FR2264558A1 - Polymixin-methyl tetracycline salt antibiotics - active against Gram positive and negative bacteria, viruses and protozoa - Google Patents
Polymixin-methyl tetracycline salt antibiotics - active against Gram positive and negative bacteria, viruses and protozoaInfo
- Publication number
- FR2264558A1 FR2264558A1 FR7409510A FR7409510A FR2264558A1 FR 2264558 A1 FR2264558 A1 FR 2264558A1 FR 7409510 A FR7409510 A FR 7409510A FR 7409510 A FR7409510 A FR 7409510A FR 2264558 A1 FR2264558 A1 FR 2264558A1
- Authority
- FR
- France
- Prior art keywords
- polymixin
- protozoa
- viruses
- formula
- active against
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Polymixin-methyl tetracycline salts of formula (I) are new: (TH+-CO-NH2-CH2-NH)N-QxNA- .mHB (I) (where m and n are integers up to 6; A- and B- are mineral or organic anion; T is the residue of a prim.amid gp. contg. tetracycline antibiotic of formula: T-CO-NH2; Q is the residue of a polymixin polypeptide antibiotic, pref. of formula: Q-(NH2)n, esp. colistin). (I) are broad-spectrum antibiotics active against Gram-positive and -negative bacteria, viruses, protozoa and certain flagellates. Compared with a mixt. of the corresp. tetracycline and polymixin, (I) have lower toxicity and higher in vivo and in vitro antibacterial activity, and also can permeate completely through the gastrointestinal wall. (I) are esp. useful for the oral treatment of Gram-negative infections of the respiratory, urinary and digestive tracts and gynaecological infections, in human and veterinary medicine. (I) are stable in the dry state or in neutral or weakly alkaline soln. (e.g., at pH 8.5).
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7409510A FR2264558A1 (en) | 1974-03-20 | 1974-03-20 | Polymixin-methyl tetracycline salt antibiotics - active against Gram positive and negative bacteria, viruses and protozoa |
CA222,417A CA1070675A (en) | 1974-03-20 | 1975-03-18 | Polymyxin methyl tetracycline |
DE19752511852 DE2511852A1 (en) | 1974-03-20 | 1975-03-18 | NEW WIDE-SPECTRUM ANTIBIOTICS |
JP50034211A JPS51125715A (en) | 1974-03-20 | 1975-03-19 | Production of polymixin methyltetracycline and its salt |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7409510A FR2264558A1 (en) | 1974-03-20 | 1974-03-20 | Polymixin-methyl tetracycline salt antibiotics - active against Gram positive and negative bacteria, viruses and protozoa |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2264558A1 true FR2264558A1 (en) | 1975-10-17 |
FR2264558B1 FR2264558B1 (en) | 1979-07-13 |
Family
ID=9136607
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7409510A Granted FR2264558A1 (en) | 1974-03-20 | 1974-03-20 | Polymixin-methyl tetracycline salt antibiotics - active against Gram positive and negative bacteria, viruses and protozoa |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPS51125715A (en) |
CA (1) | CA1070675A (en) |
DE (1) | DE2511852A1 (en) |
FR (1) | FR2264558A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994009806A1 (en) * | 1992-10-29 | 1994-05-11 | Rainer Denecke | Preparation for therapeutic and especially prophylactic treatment of digestive tract disorders |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4307352A1 (en) * | 1992-10-29 | 1994-05-05 | Denecke Rainer Dr Med Vet | Preparation for therapy and especially prophylaxis of diseases of the digestive tract |
JP4917210B2 (en) * | 2001-04-11 | 2012-04-18 | ロンシール工業株式会社 | Parting material |
JP4917214B2 (en) * | 2001-05-14 | 2012-04-18 | ロンシール工業株式会社 | Waist wall baseboard and its construction method |
-
1974
- 1974-03-20 FR FR7409510A patent/FR2264558A1/en active Granted
-
1975
- 1975-03-18 DE DE19752511852 patent/DE2511852A1/en active Pending
- 1975-03-18 CA CA222,417A patent/CA1070675A/en not_active Expired
- 1975-03-19 JP JP50034211A patent/JPS51125715A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1994009806A1 (en) * | 1992-10-29 | 1994-05-11 | Rainer Denecke | Preparation for therapeutic and especially prophylactic treatment of digestive tract disorders |
Also Published As
Publication number | Publication date |
---|---|
DE2511852A1 (en) | 1975-10-09 |
CA1070675A (en) | 1980-01-29 |
JPS51125715A (en) | 1976-11-02 |
FR2264558B1 (en) | 1979-07-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |