FR2246547A1 - Oxapenicillin and azacephalosporin antibiotics - via beta-lactamase inhibiting azetidin-2-one intermediates - Google Patents

Oxapenicillin and azacephalosporin antibiotics - via beta-lactamase inhibiting azetidin-2-one intermediates

Info

Publication number
FR2246547A1
FR2246547A1 FR7335970A FR7335970A FR2246547A1 FR 2246547 A1 FR2246547 A1 FR 2246547A1 FR 7335970 A FR7335970 A FR 7335970A FR 7335970 A FR7335970 A FR 7335970A FR 2246547 A1 FR2246547 A1 FR 2246547A1
Authority
FR
France
Prior art keywords
azetidin
oxapenicillin
azacephalosporin
antibiotics
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7335970A
Other languages
French (fr)
Other versions
FR2246547B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Queens University at Kingston
Original Assignee
Queens University at Kingston
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Queens University at Kingston filed Critical Queens University at Kingston
Priority to FR7335970A priority Critical patent/FR2246547A1/en
Publication of FR2246547A1 publication Critical patent/FR2246547A1/en
Application granted granted Critical
Publication of FR2246547B1 publication Critical patent/FR2246547B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel title cpds of formulae (I) and (II): (where RCO is acyl) and their salts are predp from novel beta-lactamase inhibiting azetidin-2-one inters. (I) and (II) are used in doses of 5-200 mg/kg/day.
FR7335970A 1973-10-09 1973-10-09 Oxapenicillin and azacephalosporin antibiotics - via beta-lactamase inhibiting azetidin-2-one intermediates Granted FR2246547A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7335970A FR2246547A1 (en) 1973-10-09 1973-10-09 Oxapenicillin and azacephalosporin antibiotics - via beta-lactamase inhibiting azetidin-2-one intermediates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7335970A FR2246547A1 (en) 1973-10-09 1973-10-09 Oxapenicillin and azacephalosporin antibiotics - via beta-lactamase inhibiting azetidin-2-one intermediates

Publications (2)

Publication Number Publication Date
FR2246547A1 true FR2246547A1 (en) 1975-05-02
FR2246547B1 FR2246547B1 (en) 1978-04-28

Family

ID=9126109

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7335970A Granted FR2246547A1 (en) 1973-10-09 1973-10-09 Oxapenicillin and azacephalosporin antibiotics - via beta-lactamase inhibiting azetidin-2-one intermediates

Country Status (1)

Country Link
FR (1) FR2246547A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2361365A1 (en) * 1976-08-09 1978-03-10 Shionogi & Co PROCESS FOR PREPARING INTERMEDIATE COMPOUNDS FOR THE SYNTHESIS OF 1-OXACEPHALOSPORINS AND NEW PRODUCTS THUS OBTAINED
EP0004134A1 (en) * 1978-03-04 1979-09-19 Beecham Group Plc Beta-lactam antibacterial agents, their pharmaceutical compositions and process for their preparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2361365A1 (en) * 1976-08-09 1978-03-10 Shionogi & Co PROCESS FOR PREPARING INTERMEDIATE COMPOUNDS FOR THE SYNTHESIS OF 1-OXACEPHALOSPORINS AND NEW PRODUCTS THUS OBTAINED
EP0004134A1 (en) * 1978-03-04 1979-09-19 Beecham Group Plc Beta-lactam antibacterial agents, their pharmaceutical compositions and process for their preparation

Also Published As

Publication number Publication date
FR2246547B1 (en) 1978-04-28

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Legal Events

Date Code Title Description
ST Notification of lapse