|
US5506231A
(en)
*
|
1989-03-31 |
1996-04-09 |
The Children's Medical Center Corporation |
Treatment of aids dementia, myelopathy and blindness
|
|
US5334618A
(en)
*
|
1991-04-04 |
1994-08-02 |
The Children's Medical Center Corporation |
Method of preventing NMDA receptor-mediated neuronal damage
|
|
US5455279A
(en)
*
|
1991-04-19 |
1995-10-03 |
The Children's Medical Center Corporation |
Regimen method of mediating neuronal damage using nitroglycerine
|
|
WO1992017168A1
(en)
*
|
1991-04-04 |
1992-10-15 |
The Children's Medical Center Corporation |
Method of preventing nmda receptor-mediated neuronal damage
|
|
US5614560A
(en)
*
|
1991-04-04 |
1997-03-25 |
Children's Medical Center Corporation |
Method of preventing NMDA receptor-mediated neuronal damage
|
|
DE4225730C2
(de)
*
|
1992-08-04 |
2003-04-30 |
Merz Pharma Gmbh & Co Kgaa |
Verfahren zur Herstellung von festen Arzneiformkörpern mit protrahierter 2-Stufen-Freisetzung
|
|
US5866585A
(en)
*
|
1997-05-22 |
1999-02-02 |
Synchroneuron, Llc |
Methods of treating tardive dyskinesia using NMDA receptor antagonists
|
|
US6057373A
(en)
*
|
1997-05-22 |
2000-05-02 |
Synchroneuron, Llc |
Methods of treating tardive dyskinesia and other movement disorders using NMDA receptor antagonists
|
|
US6294583B1
(en)
*
|
1998-01-13 |
2001-09-25 |
Synchroneuron, Llc |
Methods of treating tardive dyskinesia and other movement disorders
|
|
US5952389A
(en)
*
|
1998-01-13 |
1999-09-14 |
Synchroneuron |
Methods of treating tardive dyskinesia and other movement disorders
|
|
US6444702B1
(en)
|
2000-02-22 |
2002-09-03 |
Neuromolecular, Inc. |
Aminoadamantane derivatives as therapeutic agents
|
|
NZ531785A
(en)
*
|
2001-08-20 |
2007-03-30 |
Maiken Nedergaard |
Treatment of glial tumors with ionotropic glutamate receptor antagonists
|
|
EP1298581A1
(fr)
*
|
2001-09-27 |
2003-04-02 |
C.S.E.M. Centre Suisse D'electronique Et De Microtechnique Sa |
Procédé et dispositif pour calculer les valeurs des neurones d'un réseau neuronal
|
|
AU2003274353B2
(en)
|
2002-10-24 |
2007-04-05 |
Merz Pharma Gmbh & Co. Kgaa |
Combination therapy using 1-aminocyclohexane derivatives and acetylcholinesterase inhibitors
|
|
RU2246482C2
(ru)
*
|
2002-12-25 |
2005-02-20 |
ООО "Циклан" |
Способ получения гидрохлорида 1-амино-3,5-диметиладамантана
|
|
CA2528622C
(en)
*
|
2003-05-27 |
2010-08-03 |
Forest Laboratories, Inc. |
Combination of an nmda receptor antagonist and a selective serotonin reuptake inhibitor for the treatment of depression and other mood disorders
|
|
CN1240668C
(zh)
*
|
2003-09-10 |
2006-02-08 |
上海医药工业研究院 |
一种新的盐酸美金刚制备方法
|
|
WO2005079779A1
(en)
*
|
2003-10-22 |
2005-09-01 |
Merz Pharma Gmbh & Co. Kgaa |
THE USE OF 1-AMINOCYCLOHEXANE DERIVATIVES TO MODIFY DEPOSITION OF FIBRILLOGENIC Aß PEPTIDES IN AMYLOIDOPATHIES
|
|
AR046314A1
(es)
|
2003-11-05 |
2005-11-30 |
Merz Pharma Gmbh & Co Kgaa |
Composiciones que comprenden ciclohexilaminas y aminoadamantanos
|
|
WO2005069742A2
(en)
*
|
2003-12-10 |
2005-08-04 |
Sun Pharmaceutical Industries Limited |
Crystal form ii of memantine hydrochloride
|
|
RS51540B
(sr)
*
|
2004-01-05 |
2011-06-30 |
Merz Pharma Gmbh. & Co. Kgaa. |
Memantin za lečenje blage do umerene alzhajmerove bolesti
|
|
CN100363329C
(zh)
*
|
2004-01-09 |
2008-01-23 |
南京大学 |
合成美金刚胺盐酸盐的方法
|
|
US7456224B2
(en)
*
|
2004-04-05 |
2008-11-25 |
Forest Laboratories Holdings, Ltd. |
Method for treating autism
|
|
US20060002999A1
(en)
|
2004-06-17 |
2006-01-05 |
Forest Laboratories, Inc. |
Immediate release formulations of 1-aminocyclohexane compounds, memantine and neramexane
|
|
EP2601937A1
(en)
|
2004-06-17 |
2013-06-12 |
Merz Pharma GmbH & Co. KGaA |
Drinkable immediate release tablet made with direct compression of memantine or neramexane
|
|
CN1968684A
(zh)
*
|
2004-06-17 |
2007-05-23 |
森林实验室公司 |
美金刚的调释制剂
|
|
TW200616608A
(en)
*
|
2004-07-09 |
2006-06-01 |
Forest Laboratories |
Memantine as adjunctive treatment to atypical antipsychotics in schizophrenia patients
|
|
KR20070046185A
(ko)
*
|
2004-09-23 |
2007-05-02 |
메르츠 파마 게엠베하 운트 코. 카가아 |
소아 행동장애의 치료를 위한 메만틴
|
|
US20060205822A1
(en)
*
|
2004-12-22 |
2006-09-14 |
Forest Laboratories, Inc. |
1-Aminocyclohexane derivatives for the treatment of multiple sclerosis, emotional lability and pseudobulbar affect
|
|
MX2007007301A
(es)
*
|
2005-01-11 |
2008-02-11 |
Teva Pharm Fine Chemicals Srl |
Polimorfos de clorhidrato de memantina.
|
|
ITMI20050833A1
(it)
*
|
2005-05-10 |
2006-11-11 |
A M S A S P A Anonima Materie Sintetiche Affini |
Nuovo procedimento per la sintesi di aminoadamantani
|
|
CA2607600A1
(en)
*
|
2005-06-16 |
2006-12-28 |
Forest Laboratories, Inc. |
Modified and immediate release memantine bead formulation
|
|
CN101272781A
(zh)
|
2005-07-27 |
2008-09-24 |
多夫药品公司 |
新的1-芳基-3-氮杂二环[3.1.0]己烷：其制备方法和用于治疗神经精神障碍的用途
|
|
US20070099947A1
(en)
*
|
2005-11-03 |
2007-05-03 |
Alkermes, Inc. |
Methods and compositions for the treatment of brain reward system disorders by combination therapy
|
|
PT1820792E
(pt)
*
|
2006-02-21 |
2012-04-10 |
Hexal Ag |
Processo para a preparação de adamantanaminas
|
|
EP1999100A1
(en)
*
|
2006-03-27 |
2008-12-10 |
Teva Pharmaceutical Fine Chemicals S.R.L. |
Process for preparing memantine hydrochloride substantially free of impurities
|
|
ATE494289T1
(de)
|
2006-08-04 |
2011-01-15 |
Merz Pharma Gmbh & Co Kgaa |
Substituierte pyrazolopyrimidine, ein verfahren zu ihrer herstellung und ihre verwendung als medizin
|
|
EP1908748A1
(en)
*
|
2006-10-05 |
2008-04-09 |
Krka |
Process for the preparation of memantine and its hydrochloric acid salt form
|
|
WO2008063847A2
(en)
*
|
2006-11-03 |
2008-05-29 |
Forest Laboratories Holdings Limited |
Method for treating autism
|
|
MX2009006672A
(es)
|
2006-12-19 |
2009-10-26 |
Univ Virginia |
Efectos combinados de topiramato y ondansetron sobre el consumo de alcohol.
|
|
AU2008220104B2
(en)
|
2007-02-28 |
2012-09-27 |
Asahi Kasei Pharma Corporation |
Sulfonamide derivative
|
|
US9133159B2
(en)
|
2007-06-06 |
2015-09-15 |
Neurovance, Inc. |
1-heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
|
|
WO2008153937A2
(en)
|
2007-06-06 |
2008-12-18 |
Dov Pharmaceutical, Inc. |
Novel 1- heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
|
|
GB0713930D0
(en)
|
2007-07-18 |
2007-08-29 |
Generics Uk Ltd |
Novel assay methods
|
|
EP2090576A1
(en)
|
2008-02-01 |
2009-08-19 |
Merz Pharma GmbH & Co.KGaA |
6-halo-pyrazolo[1,5-a]pyridines, a process for their preparation and their use as metabotropic glutamate receptor (mGluR) modulators
|
|
EP2085398A1
(en)
|
2008-02-01 |
2009-08-05 |
Merz Pharma GmbH & Co. KGaA |
Pyrazolopyrimidines, a process for their preparation and their use as medicine
|
|
US20090247644A1
(en)
*
|
2008-03-28 |
2009-10-01 |
Forest Laboratories Holdings Limited |
Memantine formulations
|
|
US20110034565A1
(en)
|
2008-04-18 |
2011-02-10 |
University College Dublin, National University Of Ireland, Dublin |
Psycho-pharmaceuticals
|
|
EP2111858A1
(en)
|
2008-04-25 |
2009-10-28 |
EPFL Ecole Polytechnique Fédérale de Lausanne |
Novel treatment for alzheimer's disease
|
|
US20090275597A1
(en)
*
|
2008-05-02 |
2009-11-05 |
Forest Laboratories Holdings Limited |
Methods of treating cns disorders
|
|
EP2138173A1
(en)
|
2008-06-26 |
2009-12-30 |
Merz Pharma GmbH & Co.KGaA |
Pharmaceutical compositions comprising aminoadamantane derivatives
|
|
JP5195256B2
(ja)
*
|
2008-10-10 |
2013-05-08 |
東ソー株式会社 |
アミノアダマンタン誘導体の製造方法
|
|
HRP20090186A2
(hr)
|
2009-03-31 |
2010-10-31 |
Institut Ruđer Bošković |
Adamantanski bisureidni derivati, metoda priprave i primjena u detekciji aniona
|
|
WO2010112221A1
(en)
|
2009-04-03 |
2010-10-07 |
Synthon B.V. |
Pharmaceutical compositions comprising memantine
|
|
CN102070463A
(zh)
*
|
2009-06-11 |
2011-05-25 |
辽宁利锋科技开发有限公司 |
具有金刚烷结构药物美金刚胺及其衍生物和类似物抗肿瘤新适应症的应用
|
|
TW201116532A
(en)
|
2009-08-05 |
2011-05-16 |
Merz Pharma Gmbh & Co Kgaa |
Metabotropic glutamate receptor modulators
|
|
BR112012013487A2
(pt)
|
2009-12-02 |
2017-10-03 |
Adamas Pharmaceuticals Inc |
Composições de amantadina e métodos de uso
|
|
US20110251239A1
(en)
|
2010-04-07 |
2011-10-13 |
Eisai Inc. |
Combination therapy for the treatment of dementia
|
|
AR083475A1
(es)
|
2010-10-18 |
2013-02-27 |
Merz Pharma Gmbh & Co Kgaa |
Moduladores de receptores de glutamato metabotropicos
|
|
BR112013010549A2
(pt)
|
2010-10-29 |
2017-10-24 |
Merz Pharma Gmbh & Co Kgaa |
derivados indol e processo para sua preparação
|
|
MX383953B
(es)
|
2010-11-15 |
2025-03-14 |
Agenebio Inc |
Derivados de piridazina, composiciones y metodos para tratar deterioro cognitivo.
|
|
AR084516A1
(es)
|
2010-12-22 |
2013-05-22 |
Merz Pharma Gmbh & Co Kgaa |
Moduladores de receptores de glutamato metabotropicos
|
|
WO2012085167A1
(en)
|
2010-12-22 |
2012-06-28 |
Merz Pharma Gmbh & Co. Kgaa |
Metabotropic glutamate receptor modulators
|
|
CN102241678B
(zh)
|
2011-04-26 |
2014-10-29 |
辽宁利锋科技开发有限公司 |
含有脂环结构化合物的抗肿瘤作用与应用
|
|
WO2012152854A1
(en)
|
2011-05-12 |
2012-11-15 |
Merz Pharma Gmbh & Co. Kgaa |
Metabotropic glutamate receptor modulators
|
|
WO2012172093A1
(en)
|
2011-06-17 |
2012-12-20 |
Merz Pharma Gmbh & Co. Kgaa |
Dihydroindolizine derivate as metabotropic glutamate receptor modulators
|
|
US20140206740A1
(en)
|
2011-07-30 |
2014-07-24 |
Neurovance, Inc. |
Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters
|
|
CN103288650B
(zh)
*
|
2012-02-28 |
2015-09-30 |
广州白云山制药股份有限公司广州白云山制药总厂 |
一种盐酸1-氨基-3,5-二甲基金刚烷的制备方法
|
|
EP2650284A1
(en)
|
2012-04-10 |
2013-10-16 |
Merz Pharma GmbH & Co. KGaA |
Heterocyclic derivatives as metabotropic glutamate receptor modulators
|
|
RU2488388C1
(ru)
|
2012-05-24 |
2013-07-27 |
Ооо "Валента Интеллект" |
Фармацевтическая композиция для профилактики и лечения психических, поведенческих, когнитивных расстройств
|
|
WO2014204933A1
(en)
|
2013-06-17 |
2014-12-24 |
Adamas Pharmaceuticals, Inc. |
Amantadine compositions and methods of use
|
|
US9566264B2
(en)
|
2013-07-01 |
2017-02-14 |
Euthymics Bioscience, Inc. |
Combinations and methods
|
|
MX381561B
(es)
|
2013-12-20 |
2025-03-12 |
Agenebio Inc |
Derivados de benzodiazepina, composiciones, y métodos para tratar el deterioro cognitivo.
|
|
US20150216849A1
(en)
|
2014-02-04 |
2015-08-06 |
Forest Laboratories Holdings Ltd. |
Donepezil compositions and methods of treating alzheimers disease
|
|
US10815242B2
(en)
|
2015-06-19 |
2020-10-27 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
JP6354701B2
(ja)
*
|
2015-08-19 |
2018-07-11 |
大日本印刷株式会社 |
高純度メマンチン塩酸塩の製造法
|
|
IL303255A
(en)
|
2015-12-30 |
2023-07-01 |
Corium Inc |
Systems and methods for long term transdermal administration
|
|
JP7174632B2
(ja)
|
2016-06-23 |
2022-11-17 |
コリウム， インコーポレイテッド |
親水性ドメインおよび疎水性ドメインならびに処置剤との接着剤マトリックス
|
|
WO2018022814A1
(en)
|
2016-07-27 |
2018-02-01 |
Corium International, Inc. |
Transdermal delivery systems with pharmacokinetics bioequivalent to oral delivery
|
|
KR102508993B1
(ko)
|
2016-07-27 |
2023-03-10 |
코리움, 인크. |
메만틴 경피 송달 시스템
|
|
KR102406536B1
(ko)
|
2016-07-27 |
2022-06-08 |
코리움, 인크. |
도네페질 경피 전달 시스템
|
|
US11505555B2
(en)
|
2016-12-19 |
2022-11-22 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
US20180170941A1
(en)
|
2016-12-19 |
2018-06-21 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
US10369187B2
(en)
|
2017-02-09 |
2019-08-06 |
Vanderbilt University |
Peptide regulators of JNK family kinases
|
|
JP2019094304A
(ja)
*
|
2017-11-27 |
2019-06-20 |
学校法人順天堂 |
オートファジー誘導剤
|
|
AU2018392686A1
(en)
|
2017-12-20 |
2020-07-09 |
Corium Pharma Solutions, Inc. |
Transdermal adhesive composition comprising a volatile liquid therapeutic agent having low melting point
|
|
CA3104478A1
(en)
|
2018-06-19 |
2019-12-26 |
Agenebio, Inc. |
Benzodiazepine derivatives, compositions, and methods for treating cognitive impairment
|
|
EP3721857A1
(en)
*
|
2019-04-11 |
2020-10-14 |
Dentsply DeTrey GmbH |
Dental composition
|
|
US11639328B2
(en)
|
2020-05-19 |
2023-05-02 |
Shandong Holly Pharmaceutical Co., Ltd. |
Method for preparing amantadine
|
|
WO2024039886A1
(en)
|
2022-08-19 |
2024-02-22 |
Agenebio, Inc. |
Benzazepine derivatives, compositions, and methods for treating cognitive impairment
|