FR2162045A1 - 8-pyrimidylaminomethyl-ergoline derivs - with adrenolytic activity - Google Patents
8-pyrimidylaminomethyl-ergoline derivs - with adrenolytic activityInfo
- Publication number
- FR2162045A1 FR2162045A1 FR7242381A FR7242381A FR2162045A1 FR 2162045 A1 FR2162045 A1 FR 2162045A1 FR 7242381 A FR7242381 A FR 7242381A FR 7242381 A FR7242381 A FR 7242381A FR 2162045 A1 FR2162045 A1 FR 2162045A1
- Authority
- FR
- France
- Prior art keywords
- pyrimidylaminomethyl
- ergoline
- derivs
- dihydrolysergamine
- cpd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000002908 adrenolytic effect Effects 0.000 title abstract 2
- NTJROICYWGNJJU-VUOSCMKMSA-N N-[[(6aR,10aR)-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinolin-9-yl]methyl]pyrimidin-2-amine Chemical compound N1=C(N=CC=C1)NCC1CN[C@@H]2CC3=CNC4=CC=CC([C@H]2C1)=C34 NTJROICYWGNJJU-VUOSCMKMSA-N 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005518 carboxamido group Chemical group 0.000 abstract 1
- QUPDWYMUPZLYJZ-UHFFFAOYSA-N ethyl Chemical compound C[CH2] QUPDWYMUPZLYJZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT3193271 | 1971-12-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2162045A1 true FR2162045A1 (en) | 1973-07-13 |
| FR2162045B1 FR2162045B1 (enrdf_load_stackoverflow) | 1976-06-11 |
Family
ID=11234509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7242381A Granted FR2162045A1 (en) | 1971-12-02 | 1972-11-29 | 8-pyrimidylaminomethyl-ergoline derivs - with adrenolytic activity |
Country Status (20)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL7416120A (nl) * | 1973-12-21 | 1975-06-24 | Farmaceutici Italia | Werkwijze voor het bereiden van pyrimidinoami- nomethylergolinederivaten. |
-
0
- BE BE792188D patent/BE792188A/xx not_active IP Right Cessation
-
1972
- 1972-11-22 NL NL727215817A patent/NL153197B/xx not_active IP Right Cessation
- 1972-11-27 GB GB5474372A patent/GB1357238A/en not_active Expired
- 1972-11-27 SU SU721851316A patent/SU617014A3/ru active
- 1972-11-28 CA CA157,696A patent/CA975773A/en not_active Expired
- 1972-11-28 IL IL40944A patent/IL40944A/en unknown
- 1972-11-28 NO NO4351/72A patent/NO136643C/no unknown
- 1972-11-28 IE IE1653/72A patent/IE37429B1/xx unknown
- 1972-11-28 AU AU49351/72A patent/AU465155B2/en not_active Expired
- 1972-11-28 AT AT1011572A patent/AT321478B/de active
- 1972-11-29 FR FR7242381A patent/FR2162045A1/fr active Granted
- 1972-11-29 ZA ZA728459A patent/ZA728459B/xx unknown
- 1972-11-29 SE SE7215545A patent/SE385301B/xx unknown
- 1972-11-29 DK DK595972AA patent/DK138689B/da unknown
- 1972-11-30 CS CS8190A patent/CS173612B2/cs unknown
- 1972-11-30 JP JP11945772A patent/JPS5634597B2/ja not_active Expired
- 1972-12-01 HU HUFA933A patent/HU165530B/hu unknown
- 1972-12-01 DE DE2259012A patent/DE2259012C3/de not_active Expired
- 1972-12-01 ES ES409189A patent/ES409189A1/es not_active Expired
- 1972-12-01 CH CH1756672A patent/CH590276A5/xx not_active IP Right Cessation
Non-Patent Citations (1)
| Title |
|---|
| NEANT * |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ST | Notification of lapse |