FR2334357A1 - Nouvelles imidazo (1,2-a) pyridines substituees et leur procede de preparation - Google Patents

Nouvelles imidazo (1,2-a) pyridines substituees et leur procede de preparation

Info

Publication number
FR2334357A1
FR2334357A1 FR7636779A FR7636779A FR2334357A1 FR 2334357 A1 FR2334357 A1 FR 2334357A1 FR 7636779 A FR7636779 A FR 7636779A FR 7636779 A FR7636779 A FR 7636779A FR 2334357 A1 FR2334357 A1 FR 2334357A1
Authority
FR
France
Prior art keywords
preparation process
substituted pyridines
new imidazo
imidazo
new
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7636779A
Other languages
English (en)
Other versions
FR2334357B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of FR2334357A1 publication Critical patent/FR2334357A1/fr
Application granted granted Critical
Publication of FR2334357B1 publication Critical patent/FR2334357B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/42—Radicals substituted by singly-bound nitrogen atoms having hetero atoms attached to the substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/53—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/86—Hydrazides; Thio or imino analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
FR7636779A 1975-12-09 1976-12-07 Nouvelles imidazo (1,2-a) pyridines substituees et leur procede de preparation Granted FR2334357A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US63903475A 1975-12-09 1975-12-09

Publications (2)

Publication Number Publication Date
FR2334357A1 true FR2334357A1 (fr) 1977-07-08
FR2334357B1 FR2334357B1 (fr) 1982-10-15

Family

ID=24562456

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7636779A Granted FR2334357A1 (fr) 1975-12-09 1976-12-07 Nouvelles imidazo (1,2-a) pyridines substituees et leur procede de preparation

Country Status (25)

Country Link
US (1) US4096264A (fr)
JP (1) JPS5273896A (fr)
AR (1) AR222960A1 (fr)
AT (1) AT361475B (fr)
AU (1) AU505045B2 (fr)
BE (1) BE849123A (fr)
CA (1) CA1084930A (fr)
CH (1) CH626362A5 (fr)
DE (1) DE2655681A1 (fr)
DK (1) DK529276A (fr)
ES (1) ES453947A1 (fr)
FI (1) FI763343A (fr)
FR (1) FR2334357A1 (fr)
GB (1) GB1524589A (fr)
GR (1) GR62009B (fr)
IL (1) IL51024A (fr)
NL (1) NL7613160A (fr)
NO (1) NO764025L (fr)
NZ (1) NZ182756A (fr)
OA (1) OA05506A (fr)
PH (1) PH12259A (fr)
PL (1) PL103751B1 (fr)
PT (1) PT65915B (fr)
SE (1) SE430504B (fr)
ZA (1) ZA767331B (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2385715A1 (fr) * 1977-03-28 1978-10-27 Merck & Co Inc Nouvelles imidazo (1,2-a)pyridines substituees heterocycliques utiles comme medicaments
WO2008150015A1 (fr) * 2007-06-05 2008-12-11 Takeda Pharmaceutical Company Limited Composés hétérobicycliques comme inhibiteurs de kinase

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4154835A (en) * 1977-10-12 1979-05-15 Merck & Co., Inc. Anthelmintic imidazo [1,2-a] pyridines
US4250174A (en) * 1979-05-02 1981-02-10 Merck & Co., Inc. 3-Substituted imidazo [1,2-A] pyridines
US4221796A (en) * 1979-09-19 1980-09-09 E. R. Squibb & Sons, Inc. Substituted imidazolo-pyridines and method
ZA81219B (en) * 1980-01-23 1982-01-27 Schering Corp Imidazo (1,2-a) pyridines ,process for their preparation and pharmaceutical compositions containing them
US4507481A (en) * 1983-07-29 1985-03-26 Pennwalt Corporation Pyrrolo[1,2-a]imidazoles and imidazo[1,2-a]pyridines
IT1173196B (it) * 1984-02-02 1987-06-18 Bellon Roger Schoum Rbs Pharma Composti imidazopiridinici farmacologicamente attivi
US5214138A (en) * 1989-12-20 1993-05-25 Case Western Reserve University Imidazopyridinium compound and processes for isolating, identifying, and chemically synthesizing same
EP0471236B1 (fr) * 1990-07-30 1995-03-15 Takeda Chemical Industries, Ltd. Dérivés de l'imidazopyridine et leur application
WO1999059587A1 (fr) * 1998-05-20 1999-11-25 Eli Lilly And Company Composes anti-viraux
US6358971B1 (en) 1998-05-20 2002-03-19 Eli Lilly And Company Anti-viral compounds
DE10117184A1 (de) * 2001-04-05 2002-10-17 Gruenenthal Gmbh Substituierte Imidazol[1,2-a]-pyridin-3-yl-amid- und -aminverbindungen
US7563788B2 (en) * 2004-03-19 2009-07-21 Pfizer Inc. Substituted Imidazo[1,2-a]pyridines as Antibacterial Agents
WO2006020830A2 (fr) * 2004-08-12 2006-02-23 Amgen Inc. Biaryle-sulfonamides
US8431608B2 (en) 2007-08-17 2013-04-30 Icagen Inc. Heterocycles as potassium channel modulators
JP5463287B2 (ja) * 2007-08-17 2014-04-09 アイカジェン， インコーポレイテッド カリウムチャネル調節物質としての複素環
US8324395B2 (en) * 2007-08-23 2012-12-04 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
WO2009028629A1 (fr) * 2007-08-29 2009-03-05 Takeda Pharmaceutical Company Limited Composé hétérocyclique et son utilisation
US20110105457A1 (en) * 2008-04-18 2011-05-05 Shionogi & Co., Ltd. Heterocyclic compound having inhibitory activity on pi3k
US8445509B2 (en) * 2008-05-08 2013-05-21 Takeda Pharmaceutical Company Limited Fused heterocyclic derivatives and use thereof
JP5579619B2 (ja) * 2008-12-01 2014-08-27 武田薬品工業株式会社 複素環化合物およびその用途
JO3101B1 (ar) 2008-12-02 2017-09-20 Takeda Pharmaceuticals Co مشتقات بنزوثيازول كعوامل مضادة للسرطان
CA2771190C (fr) * 2009-08-17 2020-01-21 Memorial Sloan-Kettering Cancer Center Composes de liaison a une proteine de choc thermique, compositions et procedes pour les fabriquer et les utiliser
SG11201609336PA (en) 2014-05-13 2016-12-29 Sloan Kettering Inst Cancer Hsp70 modulators and methods for making and using the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3701780A (en) * 1970-09-18 1972-10-31 Merck & Co Inc Imidazo(1,2-a)pyridines
JPS5124517B1 (fr) * 1971-03-15 1976-07-24

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2385715A1 (fr) * 1977-03-28 1978-10-27 Merck & Co Inc Nouvelles imidazo (1,2-a)pyridines substituees heterocycliques utiles comme medicaments
WO2008150015A1 (fr) * 2007-06-05 2008-12-11 Takeda Pharmaceutical Company Limited Composés hétérobicycliques comme inhibiteurs de kinase

Also Published As

Publication number Publication date
US4096264A (en) 1978-06-20
OA05506A (fr) 1981-04-30
AU2010276A (en) 1978-06-08
GR62009B (en) 1979-02-15
PT65915B (en) 1978-11-07
NO764025L (fr) 1977-06-10
PH12259A (en) 1978-12-12
DE2655681A1 (de) 1977-06-16
JPS5273896A (en) 1977-06-21
IL51024A (en) 1981-12-31
ES453947A1 (es) 1978-03-01
IL51024A0 (en) 1977-01-31
PT65915A (en) 1977-01-01
AR222960A1 (es) 1981-07-15
AT361475B (de) 1981-03-10
PL103751B1 (pl) 1979-07-31
GB1524589A (en) 1978-09-13
BE849123A (fr) 1977-06-07
DK529276A (da) 1977-06-10
JPS6126545B2 (fr) 1986-06-20
NL7613160A (nl) 1977-06-13
CH626362A5 (fr) 1981-11-13
SE430504B (sv) 1983-11-21
FR2334357B1 (fr) 1982-10-15
ZA767331B (en) 1978-07-26
AU505045B2 (en) 1979-11-08
NZ182756A (en) 1979-11-01
SE7613128L (sv) 1977-06-10
FI763343A (fr) 1977-06-10
CA1084930A (fr) 1980-09-02
ATA901876A (de) 1980-08-15

Similar Documents

Publication Publication Date Title
BE849123A (fr) NOUVELLES IMIDAZO (1, 2-a) PYRIDINES SUBSTITUEES ET LEUR PROCEDE DE PREPARATION
FR2326924A1 (fr) Pyrido(2,1-b)quinazolin-ones et leur procede de preparation
FR2315930A1 (fr) Derives de 1,4-dihydropyridine et leur procede de preparation
FR2299362A1 (fr) Spheres creuses et procede de leur preparation
FR2331584A1 (fr) Poly (arylato-sulfones) et leur procede de preparation
FR2301521A1 (fr) Nouvelles n-acyl-n-norsalutaridines et leur procede de preparation
FR2299032A1 (fr) Derives de tetrahydroisoquinoleine et leur procede de preparation
FR2307530A1 (fr) Triaryl-1,1,1 alkylamines et leur procede de preparation
FR2321886A1 (fr) 3-phenylspiro-(isobenzofuranne-1,4'-piperidine)-sulfenamides, leur procede de preparation et leurs applications
FR2316239A1 (fr) Procede de preparation de 2,4-dioxo-1,2,3,4-tetrahydro-s-triazino-(1,2-a)-benzimidazoles
FR2324301A1 (fr) Nouvelles pyrazolo(3,4-b)pyridyl-5 cetones et procede de leur preparation
FR2347370A1 (fr) 7-amino-3-tetrazolyl substitue-thiomethyl-cephalosporines et leur procede de preparation
FR2299865A1 (fr) Arylmethyl-1 imidazolidones-2 et leur procede de preparation
BE863759A (fr) Nouvelles imidazo (1,5-b) pyridazines et procede pour leur preparation
BE846402A (fr) 4-hydroxymethyl-2-pyrrolidinones et leur procede de preparation
BE843576A (fr) Derives de 1,4-dihydropyridine et leur procede de preparation
BE842687A (fr) Nouvelles thienyl-prostaglandines, leur procede de preparation et leur application
FR2329267A2 (fr) Styrylamidines et leur procede de preparation
BE826926A (fr) Pyrrolo (3,4-b) pyridines et leur preparation
FR2313073A1 (fr) Cholestenes-5 aminomethyles en 6 et oxygenes en 3 et leur procede de preparation
FR2311537A1 (fr) Derives de 3-nitropyrazole et leur procede de preparation
FR2309230A1 (fr) Derives de triazolocycloalkylthiadiazine et leur procede de preparation
FR2314198A1 (fr) D-homo 5a-pregnene-9(11)ones-20, et leur procede de preparation
BE840937A (fr) Nouvelles iminopyrrolinones et leur procede de preparation
FR2296424A1 (fr) Nouvelles triazolo(4,3-d)benzodiazepine-1,4 ones-6 et procedes de leur preparation

Legal Events

Date Code Title Description
ST Notification of lapse