FR2305186A1 - Antibacterial cephalosporins - viz 3-heterocyclylthiomethyl-7-(alpha-amino or-hydroxy-phenylacetamido)-3-cephem-4-carboxylic acids (BE270976) - Google Patents

Antibacterial cephalosporins - viz 3-heterocyclylthiomethyl-7-(alpha-amino or-hydroxy-phenylacetamido)-3-cephem-4-carboxylic acids (BE270976)

Info

Publication number
FR2305186A1
FR2305186A1 FR7608977A FR7608977A FR2305186A1 FR 2305186 A1 FR2305186 A1 FR 2305186A1 FR 7608977 A FR7608977 A FR 7608977A FR 7608977 A FR7608977 A FR 7608977A FR 2305186 A1 FR2305186 A1 FR 2305186A1
Authority
FR
France
Prior art keywords
heterocyclylthiomethyl
phenylacetamido
cephem
viz
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7608977A
Other languages
French (fr)
Other versions
FR2305186B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Original Assignee
Pfizer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB7512813A external-priority patent/GB1542397A/en
Application filed by Pfizer Corp filed Critical Pfizer Corp
Publication of FR2305186A1 publication Critical patent/FR2305186A1/en
Application granted granted Critical
Publication of FR2305186B1 publication Critical patent/FR2305186B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Cephalosporins of formula (I) and their salts are new (where R is H or OH; Y is NH2, OH or OR4, where R4 is lower alkanoyl, lower alkoxycarbonyl or benzoyl; X is O, S. NH or NMe; Z is H, lower alkyl, benzhydrylphenyl, indan-5-yl, R'OCOCH2 (R' = lower alkyl), R'OOCOCH(Me) or phthalidyl; R1 is CH2oCH2COOH, CH2OCH2COOR', CH2OCH2CONR2R3 or CONR2R3; R2 and r3 are H or lower alkyl). Cpds. (I) are antibacterials active against Gram-positive and -negative bacteria.
FR7608977A 1975-03-27 1976-03-26 Antibacterial cephalosporins - viz 3-heterocyclylthiomethyl-7-(alpha-amino or-hydroxy-phenylacetamido)-3-cephem-4-carboxylic acids (BE270976) Granted FR2305186A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7512813A GB1542397A (en) 1975-03-27 1975-03-27 Cephem compounds
GB4393575 1975-10-24

Publications (2)

Publication Number Publication Date
FR2305186A1 true FR2305186A1 (en) 1976-10-22
FR2305186B1 FR2305186B1 (en) 1980-07-04

Family

ID=26249284

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7608977A Granted FR2305186A1 (en) 1975-03-27 1976-03-26 Antibacterial cephalosporins - viz 3-heterocyclylthiomethyl-7-(alpha-amino or-hydroxy-phenylacetamido)-3-cephem-4-carboxylic acids (BE270976)

Country Status (15)

Country Link
JP (1) JPS51138694A (en)
AU (1) AU1244276A (en)
DD (1) DD124601A5 (en)
DE (1) DE2612760A1 (en)
DK (1) DK132876A (en)
ES (1) ES446353A1 (en)
FI (1) FI760793A (en)
FR (1) FR2305186A1 (en)
IE (1) IE43541B1 (en)
IL (1) IL49183A0 (en)
LU (1) LU74651A1 (en)
NL (1) NL7603116A (en)
NO (1) NO761052L (en)
PT (1) PT64951B (en)
SE (1) SE7603699L (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA999574A (en) * 1972-06-14 1976-11-09 Smith Kline And French Canada Ltd. 7-hydroxyhalophenylacetamido-3-h heterocyclicthiomethyl cephalosporins
FR2215942B1 (en) * 1973-01-31 1978-12-22 Bristol Myers Co
US3989694A (en) * 1974-12-27 1976-11-02 Smithkline Corporation 7-Acyl-3-(substituted triazolyl thiomethyl)cephalosporins

Also Published As

Publication number Publication date
NO761052L (en) 1976-09-28
LU74651A1 (en) 1977-10-10
DK132876A (en) 1976-09-28
IL49183A0 (en) 1976-05-31
ES446353A1 (en) 1977-11-16
SE7603699L (en) 1976-09-28
PT64951B (en) 1977-08-26
FR2305186B1 (en) 1980-07-04
DE2612760A1 (en) 1976-10-07
IE43541L (en) 1976-09-27
PT64951A (en) 1976-04-01
DD124601A5 (en) 1977-03-02
FI760793A (en) 1976-09-28
AU1244276A (en) 1977-10-06
IE43541B1 (en) 1981-03-25
JPS51138694A (en) 1976-11-30
NL7603116A (en) 1976-09-29

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