ZA745732B - Hypolipidemic 4-(monoalkylamino) benzoic acid derivatives - Google Patents
Hypolipidemic 4-(monoalkylamino) benzoic acid derivativesInfo
- Publication number
- ZA745732B ZA745732B ZA00745732A ZA745732A ZA745732B ZA 745732 B ZA745732 B ZA 745732B ZA 00745732 A ZA00745732 A ZA 00745732A ZA 745732 A ZA745732 A ZA 745732A ZA 745732 B ZA745732 B ZA 745732B
- Authority
- ZA
- South Africa
- Prior art keywords
- hypolipidemic
- monoalkylamino
- benzoic acid
- acid derivatives
- derivatives
- Prior art date
Links
- 150000001558 benzoic acid derivatives Chemical class 0.000 title 1
- 230000000055 hyoplipidemic effect Effects 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/60—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in meta- or para- positions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US402212A US3868416A (en) | 1973-10-01 | 1973-10-01 | Hypolipidemic 4-(monoalkylamino)benzoic acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA745732B true ZA745732B (en) | 1975-09-24 |
Family
ID=23590998
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA00745732A ZA745732B (en) | 1973-10-01 | 1974-09-09 | Hypolipidemic 4-(monoalkylamino) benzoic acid derivatives |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US3868416A (en) |
| JP (1) | JPS5747901B2 (en) |
| AR (1) | AR211687A1 (en) |
| AT (1) | AT338250B (en) |
| BE (1) | BE820542A (en) |
| CA (1) | CA1077957A (en) |
| CH (1) | CH609676A5 (en) |
| DD (1) | DD116031A5 (en) |
| DE (1) | DE2446010C2 (en) |
| DK (1) | DK141844B (en) |
| ES (1) | ES430574A1 (en) |
| FR (1) | FR2246267B1 (en) |
| GB (1) | GB1488674A (en) |
| GT (1) | GT197851174A (en) |
| HU (1) | HU175875B (en) |
| IE (1) | IE40527B1 (en) |
| IL (1) | IL45643A (en) |
| NL (1) | NL179725C (en) |
| SE (1) | SE410595B (en) |
| SU (1) | SU590311A1 (en) |
| YU (1) | YU262274A (en) |
| ZA (1) | ZA745732B (en) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1471431A (en) * | 1974-04-30 | 1977-04-27 | Science Union & Cie | Alkanolamine derivatives processes for their preparation and pharmaceutical compositions containing them |
| US4185115A (en) * | 1975-03-12 | 1980-01-22 | American Cyanamid Company | Antilipidemic para-[aryl(alkyl or alkenyl)amino]-benzoic acid derivatives |
| US4350822A (en) * | 1975-03-12 | 1982-09-21 | American Cyanamid Company | Antilipidemicpara-[aryl(alkyl or alkenyl)amino]benzoic acid derivatives |
| US4058550A (en) * | 1975-10-28 | 1977-11-15 | American Cyanamid Company | Polysubstituted-alkyl esters of 4-alkylaminobenzoic acids |
| US4182776A (en) * | 1975-12-09 | 1980-01-08 | American Cyanamid Company | Method of treating lipidemia with aryloxyalkylaminobenzoic acids and esters |
| AU500881B2 (en) * | 1976-01-19 | 1979-06-07 | Dow Chemical Company, The | Hypolipidemic p-aminobenzoic acids |
| GB1576007A (en) * | 1976-02-11 | 1980-10-01 | Beecham Group Ltd | Hypolipidaemic compositions |
| US4105791A (en) * | 1976-03-22 | 1978-08-08 | The Dow Chemical Company | Hypolipidemic cycloalkylaminobenzoic acids |
| US4133890A (en) * | 1977-01-05 | 1979-01-09 | The Dow Chemical Company | Hypolipidemic compositions and method employing derivatives of 4-(((1,3-benzodioxol-5-yl)methyl)amino)benzoic acid |
| US4117158A (en) * | 1977-09-27 | 1978-09-26 | American Cyanamid Company | 4-(monoalkylamino)benzonitriles useful as anti-atherosclerotic agents |
| US4245120A (en) * | 1977-09-27 | 1981-01-13 | American Cyanamid Company | 4-(Monoalkylamino)benzene polycarboxylic acids |
| US4136256A (en) * | 1977-09-27 | 1979-01-23 | American Cyanamid Company | 4-(monoalkylamino)benzoic acid imidates |
| US4245119A (en) * | 1977-09-27 | 1981-01-13 | American Cyanamid Company | 4-(Monoalkylamino) benzene polycarboxylic acids |
| US4242273A (en) * | 1977-09-27 | 1980-12-30 | American Cyanamid Company | 4-(Monoalkylamino)benzoic acid amides and imidates |
| US4154756A (en) * | 1977-12-15 | 1979-05-15 | American Cyanamid Company | 2-Substituted-4'-(monoalkylamino)-acetophenones |
| US4348399A (en) * | 1978-02-02 | 1982-09-07 | American Cyanamid Company | Antiatherosclerotic and hypolipidemic 4-(monoalkylamino)phenyl alkane, alkene and alkyne carbinols, aldehydes, carboxylic acids and derivatives |
| US4272546A (en) * | 1977-12-19 | 1981-06-09 | American Cyanamid Company | Esters of 4-(monoalkylamino)benzoic hydroxyalkanoic acids |
| US4254138A (en) * | 1977-12-19 | 1981-03-03 | American Cyanamid Company | Esters of 4-(monoalkylamino)benzoic hydroxyalkanoic acids |
| US4333940A (en) * | 1978-02-02 | 1982-06-08 | American Cyanamid Company | Ring-fluorinated 4-(monosubstituted-amino) phenyl compounds in inhibiting atherosclerotic lesion development |
| US4230628A (en) * | 1978-04-12 | 1980-10-28 | American Cyanamid Company | 4-[(Carboxyl- and sulfamyl-substituted alkyl)-amino] benzoic acids and analogs |
| US4205085A (en) * | 1978-03-09 | 1980-05-27 | American Cyanamid Company | Hypolipidemic and antiatherosclerotic 4-(polyfluoroalkylamino)phenyl compounds |
| US4245097A (en) * | 1978-02-27 | 1981-01-13 | American Cyanamid Company | 4-[(Monosubstituted-alkyl) amino] benzoic acids and analogs as hypolipidemic and antiatherosclerotic agents |
| IL56517A0 (en) * | 1978-02-02 | 1979-03-12 | American Cyanamid Co | Novel 4-(cycloalkyl or cyclalkenyl substituted) amino, alkylamino or alkenylamino benzoic acids, salts and derivatives |
| US4230878A (en) * | 1978-03-08 | 1980-10-28 | American Cyanamid Company | Hypolipidemic and antiatherosclerotic 4-[(cyclopropyl alkyl)amino]benzoic acids and derivatives |
| US4243609A (en) * | 1978-02-02 | 1981-01-06 | American Cyanamid Company | Ring-fluorinated 4-(hexadecyl-amino) N-substituted benzamide compounds |
| US4311846A (en) * | 1978-02-27 | 1982-01-19 | American Cyanamid Company | 4-[(Monosubstituted-alkyl) amino]benzoic acids and analogs as hypolipidemic and antiatherosclerotic agents |
| US4178385A (en) * | 1978-03-03 | 1979-12-11 | The Dow Chemical Company | Method for treating hyperlipidemia in primates using 4-((4-fluorophenylmethyl)amino)benzoic acid |
| US4310545A (en) * | 1978-03-09 | 1982-01-12 | American Cyanamid Company | Hypolipidemic and antiatherosclerotic 4-(polyfluoroalkylamino) phenyl compounds |
| US4318914A (en) * | 1978-03-09 | 1982-03-09 | American Cyanamid Company | Hypolipidemic and antiatherosclerotic 4-(polyfluoro-alkylamino)phenyl compounds |
| US4305959A (en) * | 1978-03-09 | 1981-12-15 | American Cyanamid Company | Hypolipidemic and antiatherosclerotic 4-(polyfluoro-alkylamino)phenyl compounds |
| US4307113A (en) * | 1978-04-20 | 1981-12-22 | Sandoz, Inc. | Anthranilic acid derivatives |
| US4181737A (en) * | 1978-05-18 | 1980-01-01 | The Dow Chemical Company | 4-((3-Methoxyphenyl)amino)benzoic acid, a method for treating hyperlipidemia, and compositions thereof |
| US4206223A (en) * | 1979-01-05 | 1980-06-03 | The Dow Chemical Company | Method for treating hyperglycemia in mammals using 4-(((1,3-benzodioxol-5-yl)methyl)amino)benzoic acid or derivatives thereof |
| US4281019A (en) * | 1979-02-01 | 1981-07-28 | American Cyanamid Company | 4-[(Unsaturated or cyclopropylated alkyl)amino]phenyl compounds useful as hypolipidemic and antiatherosclerotic agents |
| YU57979A (en) * | 1979-03-09 | 1982-10-31 | Lek Tovarna Farmacevtskih | Process for preparing 4-9n-hexadecylamino0-benzoic acid |
| US4263320A (en) * | 1979-06-04 | 1981-04-21 | The Dow Chemical Company | Hypoglycemic phenylpropynylamino benzoic acids |
| US4311694A (en) * | 1979-12-31 | 1982-01-19 | American Cyanamid Company | Amorphous coprecipitates of 4-(monoalkylamino) benzoic acid and derivatives and certain water-soluble materials |
| US4375478A (en) * | 1982-03-02 | 1983-03-01 | Abbott Laboratories | Aminobenzoic acid derivatives |
| JP2659488B2 (en) * | 1992-01-22 | 1997-09-30 | 川崎重工業株式会社 | Sliding door device |
| US20080045573A1 (en) * | 1993-09-20 | 2008-02-21 | Bova David J | Methods and Sustained Release Nicotinic Acid Compositions for Treating Hyperlipidemia |
| US6818229B1 (en) | 1993-09-20 | 2004-11-16 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia |
| US6129930A (en) * | 1993-09-20 | 2000-10-10 | Bova; David J. | Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night |
| US6676967B1 (en) | 1993-09-20 | 2004-01-13 | Kos Pharmaceuticals, Inc. | Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia |
| US6746691B2 (en) | 1993-09-20 | 2004-06-08 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics |
| US6080428A (en) * | 1993-09-20 | 2000-06-27 | Bova; David J. | Nicotinic acid compositions for treating hyperlipidemia and related methods therefor |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3758561A (en) * | 1968-10-18 | 1973-09-11 | Merck & Co Inc | 2-loweralkylamino-4-amino benzoic acids, their salts and esters, and acid addition salts thereof |
| US3716644A (en) * | 1971-07-15 | 1973-02-13 | American Cyanamid Co | Hypolipidemic agents |
-
1973
- 1973-10-01 US US402212A patent/US3868416A/en not_active Expired - Lifetime
-
1974
- 1974-09-09 ZA ZA00745732A patent/ZA745732B/en unknown
- 1974-09-11 IL IL45643A patent/IL45643A/en unknown
- 1974-09-17 GB GB40539/74A patent/GB1488674A/en not_active Expired
- 1974-09-23 AR AR255678A patent/AR211687A1/en active
- 1974-09-26 DE DE2446010A patent/DE2446010C2/en not_active Expired
- 1974-09-27 IE IE2015/74A patent/IE40527B1/en unknown
- 1974-09-27 YU YU02622/74A patent/YU262274A/en unknown
- 1974-09-30 SE SE7412307A patent/SE410595B/en not_active IP Right Cessation
- 1974-09-30 FR FR7432894A patent/FR2246267B1/fr not_active Expired
- 1974-09-30 BE BE149073A patent/BE820542A/en not_active IP Right Cessation
- 1974-09-30 CA CA210,303A patent/CA1077957A/en not_active Expired
- 1974-09-30 DK DK515474AA patent/DK141844B/en not_active IP Right Cessation
- 1974-10-01 SU SU742065154A patent/SU590311A1/en active
- 1974-10-01 NL NLAANVRAGE7412956,A patent/NL179725C/en not_active IP Right Cessation
- 1974-10-01 DD DD181444A patent/DD116031A5/xx unknown
- 1974-10-01 AT AT788574A patent/AT338250B/en not_active IP Right Cessation
- 1974-10-01 CH CH1321774A patent/CH609676A5/xx not_active IP Right Cessation
- 1974-10-01 JP JP49113271A patent/JPS5747901B2/ja not_active Expired
- 1974-10-01 HU HU74AE427A patent/HU175875B/en unknown
- 1974-10-02 ES ES430574A patent/ES430574A1/en not_active Expired
- 1974-10-25 US US518022A patent/US3924001A/en not_active Expired - Lifetime
-
1978
- 1978-03-01 GT GT197851174A patent/GT197851174A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU175875B (en) | 1980-11-28 |
| DK515474A (en) | 1975-06-09 |
| NL179725B (en) | 1986-06-02 |
| CH609676A5 (en) | 1979-03-15 |
| DK141844C (en) | 1980-11-10 |
| AR211687A1 (en) | 1978-02-28 |
| GB1488674A (en) | 1977-10-12 |
| DE2446010C2 (en) | 1985-05-15 |
| ES430574A1 (en) | 1977-02-16 |
| JPS5747901B2 (en) | 1982-10-13 |
| DE2446010A1 (en) | 1975-04-03 |
| SU590311A1 (en) | 1978-01-30 |
| CA1077957A (en) | 1980-05-20 |
| NL7412956A (en) | 1975-04-03 |
| DK141844B (en) | 1980-06-30 |
| NL179725C (en) | 1986-11-03 |
| GT197851174A (en) | 1979-08-23 |
| YU262274A (en) | 1982-02-25 |
| SE410595B (en) | 1979-10-22 |
| AT338250B (en) | 1977-08-10 |
| DD116031A5 (en) | 1975-11-05 |
| IE40527B1 (en) | 1979-06-20 |
| IL45643A0 (en) | 1974-11-29 |
| SE7412307L (en) | 1975-04-02 |
| IL45643A (en) | 1979-09-30 |
| US3924001A (en) | 1975-12-02 |
| US3868416A (en) | 1975-02-25 |
| FR2246267B1 (en) | 1977-10-28 |
| FR2246267A1 (en) | 1975-05-02 |
| ATA788574A (en) | 1976-12-15 |
| JPS5059347A (en) | 1975-05-22 |
| IE40527L (en) | 1975-04-01 |
| BE820542A (en) | 1975-04-01 |
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