FR2263767A1 - Antibiotic tolypomycinone derivs - with good acid stability, suitable for oral administration - Google Patents
Antibiotic tolypomycinone derivs - with good acid stability, suitable for oral administrationInfo
- Publication number
- FR2263767A1 FR2263767A1 FR7507705A FR7507705A FR2263767A1 FR 2263767 A1 FR2263767 A1 FR 2263767A1 FR 7507705 A FR7507705 A FR 7507705A FR 7507705 A FR7507705 A FR 7507705A FR 2263767 A1 FR2263767 A1 FR 2263767A1
- Authority
- FR
- France
- Prior art keywords
- tolypomycinone
- oral administration
- derivs
- antibiotic
- acid stability
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002253 acid Substances 0.000 title abstract 3
- ATGMUGGQHFXWNQ-UHFFFAOYSA-N Tolypomycinone Natural products O=C1C(C(O)=C2C)=C3C(=O)C=C1NC(=O)C(C)=CC(=O)C1CC1C(O)C(C)C(O)C(C)C(OC(C)=O)C(C)C(OC)C=COC1(C)OC2=C3C1=O ATGMUGGQHFXWNQ-UHFFFAOYSA-N 0.000 title abstract 2
- ATGMUGGQHFXWNQ-POLRJCGMSA-N chembl309344 Chemical compound O=C1C(C(O)=C2C)=C3C(=O)C=C1NC(=O)\C(C)=C/C(=O)C1CC1C(O)C(C)C(O)C(C)C(OC(C)=O)C(C)C(OC)\C=C\OC1(C)OC2=C3C1=O ATGMUGGQHFXWNQ-POLRJCGMSA-N 0.000 title abstract 2
- 230000003115 biocidal effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 2
- 208000015181 infectious disease Diseases 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 206010035664 Pneumonia Diseases 0.000 abstract 1
- RYCBEGMWBUYSAD-UHFFFAOYSA-N Tolypomycin Y Natural products COC1C=COC2(C)Oc3c(C)c(O)c4C(=O)C(=CC(=N/C5CCC(O)OC5C)c4c3C2=O)NC(=O)C(=C/C(=O)C6CC6C(O)C(C)C(O)C(C)C(OC(=O)C)C1C)C RYCBEGMWBUYSAD-UHFFFAOYSA-N 0.000 abstract 1
- RYCBEGMWBUYSAD-GBHYQGRQSA-N [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,20R,22Z)-2,15,17-trihydroxy-28-[(2S,3R,6S)-6-hydroxy-2-methyloxan-3-yl]imino-11-methoxy-3,7,12,14,16,23-hexamethyl-6,21,24,30-tetraoxo-8,31-dioxa-25-azapentacyclo[24.3.1.14,7.05,29.018,20]hentriaconta-1(29),2,4,9,22,26-hexaen-13-yl] acetate Chemical compound C[C@@H]1[C@H](/C=C/O[C@@]2(C(=O)C3=C(O2)C(=C(C4=C3C(=N[C@@H]5CC[C@H](O[C@H]5C)O)C=C(C4=O)NC(=O)/C(=C\C(=O)[C@@H]6C[C@@H]6[C@@H]([C@H]([C@H]([C@H]([C@@H]1OC(=O)C)C)O)C)O)/C)O)C)C)OC RYCBEGMWBUYSAD-GBHYQGRQSA-N 0.000 abstract 1
- 206010000269 abscess Diseases 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000003899 bactericide agent Substances 0.000 abstract 1
- 210000001035 gastrointestinal tract Anatomy 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1167474A GB1498033A (en) | 1974-03-15 | 1974-03-15 | Tolypomycinone derivatives and process for their preparation |
| GB4739874 | 1974-11-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2263767A1 true FR2263767A1 (en) | 1975-10-10 |
| FR2263767B1 FR2263767B1 (enrdf_load_stackoverflow) | 1980-01-04 |
Family
ID=26248441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7507705A Granted FR2263767A1 (en) | 1974-03-15 | 1975-03-12 | Antibiotic tolypomycinone derivs - with good acid stability, suitable for oral administration |
Country Status (14)
-
1975
- 1975-03-10 PH PH16897A patent/PH13558A/en unknown
- 1975-03-12 FR FR7507705A patent/FR2263767A1/fr active Granted
- 1975-03-12 LU LU72029A patent/LU72029A1/xx unknown
- 1975-03-13 JP JP3062875A patent/JPS5341680B2/ja not_active Expired
- 1975-03-13 DE DE19752510931 patent/DE2510931A1/de not_active Withdrawn
- 1975-03-13 IT IT03359/75A patent/IT1060152B/it active
- 1975-03-13 NL NL7502980.A patent/NL159986C/xx not_active IP Right Cessation
- 1975-03-14 CA CA222,075A patent/CA1063604A/en not_active Expired
- 1975-03-14 FI FI750743A patent/FI59101C/fi not_active IP Right Cessation
- 1975-03-14 DK DK104075A patent/DK104075A/da unknown
- 1975-03-14 ES ES435620A patent/ES435620A1/es not_active Expired
- 1975-03-14 AR AR257966A patent/AR208540A1/es active
- 1975-03-14 AT AT195975A patent/AT335610B/de not_active IP Right Cessation
- 1975-03-14 SE SE7502882A patent/SE7502882L/xx unknown
-
1976
- 1976-01-23 AR AR262003A patent/AR213283A1/es active
Also Published As
| Publication number | Publication date |
|---|---|
| LU72029A1 (enrdf_load_stackoverflow) | 1976-02-04 |
| JPS5341680B2 (enrdf_load_stackoverflow) | 1978-11-06 |
| NL7502980A (nl) | 1975-09-17 |
| FI750743A7 (enrdf_load_stackoverflow) | 1975-09-16 |
| SE7502882L (sv) | 1975-09-16 |
| IT1060152B (it) | 1982-07-10 |
| PH13558A (en) | 1980-06-26 |
| NL159986B (nl) | 1979-04-17 |
| CA1063604A (en) | 1979-10-02 |
| ES435620A1 (es) | 1977-05-01 |
| JPS50157399A (enrdf_load_stackoverflow) | 1975-12-19 |
| FR2263767B1 (enrdf_load_stackoverflow) | 1980-01-04 |
| FI59101C (fi) | 1981-06-10 |
| AT335610B (de) | 1977-03-25 |
| AR208540A1 (es) | 1977-02-15 |
| DE2510931A1 (de) | 1975-11-13 |
| FI59101B (fi) | 1981-02-27 |
| DK104075A (enrdf_load_stackoverflow) | 1975-09-16 |
| NL159986C (nl) | 1979-09-17 |
| ATA195975A (de) | 1976-07-15 |
| AR213283A1 (es) | 1979-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |