IE43541L - 3-(heterocyclic) thiomethyl cephalosporin derivatives. - Google Patents

3-(heterocyclic) thiomethyl cephalosporin derivatives.

Info

Publication number
IE43541L
IE43541L IE760624A IE62476A IE43541L IE 43541 L IE43541 L IE 43541L IE 760624 A IE760624 A IE 760624A IE 62476 A IE62476 A IE 62476A IE 43541 L IE43541 L IE 43541L
Authority
IE
Ireland
Prior art keywords
heterocyclic
cephalosporin derivatives
lower alkyl
thiomethyl
thiomethyl cephalosporin
Prior art date
Application number
IE760624A
Other versions
IE43541B1 (en
Original Assignee
Pfizer Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB7512813A external-priority patent/GB1542397A/en
Application filed by Pfizer Ltd filed Critical Pfizer Ltd
Publication of IE43541L publication Critical patent/IE43541L/en
Publication of IE43541B1 publication Critical patent/IE43541B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Cephalosporins of formula (I) and their salts are new (where R is H or OH; Y is NH2, OH or OR4, where R4 is lower alkanoyl, lower alkoxycarbonyl or benzoyl; X is O, S. NH or NMe; Z is H, lower alkyl, benzhydrylphenyl, indan-5-yl, R'OCOCH2 (R' = lower alkyl), R'OOCOCH(Me) or phthalidyl; R1 is CH2oCH2COOH, CH2OCH2COOR', CH2OCH2CONR2R3 or CONR2R3; R2 and r3 are H or lower alkyl). Cpds. (I) are antibacterials active against Gram-positive and -negative bacteria. [FR2305186A1]
IE624/76A 1975-03-27 1976-03-25 Cephem compounds IE43541B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB7512813A GB1542397A (en) 1975-03-27 1975-03-27 Cephem compounds
GB4393575 1975-10-24

Publications (2)

Publication Number Publication Date
IE43541L true IE43541L (en) 1976-09-27
IE43541B1 IE43541B1 (en) 1981-03-25

Family

ID=26249284

Family Applications (1)

Application Number Title Priority Date Filing Date
IE624/76A IE43541B1 (en) 1975-03-27 1976-03-25 Cephem compounds

Country Status (15)

Country Link
JP (1) JPS51138694A (en)
AU (1) AU1244276A (en)
DD (1) DD124601A5 (en)
DE (1) DE2612760A1 (en)
DK (1) DK132876A (en)
ES (1) ES446353A1 (en)
FI (1) FI760793A (en)
FR (1) FR2305186A1 (en)
IE (1) IE43541B1 (en)
IL (1) IL49183A0 (en)
LU (1) LU74651A1 (en)
NL (1) NL7603116A (en)
NO (1) NO761052L (en)
PT (1) PT64951B (en)
SE (1) SE7603699L (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA999574A (en) * 1972-06-14 1976-11-09 Smith Kline And French Canada Ltd. 7-hydroxyhalophenylacetamido-3-h heterocyclicthiomethyl cephalosporins
NL7401361A (en) * 1973-01-31 1974-08-02
US3989694A (en) * 1974-12-27 1976-11-02 Smithkline Corporation 7-Acyl-3-(substituted triazolyl thiomethyl)cephalosporins

Also Published As

Publication number Publication date
PT64951A (en) 1976-04-01
LU74651A1 (en) 1977-10-10
DK132876A (en) 1976-09-28
DD124601A5 (en) 1977-03-02
DE2612760A1 (en) 1976-10-07
NL7603116A (en) 1976-09-29
JPS51138694A (en) 1976-11-30
IL49183A0 (en) 1976-05-31
FI760793A (en) 1976-09-28
NO761052L (en) 1976-09-28
ES446353A1 (en) 1977-11-16
FR2305186A1 (en) 1976-10-22
PT64951B (en) 1977-08-26
FR2305186B1 (en) 1980-07-04
IE43541B1 (en) 1981-03-25
SE7603699L (en) 1976-09-28
AU1244276A (en) 1977-10-06

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