FR2359823A1 - 2-benzyl-pyrrolidines, procede pour leur preparation et medicament contenant ces composes - Google Patents

2-benzyl-pyrrolidines, procede pour leur preparation et medicament contenant ces composes

Info

Publication number
FR2359823A1
FR2359823A1 FR7723030A FR7723030A FR2359823A1 FR 2359823 A1 FR2359823 A1 FR 2359823A1 FR 7723030 A FR7723030 A FR 7723030A FR 7723030 A FR7723030 A FR 7723030A FR 2359823 A1 FR2359823 A1 FR 2359823A1
Authority
FR
France
Prior art keywords
pyrrolidines
benzyl
compounds
preparation
product containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7723030A
Other languages
English (en)
Other versions
FR2359823B1 (fr
Inventor
Klaus Eistetter
Heinz Gunter Menge
Hartmann Schaeffer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda GmbH
Original Assignee
Byk Gulden Lomberg Chemische Fabrik GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chemische Fabrik GmbH filed Critical Byk Gulden Lomberg Chemische Fabrik GmbH
Publication of FR2359823A1 publication Critical patent/FR2359823A1/fr
Application granted granted Critical
Publication of FR2359823B1 publication Critical patent/FR2359823B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

L'invention concerne des 2-benzyl-pyrrolidines substituées ainsi que les dérivés alkylpyrrolidinium quaternaires correspondants et leurs sels d'addition avec les acides. Ces composés peuvent être préparés par réduction de 2-benzyl-pyrrolidines correspondantes, par introduction d'une fonction chimique dans des 2-benzyl-pyrrolidines correspondantes ou réduction de N-acyl-2-benzyl-pyrrolidines. Ces composés sont utilisés comme médicaments agissant sur le système nerveux central, la tension et les états douloureux des humains et des animaux à sang chaud.
FR7723030A 1976-07-28 1977-07-27 2-benzyl-pyrrolidines, procede pour leur preparation et medicament contenant ces composes Granted FR2359823A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU75478A LU75478A1 (fr) 1976-07-28 1976-07-28

Publications (2)

Publication Number Publication Date
FR2359823A1 true FR2359823A1 (fr) 1978-02-24
FR2359823B1 FR2359823B1 (fr) 1980-11-21

Family

ID=19728311

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7723030A Granted FR2359823A1 (fr) 1976-07-28 1977-07-27 2-benzyl-pyrrolidines, procede pour leur preparation et medicament contenant ces composes

Country Status (23)

Country Link
US (1) US4279918A (fr)
JP (1) JPS5315367A (fr)
AT (1) AT373580B (fr)
AU (1) AU509015B2 (fr)
BE (1) BE857289A (fr)
CA (1) CA1104572A (fr)
CH (1) CH639368A5 (fr)
DE (2) DE2733817A1 (fr)
DK (1) DK339677A (fr)
ES (1) ES461077A1 (fr)
FR (1) FR2359823A1 (fr)
GB (1) GB1566761A (fr)
GR (1) GR61367B (fr)
IE (1) IE45320B1 (fr)
IL (1) IL52611A (fr)
IT (1) IT1085949B (fr)
LU (1) LU75478A1 (fr)
NL (1) NL7708306A (fr)
NZ (1) NZ184755A (fr)
PT (1) PT66858B (fr)
SE (1) SE429338B (fr)
YU (1) YU184277A (fr)
ZA (1) ZA774553B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU518986B2 (en) * 1977-10-11 1981-10-29 Takeda Chemical Industries Ltd. Lactams
DE2952382A1 (de) * 1979-12-24 1981-07-16 Basf Ag, 6700 Ludwigshafen Phenylpropylammoniumsalze, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
US4826869A (en) * 1988-02-19 1989-05-02 Syntex (U.S.A.) Inc. N-(lower alkyl)-2-(3'ureidobenzyl)pyrrolidines
US5135944A (en) * 1989-06-21 1992-08-04 Syntex (U.S.A.) Inc. Bis(benzylpyrrolidine) derivatives useful for treating congestive heart failure and acute renal failure
US5100912A (en) * 1990-05-14 1992-03-31 Syntex (U.S.A.) Inc. Bis(benzylpyrrolidine) derivatives as dopamine agonists
EP0404115A1 (fr) * 1989-06-21 1990-12-27 Syntex (U.S.A.) Inc. Dérivés de bis(benzylpyrrolidine) à titre d'agonistes de la dopamine
US5093355A (en) * 1989-10-30 1992-03-03 Syntex (U.S.A.) Inc. Benzylpyrrolidine derivatives as dopamine agonists
US5130432A (en) * 1990-12-21 1992-07-14 Syntex (U.S.A.) Inc. Process for preparing cyclic amines and intermediate products thereof
EP0562185A1 (fr) * 1992-03-17 1993-09-29 Council of Scientific and Industrial Research 3-(Arylméthyl)-1-(3'-diéthylaminopropyl)-pyrrolidines et procédé pour leur préparation
US5248690A (en) * 1992-07-07 1993-09-28 R. J. Reynolds Tobacco Company Method for treatment of neurodegenerative diseases
US7208517B1 (en) * 1994-08-19 2007-04-24 Abbott Labortories Endothelin antagonists
CN104292143A (zh) * 2014-08-17 2015-01-21 湖南华腾制药有限公司 一种2-(4-溴苄基)吡咯烷的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1049380B (de) * 1959-01-29 Bergisch Gladbach Adolf Christian Josef Opfermann Verfahren zur Herstellung von a-substituierten Pyrrolidinen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR86099E (fr) 1963-08-20 1965-12-03 Pechiney Saint Gobain Dérivés de la delta1-pyrroline
DE1470387A1 (de) 1963-12-20 1969-05-29 Union Carbide Corp Verfahren zur Herstellung von substituierten Pyrrolderivaten
GB1168797A (en) 1965-12-09 1969-10-29 Nat Res Dev Cyclopropane Carboxylic Acid Derivatives and their use as Insecticides
US3635982A (en) * 1969-04-08 1972-01-18 American Home Prod Amino-substituted-quinoxalinyloxazolidines and -oxazines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1049380B (de) * 1959-01-29 Bergisch Gladbach Adolf Christian Josef Opfermann Verfahren zur Herstellung von a-substituierten Pyrrolidinen

Also Published As

Publication number Publication date
DE2733817A1 (de) 1978-02-02
IL52611A (en) 1981-10-30
YU184277A (en) 1983-02-28
SE7708621L (sv) 1978-01-29
FR2359823B1 (fr) 1980-11-21
ES461077A1 (es) 1978-12-01
US4279918A (en) 1981-07-21
NL7708306A (nl) 1978-01-31
LU75478A1 (fr) 1978-02-08
IT1085949B (it) 1985-05-28
CA1104572A (fr) 1981-07-07
CH639368A5 (de) 1983-11-15
GB1566761A (en) 1980-05-08
IE45320L (en) 1978-01-28
PT66858B (de) 1979-03-13
AU509015B2 (en) 1980-04-17
NZ184755A (en) 1979-12-11
AT373580B (de) 1984-02-10
BE857289A (fr) 1978-01-30
JPS5315367A (en) 1978-02-13
ZA774553B (en) 1978-06-28
IL52611A0 (en) 1977-10-31
PT66858A (de) 1977-08-01
IE45320B1 (en) 1982-07-28
DE2733753A1 (de) 1978-02-02
AU2736577A (en) 1979-02-01
ATA548177A (de) 1983-06-15
DK339677A (da) 1978-01-29
GR61367B (en) 1978-10-30
SE429338B (sv) 1983-08-29

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ST Notification of lapse