SE429338B - Forfarande for framstellning av substituerade 2-bensylpyrrolidiner med terapeutisk verkan - Google Patents
Forfarande for framstellning av substituerade 2-bensylpyrrolidiner med terapeutisk verkanInfo
- Publication number
- SE429338B SE429338B SE7708621A SE7708621A SE429338B SE 429338 B SE429338 B SE 429338B SE 7708621 A SE7708621 A SE 7708621A SE 7708621 A SE7708621 A SE 7708621A SE 429338 B SE429338 B SE 429338B
- Authority
- SE
- Sweden
- Prior art keywords
- benzylpyrrolidines
- substituted
- procedure
- preparation
- therapeutic effect
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU75478A LU75478A1 (xx) | 1976-07-28 | 1976-07-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7708621L SE7708621L (sv) | 1978-01-29 |
| SE429338B true SE429338B (sv) | 1983-08-29 |
Family
ID=19728311
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7708621A SE429338B (sv) | 1976-07-28 | 1977-07-27 | Forfarande for framstellning av substituerade 2-bensylpyrrolidiner med terapeutisk verkan |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4279918A (xx) |
| JP (1) | JPS5315367A (xx) |
| AT (1) | AT373580B (xx) |
| AU (1) | AU509015B2 (xx) |
| BE (1) | BE857289A (xx) |
| CA (1) | CA1104572A (xx) |
| CH (1) | CH639368A5 (xx) |
| DE (2) | DE2733817A1 (xx) |
| DK (1) | DK339677A (xx) |
| ES (1) | ES461077A1 (xx) |
| FR (1) | FR2359823A1 (xx) |
| GB (1) | GB1566761A (xx) |
| GR (1) | GR61367B (xx) |
| IE (1) | IE45320B1 (xx) |
| IL (1) | IL52611A (xx) |
| IT (1) | IT1085949B (xx) |
| LU (1) | LU75478A1 (xx) |
| NL (1) | NL7708306A (xx) |
| NZ (1) | NZ184755A (xx) |
| PT (1) | PT66858B (xx) |
| SE (1) | SE429338B (xx) |
| YU (1) | YU184277A (xx) |
| ZA (1) | ZA774553B (xx) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU518986B2 (en) * | 1977-10-11 | 1981-10-29 | Takeda Chemical Industries Ltd. | Lactams |
| DE2952382A1 (de) * | 1979-12-24 | 1981-07-16 | Basf Ag, 6700 Ludwigshafen | Phenylpropylammoniumsalze, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel |
| US4826869A (en) * | 1988-02-19 | 1989-05-02 | Syntex (U.S.A.) Inc. | N-(lower alkyl)-2-(3'ureidobenzyl)pyrrolidines |
| US5135944A (en) * | 1989-06-21 | 1992-08-04 | Syntex (U.S.A.) Inc. | Bis(benzylpyrrolidine) derivatives useful for treating congestive heart failure and acute renal failure |
| US5100912A (en) * | 1990-05-14 | 1992-03-31 | Syntex (U.S.A.) Inc. | Bis(benzylpyrrolidine) derivatives as dopamine agonists |
| EP0404115A1 (en) * | 1989-06-21 | 1990-12-27 | Syntex (U.S.A.) Inc. | Bis(benzylpyrrolidine)Derivatives as dopamine agonists |
| US5093355A (en) * | 1989-10-30 | 1992-03-03 | Syntex (U.S.A.) Inc. | Benzylpyrrolidine derivatives as dopamine agonists |
| US5130432A (en) * | 1990-12-21 | 1992-07-14 | Syntex (U.S.A.) Inc. | Process for preparing cyclic amines and intermediate products thereof |
| EP0562185A1 (en) * | 1992-03-17 | 1993-09-29 | Council of Scientific and Industrial Research | 3-(Arylmethyl)-1-(3'-diethylaminopropyl) pyrrolidines and process of preparation thereof |
| US5248690A (en) * | 1992-07-07 | 1993-09-28 | R. J. Reynolds Tobacco Company | Method for treatment of neurodegenerative diseases |
| US7208517B1 (en) * | 1994-08-19 | 2007-04-24 | Abbott Labortories | Endothelin antagonists |
| CN104292143A (zh) * | 2014-08-17 | 2015-01-21 | 湖南华腾制药有限公司 | 一种2-(4-溴苄基)吡咯烷的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1049380B (de) * | 1959-01-29 | Bergisch Gladbach Adolf Christian Josef Opfermann | Verfahren zur Herstellung von a-substituierten Pyrrolidinen | |
| FR86099E (fr) | 1963-08-20 | 1965-12-03 | Pechiney Saint Gobain | Dérivés de la delta1-pyrroline |
| DE1470387A1 (de) | 1963-12-20 | 1969-05-29 | Union Carbide Corp | Verfahren zur Herstellung von substituierten Pyrrolderivaten |
| GB1168797A (en) | 1965-12-09 | 1969-10-29 | Nat Res Dev | Cyclopropane Carboxylic Acid Derivatives and their use as Insecticides |
| US3635982A (en) * | 1969-04-08 | 1972-01-18 | American Home Prod | Amino-substituted-quinoxalinyloxazolidines and -oxazines |
-
1976
- 1976-07-28 LU LU75478A patent/LU75478A1/xx unknown
-
1977
- 1977-07-26 YU YU01842/77A patent/YU184277A/xx unknown
- 1977-07-26 GB GB31267/77A patent/GB1566761A/en not_active Expired
- 1977-07-27 NL NL7708306A patent/NL7708306A/xx not_active Application Discontinuation
- 1977-07-27 ZA ZA00774553A patent/ZA774553B/xx unknown
- 1977-07-27 ES ES461077A patent/ES461077A1/es not_active Expired
- 1977-07-27 DE DE19772733817 patent/DE2733817A1/de not_active Ceased
- 1977-07-27 DE DE19772733753 patent/DE2733753A1/de not_active Withdrawn
- 1977-07-27 FR FR7723030A patent/FR2359823A1/fr active Granted
- 1977-07-27 CH CH929477A patent/CH639368A5/de not_active IP Right Cessation
- 1977-07-27 PT PT66858A patent/PT66858B/pt unknown
- 1977-07-27 DK DK339677A patent/DK339677A/da not_active Application Discontinuation
- 1977-07-27 CA CA283,611A patent/CA1104572A/en not_active Expired
- 1977-07-27 IL IL52611A patent/IL52611A/xx unknown
- 1977-07-27 IE IE1567/77A patent/IE45320B1/en unknown
- 1977-07-27 US US05/819,460 patent/US4279918A/en not_active Expired - Lifetime
- 1977-07-27 NZ NZ184755A patent/NZ184755A/xx unknown
- 1977-07-27 GR GR54055A patent/GR61367B/el unknown
- 1977-07-27 AT AT0548177A patent/AT373580B/de active
- 1977-07-27 AU AU27365/77A patent/AU509015B2/en not_active Expired
- 1977-07-27 IT IT26204/77A patent/IT1085949B/it active
- 1977-07-27 JP JP8939377A patent/JPS5315367A/ja active Pending
- 1977-07-27 SE SE7708621A patent/SE429338B/xx unknown
- 1977-07-28 BE BE6046095A patent/BE857289A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE2733817A1 (de) | 1978-02-02 |
| IL52611A (en) | 1981-10-30 |
| YU184277A (en) | 1983-02-28 |
| FR2359823A1 (fr) | 1978-02-24 |
| SE7708621L (sv) | 1978-01-29 |
| FR2359823B1 (xx) | 1980-11-21 |
| ES461077A1 (es) | 1978-12-01 |
| US4279918A (en) | 1981-07-21 |
| NL7708306A (nl) | 1978-01-31 |
| LU75478A1 (xx) | 1978-02-08 |
| IT1085949B (it) | 1985-05-28 |
| CA1104572A (en) | 1981-07-07 |
| CH639368A5 (de) | 1983-11-15 |
| GB1566761A (en) | 1980-05-08 |
| IE45320L (en) | 1978-01-28 |
| PT66858B (de) | 1979-03-13 |
| AU509015B2 (en) | 1980-04-17 |
| NZ184755A (en) | 1979-12-11 |
| AT373580B (de) | 1984-02-10 |
| BE857289A (fr) | 1978-01-30 |
| JPS5315367A (en) | 1978-02-13 |
| ZA774553B (en) | 1978-06-28 |
| IL52611A0 (en) | 1977-10-31 |
| PT66858A (de) | 1977-08-01 |
| IE45320B1 (en) | 1982-07-28 |
| DE2733753A1 (de) | 1978-02-02 |
| AU2736577A (en) | 1979-02-01 |
| ATA548177A (de) | 1983-06-15 |
| DK339677A (da) | 1978-01-29 |
| GR61367B (en) | 1978-10-30 |
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