FR2281132A1 - Peptides ayant une forte activite d'hormone liberant l'hormone luteinisante ou d'hormone liberant l'hormone folliculostimulante (hl-hl/hl-hfs) et leur procede de preparation et leur application - Google Patents

Peptides ayant une forte activite d'hormone liberant l'hormone luteinisante ou d'hormone liberant l'hormone folliculostimulante (hl-hl/hl-hfs) et leur procede de preparation et leur application

Info

Publication number
FR2281132A1
FR2281132A1 FR7524951A FR7524951A FR2281132A1 FR 2281132 A1 FR2281132 A1 FR 2281132A1 FR 7524951 A FR7524951 A FR 7524951A FR 7524951 A FR7524951 A FR 7524951A FR 2281132 A1 FR2281132 A1 FR 2281132A1
Authority
FR
France
Prior art keywords
hormone
releasing
folliculostimulating
hfs
humanizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7524951A
Other languages
English (en)
Other versions
FR2281132B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of FR2281132A1 publication Critical patent/FR2281132A1/fr
Application granted granted Critical
Publication of FR2281132B1 publication Critical patent/FR2281132B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
FR7524951A 1974-08-09 1975-08-11 Peptides ayant une forte activite d'hormone liberant l'hormone luteinisante ou d'hormone liberant l'hormone folliculostimulante (hl-hl/hl-hfs) et leur procede de preparation et leur application Granted FR2281132A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2438350A DE2438350C3 (de) 1974-08-09 1974-08-09 Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen

Publications (2)

Publication Number Publication Date
FR2281132A1 true FR2281132A1 (fr) 1976-03-05
FR2281132B1 FR2281132B1 (fr) 1979-09-14

Family

ID=5922833

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7524951A Granted FR2281132A1 (fr) 1974-08-09 1975-08-11 Peptides ayant une forte activite d'hormone liberant l'hormone luteinisante ou d'hormone liberant l'hormone folliculostimulante (hl-hl/hl-hfs) et leur procede de preparation et leur application

Country Status (15)

Country Link
US (1) US4024248A (fr)
JP (1) JPS5761268B2 (fr)
AT (1) AT364093B (fr)
BE (1) BE832310A (fr)
CA (1) CA1069888A (fr)
CH (1) CH613186A5 (fr)
DE (1) DE2438350C3 (fr)
DK (1) DK148905C (fr)
FR (1) FR2281132A1 (fr)
GB (1) GB1523623A (fr)
IE (1) IE41510B1 (fr)
IL (1) IL47880A (fr)
LU (1) LU73166A1 (fr)
NL (1) NL182051C (fr)
SE (2) SE424184B (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000764A1 (fr) * 1977-08-06 1979-02-21 Hoechst Aktiengesellschaft Agent anticonceptionnel contenant une peptide
FR2450109A1 (fr) * 1977-11-08 1980-09-26 Roussel Uclaf Nouvelle methode de traitement utilisant la lh-rh, ou des agonistes
FR2458538A1 (fr) * 1979-06-11 1981-01-02 Syntex Inc Derives nonapeptidiques et decapeptidiques de l'hormone liberant l'hormone luteinisante, leur procede de production et composition pharmaceutique les contenant
EP0021234A1 (fr) * 1979-06-11 1981-01-07 Syntex (U.S.A.) Inc. Dérivés nona- décapeptidiques de l'hormone libérant l'hormone lutéinisante, leur préparation et compositions pharmaceutiques les contenant
EP0220654A2 (fr) * 1985-10-22 1987-05-06 Richter Gedeon Vegyeszeti Gyar Rt. Analogues de gonadolibérine, leur procédé de préparation, composition pharmaceutique et emploi

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2617646C2 (de) * 1976-04-22 1986-07-31 Hoechst Ag, 6230 Frankfurt Nonapeptid-amide und Decapeptid-amide mit Gonadoliberin-Wirkung, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
GB1524747A (en) * 1976-05-11 1978-09-13 Ici Ltd Polypeptide
DE3020941A1 (de) * 1980-06-03 1981-12-17 Hoechst Ag, 6000 Frankfurt Nonapeptid, verfahren zu seiner herstellung, dieses enthaltendes mittel und seine verwendung
HU185535B (en) * 1982-05-25 1985-02-28 Mta Koezponti Hivatala Process for preparing new gonadoliberin derivatives
HU187503B (en) * 1983-03-29 1986-01-28 Magyar Tudomanyos Akademia,Hu Process for preparing gonadoliberine derivatives containing beta-aspartyl group
AT390066B (de) * 1983-03-29 1990-03-12 Richter Gedeon Vegyeszet Verfahren zur herstellung von neuen gonadoliberin-derivaten
DE3411224A1 (de) * 1984-03-27 1985-10-10 Hoechst Ag, 6230 Frankfurt Verfahren zur racematarmen herstellung von peptidzwischenprodukten der gonadorelin- und gonadorelinanaloga-synthese und neue zwischenprodukte bei diesem verfahren
US4666885A (en) * 1985-02-08 1987-05-19 Fernand Labrie Combination therapy for treatment of female breast cancer
US4775660A (en) * 1984-08-02 1988-10-04 Fernand Labrie Treatment of breast cancer by combination therapy
US4760053A (en) * 1984-08-02 1988-07-26 Fernand Labrie Combination therapy for selected sex steroid dependent cancers
HU193093B (en) * 1985-04-16 1987-08-28 Innofinance Process for stimulating sexual activity of birds and domestic mammalians and process for producing spermatocytes for their propagation
HU221589B (hu) * 1989-03-10 2002-11-28 Endorecherche Inc. Emlő- és méhrák kezelésére alkalmas kombinációs gyógyszerkészítmény és eljárás előállítására
US5372996A (en) * 1989-03-10 1994-12-13 Endorecherche, Inc. Method of treatment of androgen-related diseases
JPH0235232A (ja) * 1989-06-29 1990-02-05 Nhk Spring Co Ltd 気室と液室を有する圧力容器
ATE170753T1 (de) * 1989-07-07 1998-09-15 Endorecherche Inc Androgenderivate zur hemming der aktivität der sexualsteroide
ATE230994T1 (de) * 1989-07-07 2003-02-15 Endorech Inc Methode zur behandlung androgenbedingter krankheiten
CA2029018A1 (fr) * 1989-11-01 1991-05-02 Robert P. Millar Analogues de l'hormone liberant de la gonadotrophine
JPH0474770U (fr) * 1990-10-31 1992-06-30
WO1993023053A1 (fr) * 1992-05-21 1993-11-25 Endorecherche Inc. INHIBITEURS D'ACTIVITE DE LA TESTOSTERONE 5α-REDUCTASE
US6413536B1 (en) 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
US7833543B2 (en) * 1995-06-07 2010-11-16 Durect Corporation High viscosity liquid controlled delivery system and medical or surgical device
CA2192782C (fr) 1995-12-15 2008-10-14 Nobuyuki Takechi Production de microsphere
CA2192773C (fr) 1995-12-15 2008-09-23 Hiroaki Okada Obtention d'une preparation a liberation prolongee pour injection
US6051558A (en) * 1997-05-28 2000-04-18 Southern Biosystems, Inc. Compositions suitable for controlled release of the hormone GnRH and its analogs
US20060025328A1 (en) * 1997-05-28 2006-02-02 Burns Patrick J Compositions suitable for controlled release of the hormone GnRH and its analogs
US6242421B1 (en) 1997-11-06 2001-06-05 Richard Lloyd Bowen Methods for preventing and treating Alzheimer's disease
ES2154590B1 (es) 1999-05-20 2001-11-01 Lipotec Sa Procedimiento de sintesis de peptidos en fase solida
AR023940A1 (es) 2000-05-03 2002-09-04 Eriochem Sa Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua
CA2451187C (fr) 2001-06-22 2012-08-14 Southern Biosystems, Inc. Implants coaxiaux a liberation prolongee d'ordre 0
US20060287282A1 (en) * 2001-06-25 2006-12-21 Steiner Mitchell S Compositions comprising a SARM ad GnRH agonist or a GnRH antagonist, and methods of use thereof
WO2003015820A1 (fr) * 2001-08-10 2003-02-27 Takeda Chemical Industries, Ltd. Medicaments combines d'agoniste de la gnrh
US7812044B2 (en) 2001-11-13 2010-10-12 Takeda Pharmaceutical Company Limited Anticancer agents
US20030144203A1 (en) * 2001-12-19 2003-07-31 Voyager Pharmaceutical Corporation Methods for slowing senescence and treating and preventing diseases associated with senescence
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
DK2218448T3 (en) * 2002-12-13 2016-01-11 Durect Corp An oral drug delivery system comprising liquid carrier materials of high viscosity
GB0307777D0 (en) * 2003-04-04 2003-05-07 Medical Res Council Conjugate compounds
BRPI0515372B8 (pt) 2004-09-17 2021-05-25 Durect Corp composição líquida para fornecer anestesia local prolongada após administração a um indivíduo, e, uso de bupivacaína, acetato isobutirato de sacarose e álcool benzílico
WO2006077428A1 (fr) 2005-01-21 2006-07-27 Astex Therapeutics Limited Composes pharmaceutiques
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US8882747B2 (en) * 2005-11-09 2014-11-11 The Invention Science Fund I, Llc Substance delivery system
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
JP5528807B2 (ja) 2006-10-12 2014-06-25 アステックス、セラピューティックス、リミテッド 複合薬剤
WO2008066642A2 (fr) 2006-11-03 2008-06-05 Durect Corporation Systèmes d'administration par voie transdermique
AU2008335809A1 (en) * 2007-12-06 2009-06-18 Durect Corporation Methods useful for the treatment of pain, arthritic conditions, or inflammation associated with a chronic condition
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
RU2444525C2 (ru) * 2010-06-09 2012-03-10 Закрытое Акционерное Общество "Фарм-Синтез" Способ получения нонапептидэтиламида и промежуточные соединения для его получения
KR20170127044A (ko) 2010-06-16 2017-11-20 앙도르쉐르슈 인코포레이티드 에스트로겐-관련 질병의 치료 또는 예방 방법
US9555113B2 (en) 2013-03-15 2017-01-31 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
KR20220140711A (ko) 2020-01-13 2022-10-18 듀렉트 코퍼레이션 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896104A (en) * 1974-05-22 1975-07-22 American Home Prod P-glu-his-trp-ser-tyr-d-lys-leu-arg-pro-gly-nh' 2 'and intermediates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5726506B2 (fr) * 1974-03-08 1982-06-04
US3914412A (en) * 1973-10-11 1975-10-21 Abbott Lab {8 Des{13 Gly{9 {0 10 -Gn{13 RH nonapeptide amide analogs in position 6 having ovulation-inducing activity
US3901872A (en) * 1974-03-13 1975-08-26 American Home Prod P-glu-his-trp-ser-tyr-d-pgl-leu-arg-pro-gly-nh' 2 'and intermediates

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3896104A (en) * 1974-05-22 1975-07-22 American Home Prod P-glu-his-trp-ser-tyr-d-lys-leu-arg-pro-gly-nh' 2 'and intermediates

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0000764A1 (fr) * 1977-08-06 1979-02-21 Hoechst Aktiengesellschaft Agent anticonceptionnel contenant une peptide
FR2450109A1 (fr) * 1977-11-08 1980-09-26 Roussel Uclaf Nouvelle methode de traitement utilisant la lh-rh, ou des agonistes
FR2458538A1 (fr) * 1979-06-11 1981-01-02 Syntex Inc Derives nonapeptidiques et decapeptidiques de l'hormone liberant l'hormone luteinisante, leur procede de production et composition pharmaceutique les contenant
EP0021234A1 (fr) * 1979-06-11 1981-01-07 Syntex (U.S.A.) Inc. Dérivés nona- décapeptidiques de l'hormone libérant l'hormone lutéinisante, leur préparation et compositions pharmaceutiques les contenant
EP0220654A2 (fr) * 1985-10-22 1987-05-06 Richter Gedeon Vegyeszeti Gyar Rt. Analogues de gonadolibérine, leur procédé de préparation, composition pharmaceutique et emploi
EP0220654A3 (fr) * 1985-10-22 1989-09-06 Richter Gedeon Vegyeszeti Gyar Rt. Analogues de gonadolibérine, leur procédé de préparation, composition pharmaceutique et emploi

Also Published As

Publication number Publication date
DK361875A (da) 1976-02-10
NL182051C (nl) 1988-01-04
NL7509260A (nl) 1976-02-11
AU8374475A (en) 1977-02-10
IE41510B1 (en) 1980-01-16
ATA618975A (de) 1981-02-15
AT364093B (de) 1981-09-25
IE41510L (en) 1976-02-09
BE832310A (fr) 1976-02-11
DK148905B (da) 1985-11-11
US4024248A (en) 1977-05-17
NL182051B (nl) 1987-08-03
FR2281132B1 (fr) 1979-09-14
DE2438350C3 (de) 1979-06-13
SE7508926L (sv) 1976-02-10
GB1523623A (en) 1978-09-06
CH613186A5 (fr) 1979-09-14
SE424184B (sv) 1982-07-05
IL47880A (en) 1978-10-31
IL47880A0 (en) 1975-11-25
DK148905C (da) 1986-04-07
SE7805545L (fr) 1978-05-16
JPS5761268B2 (fr) 1982-12-23
DE2438350A1 (de) 1976-02-26
DE2438350B2 (de) 1978-10-26
LU73166A1 (fr) 1977-04-13
CA1069888A (fr) 1980-01-15
JPS5148659A (fr) 1976-04-26

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Legal Events

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CC Supplementary protection certificate (spc) laid open to the public (law of 25 june 1990)

Free format text: 92C0311, 920526

CB Supplementary protection certificate (spc) granted (law of 25 june 1990)

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