FR2438658A1 - Condensed-ring derivs. of purine(s) - for treatment of cardiovascular disorders - Google Patents
Condensed-ring derivs. of purine(s) - for treatment of cardiovascular disordersInfo
- Publication number
- FR2438658A1 FR2438658A1 FR7829000A FR7829000A FR2438658A1 FR 2438658 A1 FR2438658 A1 FR 2438658A1 FR 7829000 A FR7829000 A FR 7829000A FR 7829000 A FR7829000 A FR 7829000A FR 2438658 A1 FR2438658 A1 FR 2438658A1
- Authority
- FR
- France
- Prior art keywords
- purine
- derivs
- treatment
- cardiovascular disorders
- condensed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Purine derivs. of formula (I) and their acid-addition salts are new (where R is OH, alkoxy or acyloxy; R is S or =N.R1; R1 is H. 1-5C alkyl or aralkyl, or 2-4C acyl). Six specifically claimed cpds. include 1,3-dimethyl-2,4-dioxo-7-hydroxy-9-benzyl-6,7,8,9-tetrahydro-pyri- mido 2,1-f purine and 1,3-dimethyl-2,4-dioxo-7-acetoxy-6,7,8,9-tetrahydro-thiazino 2,1-- f -purine. Used for the treatment of cardiovascular disorders. A typical cpd., 1,3-dimethyl-2,4-dioxo-7-hydroxy-9-benzyl-6,7,8,9-tetrahydropyrim- ido 2,1-f)purine, was prepd. by heating a mixt. of 8-benzylaminotheophylline and epichlorohydrin for 110h.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7829000A FR2438658A1 (en) | 1978-10-11 | 1978-10-11 | Condensed-ring derivs. of purine(s) - for treatment of cardiovascular disorders |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7829000A FR2438658A1 (en) | 1978-10-11 | 1978-10-11 | Condensed-ring derivs. of purine(s) - for treatment of cardiovascular disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2438658A1 true FR2438658A1 (en) | 1980-05-09 |
FR2438658B1 FR2438658B1 (en) | 1981-07-03 |
Family
ID=9213605
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7829000A Granted FR2438658A1 (en) | 1978-10-11 | 1978-10-11 | Condensed-ring derivs. of purine(s) - for treatment of cardiovascular disorders |
Country Status (1)
Country | Link |
---|---|
FR (1) | FR2438658A1 (en) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1809013A1 (en) * | 1968-01-05 | 1969-08-07 | Pfizer & Co C | Process for the preparation of heterocyclic compounds and new heterocycloimidazoles |
FR2157726A1 (en) * | 1971-10-29 | 1973-06-08 | Brun Lab Sa Le | Cyclic derivs of 8-aminotheophylline - with analgesic activity |
FR2303551A1 (en) * | 1975-03-12 | 1976-10-08 | Brun Lab Sa Le | 8-AMINO THEOPHYLLINE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS |
-
1978
- 1978-10-11 FR FR7829000A patent/FR2438658A1/en active Granted
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1809013A1 (en) * | 1968-01-05 | 1969-08-07 | Pfizer & Co C | Process for the preparation of heterocyclic compounds and new heterocycloimidazoles |
FR2157726A1 (en) * | 1971-10-29 | 1973-06-08 | Brun Lab Sa Le | Cyclic derivs of 8-aminotheophylline - with analgesic activity |
FR2303551A1 (en) * | 1975-03-12 | 1976-10-08 | Brun Lab Sa Le | 8-AMINO THEOPHYLLINE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATIONS |
Also Published As
Publication number | Publication date |
---|---|
FR2438658B1 (en) | 1981-07-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |