FR2246267B1 - - Google Patents

Info

Publication number
FR2246267B1
FR2246267B1 FR7432894A FR7432894A FR2246267B1 FR 2246267 B1 FR2246267 B1 FR 2246267B1 FR 7432894 A FR7432894 A FR 7432894A FR 7432894 A FR7432894 A FR 7432894A FR 2246267 B1 FR2246267 B1 FR 2246267B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7432894A
Other versions
FR2246267A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of FR2246267A1 publication Critical patent/FR2246267A1/fr
Application granted granted Critical
Publication of FR2246267B1 publication Critical patent/FR2246267B1/fr
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
FR7432894A 1973-10-01 1974-09-30 Expired FR2246267B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US402212A US3868416A (en) 1973-10-01 1973-10-01 Hypolipidemic 4-(monoalkylamino)benzoic acid derivatives

Publications (2)

Publication Number Publication Date
FR2246267A1 FR2246267A1 (fr) 1975-05-02
FR2246267B1 true FR2246267B1 (fr) 1977-10-28

Family

ID=23590998

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7432894A Expired FR2246267B1 (fr) 1973-10-01 1974-09-30

Country Status (22)

Country Link
US (2) US3868416A (fr)
JP (1) JPS5747901B2 (fr)
AR (1) AR211687A1 (fr)
AT (1) AT338250B (fr)
BE (1) BE820542A (fr)
CA (1) CA1077957A (fr)
CH (1) CH609676A5 (fr)
DD (1) DD116031A5 (fr)
DE (1) DE2446010C2 (fr)
DK (1) DK141844B (fr)
ES (1) ES430574A1 (fr)
FR (1) FR2246267B1 (fr)
GB (1) GB1488674A (fr)
GT (1) GT197851174A (fr)
HU (1) HU175875B (fr)
IE (1) IE40527B1 (fr)
IL (1) IL45643A (fr)
NL (1) NL179725C (fr)
SE (1) SE410595B (fr)
SU (1) SU590311A1 (fr)
YU (1) YU262274A (fr)
ZA (1) ZA745732B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230878A (en) 1978-03-08 1980-10-28 American Cyanamid Company Hypolipidemic and antiatherosclerotic 4-[(cyclopropyl alkyl)amino]benzoic acids and derivatives

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1471431A (en) * 1974-04-30 1977-04-27 Science Union & Cie Alkanolamine derivatives processes for their preparation and pharmaceutical compositions containing them
US4350822A (en) * 1975-03-12 1982-09-21 American Cyanamid Company Antilipidemicpara-[aryl(alkyl or alkenyl)amino]benzoic acid derivatives
US4185115A (en) * 1975-03-12 1980-01-22 American Cyanamid Company Antilipidemic para-[aryl(alkyl or alkenyl)amino]-benzoic acid derivatives
US4058550A (en) * 1975-10-28 1977-11-15 American Cyanamid Company Polysubstituted-alkyl esters of 4-alkylaminobenzoic acids
US4182776A (en) * 1975-12-09 1980-01-08 American Cyanamid Company Method of treating lipidemia with aryloxyalkylaminobenzoic acids and esters
AU500881B2 (en) * 1976-01-19 1979-06-07 Dow Chemical Company, The Hypolipidemic p-aminobenzoic acids
GB1576007A (en) * 1976-02-11 1980-10-01 Beecham Group Ltd Hypolipidaemic compositions
US4105791A (en) * 1976-03-22 1978-08-08 The Dow Chemical Company Hypolipidemic cycloalkylaminobenzoic acids
US4133890A (en) * 1977-01-05 1979-01-09 The Dow Chemical Company Hypolipidemic compositions and method employing derivatives of 4-(((1,3-benzodioxol-5-yl)methyl)amino)benzoic acid
US4154756A (en) * 1977-12-15 1979-05-15 American Cyanamid Company 2-Substituted-4'-(monoalkylamino)-acetophenones
US4242273A (en) * 1977-09-27 1980-12-30 American Cyanamid Company 4-(Monoalkylamino)benzoic acid amides and imidates
US4117158A (en) * 1977-09-27 1978-09-26 American Cyanamid Company 4-(monoalkylamino)benzonitriles useful as anti-atherosclerotic agents
US4348399A (en) * 1978-02-02 1982-09-07 American Cyanamid Company Antiatherosclerotic and hypolipidemic 4-(monoalkylamino)phenyl alkane, alkene and alkyne carbinols, aldehydes, carboxylic acids and derivatives
US4136256A (en) * 1977-09-27 1979-01-23 American Cyanamid Company 4-(monoalkylamino)benzoic acid imidates
US4245120A (en) * 1977-09-27 1981-01-13 American Cyanamid Company 4-(Monoalkylamino)benzene polycarboxylic acids
US4245119A (en) * 1977-09-27 1981-01-13 American Cyanamid Company 4-(Monoalkylamino) benzene polycarboxylic acids
US4272546A (en) * 1977-12-19 1981-06-09 American Cyanamid Company Esters of 4-(monoalkylamino)benzoic hydroxyalkanoic acids
US4254138A (en) * 1977-12-19 1981-03-03 American Cyanamid Company Esters of 4-(monoalkylamino)benzoic hydroxyalkanoic acids
IL56517A0 (en) * 1978-02-02 1979-03-12 American Cyanamid Co Novel 4-(cycloalkyl or cyclalkenyl substituted) amino, alkylamino or alkenylamino benzoic acids, salts and derivatives
US4205085A (en) * 1978-03-09 1980-05-27 American Cyanamid Company Hypolipidemic and antiatherosclerotic 4-(polyfluoroalkylamino)phenyl compounds
US4333940A (en) * 1978-02-02 1982-06-08 American Cyanamid Company Ring-fluorinated 4-(monosubstituted-amino) phenyl compounds in inhibiting atherosclerotic lesion development
US4230628A (en) * 1978-04-12 1980-10-28 American Cyanamid Company 4-[(Carboxyl- and sulfamyl-substituted alkyl)-amino] benzoic acids and analogs
US4245097A (en) * 1978-02-27 1981-01-13 American Cyanamid Company 4-[(Monosubstituted-alkyl) amino] benzoic acids and analogs as hypolipidemic and antiatherosclerotic agents
US4243609A (en) * 1978-02-02 1981-01-06 American Cyanamid Company Ring-fluorinated 4-(hexadecyl-amino) N-substituted benzamide compounds
US4311846A (en) * 1978-02-27 1982-01-19 American Cyanamid Company 4-[(Monosubstituted-alkyl) amino]benzoic acids and analogs as hypolipidemic and antiatherosclerotic agents
US4178385A (en) * 1978-03-03 1979-12-11 The Dow Chemical Company Method for treating hyperlipidemia in primates using 4-((4-fluorophenylmethyl)amino)benzoic acid
US4310545A (en) * 1978-03-09 1982-01-12 American Cyanamid Company Hypolipidemic and antiatherosclerotic 4-(polyfluoroalkylamino) phenyl compounds
US4318914A (en) * 1978-03-09 1982-03-09 American Cyanamid Company Hypolipidemic and antiatherosclerotic 4-(polyfluoro-alkylamino)phenyl compounds
US4305959A (en) * 1978-03-09 1981-12-15 American Cyanamid Company Hypolipidemic and antiatherosclerotic 4-(polyfluoro-alkylamino)phenyl compounds
US4307113A (en) * 1978-04-20 1981-12-22 Sandoz, Inc. Anthranilic acid derivatives
US4181737A (en) * 1978-05-18 1980-01-01 The Dow Chemical Company 4-((3-Methoxyphenyl)amino)benzoic acid, a method for treating hyperlipidemia, and compositions thereof
US4206223A (en) * 1979-01-05 1980-06-03 The Dow Chemical Company Method for treating hyperglycemia in mammals using 4-(((1,3-benzodioxol-5-yl)methyl)amino)benzoic acid or derivatives thereof
US4281019A (en) * 1979-02-01 1981-07-28 American Cyanamid Company 4-[(Unsaturated or cyclopropylated alkyl)amino]phenyl compounds useful as hypolipidemic and antiatherosclerotic agents
YU57979A (en) * 1979-03-09 1982-10-31 Lek Tovarna Farmacevtskih Process for preparing 4-9n-hexadecylamino0-benzoic acid
US4263320A (en) * 1979-06-04 1981-04-21 The Dow Chemical Company Hypoglycemic phenylpropynylamino benzoic acids
US4311694A (en) * 1979-12-31 1982-01-19 American Cyanamid Company Amorphous coprecipitates of 4-(monoalkylamino) benzoic acid and derivatives and certain water-soluble materials
US4375478A (en) * 1982-03-02 1983-03-01 Abbott Laboratories Aminobenzoic acid derivatives
JP2659488B2 (ja) * 1992-01-22 1997-09-30 川崎重工業株式会社 引戸装置
US6129930A (en) * 1993-09-20 2000-10-10 Bova; David J. Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night
US20080045573A1 (en) * 1993-09-20 2008-02-21 Bova David J Methods and Sustained Release Nicotinic Acid Compositions for Treating Hyperlipidemia
US6746691B2 (en) 1993-09-20 2004-06-08 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics
US6818229B1 (en) 1993-09-20 2004-11-16 Kos Pharmaceuticals, Inc. Intermediate release nicotinic acid compositions for treating hyperlipidemia
US6676967B1 (en) 1993-09-20 2004-01-13 Kos Pharmaceuticals, Inc. Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia
US6080428A (en) * 1993-09-20 2000-06-27 Bova; David J. Nicotinic acid compositions for treating hyperlipidemia and related methods therefor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3758561A (en) * 1968-10-18 1973-09-11 Merck & Co Inc 2-loweralkylamino-4-amino benzoic acids, their salts and esters, and acid addition salts thereof
US3716644A (en) * 1971-07-15 1973-02-13 American Cyanamid Co Hypolipidemic agents

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230878A (en) 1978-03-08 1980-10-28 American Cyanamid Company Hypolipidemic and antiatherosclerotic 4-[(cyclopropyl alkyl)amino]benzoic acids and derivatives

Also Published As

Publication number Publication date
ES430574A1 (es) 1977-02-16
ATA788574A (de) 1976-12-15
CA1077957A (fr) 1980-05-20
IL45643A0 (en) 1974-11-29
JPS5747901B2 (fr) 1982-10-13
ZA745732B (en) 1975-09-24
SE7412307L (fr) 1975-04-02
DK515474A (fr) 1975-06-09
US3924001A (en) 1975-12-02
HU175875B (en) 1980-11-28
IE40527B1 (en) 1979-06-20
DD116031A5 (fr) 1975-11-05
DE2446010C2 (de) 1985-05-15
DK141844C (fr) 1980-11-10
SU590311A1 (ru) 1978-01-30
SE410595B (sv) 1979-10-22
NL7412956A (nl) 1975-04-03
NL179725C (nl) 1986-11-03
CH609676A5 (fr) 1979-03-15
GT197851174A (es) 1979-08-23
DK141844B (da) 1980-06-30
FR2246267A1 (fr) 1975-05-02
US3868416A (en) 1975-02-25
AT338250B (de) 1977-08-10
GB1488674A (en) 1977-10-12
IL45643A (en) 1979-09-30
JPS5059347A (fr) 1975-05-22
NL179725B (nl) 1986-06-02
AR211687A1 (es) 1978-02-28
BE820542A (fr) 1975-04-01
IE40527L (en) 1975-04-01
YU262274A (en) 1982-02-25
DE2446010A1 (de) 1975-04-03

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Legal Events

Date Code Title Description
ST Notification of lapse