FR2276042A1 - Nouvelles guanidines, leur procede de preparation et leurs applications - Google Patents

Nouvelles guanidines, leur procede de preparation et leurs applications

Info

Publication number
FR2276042A1
FR2276042A1 FR7519669A FR7519669A FR2276042A1 FR 2276042 A1 FR2276042 A1 FR 2276042A1 FR 7519669 A FR7519669 A FR 7519669A FR 7519669 A FR7519669 A FR 7519669A FR 2276042 A1 FR2276042 A1 FR 2276042A1
Authority
FR
France
Prior art keywords
applications
preparation process
guanidines
new
new guanidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7519669A
Other languages
English (en)
Other versions
FR2276042B1 (fr
Inventor
Graham John Durant
Charon Robin Ganellin
Geoffrey Robert Owen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
GlaxoSmithKline LLC
Original Assignee
Smith Kline and French Laboratories Ltd
GlaxoSmithKline LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd, GlaxoSmithKline LLC filed Critical Smith Kline and French Laboratories Ltd
Publication of FR2276042A1 publication Critical patent/FR2276042A1/fr
Application granted granted Critical
Publication of FR2276042B1 publication Critical patent/FR2276042B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/32—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
FR7519669A 1974-06-28 1975-06-24 Nouvelles guanidines, leur procede de preparation et leurs applications Granted FR2276042A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB28722/74A GB1497260A (en) 1974-06-28 1974-06-28 Guanidine derivatives

Publications (2)

Publication Number Publication Date
FR2276042A1 true FR2276042A1 (fr) 1976-01-23
FR2276042B1 FR2276042B1 (fr) 1980-04-25

Family

ID=10280055

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7519669A Granted FR2276042A1 (fr) 1974-06-28 1975-06-24 Nouvelles guanidines, leur procede de preparation et leurs applications

Country Status (20)

Country Link
US (1) US4034101A (fr)
JP (1) JPS5946221B2 (fr)
AU (1) AU503858B2 (fr)
BE (1) BE830272A (fr)
CA (1) CA1076579A (fr)
CH (1) CH615669A5 (fr)
DE (1) DE2528639A1 (fr)
DK (1) DK268975A (fr)
ES (1) ES438944A1 (fr)
FR (1) FR2276042A1 (fr)
GB (1) GB1497260A (fr)
IE (1) IE41625B1 (fr)
IL (1) IL47394A (fr)
LU (1) LU72835A1 (fr)
NL (1) NL7506951A (fr)
NO (1) NO143942C (fr)
PH (1) PH14275A (fr)
PL (1) PL98616B1 (fr)
SE (1) SE417961B (fr)
ZA (1) ZA753455B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010893A1 (fr) * 1978-10-16 1980-05-14 Imperial Chemical Industries Plc Dérivés antisécrétoires hétérocycliques de la guanidine comprenant des chaînes ramifiées, procédés pour leur préparation, produits intermédiaires et compositions pharmaceutiques contenant lesdits dérivés

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5014808U (fr) * 1973-06-06 1975-02-17
JPS55822B2 (fr) * 1973-07-09 1980-01-10
GB1493931A (en) * 1974-02-07 1977-11-30 Smith Kline French Lab Guanidines isothioureas and thioureas
US4197305A (en) * 1974-02-07 1980-04-08 Smith Kline & French Laboratories Limited Thiazole, isothiazole, oxazole and isoxazole compounds
US4133886A (en) * 1974-02-07 1979-01-09 Smith Kline & French Laboratories Limited Guanidino, thioureido, isothioureido and nitrovinylamino derivatives of pyridine
GB1496787A (en) * 1974-03-12 1978-01-05 Smith Kline French Lab Heteroalkylthioalkyl amidine derivatives
US4170652A (en) * 1974-03-12 1979-10-09 Smith Kline & French Laboratories Limited Heterocyclic-methylthioalkyl-guanidines
JPS5912767Y2 (ja) * 1974-03-28 1984-04-17 アイワ カブシキガイシヤ 回転機器の作動切換装置
US4093729A (en) * 1974-06-28 1978-06-06 Smith Kline & French Laboratories Limited N-Oxy and N-amino guanidines
IL49528A (en) * 1975-05-21 1980-11-30 Smith Kline French Lab Imidazolyl(or thiazolyl)methylthio(or butyl)guanidine or thiourea derivatives,their preparation and pharmaceutical compositions comprising them
US4192879A (en) * 1975-05-21 1980-03-11 Smith Kline & French Laboratories Limited Imidazolyl alkylamino nitroethylene compounds
GB1564502A (en) * 1975-07-31 1980-04-10 Smith Kline French Lab Guanidines thioureas and 1,1-diamino-2-nitroethylene derivatives
US4165378A (en) 1977-04-20 1979-08-21 Ici Americas Inc. Guanidine derivatives of imidazoles and thiazoles
ZA782129B (en) 1977-04-20 1979-03-28 Ici Ltd Hertocyclic derivatives
GB1602458A (en) * 1977-05-05 1981-11-11 Smith Kline French Lab Bisamidines as histamine h2-antagonists
US4108859A (en) * 1977-06-06 1978-08-22 The Dow Chemical Company Microbicidal (pyridinylamino) alkyl guanidines
US4233302A (en) 1977-12-23 1980-11-11 Glaxo Group Limited Amine derivatives and pharmaceutical compositions containing them
ATE1353T1 (de) 1978-05-24 1982-08-15 Imperial Chemical Industries Plc Anti-sekretion thiadiazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zusammensetzungen.
JPS56124143A (en) * 1980-02-29 1981-09-29 Sanyo Electric Co Ltd Control mechanism of tape recorder
AU2222083A (en) * 1982-12-14 1984-06-21 Smith Kline & French Laboratories Limited Pyridine derivatives
JPS6156012U (fr) * 1984-09-19 1986-04-15
JPS61228914A (ja) * 1985-04-04 1986-10-13 Sumitomo Heavy Ind Ltd 成形用金型
JPH0347862Y2 (fr) * 1985-12-14 1991-10-14
EP4196793A1 (fr) 2020-08-11 2023-06-21 Université de Strasbourg Bloqueurs de h2 ciblant des macrophages du foie pour la prévention et le traitement d'une maladie du foie et du cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE758146A (fr) * 1969-10-29 1971-04-28 Smith Kline French Lab Derives de l'amidine
GB1338169A (en) * 1971-03-09 1973-11-21 Smith Kline French Lab Ureas thioureas and guanidines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010893A1 (fr) * 1978-10-16 1980-05-14 Imperial Chemical Industries Plc Dérivés antisécrétoires hétérocycliques de la guanidine comprenant des chaînes ramifiées, procédés pour leur préparation, produits intermédiaires et compositions pharmaceutiques contenant lesdits dérivés

Also Published As

Publication number Publication date
SE7507364L (sv) 1975-12-29
IL47394A (en) 1980-01-31
NO752330L (fr) 1975-12-30
DK268975A (da) 1975-12-29
IE41625B1 (en) 1980-02-13
ZA753455B (en) 1976-04-28
BE830272A (fr) 1975-12-16
DE2528639A1 (de) 1976-01-15
SE417961B (sv) 1981-04-27
ES438944A1 (es) 1977-02-16
CA1076579A (fr) 1980-04-29
FR2276042B1 (fr) 1980-04-25
JPS5119766A (fr) 1976-02-17
AU503858B2 (en) 1979-09-27
PH14275A (en) 1981-04-29
GB1497260A (en) 1978-01-05
NL7506951A (nl) 1975-12-30
CH615669A5 (fr) 1980-02-15
JPS5946221B2 (ja) 1984-11-10
AU8230475A (en) 1976-12-23
US4034101A (en) 1977-07-05
LU72835A1 (fr) 1975-10-08
PL98616B1 (pl) 1978-05-31
NO143942C (no) 1981-05-13
NO143942B (no) 1981-02-02
IE41625L (en) 1975-12-28
IL47394A0 (en) 1975-07-28

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