FR2264558A1 - Polymixin-methyl tetracycline salt antibiotics - active against Gram positive and negative bacteria, viruses and protozoa - Google Patents

Polymixin-methyl tetracycline salt antibiotics - active against Gram positive and negative bacteria, viruses and protozoa

Info

Publication number
FR2264558A1
FR2264558A1 FR7409510A FR7409510A FR2264558A1 FR 2264558 A1 FR2264558 A1 FR 2264558A1 FR 7409510 A FR7409510 A FR 7409510A FR 7409510 A FR7409510 A FR 7409510A FR 2264558 A1 FR2264558 A1 FR 2264558A1
Authority
FR
France
Prior art keywords
polymixin
protozoa
viruses
formula
active against
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7409510A
Other languages
French (fr)
Other versions
FR2264558B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NIVIERE PIERRE FR
Original Assignee
NIVIERE PIERRE FR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NIVIERE PIERRE FR filed Critical NIVIERE PIERRE FR
Priority to FR7409510A priority Critical patent/FR2264558A1/en
Priority to CA222,417A priority patent/CA1070675A/en
Priority to DE19752511852 priority patent/DE2511852A1/en
Priority to JP50034211A priority patent/JPS51125715A/en
Publication of FR2264558A1 publication Critical patent/FR2264558A1/en
Application granted granted Critical
Publication of FR2264558B1 publication Critical patent/FR2264558B1/fr
Granted legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Polymixin-methyl tetracycline salts of formula (I) are new: (TH+-CO-NH2-CH2-NH)N-QxNA- .mHB (I) (where m and n are integers up to 6; A- and B- are mineral or organic anion; T is the residue of a prim.amid gp. contg. tetracycline antibiotic of formula: T-CO-NH2; Q is the residue of a polymixin polypeptide antibiotic, pref. of formula: Q-(NH2)n, esp. colistin). (I) are broad-spectrum antibiotics active against Gram-positive and -negative bacteria, viruses, protozoa and certain flagellates. Compared with a mixt. of the corresp. tetracycline and polymixin, (I) have lower toxicity and higher in vivo and in vitro antibacterial activity, and also can permeate completely through the gastrointestinal wall. (I) are esp. useful for the oral treatment of Gram-negative infections of the respiratory, urinary and digestive tracts and gynaecological infections, in human and veterinary medicine. (I) are stable in the dry state or in neutral or weakly alkaline soln. (e.g., at pH 8.5).
FR7409510A 1974-03-20 1974-03-20 Polymixin-methyl tetracycline salt antibiotics - active against Gram positive and negative bacteria, viruses and protozoa Granted FR2264558A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
FR7409510A FR2264558A1 (en) 1974-03-20 1974-03-20 Polymixin-methyl tetracycline salt antibiotics - active against Gram positive and negative bacteria, viruses and protozoa
CA222,417A CA1070675A (en) 1974-03-20 1975-03-18 Polymyxin methyl tetracycline
DE19752511852 DE2511852A1 (en) 1974-03-20 1975-03-18 NEW WIDE-SPECTRUM ANTIBIOTICS
JP50034211A JPS51125715A (en) 1974-03-20 1975-03-19 Production of polymixin methyltetracycline and its salt

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7409510A FR2264558A1 (en) 1974-03-20 1974-03-20 Polymixin-methyl tetracycline salt antibiotics - active against Gram positive and negative bacteria, viruses and protozoa

Publications (2)

Publication Number Publication Date
FR2264558A1 true FR2264558A1 (en) 1975-10-17
FR2264558B1 FR2264558B1 (en) 1979-07-13

Family

ID=9136607

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7409510A Granted FR2264558A1 (en) 1974-03-20 1974-03-20 Polymixin-methyl tetracycline salt antibiotics - active against Gram positive and negative bacteria, viruses and protozoa

Country Status (4)

Country Link
JP (1) JPS51125715A (en)
CA (1) CA1070675A (en)
DE (1) DE2511852A1 (en)
FR (1) FR2264558A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994009806A1 (en) * 1992-10-29 1994-05-11 Rainer Denecke Preparation for therapeutic and especially prophylactic treatment of digestive tract disorders

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4307352A1 (en) * 1992-10-29 1994-05-05 Denecke Rainer Dr Med Vet Preparation for therapy and especially prophylaxis of diseases of the digestive tract
JP4917210B2 (en) * 2001-04-11 2012-04-18 ロンシール工業株式会社 Parting material
JP4917214B2 (en) * 2001-05-14 2012-04-18 ロンシール工業株式会社 Waist wall baseboard and its construction method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994009806A1 (en) * 1992-10-29 1994-05-11 Rainer Denecke Preparation for therapeutic and especially prophylactic treatment of digestive tract disorders

Also Published As

Publication number Publication date
DE2511852A1 (en) 1975-10-09
CA1070675A (en) 1980-01-29
JPS51125715A (en) 1976-11-02
FR2264558B1 (en) 1979-07-13

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