BE857289A - 2-benzyl-pyrrolidines, procede pour leur preparation et medicaments contenant ces composes - Google Patents

2-benzyl-pyrrolidines, procede pour leur preparation et medicaments contenant ces composes

Info

Publication number
BE857289A
BE857289A BE6046095A BE6046095A BE857289A BE 857289 A BE857289 A BE 857289A BE 6046095 A BE6046095 A BE 6046095A BE 6046095 A BE6046095 A BE 6046095A BE 857289 A BE857289 A BE 857289A
Authority
BE
Belgium
Prior art keywords
pyrrolidines
benzyl
compounds
preparation
products containing
Prior art date
Application number
BE6046095A
Other languages
English (en)
Inventor
K Eistetter
H Schaefer
H G Menge
Original Assignee
Byk Gulden Lomberg Chem Fab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab
Publication of BE857289A publication Critical patent/BE857289A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
BE6046095A 1976-07-28 1977-07-28 2-benzyl-pyrrolidines, procede pour leur preparation et medicaments contenant ces composes BE857289A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU75478A LU75478A1 (fr) 1976-07-28 1976-07-28

Publications (1)

Publication Number Publication Date
BE857289A true BE857289A (fr) 1978-01-30

Family

ID=19728311

Family Applications (1)

Application Number Title Priority Date Filing Date
BE6046095A BE857289A (fr) 1976-07-28 1977-07-28 2-benzyl-pyrrolidines, procede pour leur preparation et medicaments contenant ces composes

Country Status (23)

Country Link
US (1) US4279918A (fr)
JP (1) JPS5315367A (fr)
AT (1) AT373580B (fr)
AU (1) AU509015B2 (fr)
BE (1) BE857289A (fr)
CA (1) CA1104572A (fr)
CH (1) CH639368A5 (fr)
DE (2) DE2733817A1 (fr)
DK (1) DK339677A (fr)
ES (1) ES461077A1 (fr)
FR (1) FR2359823A1 (fr)
GB (1) GB1566761A (fr)
GR (1) GR61367B (fr)
IE (1) IE45320B1 (fr)
IL (1) IL52611A (fr)
IT (1) IT1085949B (fr)
LU (1) LU75478A1 (fr)
NL (1) NL7708306A (fr)
NZ (1) NZ184755A (fr)
PT (1) PT66858B (fr)
SE (1) SE429338B (fr)
YU (1) YU184277A (fr)
ZA (1) ZA774553B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU518986B2 (en) * 1977-10-11 1981-10-29 Takeda Chemical Industries Ltd. Lactams
DE2952382A1 (de) * 1979-12-24 1981-07-16 Basf Ag, 6700 Ludwigshafen Phenylpropylammoniumsalze, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
US4826869A (en) * 1988-02-19 1989-05-02 Syntex (U.S.A.) Inc. N-(lower alkyl)-2-(3'ureidobenzyl)pyrrolidines
KR910000641A (ko) * 1989-06-21 1991-01-29 허비히 폰 모르츠 도파민 효능제 비스 (벤질피롤리딘) 유도체
US5135944A (en) * 1989-06-21 1992-08-04 Syntex (U.S.A.) Inc. Bis(benzylpyrrolidine) derivatives useful for treating congestive heart failure and acute renal failure
US5100912A (en) * 1990-05-14 1992-03-31 Syntex (U.S.A.) Inc. Bis(benzylpyrrolidine) derivatives as dopamine agonists
US5093355A (en) * 1989-10-30 1992-03-03 Syntex (U.S.A.) Inc. Benzylpyrrolidine derivatives as dopamine agonists
US5130432A (en) * 1990-12-21 1992-07-14 Syntex (U.S.A.) Inc. Process for preparing cyclic amines and intermediate products thereof
EP0562185A1 (fr) * 1992-03-17 1993-09-29 Council of Scientific and Industrial Research 3-(Arylméthyl)-1-(3'-diéthylaminopropyl)-pyrrolidines et procédé pour leur préparation
US5248690A (en) * 1992-07-07 1993-09-28 R. J. Reynolds Tobacco Company Method for treatment of neurodegenerative diseases
US7208517B1 (en) * 1994-08-19 2007-04-24 Abbott Labortories Endothelin antagonists
CN104292143A (zh) * 2014-08-17 2015-01-21 湖南华腾制药有限公司 一种2-(4-溴苄基)吡咯烷的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1049380B (de) * 1959-01-29 Bergisch Gladbach Adolf Christian Josef Opfermann Verfahren zur Herstellung von a-substituierten Pyrrolidinen
FR86099E (fr) 1963-08-20 1965-12-03 Pechiney Saint Gobain Dérivés de la delta1-pyrroline
DE1470387A1 (de) 1963-12-20 1969-05-29 Union Carbide Corp Verfahren zur Herstellung von substituierten Pyrrolderivaten
GB1168797A (en) 1965-12-09 1969-10-29 Nat Res Dev Cyclopropane Carboxylic Acid Derivatives and their use as Insecticides
US3647790A (en) * 1969-04-08 1972-03-07 American Home Prod Ouinoxalinyl-oxazolidines and -oxazines

Also Published As

Publication number Publication date
FR2359823A1 (fr) 1978-02-24
IE45320B1 (en) 1982-07-28
CA1104572A (fr) 1981-07-07
GB1566761A (en) 1980-05-08
SE429338B (sv) 1983-08-29
YU184277A (en) 1983-02-28
ES461077A1 (es) 1978-12-01
NZ184755A (en) 1979-12-11
CH639368A5 (de) 1983-11-15
PT66858B (de) 1979-03-13
JPS5315367A (en) 1978-02-13
LU75478A1 (fr) 1978-02-08
AU2736577A (en) 1979-02-01
IT1085949B (it) 1985-05-28
FR2359823B1 (fr) 1980-11-21
DE2733753A1 (de) 1978-02-02
IL52611A0 (en) 1977-10-31
AT373580B (de) 1984-02-10
DE2733817A1 (de) 1978-02-02
IE45320L (en) 1978-01-28
US4279918A (en) 1981-07-21
GR61367B (en) 1978-10-30
ZA774553B (en) 1978-06-28
ATA548177A (de) 1983-06-15
SE7708621L (sv) 1978-01-29
AU509015B2 (en) 1980-04-17
PT66858A (de) 1977-08-01
IL52611A (en) 1981-10-30
NL7708306A (nl) 1978-01-31
DK339677A (da) 1978-01-29

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: BYK GULDEN LOMBERG CHEMISCHE FABRIK G.M.B.H.

Effective date: 19840728