126147A (en) * 1990-02-08 1992-06-30 Biosearch, Inc. Sustained release dosage form
US5595732A (en) * 1991-03-25 1997-01-21 Hoffmann-La Roche Inc. Polyethylene-protein conjugates
AU662155B2 (en) 1991-05-10 1995-08-24 Celtrix Pharmaceuticals, Inc. Targeted delivery of bone growth factors
WO1993012145A1 (fr) * 1991-12-19 1993-06-24 Baylor College Of Medicine Conjugues d'alcool polyvinylique ou de polyethyleneglycol de peptides utilises dans l'immunodepression specifique d'epitotes
US5382657A (en) * 1992-08-26 1995-01-17 Hoffmann-La Roche Inc. Peg-interferon conjugates
WO1994021281A1 (fr) * 1993-03-23 1994-09-29 Liposome Technology, Inc. Composition polymere-polypeptide et procede d'administration de ladite composition
KR100361933B1 (ko) * 1993-09-08 2003-02-14 라 졸라 파마슈티칼 컴파니 화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
US6030613A (en) * 1995-01-17 2000-02-29 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
US6086875A (en) * 1995-01-17 2000-07-11 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of immunogens
US6485726B1 (en) 1995-01-17 2002-11-26 The Brigham And Women's Hospital, Inc. Receptor specific transepithelial transport of therapeutics
DK0876165T3 (da) * 1995-12-18 2007-08-06 Angiotech Biomaterials Corp Tværbundne polymersammensætninger og fremgangsmåder til deres fremstilling
US6833408B2 (en) * 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
US7883693B2 (en) * 1995-12-18 2011-02-08 Angiodevice International Gmbh Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
WO1998051341A1 (fr) * 1997-05-14 1998-11-19 The University Of Manitoba CONJUGUES ANTIGENE-mPEG SUPPRIMANT DES REPONSES IMMUNITAIRES HUMORALES ET A MEDIATION CELLULAIRE
WO1999022762A1 (fr) 1997-10-30 1999-05-14 C.B.F. Leti, S.A. Fragments tolerogenes d'allergenes naturels
AU764144B2 (en) 1998-08-28 2003-08-14 Gryphon Therapeutics, Inc. Polyamide chains of precise length, methods to manufacture them and their conjugates
US6458953B1 (en) * 1998-12-09 2002-10-01 La Jolla Pharmaceutical Company Valency platform molecules comprising carbamate linkages
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WO2001093914A2 (fr) 2000-06-08 2001-12-13 La Jolla Pharmaceutical Company Molecules a plate-forme polyvalentes comprenant un poly(ethylene oxyde) de poids moleculaire eleve
DE10112825A1 (de) * 2001-03-16 2002-10-02 Fresenius Kabi De Gmbh HESylierung von Wirkstoffen in wässriger Lösung
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DE10209821A1 (de) * 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Kopplung von Proteinen an ein modifiziertes Polysaccharid
BR0308710A (pt) * 2002-03-26 2007-01-09 Biosynexus Inc conjugados poliméricos antimicrobianos
DE10242076A1 (de) * 2002-09-11 2004-03-25 Fresenius Kabi Deutschland Gmbh HAS-Allergen-Konjugate
IL166506A0 (en) * 2002-09-11 2006-01-15 Fresenius Kabi De Gmbh Hasylated polypeptides especially hasylated erythropoietin
US8129330B2 (en) * 2002-09-30 2012-03-06 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
US20040062748A1 (en) * 2002-09-30 2004-04-01 Mountain View Pharmaceuticals, Inc. Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
ES2314238T3 (es) * 2002-10-08 2009-03-16 Fresenius Kabi Deutschland Gmbh Conjugados de oligosacaridos farmaceuticamente activos.
TWI364295B (en) * 2002-12-26 2012-05-21 Mountain View Pharmaceuticals Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity
AU2003303635B2 (en) * 2002-12-26 2009-07-23 Mountain View Pharmaceuticals, Inc. Polymer conjugates of interferon-beta with enhanced biological potency
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US20080274948A1 (en) * 2003-08-08 2008-11-06 Fresenius Kabi Deutschland Gmbh Conjugates of Hydroxyalkyl Starch and G-Csf
US20080206182A1 (en) * 2003-08-08 2008-08-28 Fresenius Kabi Deutschland Gmbh Conjugates of a Polymer and a Protein Linked by an Oxime Group
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EP2070951A1 (fr) * 2007-12-14 2009-06-17 Fresenius Kabi Deutschland GmbH Procédé de production d'un dérivé hydroxyalkyle de l'amidon avec deux liens
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WO2023194333A1 (fr) 2022-04-04 2023-10-12 Swiftpharma Bv Protéines de collagène recombinantes renforcées par de la soie d'araignée produites dans des plantes et leur utilisation

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FR1296529A (fr) * 1960-03-24 1962-06-22 Leurquin Lab Procédé de solubilisation de la terpine dans l'eau
GB1016606A (en) * 1961-11-08 1966-01-12 Ethan Allan Brown Therapeutic compositions for injection
US3487046A (en) * 1961-04-24 1969-12-30 Georges Negrevergne Novel pyrazolidone derivatives substituted on the 4 position with a phenolhcho-polyamine ion exchange resin
FR2346065A1 (fr) * 1976-03-29 1977-10-28 Muratov Rustem Dispositif pour le filage des pieces creuses

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FR1296529A (fr) * 1960-03-24 1962-06-22 Leurquin Lab Procédé de solubilisation de la terpine dans l'eau
US3487046A (en) * 1961-04-24 1969-12-30 Georges Negrevergne Novel pyrazolidone derivatives substituted on the 4 position with a phenolhcho-polyamine ion exchange resin
GB1016606A (en) * 1961-11-08 1966-01-12 Ethan Allan Brown Therapeutic compositions for injection
FR2346065A1 (fr) * 1976-03-29 1977-10-28 Muratov Rustem Dispositif pour le filage des pieces creuses

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2382458A1 (fr) * 1976-10-12 1978-09-29 Research Corp Complexe antigene proteine pour bloquer les reactions allergiques
FR2382460A1 (fr) * 1976-10-12 1978-09-29 Research Corp Complexe antigene proteine pour bloquer les reactions allergiques
WO1995012413A1 (fr) * 1993-11-03 1995-05-11 O'brien, Caroline, Jane Regulation et suppression cellulaires
US6383489B1 (en) 1993-11-03 2002-05-07 Alec Sehon Inactivation of granulocytes in the treatment of established allergic responses
WO1998059064A1 (fr) * 1997-06-20 1998-12-30 Boehringer Ingelheim International Gmbh Complexes pour le transport d'acide nucleique dans des cellules eucaryotes superieures

Also Published As

Publication number Publication date
AU520366B2 (en) 1982-01-28
JPS5324033A (en) 1978-03-06
GB1578348A (en) 1980-11-05
BE857869A (fr) 1978-02-17
AU2794277A (en) 1979-02-22
NO148281C (no) 1983-09-14
CH641681A5 (de) 1984-03-15
DE2736223C2 (fr) 1987-04-23
DE2736223A1 (de) 1978-02-23
CA1091153A (fr) 1980-12-09
JPH0116812B2 (fr) 1989-03-27
SE7709233L (sv) 1978-02-18
ATA592477A (de) 1980-04-15
NO772848L (no) 1977-02-20
AT359637B (de) 1980-11-25
DK158359C (da) 1990-10-01
US4261973A (en) 1981-04-14
DK364277A (da) 1978-02-18
FR2362156B1 (fr) 1981-07-24
NO148281B (no) 1983-06-06
DK158359B (da) 1990-05-07
NL7709025A (nl) 1978-02-21
SE448147B (sv) 1987-01-26

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