FR2329276A1 - Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant - Google Patents

Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant

Info

Publication number
FR2329276A1
FR2329276A1 FR7533084A FR7533084A FR2329276A1 FR 2329276 A1 FR2329276 A1 FR 2329276A1 FR 7533084 A FR7533084 A FR 7533084A FR 7533084 A FR7533084 A FR 7533084A FR 2329276 A1 FR2329276 A1 FR 2329276A1
Authority
FR
France
Prior art keywords
imidazolidines
preparation
application
compositions containing
medicinal product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7533084A
Other languages
English (en)
French (fr)
Other versions
FR2329276B1 (US07655688-20100202-C00548.png
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to FR7533084A priority Critical patent/FR2329276A1/fr
Priority to SE7610859A priority patent/SE430502B/xx
Priority to NLAANVRAGE7611576,A priority patent/NL187102C/xx
Priority to US05/734,557 priority patent/US4097578A/en
Priority to SU762414002A priority patent/SU596165A3/ru
Priority to ES452746A priority patent/ES452746A1/es
Priority to LU76085A priority patent/LU76085A1/xx
Priority to DK487476A priority patent/DK152125C/da
Priority to AU19095/76A priority patent/AU500542B2/en
Priority to CA264,606A priority patent/CA1086751A/fr
Priority to BE171876A priority patent/BE847742A/xx
Priority to DE2649925A priority patent/DE2649925C2/de
Priority to IE2419/76A priority patent/IE43875B1/en
Priority to JP51129586A priority patent/JPS6011701B2/ja
Priority to CH1369176A priority patent/CH599164A5/de
Priority to GB45034/76A priority patent/GB1518444A/en
Publication of FR2329276A1 publication Critical patent/FR2329276A1/fr
Application granted granted Critical
Publication of FR2329276B1 publication Critical patent/FR2329276B1/fr
Priority to LU88282C priority patent/LU88282I2/fr
Priority to NL930079C priority patent/NL930079I2/nl
Priority to GEAP19931536A priority patent/GEP19970948B/en
Priority to BG98507A priority patent/BG60533B2/bg
Priority to MD94-0279A priority patent/MD246C2/ro
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Electromechanical Clocks (AREA)
FR7533084A 1975-01-29 1975-10-29 Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant Granted FR2329276A1 (fr)

Priority Applications (21)

Application Number Priority Date Filing Date Title
FR7533084A FR2329276A1 (fr) 1975-10-29 1975-10-29 Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant
SE7610859A SE430502B (sv) 1975-10-29 1976-09-30 Sett att framstella nya substituerade imidazolidiner
NLAANVRAGE7611576,A NL187102C (nl) 1975-10-29 1976-10-20 Werkwijze voor de bereiding van een farmaceutisch preparaat dat een 2-fenylimidazolidinon bevat, gevormd preparaat verkregen met deze werkwijze, alsmede werkwijze voor de bereiding van imidazolidinonen.
US05/734,557 US4097578A (en) 1975-10-29 1976-10-21 1-(3'-Trifluoromethyl-4'-nitrophenyl)-4,4-dimethyl imidazolidines
SU762414002A SU596165A3 (ru) 1975-10-29 1976-10-21 Способ получени имидазолидинов
ES452746A ES452746A1 (es) 1975-10-29 1976-10-27 Procedimiento de preparacion de nuevas imidazolidinas.
BE171876A BE847742A (fr) 1975-10-29 1976-10-28 Nouvelles imidazolidines, procede de preparation et compositions pharmaceutiques
DK487476A DK152125C (da) 1975-10-29 1976-10-28 Analogifremgangsmaade til fremstilling af 1-(3'-trifluormethyl-4'-nitrophenyl)-4,4-dimethylimidazolidin-2,5-dion
AU19095/76A AU500542B2 (en) 1975-01-29 1976-10-28 Imidazlidine derivatives and pharmaceutical compositions containing same which have antiandrogenic activity
CA264,606A CA1086751A (fr) 1975-10-29 1976-10-28 Procede de preparation de nouvelles imidazolidines substituees
LU76085A LU76085A1 (US07655688-20100202-C00548.png) 1975-10-29 1976-10-28
DE2649925A DE2649925C2 (de) 1975-10-29 1976-10-29 5,5-Dimethyl-3-[4-nitro-3-(trifluormethyl)-phenyl]-2-imidazolidinone, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Mittel
IE2419/76A IE43875B1 (en) 1975-10-29 1976-10-29 N-phenyl-imidazolidine derivatives,processes for preparing them and pharmaceutical compositions containing them
JP51129586A JPS6011701B2 (ja) 1975-10-29 1976-10-29 新規なイミダゾリンジン類、それらの製造法及び製薬組成物
CH1369176A CH599164A5 (US07655688-20100202-C00548.png) 1975-10-29 1976-10-29
GB45034/76A GB1518444A (en) 1975-10-29 1976-10-29 N-phenyl-imidazolidine derivatives processes for preparing them and pharmaceutical compositions containing them
LU88282C LU88282I2 (fr) 1975-10-29 1993-06-03 Anandron
NL930079C NL930079I2 (nl) 1975-10-29 1993-06-17 Werkwijze voor de bereiding van een farmaceutisch preparaat dat een 2-fenylimidazolidinon bevat, gevormd preparaat verkregen met deze werkwijze alsmede werkwijze voor de bereiding van imidazolidinonen.
GEAP19931536A GEP19970948B (en) 1975-10-29 1993-09-09 Method for Production of Imidazolidine
BG98507A BG60533B2 (bg) 1975-10-29 1994-02-22 Заместени имидазолидини,метод за получаването ими приложението им като лекарствено средство и състави,които ги съдържат
MD94-0279A MD246C2 (ro) 1975-10-29 1994-09-08 Procedeu de obţinere a imidazolidinelor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7533084A FR2329276A1 (fr) 1975-10-29 1975-10-29 Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant

Publications (2)

Publication Number Publication Date
FR2329276A1 true FR2329276A1 (fr) 1977-05-27
FR2329276B1 FR2329276B1 (US07655688-20100202-C00548.png) 1979-09-14

Family

ID=9161795

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7533084A Granted FR2329276A1 (fr) 1975-01-29 1975-10-29 Nouvelles imidazolidines substituees, procede de preparation, application comme medicament et compositions les renfermant

Country Status (18)

Country Link
US (1) US4097578A (US07655688-20100202-C00548.png)
JP (1) JPS6011701B2 (US07655688-20100202-C00548.png)
AU (1) AU500542B2 (US07655688-20100202-C00548.png)
BE (1) BE847742A (US07655688-20100202-C00548.png)
BG (1) BG60533B2 (US07655688-20100202-C00548.png)
CA (1) CA1086751A (US07655688-20100202-C00548.png)
CH (1) CH599164A5 (US07655688-20100202-C00548.png)
DE (1) DE2649925C2 (US07655688-20100202-C00548.png)
DK (1) DK152125C (US07655688-20100202-C00548.png)
ES (1) ES452746A1 (US07655688-20100202-C00548.png)
FR (1) FR2329276A1 (US07655688-20100202-C00548.png)
GB (1) GB1518444A (US07655688-20100202-C00548.png)
GE (1) GEP19970948B (US07655688-20100202-C00548.png)
IE (1) IE43875B1 (US07655688-20100202-C00548.png)
LU (2) LU76085A1 (US07655688-20100202-C00548.png)
NL (2) NL187102C (US07655688-20100202-C00548.png)
SE (1) SE430502B (US07655688-20100202-C00548.png)
SU (1) SU596165A3 (US07655688-20100202-C00548.png)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2422643A1 (fr) * 1977-10-28 1979-11-09 Hoffmann La Roche Nouveaux derives d'imidazolidine, leur preparation et leur application comme medicaments
FR2619381A1 (fr) * 1987-08-13 1989-02-17 Roussel Uclaf Nouvelles imidazolidines substituees par un radical hydroxymethyle et un radical phenyl substitue, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant et un intermediaire pour leur preparation
FR2656302A1 (fr) * 1989-12-22 1991-06-28 Roussel Uclaf Nouveau procede de preparation de l'anandron et derives de l'anandron.
FR2671348A1 (fr) * 1991-01-09 1992-07-10 Roussel Uclaf Nouvelles phenylimidazolidines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
FR2685328A1 (fr) * 1991-12-20 1993-06-25 Rhone Poulenc Agrochimie Derives de 2-imidazoline-5-ones et 2-imidazoline-5-thiones fongicides.
EP0578516A1 (fr) * 1992-07-08 1994-01-12 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant
FR2693461A1 (fr) * 1992-07-08 1994-01-14 Roussel Uclaf Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
WO1995018794A1 (fr) * 1994-01-05 1995-07-13 Roussel Uclaf Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
FR2715402A1 (fr) * 1994-01-05 1995-07-28 Roussel Uclaf Nouvelles phénylimidazolines éventuellement substituées, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
FR2724169A1 (fr) * 1994-09-06 1996-03-08 Roussel Uclaf Nouvelles phenylimidazolidines eventuellement substituees, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
EP0704448A1 (fr) * 1994-09-29 1996-04-03 Roussel Uclaf Nouvelles imidazolidines substituées par un hétérocycle, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant
US5637729A (en) * 1991-12-20 1997-06-10 Rhone-Poulenc Agrochimie Fungicidal 2-imidazolin-5-ones and 2-imidazoline-5-thiones
US5650519A (en) * 1992-12-21 1997-07-22 Rhone-Poulenc Agrochimie Optically active 5, 5-disubstituted-3-(mono- or disubstituted amino)-2-thiohydantoin intermediates to fungicidal 2-imidazolin-5-ones
US6008370A (en) * 1992-11-25 1999-12-28 Rhone-Poulenc Agrochimie Fungicidal-2-alkoxy/haloalkoxy-1-(mono- or disubstituted)amino-4,4-disubstituted-2-imidazolin-5-ones
US6960474B2 (en) * 2000-06-28 2005-11-01 Bristol-Myers Squibb Company Method for the treatment of a condition remediable by administration of a selective androgen receptor modulator
FR2896503A1 (fr) * 2006-01-23 2007-07-27 Aventis Pharma Sa Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
US8183274B2 (en) 2005-05-13 2012-05-22 The Regents Of The University Of California Treatment of hyperproliferative disorders with diarylhydantoin compounds
US8648105B2 (en) 2006-03-29 2014-02-11 The Regents Of The University Of California Diarylthiohydantoin compounds
US9896437B2 (en) 2007-10-26 2018-02-20 The Regents Of The University Of California Diarylhydantoin compounds

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CA1138334A (en) * 1977-10-28 1982-12-28 Karl Bernauer Pharmaceutical preparations containing certain urea derivatives
FI801184A (fi) * 1979-04-24 1980-10-25 Hoffmann La Roche Foerfarande foer framstaellning av imidazolidinderivat
US4775660A (en) * 1984-08-02 1988-10-04 Fernand Labrie Treatment of breast cancer by combination therapy
US4760053A (en) * 1984-08-02 1988-07-26 Fernand Labrie Combination therapy for selected sex steroid dependent cancers
US4666885A (en) * 1985-02-08 1987-05-19 Fernand Labrie Combination therapy for treatment of female breast cancer
AU594309B2 (en) * 1984-08-02 1990-03-08 Fernand Labrie Pharmaceutical composition for combination therapy of hormonedependent cancers
IT1214735B (it) * 1986-11-04 1990-01-18 Roussel Maestretti Spa Impiego di 1-(3'-trifluorometil 4'nitrofenil) 4,4-dimetilimidazolin2,5-dione per il trattamento di cancri ormonodipendenti diverso da quello della prostata
US5084472A (en) * 1986-11-04 1992-01-28 Roussel Application of 1-(3'-trifluoromethyl-4'-nitrophenyl)-4,4'-dimethylimidazoline 2,5-dione in the treatment of hormone-dependent cancers other than that of the prostate
US4895715A (en) * 1988-04-14 1990-01-23 Schering Corporation Method of treating gynecomastia
US5411981A (en) * 1991-01-09 1995-05-02 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
USRE35956E (en) * 1991-01-09 1998-11-10 Roussel Uclaf Phenylimidazolidines having antiandrogenic activity
US5656651A (en) * 1995-06-16 1997-08-12 Biophysica Inc. Androgenic directed compositions
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
US20040077605A1 (en) * 2001-06-20 2004-04-22 Salvati Mark E. Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US7001911B2 (en) 2000-06-28 2006-02-21 Bristol-Myers Squibb Company Fused cyclic modulators of nuclear hormone receptor function
EP1854798A3 (en) 2000-09-19 2007-11-28 Bristol-Myers Squibb Company Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US6953679B2 (en) 2000-09-19 2005-10-11 Bristol-Myers Squibb Company Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
US20040087548A1 (en) 2001-02-27 2004-05-06 Salvati Mark E. Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function
US7015253B2 (en) * 2001-07-10 2006-03-21 American Medical Systems, Inc. Regimen for treating prostate tissue and surgical kit for use in the regimen
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US7354933B2 (en) * 2003-01-31 2008-04-08 Aventis Pharma Sa Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
FR2850652B1 (fr) * 2003-01-31 2008-05-30 Aventis Pharma Sa Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
CA2536349A1 (en) 2003-08-22 2005-03-03 Ligand Pharmaceuticals Incorporated 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds
EP2428516A1 (en) 2003-11-19 2012-03-14 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
EP2299266A1 (en) * 2003-12-19 2011-03-23 The Regents of the University of California Methods and materials for assessing prostate cancer therapies
AU2005232526B2 (en) * 2004-02-24 2011-06-23 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies and compounds
WO2005090282A1 (en) 2004-03-12 2005-09-29 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
JP5031568B2 (ja) * 2004-09-10 2012-09-19 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 選択的アンドロゲン受容体モジュレーター（ｓａｒｍｓ）としての新規なイミダゾリジン−２−オン誘導体
PT2444085E (pt) 2005-05-13 2015-06-11 Univ California Compostos de diaril-hidantoínas como antagonistas do recetor androgénio para tratamento de cancro
CA2598216C (en) 2005-06-17 2014-04-08 Ligand Pharmaceuticals Incorporated Androgen receptor modulator compounds and methods
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
EP2656842B1 (en) 2006-03-27 2016-08-10 The Regents of The University of California Androgen receptor modulator for the treatment of prostate cancer and androgen receptor-associated diseases
ES2382009T3 (es) 2006-12-01 2012-06-04 Bristol-Myers Squibb Company Derivados de N-((3-bencil)-2,2-(bis-fenil-)-propan-1-amina como inhibidores de CETP para el tratamiento de aterosclerosis y enfermedades cardiovasculares
US9232959B2 (en) 2007-01-02 2016-01-12 Aquabeam, Llc Multi fluid tissue resection methods and devices
EP2099375B1 (en) 2007-01-02 2014-09-24 AquaBeam LLC Minimally invasive devices for the treatment of prostate diseases
US20080245375A1 (en) * 2007-04-05 2008-10-09 Medtronic Vascular, Inc. Benign Prostatic Hyperplasia Treatments
WO2009111736A1 (en) 2008-03-06 2009-09-11 Aquabeam Llc Tissue ablation and cautery with optical energy carried in fluid stream
WO2010093601A1 (en) 2009-02-10 2010-08-19 Metabasis Therapeutics, Inc. Novel sulfonic acid-containing thyromimetics, and methods for their use
US9848904B2 (en) 2009-03-06 2017-12-26 Procept Biorobotics Corporation Tissue resection and treatment with shedding pulses
WO2014127242A2 (en) 2013-02-14 2014-08-21 Procept Biorobotics Corporation Aquablation aquabeam eye surgery methods and apparatus
FR2944524B1 (fr) * 2009-04-17 2012-11-30 Ipsen Pharma Sas Derives d'imidazolidine-2,4-dione et leur utilisation comme medicament
PT3124481T (pt) 2010-02-16 2018-06-18 Aragon Pharmaceuticals Inc Moduladores do receptor de androgénios e suas utilizações
WO2012109387A1 (en) 2011-02-08 2012-08-16 Halozyme, Inc. Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia
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US10011874B2 (en) 2013-02-25 2018-07-03 Novartis Ag Androgen receptor mutation
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BR112016031037B1 (pt) 2014-06-30 2023-02-07 Procept Biorobotics Corporation Aparelho para ablação de tecido vascular
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TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
EP3500310A1 (en) 2016-08-20 2019-06-26 FTF Pharma Private Limited Pharmaceutical composition comprising an androgen receptor inhibitor
CN107216290B (zh) * 2017-06-12 2021-03-16 陕西科技大学 一种3-丁基-5,5-二甲基海因咪唑季铵盐及其制备方法
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JPS5136332B1 (US07655688-20100202-C00548.png) * 1970-12-09 1976-10-07
IL45459A (en) * 1973-09-03 1978-01-31 Ciba Geigy Ag 1-(dichlorofluoromethylthio)-3-phenyl-imidazolidine-2,4-dione derivatives their preparation and their use as bactericides and fungicides

Cited By (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2422643A1 (fr) * 1977-10-28 1979-11-09 Hoffmann La Roche Nouveaux derives d'imidazolidine, leur preparation et leur application comme medicaments
FR2619381A1 (fr) * 1987-08-13 1989-02-17 Roussel Uclaf Nouvelles imidazolidines substituees par un radical hydroxymethyle et un radical phenyl substitue, leur procede de preparation, leur application comme medicaments, les compositions pharmaceutiques les renfermant et un intermediaire pour leur preparation
EP0305270A1 (fr) * 1987-08-13 1989-03-01 Roussel-Uclaf Nouvelles imidazolidines substitués par un radical hydroxyméthyle et un radical phényl substitue,leur procédé de préparation, leur application comme médicaments, les compositions pharmaceutiques les renfermant et un intermédiaire pour leur préparation
FR2656302A1 (fr) * 1989-12-22 1991-06-28 Roussel Uclaf Nouveau procede de preparation de l'anandron et derives de l'anandron.
EP0436426A1 (fr) * 1989-12-22 1991-07-10 Roussel-Uclaf Nouveau procédé de préparation de dérivés de la 1-phénylimidazolin 2,5-dione
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US6002016A (en) * 1991-12-20 1999-12-14 Rhone-Poulenc Agrochimie Fungicidal 2-imidazolin-5-ones and 2-imidazoline-5-thiones
EP0578516A1 (fr) * 1992-07-08 1994-01-12 Roussel Uclaf Nouvelles phénylimidazolidines éventuellement substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant
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US5646172A (en) * 1994-09-29 1997-07-08 Roussel Uclaf Method of inducing antiandrogenic activity using imidazolidines substituted with a heterocycle
FR2725206A1 (fr) * 1994-09-29 1996-04-05 Roussel Uclaf Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant
EP0704448A1 (fr) * 1994-09-29 1996-04-03 Roussel Uclaf Nouvelles imidazolidines substituées par un hétérocycle, leur procédé et des intermédiaires de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant
US6960474B2 (en) * 2000-06-28 2005-11-01 Bristol-Myers Squibb Company Method for the treatment of a condition remediable by administration of a selective androgen receptor modulator
US8183274B2 (en) 2005-05-13 2012-05-22 The Regents Of The University Of California Treatment of hyperproliferative disorders with diarylhydantoin compounds
US9126941B2 (en) 2005-05-13 2015-09-08 The Regents Of The University Of California Treatment of hyperproliferative disorders with diarylhydantoin compounds
FR2896503A1 (fr) * 2006-01-23 2007-07-27 Aventis Pharma Sa Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
US8648105B2 (en) 2006-03-29 2014-02-11 The Regents Of The University Of California Diarylthiohydantoin compounds
US9896437B2 (en) 2007-10-26 2018-02-20 The Regents Of The University Of California Diarylhydantoin compounds

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GB1518444A (en) 1978-07-19
JPS6011701B2 (ja) 1985-03-27
DK487476A (da) 1977-04-30
LU88282I2 (fr) 1994-05-04
GEP19970948B (en) 1997-04-18
IE43875B1 (en) 1981-06-17
SU596165A3 (ru) 1978-02-28
LU76085A1 (US07655688-20100202-C00548.png) 1977-05-31
NL187102B (nl) 1991-01-02
FR2329276B1 (US07655688-20100202-C00548.png) 1979-09-14
SE7610859L (sv) 1977-04-30
BG60533B2 (bg) 1995-07-28
SE430502B (sv) 1983-11-21
NL187102C (nl) 1991-06-03
AU500542B2 (en) 1979-05-24
NL930079I2 (nl) 1993-10-01
ES452746A1 (es) 1977-10-01
CH599164A5 (US07655688-20100202-C00548.png) 1978-05-12
DE2649925C2 (de) 1986-08-28
BE847742A (fr) 1977-04-28
NL7611576A (nl) 1977-05-03
DE2649925A1 (de) 1977-05-12
US4097578A (en) 1978-06-27
DK152125B (da) 1988-02-01
CA1086751A (fr) 1980-09-30
DK152125C (da) 1988-06-20
AU1909576A (en) 1978-05-04
JPS5257176A (en) 1977-05-11
IE43875L (en) 1977-04-29
NL930079I1 (nl) 1993-09-16

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