FR1502831A - Nouvelles 2-(3-amino-6-halogénopyrazinamidino)-2-imidazolines et leur procédé de fabrication - Google Patents

Nouvelles 2-(3-amino-6-halogénopyrazinamidino)-2-imidazolines et leur procédé de fabrication

Info

Publication number
FR1502831A
FR1502831A FR77674A FR77674A FR1502831A FR 1502831 A FR1502831 A FR 1502831A FR 77674 A FR77674 A FR 77674A FR 77674 A FR77674 A FR 77674A FR 1502831 A FR1502831 A FR 1502831A
Authority
FR
France
Prior art keywords
halogenopyrazinamidino
imidazolines
amino
new
manufacturing process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR77674A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of FR1502831A publication Critical patent/FR1502831A/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C17/00—Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C17/00—Disintegrating by tumbling mills, i.e. mills having a container charged with the material to be disintegrated with or without special disintegrating members such as pebbles or balls
    • B02C17/18—Details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
    • B02C—CRUSHING, PULVERISING, OR DISINTEGRATING IN GENERAL; MILLING GRAIN
    • B02C21/00—Disintegrating plant with or without drying of the material
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/72—Two oxygen atoms, e.g. hydantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/06—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members
    • C07D241/08—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having one or two double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C07D265/33—Two oxygen atoms, in positions 3 and 5
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/14—Styryl dyes
    • C09B23/145—Styryl dyes the ethylene chain carrying an heterocyclic residue, e.g. heterocycle-CH=CH-C6H5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Coloring (AREA)
  • Crushing And Grinding (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Disintegrating Or Milling (AREA)
FR77674A 1965-07-17 1966-09-26 Nouvelles 2-(3-amino-6-halogénopyrazinamidino)-2-imidazolines et leur procédé de fabrication Expired FR1502831A (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DER41114A DE1281818B (de) 1965-07-17 1965-07-17 Verfahren zum gleichzeitigen Mahlen mehrerer Rohstoffe unterschiedlicher Mahlbarkeit
US492866A US3394130A (en) 1965-07-17 1965-10-04 Quaternary methine compounds
US492842A US3299063A (en) 1965-07-17 1965-10-04 Derivatives of pyrazine

Publications (1)

Publication Number Publication Date
FR1502831A true FR1502831A (fr) 1967-11-24

Family

ID=27212183

Family Applications (1)

Application Number Title Priority Date Filing Date
FR77674A Expired FR1502831A (fr) 1965-07-17 1966-09-26 Nouvelles 2-(3-amino-6-halogénopyrazinamidino)-2-imidazolines et leur procédé de fabrication

Country Status (8)

Country Link
US (3) US3299063A (fr)
BE (1) BE684235A (fr)
BR (1) BR6683227D0 (fr)
CH (2) CH471141A (fr)
DE (3) DE1281818B (fr)
FR (1) FR1502831A (fr)
GB (3) GB1098000A (fr)
NL (3) NL6610001A (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3503973A (en) * 1967-11-07 1970-03-31 Merck & Co Inc Process for preparation of pyrazinoylguanidines
US3515723A (en) * 1967-11-14 1970-06-02 Merck & Co Inc 2 - (5 - amino - 1h - 1,2,4 - triazol - 3 - yl)- 3-aminopyrazines and processes for their preparation
AT300526B (de) * 1968-10-24 1972-06-15 Vyzk Ustav Stavebnich Hmot V B Verfahren zum selbsttaetigen regeln einer rohrmuehle und anordnung zur durchfuehrung des verfahrens
US3855228A (en) * 1972-08-21 1974-12-17 Sterling Drug Inc 3,4-dihydro-1-or 3-(polyfluoroalkyl)-2(1h)-isoquinolinecarboxamidoximes
US3857333A (en) * 1973-04-05 1974-12-31 T Satake Huller
DE2600499A1 (de) * 1976-01-08 1977-07-21 Polysius Ag Verfahren und einrichtung zur verarbeitung abrasiven gutes
DE2620461A1 (de) * 1976-05-08 1977-11-24 Kloeckner Humboldt Deutz Ag Mahltrocknungsanlage
US4402959A (en) * 1980-06-02 1983-09-06 Merck & Co., Inc. Antimicrobial compositions
FI64057C (fi) * 1982-02-02 1983-10-10 Partek Ab Saett att klassificera en kristallblandning eller anrika bergarter eller blandkristaller i partikelform
US4518599A (en) * 1982-09-30 1985-05-21 Merck & Co., Inc. 2-Amino-3-cyano-5-halo-6-(substituted)pyrazine
US4517186A (en) * 1982-09-30 1985-05-14 Merck & Co., Inc. 2-Amino-3,5-dicyano-6-(substituted)pyrazine antimicrobial compounds
US4442095A (en) * 1982-12-27 1984-04-10 Merck & Co., Inc. N-[(5-Halo-2,6-(substituted)pyrazinyl)methylene]amine antimicrobial compounds, compositions and use
US4442096A (en) * 1982-12-27 1984-04-10 Merck & Co., Inc. 2-(Substituted)amino-3-cyano-5-halo-6-(substituted)-pyrazine antimicrobial compounds, compositions and use
US4512991A (en) * 1982-12-27 1985-04-23 Merck & Co., Inc. 3-Acyl-2-amino-5-halo-6-(substituted)pyrazine antimicrobial compounds
US4442097A (en) * 1982-12-27 1984-04-10 Merck & Co., Inc. 3-Acyl-2-(substituted) amino-5-halo-6-(substituted) pyrazine antimicrobial compounds, compositions and use
US4507299A (en) * 1982-12-27 1985-03-26 Merck & Co., Inc. N-[2-amino-5-halo-6-(substituted)-3-pyrazinyl)-methylene]amine antimicrobial compounds
US4481202A (en) * 1982-12-27 1984-11-06 Merek & Co., Inc. 2-Amino-3-carboxylate-5-halo-6-(substituted)pyrazine antimicrobial compounds
DE3302176A1 (de) * 1983-01-24 1984-07-26 Klöckner-Humboldt-Deutz AG, 5000 Köln Verfahren und anlage zur kontinuierlichen druckzerkleinerung sproeden mahlgutes
DE3314103A1 (de) * 1983-04-19 1984-10-25 Klöckner-Humboldt-Deutz AG, 5000 Köln Verfahren und anlage zur gemeinsamen mahlung zweier oder mehrerer unterschiedlich mahlbarer sproeder stoffe
US4479953A (en) * 1983-08-25 1984-10-30 Merck & Co., Inc. Pyrazine aldimine compounds as antimicrobial agents
US5879444A (en) * 1997-09-02 1999-03-09 Bayer Corporation Organic pigment compositions
US5950934A (en) * 1998-03-18 1999-09-14 Podesta; Robert J. Cement mixer sand spreader
US6858615B2 (en) 2002-02-19 2005-02-22 Parion Sciences, Inc. Phenyl guanidine sodium channel blockers
US6903105B2 (en) * 2003-02-19 2005-06-07 Parion Sciences, Inc. Sodium channel blockers
DE10344040A1 (de) * 2003-09-23 2005-04-14 Polysius Ag Verfahren und Vorrichtung zur Herstellung eines hydraulischen Bindemittels
US20070021439A1 (en) * 2005-07-25 2007-01-25 Parion Sciences, Inc. Methods of reducing risk of infection from pathogens with soluble amide and ester pyrazinoylguanidine sodium channel blockers
EP2066813A2 (fr) * 2006-09-28 2009-06-10 Ensemble Discovery Corporation Compositions et procedes de biodetection par chimie a matrice d'acides nucleiques
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
RS55618B1 (sr) 2012-12-17 2017-06-30 Parion Sciences Inc Derivati hloropirazin karboksamida korisni za lečenje bolesti kojima pogoduje nedovoljna hidracija sluznica
BR112015014178A2 (pt) 2012-12-17 2017-07-11 Parion Sciences Inc compostos de 3,5-diamino-6-cloro-n-(n-(4-fenilbutil)carbamimidoil) pirazina-2- carboxamida
US9102633B2 (en) 2013-12-13 2015-08-11 Parion Sciences, Inc. Arylalkyl- and aryloxyalkyl-substituted epithelial sodium channel blocking compounds

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE698311C (de) * 1937-07-18 1940-11-07 Babcock & Wilcox Dampfkessel W Kohlenmahlanlage, bei der eine Rohrmuehle und eine Hammermuehle Verwendung finden
CH241478A (de) * 1942-03-07 1946-03-15 Smidth & Co As F L Verfahren zur Regelung der Materialzufuhr einer Vermahlungsmaschine und Einrichtung zur Ausübung dieses Verfahrens.
US2835452A (en) * 1954-06-28 1958-05-20 Du Pont Process for granulating urea-formaldehyde fertilizer compositions
US2850520A (en) * 1956-07-18 1958-09-02 Sandoz Ag New water-insoluble styryl dyestuffs
US3016203A (en) * 1957-05-03 1962-01-09 Poor & Co Crushing and screening plant
DE1088327B (de) * 1958-01-10 1960-09-01 Beteiligungs & Patentverw Gmbh Verfahren zum Steuern von Brechern mit umlaufenden Schlagwerkzeugen
DE1168221B (de) * 1960-03-26 1964-04-16 Elmkalk Und Zementwerke J Schn Verfahren zur automatischen Regelung von Zementmahlanlagen mit Grob- und Feinmuehle
DE1194231B (de) * 1961-08-21 1965-06-03 Polysius Gmbh Verfahren zum Regeln von Sichtermahlanlagen
US3314614A (en) * 1964-04-15 1967-04-18 Federal Ind Ind Group Inc Analog computer grinding control

Also Published As

Publication number Publication date
US3402895A (en) 1968-09-24
BE684235A (fr) 1966-12-16
DE1620036A1 (de) 1970-03-19
GB1098000A (en) 1968-01-03
US3299063A (en) 1967-01-17
GB1165734A (en) 1969-10-01
GB1160072A (en) 1969-07-30
NL6613933A (fr) 1967-04-05
DE1619428A1 (de) 1971-09-23
NL6614001A (fr) 1967-04-05
CH471141A (de) 1969-04-15
BR6683227D0 (pt) 1973-12-26
US3394130A (en) 1968-07-23
DE1281818B (de) 1968-10-31
NL6610001A (fr) 1967-01-18
CH465107A (fr) 1968-11-15

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