FR2181744A2 - Substd quinazolones (and thiones) - as uricosuric agents - Google Patents
Substd quinazolones (and thiones) - as uricosuric agentsInfo
- Publication number
- FR2181744A2 FR2181744A2 FR7305627A FR7305627A FR2181744A2 FR 2181744 A2 FR2181744 A2 FR 2181744A2 FR 7305627 A FR7305627 A FR 7305627A FR 7305627 A FR7305627 A FR 7305627A FR 2181744 A2 FR2181744 A2 FR 2181744A2
- Authority
- FR
- France
- Prior art keywords
- alkyl
- opt
- substd
- cycloalkyl
- contg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
- C07D239/82—Oxygen atoms with an aryl radical attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
The use of cmpds. (I) as uricosuric agents. (where R is H, alkyl, alkenyl, haloalkyl, aralkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkanoyloxyalkyl, haloalkanoyloxyalkyl, hydroxyalkyl, alkylthioalkyl, CnH2nB, where n is 0-3 and B is an opt. satd. heterocyclic ring contg. one or two O, N or S atoms, or CnH2nN(R'R") or CnH2nCON(R'R") where n is 1-3 and R' and R" are alkyl; R1 and R2 are H, alkyl, alkoxy, CF3, NO2, NH2, N(alkyl)2, alkylthio, alkylsulphonyl, alkoxycarbonyl, or halogen or R1+R2 is -CH2-CnH2n-CH2- or -O-CnH2n-O, where n is 1-3; Z is O or S; A is -C(R3)=N-, -CH(R3)-N(R4)- or -C(R3)(YR5)-N(Rl), where R3 is phenyl opt. substd. cycloalkyl, pyridyl, pyrrolyl, furyl or thienyl, R4 and R5 are H, alkyl, alkenyl, aralkyl, cycloalkyl, cycloalkylalkyl, hydroxyalkyl, alkanoyloxyalkyl, alkoxyalkyl, alkylthioalkyl, phenyl opt. substd. or CnH2nN(R7R8) or CnH2nCON(R7R8) where n is 1-3, R7 and R8 are alkyl or N(R7R8) is a 5-6 membered ring opt. contg. a further O or N atom, Y is O or NR9, where R9 is H or alkyl, R6 is as R4 or R5 above but not H, or R5+R6 together with attached C and N atoms form a 5-8 membered ring opt. contg. a further O or N atom and opt. substd. by one or two alkyl groups which may be linked to form a benzene or cyclohexane ring). Uricosuric agents more effective than probenicide and less toxic.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1744272A JPS4885719A (en) | 1972-02-18 | 1972-02-18 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| FR2181744A2 true FR2181744A2 (en) | 1973-12-07 |
| FR2181744B2 FR2181744B2 (en) | 1976-05-14 |
Family
ID=11944127
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7305628A Expired FR2181745B2 (en) | 1972-02-18 | 1973-02-16 | |
| FR7305629A Expired FR2181746B2 (en) | 1972-02-18 | 1973-02-16 | |
| FR7305627A Granted FR2181744A2 (en) | 1972-02-18 | 1973-02-16 | Substd quinazolones (and thiones) - as uricosuric agents |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR7305628A Expired FR2181745B2 (en) | 1972-02-18 | 1973-02-16 | |
| FR7305629A Expired FR2181746B2 (en) | 1972-02-18 | 1973-02-16 |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS4885719A (en) |
| BE (1) | BE795519A (en) |
| DE (1) | DE2307808A1 (en) |
| FR (3) | FR2181745B2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999044612A1 (en) | 1998-03-02 | 1999-09-10 | Cocensys, Inc. | Substituted quinazolines and analogs and the use thereof |
| PT1122253E (en) * | 1998-10-16 | 2005-11-30 | Sumitomo Pharma | QUINAZOLINONE DERIVATIVES |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE771790A (en) * | 1970-08-27 | 1971-12-31 | Sumitomo Chemical Co | NEW PROCESS FOR PREPARATION OF QUINAZOLINE DERIVATIVES AND PRODUCTS OBTAINED |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2037693C3 (en) * | 1969-08-02 | 1975-01-16 | Sumitomo Chemical Co., Ltd., Osaka (Japan) | 1-Cyclopropylmethyl-2 (1 H) -quinazolinone derivatives |
| DE2118315C3 (en) * | 1970-04-20 | 1975-04-03 | Sumitomo Chemical Co., Ltd., Osaka (Japan) | 2- (1H) -quinazolinone derivatives, processes for their preparation and pharmaceuticals containing these compounds |
-
0
- BE BE795519D patent/BE795519A/en not_active IP Right Cessation
-
1972
- 1972-02-18 JP JP1744272A patent/JPS4885719A/ja active Pending
-
1973
- 1973-02-16 DE DE19732307808 patent/DE2307808A1/en active Pending
- 1973-02-16 FR FR7305628A patent/FR2181745B2/fr not_active Expired
- 1973-02-16 FR FR7305629A patent/FR2181746B2/fr not_active Expired
- 1973-02-16 FR FR7305627A patent/FR2181744A2/en active Granted
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE771790A (en) * | 1970-08-27 | 1971-12-31 | Sumitomo Chemical Co | NEW PROCESS FOR PREPARATION OF QUINAZOLINE DERIVATIVES AND PRODUCTS OBTAINED |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2181745B2 (en) | 1976-05-14 |
| FR2181746A2 (en) | 1973-12-07 |
| BE795519A (en) | 1973-06-18 |
| JPS4885719A (en) | 1973-11-13 |
| FR2181744B2 (en) | 1976-05-14 |
| AU5229973A (en) | 1974-08-22 |
| FR2181745A2 (en) | 1973-12-07 |
| DE2307808A1 (en) | 1973-08-30 |
| FR2181746B2 (en) | 1976-05-14 |
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