FR1449628A - Procédé de préparation d'indoles polynucléaires désacylés, notamment d'esters de la série de la désacétyl-vincaleucoblastine et de la désacétyl-vincristine - Google Patents
Procédé de préparation d'indoles polynucléaires désacylés, notamment d'esters de la série de la désacétyl-vincaleucoblastine et de la désacétyl-vincristine Download PDFInfo
- Publication number
- FR1449628A FR1449628A FR8509A FR8509A FR1449628A FR 1449628 A FR1449628 A FR 1449628A FR 8509 A FR8509 A FR 8509A FR 8509 A FR8509 A FR 8509A FR 1449628 A FR1449628 A FR 1449628A
- Authority
- FR
- France
- Prior art keywords
- deacetyl
- dissolved
- mixture
- vlb
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US350519A US3392173A (en) | 1964-03-09 | 1964-03-09 | Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR1449628A true FR1449628A (fr) | 1966-08-19 |
Family
ID=23377073
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR8509A Expired FR1449628A (fr) | 1964-03-09 | 1965-03-09 | Procédé de préparation d'indoles polynucléaires désacylés, notamment d'esters de la série de la désacétyl-vincaleucoblastine et de la désacétyl-vincristine |
| FR20098A Expired FR6668M (US20040152965A1-20040805-M00009.png) | 1964-03-09 | 1965-06-09 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR20098A Expired FR6668M (US20040152965A1-20040805-M00009.png) | 1964-03-09 | 1965-06-09 |
Country Status (9)
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3899493A (en) * | 1972-12-29 | 1975-08-12 | Richter Gedeon Vegyeszet | Chromic acid oxidation of vinblastine sulfate to form vincristine |
| HU165986B (US20040152965A1-20040805-M00009.png) * | 1973-02-16 | 1974-12-28 | ||
| US4012390A (en) * | 1974-10-16 | 1977-03-15 | Eli Lilly And Company | Vinblastinoic acid |
| US3954773A (en) * | 1974-11-21 | 1976-05-04 | Eli Lilly And Company | 4-Desacetoxyvinblastine |
| US3944554A (en) * | 1975-01-09 | 1976-03-16 | Eli Lilly And Company | 4-Desacetoxy-3-hydroxyvinblastine |
| US4029663A (en) * | 1975-07-10 | 1977-06-14 | Eli Lilly And Company | Dimeric anhydro-vinca derivatives |
| US4209443A (en) * | 1976-02-13 | 1980-06-24 | Richter Gedeon Vegyeszeti Gyar Rt. | Process for separating pharmaceutically active diindole alkaloids |
| US4143041A (en) * | 1977-01-19 | 1979-03-06 | Eli Lilly And Company | 4'-Deoxyvincristine and related compounds |
| HU178084B (en) * | 1977-05-31 | 1982-03-28 | Richter Gedeon Vegyeszet | New process for the extraction of native vindoline,catharantine,3',4'-anhydrovinblastine,leurosine and,if desired,of other diinodle alkaloids from vinca rosea l.drogue |
| US4195022A (en) * | 1978-03-27 | 1980-03-25 | Eli Lilly And Company | 4-Desacetoxy-4α-hydroxyvinblastine and related compounds |
| US4166810A (en) * | 1978-04-20 | 1979-09-04 | Eli Lilly And Company | Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide |
| HU178706B (en) * | 1979-04-23 | 1982-06-28 | Richter Gedeon Vegyeszet | Process for preparing bis-indole alkaloids and acid addition salts thereof |
| FR2461714A1 (fr) | 1979-07-17 | 1981-02-06 | Anvar | Nouvelle classe de composes bis-indoliques utiles comme medicaments et procede pour leur preparation |
| GR79898B (US20040152965A1-20040805-M00009.png) * | 1983-03-30 | 1984-10-31 | Lilly Industries Ltd | |
| US4522750A (en) * | 1984-02-21 | 1985-06-11 | Eli Lilly And Company | Cytotoxic compositions of transferrin coupled to vinca alkaloids |
| HU193318B (en) * | 1985-06-12 | 1987-09-28 | Richter Gedeon Vegyeszet | Process for producing new bis- indol derivatives |
| HU198074B (en) * | 1985-06-12 | 1989-07-28 | Richter Gedeon Vegyeszet | Process for producing new bis-indole derivatives and pharmaceutical compositions comprising these compounds |
| US4667030A (en) * | 1985-06-17 | 1987-05-19 | Eli Lilly And Company | Hydrazide succinimide derivatives of antineoplastic indole-dihydroindole alkaloids |
| US4801688A (en) * | 1986-05-27 | 1989-01-31 | Eli Lilly And Company | Hydrazone immunoglobulin conjugates |
| HUT76925A (hu) * | 1995-04-04 | 1998-01-28 | MTA Enzimológiai Intézet | Bisz-indol-származékok, eljárás előállításukra és az azokat tartalmazó gyógyszerkészítmények |
| US6326402B1 (en) | 1998-08-12 | 2001-12-04 | Octamer, Inc. | Methods for treating viral infections using a compound capable of inhibiting microtubules |
| ATE427948T1 (de) | 2001-04-24 | 2009-04-15 | Purdue Research Foundation | Folat-mimetika und deren folatrezeptorbindende konjugate |
| DE60326833D1 (de) * | 2002-05-15 | 2009-05-07 | Endocyte Inc | Vitamin-mitomycin-konjugate |
| EP2529758A3 (en) | 2003-01-27 | 2013-01-02 | Endocyte, Inc. | Vitamin receptor binding drug delivery conjugates |
| EP1789391B1 (en) | 2004-07-23 | 2017-06-28 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
| CN101175757B (zh) * | 2005-03-16 | 2012-11-14 | 恩多塞特公司 | 蝶酸及其缀合物的合成和纯化 |
| EP1948240A2 (en) * | 2005-08-19 | 2008-07-30 | Endocyte, Inc. | Ligand conjugates of vinca alkaloids, analogs and derivatives |
| BRPI0615354A2 (pt) | 2005-08-19 | 2011-05-17 | Endocyte Inc | conjugado de liberação de fármaco de ligação de receptor, composição farmacêutica que o compreende, bem como seu uso |
| WO2008101231A2 (en) | 2007-02-16 | 2008-08-21 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| CN103948937A (zh) * | 2007-03-14 | 2014-07-30 | 恩多塞特公司 | 结合配体连接的微管溶素递药缀合物 |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| BRPI0812970A2 (pt) | 2007-06-25 | 2019-09-24 | Endocyte Inc | conjugados contendo espaçadores hidrofílicos |
| JP2011500835A (ja) | 2007-10-25 | 2011-01-06 | エンドサイト，インコーポレイテッド | チューブリシン類および調製プロセス |
| WO2013126797A1 (en) | 2012-02-24 | 2013-08-29 | Purdue Research Foundation | Cholecystokinin b receptor targeting for imaging and therapy |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| SG11201502896XA (en) | 2012-10-16 | 2015-05-28 | Endocyte Inc | Drug delivery conjugates containing unnatural amino acids and methods for using |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3097137A (en) * | 1960-05-19 | 1963-07-09 | Canadian Patents Dev | Vincaleukoblastine |
| US3169968A (en) * | 1962-05-08 | 1965-02-16 | Ciba Geigy Corp | Esters of ajmaline and related compounds |
| US3225053A (en) * | 1963-01-10 | 1965-12-21 | Lilly Co Eli | Quebrachidine and derivatives |
-
1964
- 1964-03-09 US US350519A patent/US3392173A/en not_active Expired - Lifetime
-
1965
- 1965-03-04 CH CH304165A patent/CH507970A/de not_active IP Right Cessation
- 1965-03-05 GB GB9516/65A patent/GB1095833A/en not_active Expired
- 1965-03-08 DE DE1795823A patent/DE1795823C3/de not_active Expired
- 1965-03-08 ES ES0310240A patent/ES310240A1/es not_active Expired
- 1965-03-08 DE DE1795763A patent/DE1795763C3/de not_active Expired
- 1965-03-08 DE DE1545760A patent/DE1545760C3/de not_active Expired
- 1965-03-09 SE SE03033/65A patent/SE330700B/xx unknown
- 1965-03-09 NL NL6502977A patent/NL6502977A/xx unknown
- 1965-03-09 FR FR8509A patent/FR1449628A/fr not_active Expired
- 1965-03-09 BE BE660843A patent/BE660843A/xx unknown
- 1965-06-09 FR FR20098A patent/FR6668M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1545760B2 (de) | 1978-02-09 |
| CH507970A (de) | 1971-05-31 |
| DE1795823C3 (de) | 1982-04-15 |
| BE660843A (US20040152965A1-20040805-M00009.png) | 1965-09-09 |
| DE1545760A1 (de) | 1969-11-27 |
| DE1795763B2 (de) | 1977-11-10 |
| DE1545760C3 (de) | 1978-10-05 |
| DE1795823A1 (de) | 1976-02-05 |
| ES310240A1 (es) | 1965-10-16 |
| DE1795823B2 (de) | 1981-04-30 |
| NL6502977A (US20040152965A1-20040805-M00009.png) | 1965-09-10 |
| DE1795763A1 (de) | 1974-11-21 |
| SE330700B (US20040152965A1-20040805-M00009.png) | 1970-11-30 |
| GB1095833A (en) | 1967-12-20 |
| DE1795763C3 (de) | 1978-06-29 |
| FR6668M (US20040152965A1-20040805-M00009.png) | 1969-02-03 |
| US3392173A (en) | 1968-07-09 |
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