FR2300569A1 - Nouvelles imidazolobenzodiazepines et - Google Patents
Nouvelles imidazolobenzodiazepines etInfo
- Publication number
- FR2300569A1 FR2300569A1 FR7603457A FR7603457A FR2300569A1 FR 2300569 A1 FR2300569 A1 FR 2300569A1 FR 7603457 A FR7603457 A FR 7603457A FR 7603457 A FR7603457 A FR 7603457A FR 2300569 A1 FR2300569 A1 FR 2300569A1
- Authority
- FR
- France
- Prior art keywords
- alkyl
- certain
- imidazolobenzodiazepines
- pheny
- benzodiazepine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- IBYCDDNFZLAIAO-UHFFFAOYSA-N 2,4-dihydroimidazo[1,2-a][1,4]benzodiazepin-1-one Chemical compound C1N=CC2=CC=CC=C2N2C(=O)CN=C21 IBYCDDNFZLAIAO-UHFFFAOYSA-N 0.000 title 1
- KLNFAMGHSZQYHR-UHFFFAOYSA-N imidazo[4,5-i][1,2]benzodiazepine Chemical class C1=CC=NN=C2C3=NC=NC3=CC=C21 KLNFAMGHSZQYHR-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 206010000117 Abnormal behaviour Diseases 0.000 abstract 1
- 206010022998 Irritability Diseases 0.000 abstract 1
- 208000007101 Muscle Cramp Diseases 0.000 abstract 1
- 241000110831 Polycentropus admin Species 0.000 abstract 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 abstract 1
- 208000005392 Spasm Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000013019 agitation Methods 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000000147 hypnotic effect Effects 0.000 abstract 1
- 206010022437 insomnia Diseases 0.000 abstract 1
- 230000004118 muscle contraction Effects 0.000 abstract 1
- 230000001670 myorelaxant effect Effects 0.000 abstract 1
- 208000022821 personality disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB6509/75A GB1496426A (en) | 1975-02-15 | 1975-02-15 | 1,2-dihydro-4h-imidazo(1,2-alpha)(1,4)benzodiazepin-1-ones processes for their preparation and compositions incorporating them |
| GB4580075 | 1975-11-04 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2300569A1 true FR2300569A1 (fr) | 1976-09-10 |
| FR2300569B1 FR2300569B1 (hu) | 1979-09-21 |
Family
ID=26240753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7603457A Granted FR2300569A1 (fr) | 1975-02-15 | 1976-02-09 | Nouvelles imidazolobenzodiazepines et |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS5914034B2 (hu) |
| AR (1) | AR225721A1 (hu) |
| AT (1) | AT351030B (hu) |
| CA (1) | CA1073454A (hu) |
| CH (2) | CH613706A5 (hu) |
| DE (1) | DE2605652A1 (hu) |
| DK (1) | DK141250B (hu) |
| EG (1) | EG12462A (hu) |
| ES (1) | ES445188A1 (hu) |
| FI (1) | FI62090C (hu) |
| FR (1) | FR2300569A1 (hu) |
| GR (1) | GR60028B (hu) |
| HK (1) | HK47379A (hu) |
| HU (1) | HU173109B (hu) |
| IE (1) | IE43791B1 (hu) |
| IL (1) | IL48888A (hu) |
| IT (1) | IT8047823A0 (hu) |
| LU (1) | LU74341A1 (hu) |
| MX (1) | MX3327E (hu) |
| NL (1) | NL171585C (hu) |
| NO (1) | NO146201C (hu) |
| NZ (1) | NZ179990A (hu) |
| PH (3) | PH14669A (hu) |
| PT (1) | PT64796B (hu) |
| SE (1) | SE422686B (hu) |
| YU (1) | YU42471B (hu) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2479818A1 (en) * | 1980-04-03 | 1981-10-09 | Roussel Uclaf | 2-Substd. phenyl 7-nitro 3H 1,4-benzodiazepinyl aminoacid derivs. - are anxiolytics, tranquillisers, sedatives and anticonvulsants, prepd. by reacting aminoacid or peptide with benzodiazepin-2-thione |
| FR2502621A1 (hu) * | 1981-03-27 | 1982-10-01 | Roussel Uclaf |
-
1976
- 1976-01-21 IL IL48888A patent/IL48888A/xx unknown
- 1976-02-09 FR FR7603457A patent/FR2300569A1/fr active Granted
- 1976-02-10 AR AR261199A patent/AR225721A1/es active
- 1976-02-12 SE SE7601592A patent/SE422686B/xx not_active IP Right Cessation
- 1976-02-12 NZ NZ179990A patent/NZ179990A/xx unknown
- 1976-02-12 FI FI760347A patent/FI62090C/fi not_active IP Right Cessation
- 1976-02-12 DE DE19762605652 patent/DE2605652A1/de active Granted
- 1976-02-13 LU LU74341A patent/LU74341A1/xx unknown
- 1976-02-13 IE IE298/76A patent/IE43791B1/en not_active IP Right Cessation
- 1976-02-13 CH CH180876A patent/CH613706A5/xx not_active IP Right Cessation
- 1976-02-13 PH PH18091A patent/PH14669A/en unknown
- 1976-02-13 PT PT64796A patent/PT64796B/pt unknown
- 1976-02-13 DK DK58776AA patent/DK141250B/da not_active IP Right Cessation
- 1976-02-13 NL NLAANVRAGE7601492,A patent/NL171585C/xx not_active IP Right Cessation
- 1976-02-13 HU HU76RO879A patent/HU173109B/hu unknown
- 1976-02-13 JP JP51014122A patent/JPS5914034B2/ja not_active Expired
- 1976-02-13 YU YU345/76A patent/YU42471B/xx unknown
- 1976-02-13 NO NO760468A patent/NO146201C/no unknown
- 1976-02-14 EG EG77/76A patent/EG12462A/xx active
- 1976-02-14 GR GR50055A patent/GR60028B/el unknown
- 1976-02-14 ES ES445188A patent/ES445188A1/es not_active Expired
- 1976-02-16 CA CA245,850A patent/CA1073454A/en not_active Expired
- 1976-02-16 AT AT107376A patent/AT351030B/de not_active IP Right Cessation
- 1976-02-16 MX MX176D patent/MX3327E/es unknown
-
1978
- 1978-07-24 PH PH21416A patent/PH15282A/en unknown
- 1978-11-02 CH CH1131378A patent/CH618171A5/fr not_active IP Right Cessation
-
1979
- 1979-01-26 PH PH22113A patent/PH16286A/en unknown
- 1979-07-12 HK HK473/79A patent/HK47379A/xx unknown
-
1980
- 1980-02-06 IT IT8047823A patent/IT8047823A0/it unknown
Non-Patent Citations (1)
| Title |
|---|
| NEANT * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2479818A1 (en) * | 1980-04-03 | 1981-10-09 | Roussel Uclaf | 2-Substd. phenyl 7-nitro 3H 1,4-benzodiazepinyl aminoacid derivs. - are anxiolytics, tranquillisers, sedatives and anticonvulsants, prepd. by reacting aminoacid or peptide with benzodiazepin-2-thione |
| FR2502621A1 (hu) * | 1981-03-27 | 1982-10-01 | Roussel Uclaf |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| CC | Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990) |
Free format text: 92C0049, 920319 |
|
| CB | Supplementary protection certificate (spc) granted (law of 25 june 1990) |
Free format text: 92C0049, 760209 |
|
| CL | Concession to grant licences |