FR2272678A1 - N(6)-Disubstd. adenosine derivs - prepd. by reacting 6-(reactively substd.) purine ribosides with secondary amines - Google Patents

N(6)-Disubstd. adenosine derivs - prepd. by reacting 6-(reactively substd.) purine ribosides with secondary amines

Info

Publication number
FR2272678A1
FR2272678A1 FR7516924A FR7516924A FR2272678A1 FR 2272678 A1 FR2272678 A1 FR 2272678A1 FR 7516924 A FR7516924 A FR 7516924A FR 7516924 A FR7516924 A FR 7516924A FR 2272678 A1 FR2272678 A1 FR 2272678A1
Authority
FR
France
Prior art keywords
adenosine
derivs
prepd
reacting
disubstd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
FR7516924A
Other languages
French (fr)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of FR2272678A1 publication Critical patent/FR2272678A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Abstract

adenosine derivs. of formula (I), (where R1 is lower alkyl, cycloalkyl or bicycloalkyl; R2 is H or acyl; X is O or S; and n is 1, 2 or 3), e.g. N6-cyclopentyl-N6-(2-thenyl-adenosine, and their pharmacologically tolerable salts are new cpds. which can be prepd. by reacting a corresp. 6-Z-purine riboside (II) (where Z is a reactive residue) with an appropriate amine (III). (I) do not have the usual cardiovascular effects of adenosine derivs., but instead have strong antilipolytic, antihyperlipaemic and antihypercholesterol-aemic activity.
FR7516924A 1974-06-01 1975-05-30 N(6)-Disubstd. adenosine derivs - prepd. by reacting 6-(reactively substd.) purine ribosides with secondary amines Withdrawn FR2272678A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19742426682 DE2426682A1 (en) 1974-06-01 1974-06-01 NEW N (6) -DISUBSTITUTED ADENOSINE DERIVATIVES AND METHOD FOR MANUFACTURING THE SAME

Publications (1)

Publication Number Publication Date
FR2272678A1 true FR2272678A1 (en) 1975-12-26

Family

ID=5917125

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7516924A Withdrawn FR2272678A1 (en) 1974-06-01 1975-05-30 N(6)-Disubstd. adenosine derivs - prepd. by reacting 6-(reactively substd.) purine ribosides with secondary amines

Country Status (7)

Country Link
JP (1) JPS511493A (en)
BE (1) BE829498A (en)
DE (1) DE2426682A1 (en)
FI (1) FI751527A (en)
FR (1) FR2272678A1 (en)
NL (1) NL7506427A (en)
SE (1) SE7506024L (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985004882A1 (en) * 1984-04-18 1985-11-07 Nelson Research And Development Company N-6 substituted adenosine derivatives as cardiac vasodilators

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52108721A (en) * 1976-03-08 1977-09-12 Nippon Telegr & Teleph Corp <Ntt> Generating method of time series signal having memory function
US4657897A (en) * 1984-06-22 1987-04-14 Warner-Lambert Company N6 -substituted adenosines for treating pain
US4600707A (en) * 1985-01-25 1986-07-15 Warner-Lambert Company Benzothien-3-yl adenosine; benzothien-3-yl adenosine, S-oxide; and benzothien-3-yl, S,S-dioxide adenosine compounds
US4636493A (en) * 1985-01-25 1987-01-13 Warner-Lambert Company Benzothien-3-yl adenosine; benzothien-3-yl adenosine, S-oxide; and benzothien-3-yl, S,S-dioxide adenosine compounds
GB8729994D0 (en) * 1987-12-23 1988-02-03 Glaxo Group Ltd Chemical compounds

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985004882A1 (en) * 1984-04-18 1985-11-07 Nelson Research And Development Company N-6 substituted adenosine derivatives as cardiac vasodilators
EP0305643A2 (en) * 1984-04-18 1989-03-08 Whitby Research Incorporated N-6 thienyl substituted adenosine derivatives as cardiac vasodilators
EP0305643A3 (en) * 1984-04-18 1989-08-30 Nelson Research & Development Company N-6 thienyl substituted adenosine derivatives as cardiac vasodilators

Also Published As

Publication number Publication date
SE7506024L (en) 1975-12-02
JPS511493A (en) 1976-01-08
FI751527A (en) 1975-12-02
NL7506427A (en) 1975-12-03
DE2426682A1 (en) 1975-12-11
BE829498A (en) 1975-11-26

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