DE3464132D1 - Naphthoquinone derivatives - Google Patents

Naphthoquinone derivatives

Info

Publication number
DE3464132D1
DE3464132D1 DE8484104248T DE3464132T DE3464132D1 DE 3464132 D1 DE3464132 D1 DE 3464132D1 DE 8484104248 T DE8484104248 T DE 8484104248T DE 3464132 T DE3464132 T DE 3464132T DE 3464132 D1 DE3464132 D1 DE 3464132D1
Authority
DE
Germany
Prior art keywords
alkyl
naphthoquinone derivatives
alkoxy
halogen
naphthoquinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8484104248T
Other languages
English (en)
Inventor
Alan Thomas Hudson
Anthony Winchester Randall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of DE3464132D1 publication Critical patent/DE3464132D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/32—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/08—Saturated compounds having a carboxyl group bound to a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/15—Saturated compounds containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/39—Unsaturated compounds containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/08—Saturated compounds containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/08—Saturated compounds containing ether groups, groups, groups, or groups
    • C07C62/10—Saturated compounds containing ether groups, groups, groups, or groups with a six-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8484104248T 1983-04-14 1984-04-14 Naphthoquinone derivatives Expired DE3464132D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838310141A GB8310141D0 (en) 1983-04-14 1983-04-14 Naphthoquinone derivatives

Publications (1)

Publication Number Publication Date
DE3464132D1 true DE3464132D1 (de) 1987-07-16

Family

ID=10541105

Family Applications (2)

Application Number Title Priority Date Filing Date
DE8484104248T Expired DE3464132D1 (de) 1983-04-14 1984-04-14 Naphthoquinone derivatives
DE1994175021 Active DE19475021I2 (de) 1983-04-14 1984-04-14 Naphthochinonderivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1994175021 Active DE19475021I2 (de) 1983-04-14 1984-04-14 Naphthochinonderivate

Country Status (17)

Country Link
EP (1) EP0123238B1 (de)
JP (1) JPS59205341A (de)
AT (1) ATE27696T1 (de)
AU (1) AU574353B2 (de)
CY (1) CY1549A (de)
DE (2) DE3464132D1 (de)
DK (1) DK172273B1 (de)
GB (1) GB8310141D0 (de)
HK (1) HK56690A (de)
IL (1) IL71545A (de)
LU (1) LU88579I2 (de)
MX (1) MX9202993A (de)
MY (1) MY102117A (de)
NL (1) NL950002I2 (de)
PH (1) PH22018A (de)
SG (1) SG39390G (de)
ZA (1) ZA842797B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8310140D0 (en) * 1983-04-14 1983-05-18 Wellcome Found Antiprotozoal agents
US5175319A (en) * 1983-04-14 1992-12-29 Burroughs Wellcome Co. Naphthoquinone derivatives
EP0253501A3 (de) * 1986-07-16 1990-04-04 Imperial Chemical Industries Plc Als Fungizide verwendbare N-disubstituierte Cycloalkylmethylamine
DE3801743A1 (de) * 1987-07-03 1989-01-19 Bayer Ag Schaedlingsbekaempfungsmittel auf basis von substituierten 1,4-naphthochinonen und neue substituierte 1,4-naphthochinone
US5206268A (en) * 1988-08-16 1993-04-27 Burroughs Wellcome Co. Medicaments
GB8819477D0 (en) * 1988-08-16 1988-09-21 Wellcome Found Medicaments
AU633836B2 (en) * 1988-08-16 1993-02-11 Wellcome Foundation Limited, The Medicaments
US5225184A (en) * 1988-08-16 1993-07-06 Burroughs Wellcome Co. Medicaments
EP0567162A1 (de) * 1989-09-22 1993-10-27 The Wellcome Foundation Limited Heilmittel zur Behandlung von Toxoplasmose
GB8921516D0 (en) * 1989-09-22 1989-11-08 Wellcome Found Medicaments
GB8923254D0 (en) * 1989-10-16 1989-12-06 Wellcome Found Medicaments
GB9126874D0 (en) * 1991-12-18 1992-02-19 Wellcome Found Medicaments
GB9207517D0 (en) * 1992-04-06 1992-05-20 Wellcome Found Heterocyclic compounds
GB9216859D0 (en) * 1992-08-07 1992-09-23 Wellcome Found Medicaments
GB9224739D0 (en) * 1992-11-26 1993-01-13 Wellcome Found Medicaments
GB9226905D0 (en) * 1992-12-24 1993-02-17 Wellcome Found Pharmaceutical preparation
US5856362A (en) * 1994-09-02 1999-01-05 Glaxo Wellcome Inc. Medicaments for the treatment of toxoplasmosis
AU2004320912A1 (en) * 2004-07-16 2006-04-27 Usv Limited Novel polymorphs of atovaquone and process of preparation thereof
BRPI0513951A (pt) * 2004-07-30 2008-05-20 Japan Health Science Found agente antiprotozoário
ITMI20070941A1 (it) * 2007-05-09 2008-11-10 Chimico Internazi0Nale S P A L Procedimento per la preparazione di naftochinoni trans2,3-disostituiti
CN101774901B (zh) * 2009-01-09 2012-10-03 武汉泰祥通生物技术有限公司 一种制备阿托伐醌的方法
EP2467358B1 (de) 2009-08-20 2014-07-23 IPCA Laboratories Limited Neuer komplex zur behandlung und/oder prophylaxe von parasiteninfektionen
GB2476644B (en) 2009-12-23 2012-11-14 Haomamedica Ltd 1,4-Dihydro-1,4-dioxonaphtalene derivatives for the treatment of osteoporosis
EP2651868A2 (de) 2010-12-15 2013-10-23 Glaxo Group Limited Verfahren zur herstellung von atovaquon
EP2845588A1 (de) * 2013-09-09 2015-03-11 Centre National de la Recherche Scientifique (C.N.R.S.) PIN1-Hemmer zur Verwendung bei der Vorbeugung und/oder Behandlung von Theileriose sowie zugehörige Anwendungen

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2553647A (en) * 1946-03-20 1951-05-22 Research Corp Naphthoquinone antimalarials
EG14152A (en) * 1977-11-22 1983-12-31 Wellcome Found Antitheilerial naphtoquinone derivatives

Also Published As

Publication number Publication date
AU574353B2 (en) 1988-07-07
MX9202993A (es) 1992-07-01
IL71545A0 (en) 1984-07-31
IL71545A (en) 1987-12-20
DE19475021I2 (de) 2001-08-02
ZA842797B (en) 1985-11-27
DK193584A (da) 1984-10-15
PH22018A (en) 1988-05-13
AU2679684A (en) 1984-10-18
JPH0533212B2 (de) 1993-05-19
EP0123238A2 (de) 1984-10-31
NL950002I2 (nl) 1998-04-01
EP0123238A3 (en) 1985-10-30
ATE27696T1 (de) 1987-06-15
GB8310141D0 (en) 1983-05-18
LU88579I2 (fr) 1995-03-01
MY102117A (en) 1992-03-31
NL950002I1 (nl) 1995-03-01
SG39390G (en) 1990-11-23
HK56690A (en) 1990-08-03
CY1549A (en) 1991-03-22
DK193584D0 (da) 1984-04-13
DK172273B1 (da) 1998-02-16
EP0123238B1 (de) 1987-06-10
JPS59205341A (ja) 1984-11-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
V448 Application of spc

Free format text: PRODUCT NAME: ATOVAQUON; REGISTRATION NO/DATE: 30133.00.00, 19940804

Spc suppl protection certif: 194 75 021

Filing date: 19941205

8328 Change in the person/name/address of the agent

Free format text: TER MEER STEINMEISTER & PARTNER GBR PATENTANWAELTE, 81679 MUENCHEN

V457 Spc granted

Free format text: PRODUCT NAME: ATOVAQUON; REGISTRATION NO/DATE: 30133.00.00, 19940804

Spc suppl protection certif: 194 75 021

Filing date: 19941205

V464 Spc expired

Free format text: PRODUCT NAME: ATOVAQUON; REGISTRATION NO/DATE: 30133.00.00, 19940804

Spc suppl protection certif: 194 75 021

Filing date: 19941205