FR2250517A1 - Dihydro-dithiinyl-and-oxathiinyl-methyl cephalosporins - with broad-spectrum antibacterial activity - Google Patents

Dihydro-dithiinyl-and-oxathiinyl-methyl cephalosporins - with broad-spectrum antibacterial activity

Info

Publication number
FR2250517A1
FR2250517A1 FR7340431A FR7340431A FR2250517A1 FR 2250517 A1 FR2250517 A1 FR 2250517A1 FR 7340431 A FR7340431 A FR 7340431A FR 7340431 A FR7340431 A FR 7340431A FR 2250517 A1 FR2250517 A1 FR 2250517A1
Authority
FR
France
Prior art keywords
broad
oxathiinyl
dithiinyl
dihydro
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7340431A
Other languages
French (fr)
Other versions
FR2250517B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rhone Poulenc Industries SA
Original Assignee
Rhone Poulenc Industries SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Industries SA filed Critical Rhone Poulenc Industries SA
Priority to FR7340431A priority Critical patent/FR2250517A1/en
Priority to AR256515A priority patent/AR205728A1/en
Priority to NL7414486A priority patent/NL7414486A/en
Priority to HURO809A priority patent/HU168853B/hu
Priority to US05/523,007 priority patent/US4007176A/en
Priority to AU75284/74A priority patent/AU478597B2/en
Priority to GB4897874A priority patent/GB1430908A/en
Priority to IL46040A priority patent/IL46040A/en
Priority to ZA00747239A priority patent/ZA747239B/en
Priority to IE2325/74A priority patent/IE40206B1/en
Priority to JP49129663A priority patent/JPS5082090A/ja
Priority to DK590774A priority patent/DK590774A/da
Priority to BE150460A priority patent/BE822141A/en
Priority to NO744081A priority patent/NO744081L/no
Priority to SU7402077414A priority patent/SU566525A3/en
Priority to CH1515974A priority patent/CH608499A5/xx
Priority to SE7414263A priority patent/SE7414263L/xx
Priority to CA213,621A priority patent/CA1026745A/en
Priority to CH778377A priority patent/CH602762A5/xx
Priority to AT914274A priority patent/AT335608B/en
Priority to DE19742454109 priority patent/DE2454109A1/en
Priority to FI3300/74A priority patent/FI330074A/fi
Priority to ES431943A priority patent/ES431943A1/en
Priority to AR259958A priority patent/AR205398A1/en
Publication of FR2250517A1 publication Critical patent/FR2250517A1/en
Priority to SU7502190958A priority patent/SU576947A3/en
Priority to AT116276A priority patent/AT335065B/en
Application granted granted Critical
Publication of FR2250517B1 publication Critical patent/FR2250517B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cephalosporin derivs of formula (I) and their salts are new: (where one of A and A1 is O or S and the other is S; R1 is H, acetoxy, 5-methyl-1,3,4-thiadiazol-2-ylthio or 1-methyl-1,2,3,4-tetrazol-5-ylthio and R2 is COOH, or R1 is pyridino and R2 is COO). Cpds (I) are broad-spectrum antibacterials, e.g. active against penicillin sensitive Staph. aureus strains in concns of 0.01-50 mu g/ml and against penicillin-resistant Staph. aureus strains and E. coli (Monod strain) in concns of 0.1-50 mu g/ml.
FR7340431A 1973-11-14 1973-11-14 Dihydro-dithiinyl-and-oxathiinyl-methyl cephalosporins - with broad-spectrum antibacterial activity Granted FR2250517A1 (en)

Priority Applications (26)

Application Number Priority Date Filing Date Title
FR7340431A FR2250517A1 (en) 1973-11-14 1973-11-14 Dihydro-dithiinyl-and-oxathiinyl-methyl cephalosporins - with broad-spectrum antibacterial activity
AR256515A AR205728A1 (en) 1973-11-14 1974-01-01 PROCEDURE FOR PREPARING ((DIHYDRO-5,6-OXA) - (DI) TIINO-1,4-IL-2) ACETAMIDO) -7 CEPHALOSPORIN AND ITS SALTS
NL7414486A NL7414486A (en) 1973-11-14 1974-11-06 PROCESS FOR THE PREPARATION OF CEPHALOSPORIN DERIVATIVES AND ANTIBACTERIAL PREPARATIONS CONTAINING THESE COMPONENTS AS AN ACTIVE COMPONENT.
HURO809A HU168853B (en) 1973-11-14 1974-11-11
AU75284/74A AU478597B2 (en) 1973-11-14 1974-11-12 Derivatives of cephalosporin
GB4897874A GB1430908A (en) 1973-11-14 1974-11-12 Derivatives of cephalosporin
IL46040A IL46040A (en) 1973-11-14 1974-11-12 7(5,6-dihydro-1,4-dithin or oxathiin acetamido) cephalosporanic acid derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
ZA00747239A ZA747239B (en) 1973-11-14 1974-11-12 Derivatives of cephalosporin
IE2325/74A IE40206B1 (en) 1973-11-14 1974-11-12 Derivatives of cephalosporin
JP49129663A JPS5082090A (en) 1973-11-14 1974-11-12
US05/523,007 US4007176A (en) 1973-11-14 1974-11-12 Cephalosporin derivatives
NO744081A NO744081L (en) 1973-11-14 1974-11-13
DK590774A DK590774A (en) 1973-11-14 1974-11-13
SU7402077414A SU566525A3 (en) 1973-11-14 1974-11-13 Method of obtaining derivatives of cephalosporine and their salts with metals or nitrogen-containing bases
CH1515974A CH608499A5 (en) 1973-11-14 1974-11-13
SE7414263A SE7414263L (en) 1973-11-14 1974-11-13
CA213,621A CA1026745A (en) 1973-11-14 1974-11-13 Cephalosporin derivatives, a process for their preparation and composition in which they are used
CH778377A CH602762A5 (en) 1973-11-14 1974-11-13
BE150460A BE822141A (en) 1973-11-14 1974-11-13 NEW DERIVATIVES OF CEPHALOSPORIN
AT914274A AT335608B (en) 1973-11-14 1974-11-14 PROCESS FOR THE PREPARATION OF NEW CEPHALOSPORIN DERIVATIVES AND THEIR SALT
DE19742454109 DE2454109A1 (en) 1973-11-14 1974-11-14 NEW CEPHALOSPORIN DERIVATIVES, THEIR PRODUCTION AND COMPOSITIONS THEREOF
FI3300/74A FI330074A (en) 1973-11-14 1974-11-14
ES431943A ES431943A1 (en) 1973-11-14 1974-11-14 Cephalosporin derivatives
AR259958A AR205398A1 (en) 1973-11-14 1975-01-01 PROCEDURE FOR PREPARING CEPHALOSPORIN DERIVATIVES
SU7502190958A SU576947A3 (en) 1973-11-14 1975-11-20 Method of preparing cephalosporine derivatives or salts thereof
AT116276A AT335065B (en) 1973-11-14 1976-02-18 PROCESS FOR THE PREPARATION OF NEW CEPHALOSPORIN DERIVATIVES AND THEIR SALT

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7340431A FR2250517A1 (en) 1973-11-14 1973-11-14 Dihydro-dithiinyl-and-oxathiinyl-methyl cephalosporins - with broad-spectrum antibacterial activity

Publications (2)

Publication Number Publication Date
FR2250517A1 true FR2250517A1 (en) 1975-06-06
FR2250517B1 FR2250517B1 (en) 1977-06-03

Family

ID=9127707

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7340431A Granted FR2250517A1 (en) 1973-11-14 1973-11-14 Dihydro-dithiinyl-and-oxathiinyl-methyl cephalosporins - with broad-spectrum antibacterial activity

Country Status (3)

Country Link
BE (1) BE822141A (en)
FR (1) FR2250517A1 (en)
ZA (1) ZA747239B (en)

Also Published As

Publication number Publication date
ZA747239B (en) 1975-11-26
BE822141A (en) 1975-05-13
FR2250517B1 (en) 1977-06-03

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