FR2186251A1 - 1-(2-benzoylethyl)-2-alkyl benzimidazoles - with antiinflammatory, hypo-tensive, analeptic, antidepressant, spasmolytic diuretic, antihistaminic activity - Google Patents

1-(2-benzoylethyl)-2-alkyl benzimidazoles - with antiinflammatory, hypo-tensive, analeptic, antidepressant, spasmolytic diuretic, antihistaminic activity

Info

Publication number
FR2186251A1
FR2186251A1 FR7219540A FR7219540A FR2186251A1 FR 2186251 A1 FR2186251 A1 FR 2186251A1 FR 7219540 A FR7219540 A FR 7219540A FR 7219540 A FR7219540 A FR 7219540A FR 2186251 A1 FR2186251 A1 FR 2186251A1
Authority
FR
France
Prior art keywords
benzoylethyl
tensive
analeptic
spasmolytic
hypo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7219540A
Other languages
French (fr)
Other versions
FR2186251B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Delalande SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delalande SA filed Critical Delalande SA
Priority to FR7219540A priority Critical patent/FR2186251A1/en
Publication of FR2186251A1 publication Critical patent/FR2186251A1/en
Application granted granted Critical
Publication of FR2186251B1 publication Critical patent/FR2186251B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Title cpds of formula (I): (where Ar is phenyl opt. substd. by Cl, F, >=1-4C alkyl or alkoxy, R is 1-4C alkyl opt. substd. by 1 or 2 OH). (I) are prepd. by reaction of 2-alkylbenzimidazoles with co-piperidinopropiophenones and are useful in treating inflammatory pain, hypertension, circulating and respiratory insufficiency, depression, anxiety, gastrointestinal spasm, asthma and oedema (I) are administered in 1-5 oral doses of 50-400 mg daily or 1-2 suppositories of 50-250 mg daily.
FR7219540A 1972-05-31 1972-05-31 1-(2-benzoylethyl)-2-alkyl benzimidazoles - with antiinflammatory, hypo-tensive, analeptic, antidepressant, spasmolytic diuretic, antihistaminic activity Granted FR2186251A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7219540A FR2186251A1 (en) 1972-05-31 1972-05-31 1-(2-benzoylethyl)-2-alkyl benzimidazoles - with antiinflammatory, hypo-tensive, analeptic, antidepressant, spasmolytic diuretic, antihistaminic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7219540A FR2186251A1 (en) 1972-05-31 1972-05-31 1-(2-benzoylethyl)-2-alkyl benzimidazoles - with antiinflammatory, hypo-tensive, analeptic, antidepressant, spasmolytic diuretic, antihistaminic activity

Publications (2)

Publication Number Publication Date
FR2186251A1 true FR2186251A1 (en) 1974-01-11
FR2186251B1 FR2186251B1 (en) 1975-06-20

Family

ID=9099421

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7219540A Granted FR2186251A1 (en) 1972-05-31 1972-05-31 1-(2-benzoylethyl)-2-alkyl benzimidazoles - with antiinflammatory, hypo-tensive, analeptic, antidepressant, spasmolytic diuretic, antihistaminic activity

Country Status (1)

Country Link
FR (1) FR2186251A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2876233A (en) * 1956-10-29 1959-03-03 Gruenenthal Chemie 1-(p-halobenzyl)-2-methyl benzimidazoles and salts

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2876233A (en) * 1956-10-29 1959-03-03 Gruenenthal Chemie 1-(p-halobenzyl)-2-methyl benzimidazoles and salts

Also Published As

Publication number Publication date
FR2186251B1 (en) 1975-06-20

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Legal Events

Date Code Title Description
ST Notification of lapse