FR2230366A1 - Pyrazolo(1,5-a)-s-triazines - and their salts, with bronchospasmolytic activity - Google Patents
Pyrazolo(1,5-a)-s-triazines - and their salts, with bronchospasmolytic activityInfo
- Publication number
- FR2230366A1 FR2230366A1 FR7417821A FR7417821A FR2230366A1 FR 2230366 A1 FR2230366 A1 FR 2230366A1 FR 7417821 A FR7417821 A FR 7417821A FR 7417821 A FR7417821 A FR 7417821A FR 2230366 A1 FR2230366 A1 FR 2230366A1
- Authority
- FR
- France
- Prior art keywords
- alkyl
- atom
- subst
- atoms
- opt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000572 bronchospasmolytic effect Effects 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- JUXWUYWPUDKPSD-UHFFFAOYSA-N pyrazolo[1,5-a][1,3,5]triazine Chemical class N1=CN=CN2N=CC=C21 JUXWUYWPUDKPSD-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 16
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 7
- 125000003545 alkoxy group Chemical group 0.000 abstract 6
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 6
- 150000002367 halogens Chemical class 0.000 abstract 6
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 2
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 2
- -1 formyl acetyl Chemical group 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH725873 | 1973-05-22 | ||
| CH725973A CH581137A5 (en) | 1973-05-22 | 1973-05-22 | Pyrazolo(1,5-a)-s-triazines - and their salts, with bronchospasmolytic activity |
| CH725773 | 1973-05-22 | ||
| CH1694073 | 1973-12-04 | ||
| CH442574 | 1974-03-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2230366A1 true FR2230366A1 (en) | 1974-12-20 |
| FR2230366B1 FR2230366B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1977-11-10 |
Family
ID=27509197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7417821A Granted FR2230366A1 (en) | 1973-05-22 | 1974-05-22 | Pyrazolo(1,5-a)-s-triazines - and their salts, with bronchospasmolytic activity |
Country Status (8)
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2850653A1 (fr) * | 2003-02-04 | 2004-08-06 | Univ Pasteur | Derives de pyrazolotriazine, procede de preparation et utilisations |
| WO2004011464A3 (fr) * | 2002-07-26 | 2004-08-26 | Greenpharma Sas | Nouvelles pyrazolo[1,5-a]-1,3,5-triazines substituees et leurs analogiques, compositions pharmaceutiques les contenant, utilisation a titre de medicament et procedes pour leur preparation |
| WO2004092170A3 (en) * | 2003-04-09 | 2005-03-31 | Biogen Idec Inc | Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists |
| WO2005082908A1 (en) * | 2004-02-25 | 2005-09-09 | Schering Corporation | Pyrazolotriazines as kinase inhibitors |
| US7674791B2 (en) | 2003-04-09 | 2010-03-09 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
| US7834014B2 (en) | 2003-04-09 | 2010-11-16 | Biogen Idec Ma Inc. | A2a adenosine receptor antagonists |
| WO2023094310A1 (en) * | 2021-11-23 | 2023-06-01 | Origenis Gmbh | Pyrazolotriazine derivatives useful as cdk9 inhibitors |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH635587A5 (fr) * | 1978-01-09 | 1983-04-15 | Aron Sa | Derives amines de pyrazolo (1,5-a) s.triazine, therapeutiquement actifs et leurs procedes de preparation. |
| DE3942357A1 (de) * | 1989-12-21 | 1991-06-27 | Boehringer Mannheim Gmbh | 3-aminopyrazolo-heterocyclen, deren verwendung zur bestimmung von wasserstoffperoxid, wasserstoffperoxid-bildenden systemen, peroxidase, peroxidatisch wirksamen substanzen oder von elektronenreichen aromatischen verbindungen, entsprechende bestimmungsverfahren und hierfuer geeignete mittel |
| MX2010011069A (es) | 2008-04-07 | 2010-11-12 | Irm Llc | Compuestos y composiciones como inhibidores de cinasa. |
| US9073927B2 (en) | 2010-01-22 | 2015-07-07 | Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii | Inhibitors of PI3 kinase |
| US20130131057A1 (en) | 2010-05-13 | 2013-05-23 | Centro Nacional De Investigaciones Oncologicas (Cnio | New bicyclic compounds as pi3-k and mtor inhibitors |
| GB201410817D0 (en) * | 2014-06-17 | 2014-07-30 | Ucb Biopharma Sprl And Katholieke Universiteit Leuven K U Leuven R & D | Therapeutic agents |
| JP2018199623A (ja) * | 2015-10-22 | 2018-12-20 | 大正製薬株式会社 | 含窒素縮合複素環化合物 |
-
1974
- 1974-05-17 NL NL7406641A patent/NL7406641A/xx unknown
- 1974-05-18 DE DE2424334A patent/DE2424334A1/de active Pending
- 1974-05-19 FI FI1461/74A patent/FI146174A7/fi unknown
- 1974-05-21 JP JP49056179A patent/JPS5019769A/ja active Pending
- 1974-05-21 IL IL44873A patent/IL44873A0/xx unknown
- 1974-05-21 DD DD178657A patent/DD113907A5/xx unknown
- 1974-05-22 FR FR7417821A patent/FR2230366A1/fr active Granted
- 1974-05-22 AU AU69259/74A patent/AU6925974A/en not_active Expired
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004011464A3 (fr) * | 2002-07-26 | 2004-08-26 | Greenpharma Sas | Nouvelles pyrazolo[1,5-a]-1,3,5-triazines substituees et leurs analogiques, compositions pharmaceutiques les contenant, utilisation a titre de medicament et procedes pour leur preparation |
| WO2004072078A1 (fr) * | 2003-02-04 | 2004-08-26 | Universite Louis Pasteur | Derives de pyrazolotriazine, procedes de preparation et utilisations |
| FR2850653A1 (fr) * | 2003-02-04 | 2004-08-06 | Univ Pasteur | Derives de pyrazolotriazine, procede de preparation et utilisations |
| US7285550B2 (en) | 2003-04-09 | 2007-10-23 | Biogen Idec Ma Inc. | Triazolotriazines and pyrazolotriazines and methods of making and using the same |
| WO2004092170A3 (en) * | 2003-04-09 | 2005-03-31 | Biogen Idec Inc | Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists |
| US7834014B2 (en) | 2003-04-09 | 2010-11-16 | Biogen Idec Ma Inc. | A2a adenosine receptor antagonists |
| US7674791B2 (en) | 2003-04-09 | 2010-03-09 | Biogen Idec Ma Inc. | Triazolopyrazines and methods of making and using the same |
| US7166602B2 (en) | 2004-02-25 | 2007-01-23 | Schering Corporation | Pyrazolotriazines as kinase inhibitors |
| AU2005217617B2 (en) * | 2004-02-25 | 2007-12-06 | Schering Corporation | Pyrazolotriazines as kinase inhibitors |
| US7354921B2 (en) | 2004-02-25 | 2008-04-08 | Schering Corporation | Pyrazolotriazines as kinase inhibitors |
| US7038045B2 (en) | 2004-02-25 | 2006-05-02 | Schering Corporation | Pyrazolotriazines as kinase inhibitors |
| WO2005082908A1 (en) * | 2004-02-25 | 2005-09-09 | Schering Corporation | Pyrazolotriazines as kinase inhibitors |
| WO2023094310A1 (en) * | 2021-11-23 | 2023-06-01 | Origenis Gmbh | Pyrazolotriazine derivatives useful as cdk9 inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| AU6925974A (en) | 1975-11-27 |
| DE2424334A1 (de) | 1974-12-19 |
| JPS5019769A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-03-01 |
| DD113907A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-07-05 |
| FR2230366B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1977-11-10 |
| IL44873A0 (en) | 1974-07-31 |
| NL7406641A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-11-26 |
| FI146174A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-11-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR2230366A1 (en) | Pyrazolo(1,5-a)-s-triazines - and their salts, with bronchospasmolytic activity | |
| ES8104233A1 (es) | Procedimiento para preparar derivados de acidos quinolina- carboxilicos | |
| ES8203364A1 (es) | Un procedimiento para la preparacion de un derivado de ani- lina. | |
| ES2014523A6 (es) | Procedimiento de preparar derivados de aril-heteroarilcarbinoles. | |
| IE44280L (en) | 2,3-DIHYDRO-IMIDAZO [2,1-b] THIAZOLES HAVING ANALGESIC AND¹ANTI-INFLAMMATORY ACTIVITY | |
| DE3585980D1 (de) | Hydrazinderivate und ihre verwendung. | |
| PT80507A (de) | Neue substituierte bis-(4-aminophenyl)-sulfone ihre herstellungund ihre verwendung als arzneimittel | |
| BE815405A (en) | Pyrazolo(1,5-a)-s-triazines - and their salts, with bronchospasmolytic activity | |
| ES427218A1 (es) | Procedimiento de preparacion de azapurinonas. | |
| SE7703068L (sv) | Nya sulfonamido-bensoesyraderivat jemte sett for deras framstellning | |
| ATE156128T1 (de) | Substituierte harnstoffe, herstellung und verwendung | |
| ES450070A1 (es) | Procedimiento para la preparacion de derivados de tiazolidi-na. | |
| SE7609909L (sv) | Nya penicilliner och forfarande for framstellning derav | |
| DE3061188D1 (en) | 2-sulfonyl-quinoxalines, processes for their preparation and their use as microbicides | |
| ATE24487T1 (de) | Neue carbacycline, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel. | |
| PH27293A (en) | Aryloxy arlthip heteroaryloxy heteroarylthio-alkenylene derivatives of amine and a method of use thereof | |
| IE800900L (en) | Pyrrolidinyl-benzoic acid derivatives. | |
| IE43791L (en) | Imidazolo-benzodiazepines | |
| FR2178815A1 (en) | Furo-benzoxazole derivs - analgesics, vasodilators, diuretics, etc | |
| ES8602797A1 (es) | Procedimiento para preparar 11-piperazinil-5h-imidazo(2, 1-c) (1, 4) benzodiazepinas | |
| ATE79754T1 (de) | Dioxopiperidinderivate enthaltende arzneimittel zur verbesserung des gedaechtnisses. | |
| GB8716337D0 (en) | Antipsychotic compositions | |
| FR2150594A1 (en) | Omega-amino-1,2-diphenyl-1-alkanones - with analgesic antiinflammatory anti-ulcer,bronchodilator,spasmolytic and hypotensive | |
| FR2333510A2 (fr) | Nouveaux (aroyl-2' eth-1 yl)-1 (acetamido-4'' piperazin-1'' yl methyl)-2 benzimidazoles, leur application en therapeutique et leur procede de preparation | |
| FR2338044A1 (fr) | Glycerophosphates de papaverine et d'ethaverine |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |