FI981097A - Intermolekulära adhesionsmolekylär och deras bindelingander - Google Patents

Intermolekulära adhesionsmolekylär och deras bindelingander Download PDF

Info

Publication number
FI981097A
FI981097A FI981097A FI981097A FI981097A FI 981097 A FI981097 A FI 981097A FI 981097 A FI981097 A FI 981097A FI 981097 A FI981097 A FI 981097A FI 981097 A FI981097 A FI 981097A
Authority
FI
Finland
Prior art keywords
binding sites
adhesion molecule
intermolecular adhesion
intermolecular
molecule
Prior art date
Application number
FI981097A
Other languages
English (en)
Finnish (fi)
Other versions
FI107451B (sv
FI981097A0 (sv
Inventor
Timothy A Springer
Robert Rothlein
Steven D Marlin
Michael L Dustin
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Publication of FI981097A0 publication Critical patent/FI981097A0/sv
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Publication of FI981097A publication Critical patent/FI981097A/sv
Application granted granted Critical
Publication of FI107451B publication Critical patent/FI107451B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI981097A 1988-09-28 1998-05-18 Förfarande för att erhålla ICAM-1 (intermolekulära adhesionsmolekyler) i väsentligen ren form FI107451B (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US25044688A 1988-09-28 1988-09-28
US25044688 1988-09-28
US37388289A 1989-06-30 1989-06-30
US37388289 1989-06-30
PCT/US1989/004242 WO1990003400A1 (en) 1988-09-28 1989-09-28 Intercellular adhesion molecules, and their binding ligands
US8904242 1989-09-28

Publications (3)

Publication Number Publication Date
FI981097A0 FI981097A0 (sv) 1989-09-28
FI981097A true FI981097A (sv) 1998-05-18
FI107451B FI107451B (sv) 2001-08-15

Family

ID=26940882

Family Applications (2)

Application Number Title Priority Date Filing Date
FI902490A FI102181B1 (sv) 1988-09-28 1990-05-21 Förfarande för att erhålla ICAM-1 (intermolekulära adhesionsmolekyler) i väsentligen ren form
FI981097A FI107451B (sv) 1988-09-28 1998-05-18 Förfarande för att erhålla ICAM-1 (intermolekulära adhesionsmolekyler) i väsentligen ren form

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI902490A FI102181B1 (sv) 1988-09-28 1990-05-21 Förfarande för att erhålla ICAM-1 (intermolekulära adhesionsmolekyler) i väsentligen ren form

Country Status (7)

Country Link
JP (1) JP2976381B2 (sv)
KR (1) KR900701846A (sv)
AU (2) AU4412889A (sv)
DK (1) DK175362B1 (sv)
FI (2) FI102181B1 (sv)
HU (1) HU218904B (sv)
WO (1) WO1990003400A1 (sv)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA896668B (en) * 1988-09-01 1990-06-27 Molecular Therapeutics Inc A human rhinovirus receptor protein that inhibits virus infectivity
US6143298A (en) * 1988-09-01 2000-11-07 Bayer Corporation Soluble truncated forms of ICAM-1
ES2097748T3 (es) * 1989-03-16 1997-04-16 Blood Res Center Uso de derivados funcionales de la molecula de adhesion intercelular icam-1 en la terapia antivirica.
WO1991018010A1 (en) * 1990-05-15 1991-11-28 Swinburne Limited Inhibition of viral infection using intercellular adhesion molecule-1-like peptides and/or analogues thereof
WO1991018011A1 (en) * 1990-05-15 1991-11-28 Swinburne Limited Inhibition of cell adhesion using intercellular adhesion molecule-1-like peptides and/or analogues thereof
DK162890D0 (da) * 1990-07-06 1990-07-06 Novo Nordisk As Polypeptid
US5686582A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
US5686581A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric form of human rhinovirus receptor protein
US6107461A (en) * 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
US5283058A (en) 1990-08-30 1994-02-01 The General Hospital Corporation Methods for inhibiting rejection of transplanted tissue
CA2056143A1 (en) * 1990-11-28 1992-05-29 Michael S. Diamond The mac-1 binding site of icam-1
US5932214A (en) 1994-08-11 1999-08-03 Biogen, Inc. Treatment for inflammatory bowel disease with VLA-4 blockers
PT644768E (pt) * 1992-06-11 2002-03-28 Scripps Research Inst Metodos e composicoes para inibir a inflamacao mediada por celulas endoteliais e fibrinogenio
US5599790A (en) 1992-06-11 1997-02-04 The Scripps Research Institute Fibrinogen γ chain polypeptide and compositions thereof
EP0670734A4 (en) * 1992-10-09 1998-01-14 Blood Res Center SUB-POPULATION OF Mac-1 MOLECULES (CD11B / CD 18) THAT INDUCE NEUTROPHILIC ADHESION TO ICAM-1 AND FIBRINOGEN.
DE4335273A1 (de) * 1993-10-15 1995-04-20 Univ Ludwigs Albert Peptide zur Tumortherapie
WO1995028170A1 (en) * 1994-04-19 1995-10-26 The University Of Kansas Icam-1/lfa-1 short-chain peptides and method of using same
WO1997000956A1 (en) * 1995-06-20 1997-01-09 Trustees Of Boston University Hypoxia-responsive adhesion molecules, specific antibodies, and their uses
AU7338500A (en) * 1999-09-01 2001-03-26 Boehringer Ingelheim Pharmaceuticals, Inc. Methods and compositions for treating autoimmune disease
CA2544678C (en) 2003-11-05 2013-12-31 Sunesis Pharmaceuticals, Inc. Modulators of cellular adhesion
SI2444079T1 (sl) 2005-05-17 2017-05-31 Sarcode Bioscience Inc. Sestavki in postopki za zdravljenje očesnih motenj
EP2209371B1 (en) 2007-10-19 2017-01-04 SARcode Bioscience Inc. Compositions and methods for treatment of diabetic retinopathy
JP5554993B2 (ja) * 2007-11-15 2014-07-23 中外製薬株式会社 Ａｎｅｘｅｌｅｋｔｏに結合するモノクローナル抗体、およびその利用
US8080562B2 (en) 2008-04-15 2011-12-20 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
WO2011050175A1 (en) 2009-10-21 2011-04-28 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
US9085553B2 (en) 2012-07-25 2015-07-21 SARcode Bioscience, Inc. LFA-1 inhibitor and methods of preparation and polymorph thereof
WO2019105864A1 (en) 2017-11-30 2019-06-06 F. Hoffmann-La Roche Ag B-cell cultivation method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2080044T3 (es) * 1987-05-04 1996-02-01 Dana Farber Cancer Inst Inc Moleculas de adhesion intercelular y sus ligandos de fijacion.
EP0314863B1 (en) * 1987-11-02 1994-12-07 Baylor College Of Medicine Use of ICAM-1 or its functional derivatives for the treatment of non-specific inflammation

Also Published As

Publication number Publication date
JP2976381B2 (ja) 1999-11-10
AU4412889A (en) 1990-04-18
AU6319294A (en) 1994-08-25
JPH03501861A (ja) 1991-04-25
DK175362B1 (da) 2004-09-13
FI102181B (sv) 1998-10-30
FI107451B (sv) 2001-08-15
DK128990A (da) 1990-07-26
HU218904B (hu) 2000-12-28
WO1990003400A1 (en) 1990-04-05
FI981097A0 (sv) 1989-09-28
AU679506B2 (en) 1997-07-03
FI102181B1 (sv) 1998-10-30
DK128990D0 (da) 1990-05-25
FI902490A0 (fi) 1990-05-21
HUT56120A (en) 1991-07-29
HU896074D0 (en) 1990-11-28
KR900701846A (ko) 1990-12-04

Similar Documents

Publication Publication Date Title
FI981097A0 (sv) Intermolekulära adhesionsmolekylär och deras bindelingander
DK120391D0 (da) Sekventiel peptid- og oligonukleotidsyntese under anvendelse af immunaffinitetsteknikker
DK135189D0 (da) Polymer komposition
BR8905204A (pt) Composicao colutoria
KR900009478A (ko) 방 음 재
BR8902386A (pt) Composicao polimerica
KR900701924A (ko) 겔
DE68927982D1 (de) Polymermischungen
MX163730B (es) Composicion adhesiva mejorada
MX164890B (es) Composicion de resina aglutinante extruible
FR2634778B1 (fr) Composition adhesive
BR8906787A (pt) Composicao
FI981642A0 (sv) Intermolkulära adhesionsmolekylär och deras bindeligander
DK134088D0 (da) Mobilt vejeanlaeg
BR8902491A (pt) Composicao
NO174328C (no) Binding for tur- og langrennsski
TR26099A (tr) Islah edilmis pestisid terkip
DK445289A (da) Materialesammensaetning
BR8907528A (pt) Composicao crio-protetora
ATA150388A (de) Skibindung
ATA39488A (de) Skibindung
BR8900587A (pt) Composicoes
DK52590D0 (da) Afgivelseslukke
NO169999C (no) Langrennsski
KR890019051U (ko) 앨범지