DK148905C - Analogifremgangsmaade til fremstilling af lh-rh-analoge nonapeptidderivater - Google Patents

Analogifremgangsmaade til fremstilling af lh-rh-analoge nonapeptidderivater

Info

Publication number
DK148905C
DK148905C DK361875A DK361875A DK148905C DK 148905 C DK148905 C DK 148905C DK 361875 A DK361875 A DK 361875A DK 361875 A DK361875 A DK 361875A DK 148905 C DK148905 C DK 148905C
Authority
DK
Denmark
Prior art keywords
nonapeptid
analogue
derivatives
preparation
analogy procedure
Prior art date
Application number
DK361875A
Other languages
Danish (da)
English (en)
Other versions
DK361875A (da
DK148905B (da
Inventor
Wolfgang Koenig
Rolf Geiger
Juergen Kurt Sandow
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK361875A publication Critical patent/DK361875A/da
Priority to DK439683A priority Critical patent/DK148906C/da
Publication of DK148905B publication Critical patent/DK148905B/da
Application granted granted Critical
Publication of DK148905C publication Critical patent/DK148905C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
DK361875A 1974-08-09 1975-08-08 Analogifremgangsmaade til fremstilling af lh-rh-analoge nonapeptidderivater DK148905C (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK439683A DK148906C (da) 1974-08-09 1983-09-26 Lh-rh-analoge nonapeptidderivater til diagnostisk anvendelse

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2438350A DE2438350C3 (de) 1974-08-09 1974-08-09 Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE2438350 1974-08-09

Publications (3)

Publication Number Publication Date
DK361875A DK361875A (da) 1976-02-10
DK148905B DK148905B (da) 1985-11-11
DK148905C true DK148905C (da) 1986-04-07

Family

ID=5922833

Family Applications (1)

Application Number Title Priority Date Filing Date
DK361875A DK148905C (da) 1974-08-09 1975-08-08 Analogifremgangsmaade til fremstilling af lh-rh-analoge nonapeptidderivater

Country Status (15)

Country Link
US (1) US4024248A (fr)
JP (1) JPS5761268B2 (fr)
AT (1) AT364093B (fr)
BE (1) BE832310A (fr)
CA (1) CA1069888A (fr)
CH (1) CH613186A5 (fr)
DE (1) DE2438350C3 (fr)
DK (1) DK148905C (fr)
FR (1) FR2281132A1 (fr)
GB (1) GB1523623A (fr)
IE (1) IE41510B1 (fr)
IL (1) IL47880A (fr)
LU (1) LU73166A1 (fr)
NL (1) NL182051C (fr)
SE (2) SE424184B (fr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2617646C2 (de) * 1976-04-22 1986-07-31 Hoechst Ag, 6230 Frankfurt Nonapeptid-amide und Decapeptid-amide mit Gonadoliberin-Wirkung, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Präparate
GB1524747A (en) * 1976-05-11 1978-09-13 Ici Ltd Polypeptide
DE2735515A1 (de) * 1977-08-06 1979-02-22 Hoechst Ag Verwendung von lh-rh-peptiden als antikonzeptive
FR2450109B1 (fr) * 1977-11-08 1986-03-28 Roussel Uclaf Nouvelle methode de traitement utilisant la lh-rh, ou des agonistes
IT1149971B (it) * 1979-06-11 1986-12-10 Syntex Inc Derivati nonapeptide e decapeptide dell'ormone che rilascia l'ormone luteinizzante
US4234571A (en) * 1979-06-11 1980-11-18 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
DE3020941A1 (de) * 1980-06-03 1981-12-17 Hoechst Ag, 6000 Frankfurt Nonapeptid, verfahren zu seiner herstellung, dieses enthaltendes mittel und seine verwendung
HU185535B (en) * 1982-05-25 1985-02-28 Mta Koezponti Hivatala Process for preparing new gonadoliberin derivatives
AT390066B (de) * 1983-03-29 1990-03-12 Richter Gedeon Vegyeszet Verfahren zur herstellung von neuen gonadoliberin-derivaten
HU187503B (en) * 1983-03-29 1986-01-28 Magyar Tudomanyos Akademia,Hu Process for preparing gonadoliberine derivatives containing beta-aspartyl group
DE3411224A1 (de) * 1984-03-27 1985-10-10 Hoechst Ag, 6230 Frankfurt Verfahren zur racematarmen herstellung von peptidzwischenprodukten der gonadorelin- und gonadorelinanaloga-synthese und neue zwischenprodukte bei diesem verfahren
US4760053A (en) * 1984-08-02 1988-07-26 Fernand Labrie Combination therapy for selected sex steroid dependent cancers
US4775660A (en) * 1984-08-02 1988-10-04 Fernand Labrie Treatment of breast cancer by combination therapy
US4666885A (en) * 1985-02-08 1987-05-19 Fernand Labrie Combination therapy for treatment of female breast cancer
HU193093B (en) * 1985-04-16 1987-08-28 Innofinance Process for stimulating sexual activity of birds and domestic mammalians and process for producing spermatocytes for their propagation
HU194280B (en) * 1985-10-22 1988-01-28 Richter Gedeon Vegyeszet Process for producing new gonadoliberin analogues of high effectivity and pharmaceutical compositions containing them
ZA901847B (en) * 1989-03-10 1991-10-30 Endorecherche Inc Combination therapy for the treatment of estrogen sensitive diseases
US5372996A (en) * 1989-03-10 1994-12-13 Endorecherche, Inc. Method of treatment of androgen-related diseases
JPH0235232A (ja) * 1989-06-29 1990-02-05 Nhk Spring Co Ltd 気室と液室を有する圧力容器
GR1001164B (el) * 1989-07-07 1993-05-24 Endorecherche Inc Παραγωγα αρρενογονου ορμονης προς χρησιν εις την αναστολην δραστηριοτητος της στεροειδους ορμονης φυλου
ES2189784T3 (es) * 1989-07-07 2003-07-16 Endorech Inc Procedimiento para el tratamiento de enfermedades relacionadas con adrogenos.
CA2029018A1 (fr) * 1989-11-01 1991-05-02 Robert P. Millar Analogues de l'hormone liberant de la gonadotrophine
JPH0474770U (fr) * 1990-10-31 1992-06-30
EP0641211A1 (fr) * 1992-05-21 1995-03-08 Endorecherche Inc. INHIBITEURS D'ACTIVITE DE LA TESTOSTERONE 5$g(a)-REDUCTASE
US7833543B2 (en) * 1995-06-07 2010-11-16 Durect Corporation High viscosity liquid controlled delivery system and medical or surgical device
US6413536B1 (en) 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
CA2192773C (fr) 1995-12-15 2008-09-23 Hiroaki Okada Obtention d'une preparation a liberation prolongee pour injection
CA2192782C (fr) 1995-12-15 2008-10-14 Nobuyuki Takechi Production de microsphere
US20060025328A1 (en) * 1997-05-28 2006-02-02 Burns Patrick J Compositions suitable for controlled release of the hormone GnRH and its analogs
US6051558A (en) * 1997-05-28 2000-04-18 Southern Biosystems, Inc. Compositions suitable for controlled release of the hormone GnRH and its analogs
US6242421B1 (en) 1997-11-06 2001-06-05 Richard Lloyd Bowen Methods for preventing and treating Alzheimer's disease
ES2154590B1 (es) 1999-05-20 2001-11-01 Lipotec Sa Procedimiento de sintesis de peptidos en fase solida
AR023940A1 (es) 2000-05-03 2002-09-04 Eriochem Sa Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua
AU2002324447B2 (en) * 2001-06-22 2006-06-29 Durect Corporation Zero-order prolonged release coaxial implants
US20060287282A1 (en) * 2001-06-25 2006-12-21 Steiner Mitchell S Compositions comprising a SARM ad GnRH agonist or a GnRH antagonist, and methods of use thereof
DE60239207D1 (de) * 2001-08-10 2011-03-31 Takeda Pharmaceutical Gnrh-agonistische kombinationsmittel
CA2466659A1 (fr) 2001-11-13 2003-05-22 Takeda Chemical Industries, Ltd. Agents anticancer
US20030144203A1 (en) * 2001-12-19 2003-07-31 Voyager Pharmaceutical Corporation Methods for slowing senescence and treating and preventing diseases associated with senescence
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
CA2801155A1 (fr) * 2002-12-13 2004-07-01 Durect Corporation Systeme d'administration de medicaments par voie orale
GB0307777D0 (en) * 2003-04-04 2003-05-07 Medical Res Council Conjugate compounds
US8753665B2 (en) 2004-09-17 2014-06-17 Durect Corporation Controlled delivery system
BRPI0606455A (pt) 2005-01-21 2008-03-11 Astex Therapeutics Ltd compostos farmacêuticos
US20070027105A1 (en) 2005-07-26 2007-02-01 Alza Corporation Peroxide removal from drug delivery vehicle
US8882747B2 (en) * 2005-11-09 2014-11-11 The Invention Science Fund I, Llc Substance delivery system
EP2073807A1 (fr) 2006-10-12 2009-07-01 Astex Therapeutics Limited Combinaisons pharmaceutiques
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
DK2117521T3 (da) 2006-11-03 2012-09-03 Durect Corp Transdermale indgivelsessystemer omfattende bupivacain
CA2706931C (fr) * 2007-12-06 2015-05-12 Durect Corporation Formes posologiques pharmaceutiques orales
US20100260844A1 (en) * 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
RU2444525C2 (ru) * 2010-06-09 2012-03-10 Закрытое Акционерное Общество "Фарм-Синтез" Способ получения нонапептидэтиламида и промежуточные соединения для его получения
EP2582371B1 (fr) 2010-06-16 2019-10-16 Endorecherche, Inc. Méthodes de traitement prophylactique ou thérapeutique de maladies liées aux oestrogènes
TW201521769A (zh) 2013-03-15 2015-06-16 Durect Corp 具有流變改質劑以減少溶解變異性之組成物
CN115666621A (zh) 2020-01-13 2023-01-31 度勒科特公司 具有减少的杂质的持续释放药物递送系统及相关方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5726506B2 (fr) * 1974-03-08 1982-06-04
US3914412A (en) * 1973-10-11 1975-10-21 Abbott Lab {8 Des{13 Gly{9 {0 10 -Gn{13 RH nonapeptide amide analogs in position 6 having ovulation-inducing activity
US3901872A (en) * 1974-03-13 1975-08-26 American Home Prod P-glu-his-trp-ser-tyr-d-pgl-leu-arg-pro-gly-nh' 2 'and intermediates
US3896104A (en) * 1974-05-22 1975-07-22 American Home Prod P-glu-his-trp-ser-tyr-d-lys-leu-arg-pro-gly-nh' 2 'and intermediates

Also Published As

Publication number Publication date
IL47880A0 (en) 1975-11-25
IL47880A (en) 1978-10-31
US4024248A (en) 1977-05-17
CH613186A5 (fr) 1979-09-14
AT364093B (de) 1981-09-25
DE2438350C3 (de) 1979-06-13
JPS5148659A (fr) 1976-04-26
ATA618975A (de) 1981-02-15
SE424184B (sv) 1982-07-05
IE41510L (en) 1976-02-09
DK361875A (da) 1976-02-10
LU73166A1 (fr) 1977-04-13
SE7805545L (fr) 1978-05-16
DE2438350A1 (de) 1976-02-26
GB1523623A (en) 1978-09-06
AU8374475A (en) 1977-02-10
SE7508926L (sv) 1976-02-10
DK148905B (da) 1985-11-11
NL182051C (nl) 1988-01-04
BE832310A (fr) 1976-02-11
NL182051B (nl) 1987-08-03
CA1069888A (fr) 1980-01-15
JPS5761268B2 (fr) 1982-12-23
IE41510B1 (en) 1980-01-16
NL7509260A (nl) 1976-02-11
DE2438350B2 (de) 1978-10-26
FR2281132B1 (fr) 1979-09-14
FR2281132A1 (fr) 1976-03-05

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Legal Events

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PUP Patent expired