FR2157726A1 - Cyclic derivs of 8-aminotheophylline - with analgesic activity - Google Patents

Cyclic derivs of 8-aminotheophylline - with analgesic activity

Info

Publication number
FR2157726A1
FR2157726A1 FR7138942A FR7138942A FR2157726A1 FR 2157726 A1 FR2157726 A1 FR 2157726A1 FR 7138942 A FR7138942 A FR 7138942A FR 7138942 A FR7138942 A FR 7138942A FR 2157726 A1 FR2157726 A1 FR 2157726A1
Authority
FR
France
Prior art keywords
substd
alkyl
opt
analgesic activity
alkylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7138942A
Other languages
French (fr)
Other versions
FR2157726B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Le Brun Laboratoire SA
Original Assignee
Le Brun Laboratoire SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Le Brun Laboratoire SA filed Critical Le Brun Laboratoire SA
Priority to FR7138942A priority Critical patent/FR2157726A1/en
Publication of FR2157726A1 publication Critical patent/FR2157726A1/en
Application granted granted Critical
Publication of FR2157726B1 publication Critical patent/FR2157726B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Title cpds. are of formulae Ia and Ib and their salts where A is 2-4C alkylene opt. substd. by alkyl; R is H, haloalkyl, alkoxyalkyl, benzyl opt. substd. in the nucleus by >=1 halogen, alkyl or alkoxy, phenethyl, benzylthioalkyl, where B is alkylene; R1, R2 = H, alkyl, hydroxyalkyl, alkoxyalkyl, phenyl, trifluoromethylphenyl, benzyl opt. substd on the nucleus by >=1 alkoxy; or R1 and R2 and the attached N atom form piperazino gp opt substd in the 4-portion by alkyl, hydroxyalkyl, phenyl, providd that in formula Ia when A is 3C alkylene, R must not be H, haloalkyl, benzyl or phenethyl. The cpds. have similar props to theophylline but with less side-effects and have also analgesic activity.
FR7138942A 1971-10-29 1971-10-29 Cyclic derivs of 8-aminotheophylline - with analgesic activity Granted FR2157726A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
FR7138942A FR2157726A1 (en) 1971-10-29 1971-10-29 Cyclic derivs of 8-aminotheophylline - with analgesic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7138942A FR2157726A1 (en) 1971-10-29 1971-10-29 Cyclic derivs of 8-aminotheophylline - with analgesic activity

Publications (2)

Publication Number Publication Date
FR2157726A1 true FR2157726A1 (en) 1973-06-08
FR2157726B1 FR2157726B1 (en) 1974-11-08

Family

ID=9085078

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7138942A Granted FR2157726A1 (en) 1971-10-29 1971-10-29 Cyclic derivs of 8-aminotheophylline - with analgesic activity

Country Status (1)

Country Link
FR (1) FR2157726A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51113898A (en) * 1975-03-12 1976-10-07 Lab Ru Burun Sa 88aminootheophiline derivative * production and application thereof
FR2438658A1 (en) * 1978-10-11 1980-05-09 Chinoin Gyogyszer Es Vegyeszet Condensed-ring derivs. of purine(s) - for treatment of cardiovascular disorders
US6586429B2 (en) * 2000-11-29 2003-07-01 Cell Therapeutics, Inc. Tricyclic fused xanthine compounds and their uses

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS51113898A (en) * 1975-03-12 1976-10-07 Lab Ru Burun Sa 88aminootheophiline derivative * production and application thereof
FR2438658A1 (en) * 1978-10-11 1980-05-09 Chinoin Gyogyszer Es Vegyeszet Condensed-ring derivs. of purine(s) - for treatment of cardiovascular disorders
US6586429B2 (en) * 2000-11-29 2003-07-01 Cell Therapeutics, Inc. Tricyclic fused xanthine compounds and their uses
US7247630B2 (en) 2000-11-29 2007-07-24 Cell Therapeutics, Inc. Uses of tricyclic compounds

Also Published As

Publication number Publication date
FR2157726B1 (en) 1974-11-08

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