NL7505109A - Thebaine produced from salutaridinols - in higher yield by acid deriv. then alkali treatment - Google Patents

Thebaine produced from salutaridinols - in higher yield by acid deriv. then alkali treatment

Info

Publication number
NL7505109A
NL7505109A NL7505109A NL7505109A NL7505109A NL 7505109 A NL7505109 A NL 7505109A NL 7505109 A NL7505109 A NL 7505109A NL 7505109 A NL7505109 A NL 7505109A NL 7505109 A NL7505109 A NL 7505109A
Authority
NL
Netherlands
Prior art keywords
salutaridinols
alkali treatment
higher yield
thebaine
produced
Prior art date
Application number
NL7505109A
Other languages
Dutch (nl)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Priority to NL7505109A priority Critical patent/NL7505109A/en
Publication of NL7505109A publication Critical patent/NL7505109A/en

Links

Abstract

Thebaine is produced in high yield by (a) reacting either or both the epimeric salutaridinols with a 2-4C aliphatic acid anhydride or with SOCl2, SOBr2, POCl3, POBr3, PBr3, PCl3, PCl5, PBr5, COCl2, CH3SO2Cl and SO2, CH3SO2Br, ClCO2CH3, ClCO2CH2Ph or p-dinitrophenylchlorocarbonate opt. in the presence of an additional tert. amine and (b) treating the prod. obtd. with an alkali metal hydroxide, carbonate or phosphate. Pref. the reaction is effected at -10 to +25 degrees C. The epimeric mixt. is partic. obtd. by NaBH4 redn. of salutaridine.
NL7505109A 1975-04-29 1975-04-29 Thebaine produced from salutaridinols - in higher yield by acid deriv. then alkali treatment NL7505109A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NL7505109A NL7505109A (en) 1975-04-29 1975-04-29 Thebaine produced from salutaridinols - in higher yield by acid deriv. then alkali treatment

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7505109A NL7505109A (en) 1975-04-29 1975-04-29 Thebaine produced from salutaridinols - in higher yield by acid deriv. then alkali treatment

Publications (1)

Publication Number Publication Date
NL7505109A true NL7505109A (en) 1976-11-02

Family

ID=19823669

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7505109A NL7505109A (en) 1975-04-29 1975-04-29 Thebaine produced from salutaridinols - in higher yield by acid deriv. then alkali treatment

Country Status (1)

Country Link
NL (1) NL7505109A (en)

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Legal Events

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BV The patent application has lapsed