GB1111337A - Substituted aralkyl alcohols - Google Patents

Substituted aralkyl alcohols

Info

Publication number
GB1111337A
GB1111337A GB34309/66A GB3430966A GB1111337A GB 1111337 A GB1111337 A GB 1111337A GB 34309/66 A GB34309/66 A GB 34309/66A GB 3430966 A GB3430966 A GB 3430966A GB 1111337 A GB1111337 A GB 1111337A
Authority
GB
United Kingdom
Prior art keywords
hydrogen
carbon
alkyl
substituted
substituted aralkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB34309/66A
Inventor
George Harry Lord
Arthur Hedley Wragg
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fisons Pharmaceuticals Ltd
Original Assignee
Fisons Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fisons Pharmaceuticals Ltd filed Critical Fisons Pharmaceuticals Ltd
Publication of GB1111337A publication Critical patent/GB1111337A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/001—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain
    • C07C37/002—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by modification in a side chain by transformation of a functional group, e.g. oxo, carboxyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Novel substituted aralkyl alcohols of the formula <FORM:1111337/C2/1> where one of R2 and R3 is a group -OR7, R7 and R1 being hydrogen, alkyl, o -dialkylaminoalkyl or heterocyclic-substituted alkyl, not both of them being hydrogen, R4 and R5 and the other of R2 and R3 are hydrogen, alkyl, aralkyl or halogen, R6 is naphthyl, phenyl, halo- and/or alkyl-substituted phenyl and Y is a carbon-carbon bond or a group containing carbon and hydrogen only, at least one of R4 R5, the other of R2 and R3 to -OR7 and th substituents on R6 being other than hydrogen if Y contains less than 2 carbon atoms and acid addition salts thereof are produced by the partial reduction of the corresponding ketone. The reduction is suitably effected by KBH4 in ethanol. Preferably R1 and R7 are b -diethyl-aminoethyl groups, and exemplified compounds have Y as -C2H4-, -C3H6-, and -C4H8-groups, or R6 as p-chlorophenyl and Y as a carbon-carbon bond. Pharmaceutical preparations having amoebicidal activity comprise the above compounds with conventional pharmaceutical carriers and diluents.
GB34309/66A 1964-07-24 1964-07-24 Substituted aralkyl alcohols Expired GB1111337A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB29814/64A GB1111336A (en) 1964-07-24 1964-07-24 Aryl ketones

Publications (1)

Publication Number Publication Date
GB1111337A true GB1111337A (en) 1968-04-24

Family

ID=10297608

Family Applications (3)

Application Number Title Priority Date Filing Date
GB29814/64A Expired GB1111336A (en) 1964-07-24 1964-07-24 Aryl ketones
GB34310/66A Expired GB1111338A (en) 1964-07-24 1964-07-24 Aralkyl substituted resorcinols
GB34309/66A Expired GB1111337A (en) 1964-07-24 1964-07-24 Substituted aralkyl alcohols

Family Applications Before (2)

Application Number Title Priority Date Filing Date
GB29814/64A Expired GB1111336A (en) 1964-07-24 1964-07-24 Aryl ketones
GB34310/66A Expired GB1111338A (en) 1964-07-24 1964-07-24 Aralkyl substituted resorcinols

Country Status (4)

Country Link
CH (1) CH441370A (en)
DE (1) DE1493729A1 (en)
FR (2) FR5003M (en)
GB (3) GB1111336A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4945099A (en) * 1987-01-12 1990-07-31 Eli Lilly And Company Anti-inflammatory agents
US5098613A (en) * 1987-01-12 1992-03-24 Eli Lilly And Company Anti-inflammatory agents
US5294613A (en) * 1987-01-12 1994-03-15 Eli Lilly And Company Method of treating endotoxic shock in mammals

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR78370B (en) * 1981-12-24 1984-09-26 Delalande Sa
FR2537970B1 (en) * 1982-12-15 1986-08-14 Delalande Sa NOVEL AMINOALKOXY AROMATIC DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THERAPEUTICS
FR2518992A1 (en) * 1981-12-24 1983-07-01 Delalande Sa 1-Amino-omega-aryloxy substd. ethane and propane derivs. - with calcium antagonising activity e.g. for treating angina
CA1315279C (en) * 1987-01-12 1993-03-30 Nancy Grace Bollinger Anti-inflammatory agents
DE3825559A1 (en) * 1988-07-28 1990-02-01 Basf Ag P-HYDROXIPHENONE DERIVATIVES AND THEIR USE
ZA917369B (en) * 1990-09-20 1992-06-24 Merrell Dow Pharma Calcium uptake inhibitors
FR2670205A1 (en) * 1990-12-06 1992-06-12 Rhone Poulenc Agrochimie 2,6-ALKOXYPENYL ALKYLCETONE AND DERIVATIVES HERBICIDES.
CA2110251A1 (en) * 1992-11-30 1994-05-31 Koichi Fujimoto Alpha, omega-diarylalkane derivatives, their preparation and their use in the treatment and prevention of circulatory diseases and psychosis

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4945099A (en) * 1987-01-12 1990-07-31 Eli Lilly And Company Anti-inflammatory agents
US5098613A (en) * 1987-01-12 1992-03-24 Eli Lilly And Company Anti-inflammatory agents
US5294613A (en) * 1987-01-12 1994-03-15 Eli Lilly And Company Method of treating endotoxic shock in mammals

Also Published As

Publication number Publication date
CH441370A (en) 1967-08-15
DE1493729A1 (en) 1969-01-30
GB1111338A (en) 1968-04-24
GB1111336A (en) 1968-04-24
FR5003M (en) 1967-04-17
FR1499864A (en) 1967-11-03

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