FR2118932A1 - 2-oxo-1, 2, 3, 4-tetrahydroquinazoline derivs - sedatives antiinflammatories, analgesics, uricosurics and antimicrobials - Google Patents

2-oxo-1, 2, 3, 4-tetrahydroquinazoline derivs - sedatives antiinflammatories, analgesics, uricosurics and antimicrobials

Info

Publication number
FR2118932A1
FR2118932A1 FR7145497A FR7145497A FR2118932A1 FR 2118932 A1 FR2118932 A1 FR 2118932A1 FR 7145497 A FR7145497 A FR 7145497A FR 7145497 A FR7145497 A FR 7145497A FR 2118932 A1 FR2118932 A1 FR 2118932A1
Authority
FR
France
Prior art keywords
alkyl
substd
opt
halogen
cpds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7145497A
Other languages
French (fr)
Other versions
FR2118932B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP11833270A external-priority patent/JPS4834598B1/ja
Priority claimed from JP147771A external-priority patent/JPS4940476B1/ja
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of FR2118932A1 publication Critical patent/FR2118932A1/en
Application granted granted Critical
Publication of FR2118932B1 publication Critical patent/FR2118932B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C07D239/82—Oxygen atoms with an aryl radical attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The title cpds. of formula:- (in which R1 and R2 are H, halogen, lower alkyl, lower alkoxy, NO2, CF3, lower alkyl-mercapto or alkylsulphonyl; R3 is phenyl (opt. substd. by halogen, lower alkyl, lower alkoxy or CF3), lower cyclo-alkyl, lower cycloalkenyl, pyridyl, pyrrolyl, furyl, thienyl or napththyl; R4 is lower alkyl, lower alkenyl, aralkyl, lower cycloalkylalkyl, lower cycloalkyl, lower alkoxyalkyl, lower alkylmercaptoalkyl, lower hydroxy-alkyl, lower alkanoyloxyalkyl, phenyl (opt. substd. by halogen, CF3, lower alkyl or lower alkoxy), pyridyl or -CnH2nNR5R6 or -CnH2nCONR5R6, where n is 1, 2, 3 or 4 and R5 and R6 are lower alkyl or NR5R6 may form a 5- or 6-membered opt. substd. heterocyclic ring opt. contng. a second heteroatom; and R is H, lower alkyl, lower alkenyl, lower alkoxyalkyl, lower alkylmercapto-alkyl, aralkyl, lower cycloalkylalkyl, trihalomethylalkyl or -CnH2nNR5R6 or -CnH2nCONR5R6) are prepd. by (a) a suitably substd. 2-trihaloacetamido-5-chlorobenzo-phenone-2-imine or (b) by converting cpds. in which R=H to cpds. in which R is not = H, by reaction with a reactive deriv. of R-OH.
FR7145497A 1970-12-23 1971-12-17 2-oxo-1, 2, 3, 4-tetrahydroquinazoline derivs - sedatives antiinflammatories, analgesics, uricosurics and antimicrobials Granted FR2118932A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11833270A JPS4834598B1 (en) 1970-12-23 1970-12-23
JP147771A JPS4940476B1 (en) 1971-01-19 1971-01-19
JP3489771 1971-05-21

Publications (2)

Publication Number Publication Date
FR2118932A1 true FR2118932A1 (en) 1972-08-04
FR2118932B1 FR2118932B1 (en) 1975-10-10

Family

ID=27274937

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7145497A Granted FR2118932A1 (en) 1970-12-23 1971-12-17 2-oxo-1, 2, 3, 4-tetrahydroquinazoline derivs - sedatives antiinflammatories, analgesics, uricosurics and antimicrobials

Country Status (11)

Country Link
AU (1) AU438472B2 (en)
BE (1) BE777102A (en)
CA (1) CA981672A (en)
CH (1) CH560198A5 (en)
DD (1) DD95845A5 (en)
DE (1) DE2162327C3 (en)
DK (1) DK129996B (en)
FR (1) FR2118932A1 (en)
HU (1) HU163789B (en)
NL (1) NL7117652A (en)
SE (1) SE405729B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2501207A1 (en) * 1981-03-06 1982-09-10 Bristol Myers Co QUINAZOLINIC ANTITUMORIC COMPOUNDS AND PROCESS FOR THE PRODUCTION THEREOF
WO1993004047A1 (en) * 1991-08-16 1993-03-04 Merck & Co., Inc. Quinazoline derivatives as inhibitors of hiv reverse transcriptase
EP0530994A1 (en) * 1991-08-16 1993-03-10 Merck & Co. Inc. Quinazoline derivatives as inhibitors of HIV reverse transcriptase

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69926776T2 (en) * 1998-10-16 2006-06-08 Sumitomo Pharmaceuticals Co., Ltd. QUINALOZINON DERIVATIVES

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1932396A1 (en) * 1968-07-01 1970-01-08 Sandoz Ag Heterocyclic compounds and processes for their preparation
FR2013172A1 (en) * 1968-07-18 1970-03-27 Sumitomo Chemical Co
FR2060075A1 (en) * 1969-08-02 1971-06-11 Sumitomo Chemical Co

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1932396A1 (en) * 1968-07-01 1970-01-08 Sandoz Ag Heterocyclic compounds and processes for their preparation
FR2013172A1 (en) * 1968-07-18 1970-03-27 Sumitomo Chemical Co
FR2060075A1 (en) * 1969-08-02 1971-06-11 Sumitomo Chemical Co

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2501207A1 (en) * 1981-03-06 1982-09-10 Bristol Myers Co QUINAZOLINIC ANTITUMORIC COMPOUNDS AND PROCESS FOR THE PRODUCTION THEREOF
WO1993004047A1 (en) * 1991-08-16 1993-03-04 Merck & Co., Inc. Quinazoline derivatives as inhibitors of hiv reverse transcriptase
EP0530994A1 (en) * 1991-08-16 1993-03-10 Merck & Co. Inc. Quinazoline derivatives as inhibitors of HIV reverse transcriptase

Also Published As

Publication number Publication date
HU163789B (en) 1973-10-27
DE2162327B2 (en) 1975-01-30
DE2162327A1 (en) 1972-07-13
DK129996B (en) 1974-12-09
FR2118932B1 (en) 1975-10-10
AU3692171A (en) 1973-06-21
CA981672A (en) 1976-01-13
NL7117652A (en) 1972-06-27
DE2162327C3 (en) 1975-09-18
DD95845A5 (en) 1973-02-20
CH560198A5 (en) 1975-03-27
BE777102A (en) 1972-04-17
SE405729B (en) 1978-12-27
AU438472B2 (en) 1973-08-09
DK129996C (en) 1975-05-20

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Legal Events

Date Code Title Description
ST Notification of lapse