HUT56120A - Intercellular adhezive molekules and theyr binding ligands - Google Patents

Intercellular adhezive molekules and theyr binding ligands

Info

Publication number
HUT56120A
HUT56120A HU896074A HU607489A HUT56120A HU T56120 A HUT56120 A HU T56120A HU 896074 A HU896074 A HU 896074A HU 607489 A HU607489 A HU 607489A HU T56120 A HUT56120 A HU T56120A
Authority
HU
Hungary
Prior art keywords
molekules
adhezive
theyr
intercellular
binding ligands
Prior art date
Application number
HU896074A
Other languages
Hungarian (hu)
Other versions
HU896074D0 (en
HU218904B (en
Inventor
Timothy Alan Springer
Robert Rothlein
Steven Dean Marlin
Michael Loran Dustin
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Publication of HU896074D0 publication Critical patent/HU896074D0/en
Publication of HUT56120A publication Critical patent/HUT56120A/en
Publication of HU218904B publication Critical patent/HU218904B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HU074/89A 1988-09-28 1989-09-28 Method for producing recombinant dna coding icam-1, cells expressing icam-1, or pharmaceutical compositions for diagnosing diseases and treating inflammations derived from the answer of specific defense system HU218904B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25044688A 1988-09-28 1988-09-28
US37388289A 1989-06-30 1989-06-30

Publications (3)

Publication Number Publication Date
HU896074D0 HU896074D0 (en) 1990-11-28
HUT56120A true HUT56120A (en) 1991-07-29
HU218904B HU218904B (en) 2000-12-28

Family

ID=26940882

Family Applications (1)

Application Number Title Priority Date Filing Date
HU074/89A HU218904B (en) 1988-09-28 1989-09-28 Method for producing recombinant dna coding icam-1, cells expressing icam-1, or pharmaceutical compositions for diagnosing diseases and treating inflammations derived from the answer of specific defense system

Country Status (7)

Country Link
JP (1) JP2976381B2 (en)
KR (1) KR900701846A (en)
AU (2) AU4412889A (en)
DK (1) DK175362B1 (en)
FI (2) FI102181B1 (en)
HU (1) HU218904B (en)
WO (1) WO1990003400A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA896668B (en) * 1988-09-01 1990-06-27 Molecular Therapeutics Inc A human rhinovirus receptor protein that inhibits virus infectivity
US6143298A (en) * 1988-09-01 2000-11-07 Bayer Corporation Soluble truncated forms of ICAM-1
ES2097748T3 (en) * 1989-03-16 1997-04-16 Blood Res Center USE OF FUNCTIONAL DERIVATIVES OF THE ICAM-1 INTERCELLULAR ADHESION MOLECULA IN ANTIVIRIC THERAPY.
WO1991018011A1 (en) * 1990-05-15 1991-11-28 Swinburne Limited Inhibition of cell adhesion using intercellular adhesion molecule-1-like peptides and/or analogues thereof
WO1991018010A1 (en) * 1990-05-15 1991-11-28 Swinburne Limited Inhibition of viral infection using intercellular adhesion molecule-1-like peptides and/or analogues thereof
DK162890D0 (en) * 1990-07-06 1990-07-06 Novo Nordisk As POLYPEPTIDE
US6107461A (en) * 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
US5686581A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric form of human rhinovirus receptor protein
US5686582A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
US5283058A (en) 1990-08-30 1994-02-01 The General Hospital Corporation Methods for inhibiting rejection of transplanted tissue
CA2056143A1 (en) * 1990-11-28 1992-05-29 Michael S. Diamond The mac-1 binding site of icam-1
US5932214A (en) 1994-08-11 1999-08-03 Biogen, Inc. Treatment for inflammatory bowel disease with VLA-4 blockers
US5599790A (en) 1992-06-11 1997-02-04 The Scripps Research Institute Fibrinogen γ chain polypeptide and compositions thereof
DK0644768T3 (en) * 1992-06-11 2002-05-21 Scripps Research Inst Methods and preparations for inhibiting endothelial cell and fibrinogen-induced inflammation
CA2144738A1 (en) * 1992-10-09 1994-04-28 Michael Diamond A subpopulation of mac-1 (cd11b/cd18) molecules which mediate neutrophil adhesion to icam-1 and fibrinogen
DE4335273A1 (en) * 1993-10-15 1995-04-20 Univ Ludwigs Albert Peptides for tumor therapy
WO1995028170A1 (en) * 1994-04-19 1995-10-26 The University Of Kansas Icam-1/lfa-1 short-chain peptides and method of using same
AU6390696A (en) * 1995-06-20 1997-01-22 Trustees Of Boston University Hypoxia-responsive adhesion molecules, specific antibodies, nd their uses
EP1218064B1 (en) * 1999-09-01 2005-06-01 Boehringer Ingelheim Pharmaceuticals Inc. COMPOSITIONS FOR TREATING AUTOIMMUNE DISEASEs CONTAINING A COMPOUND WHICH INHIBITS ICAM-LFA-1 INTERACTION AND A COMPOUND WHICH INHIBITS CD40-CD40 LIGAND INTERACTION
ES2383525T3 (en) 2003-11-05 2012-06-21 Sarcode Bioscience Inc. Cell adhesion modulators
WO2006125119A1 (en) 2005-05-17 2006-11-23 Sarcode Corporation Compositions and methods for treatment of eye disorders
CA3105972A1 (en) 2007-10-19 2009-04-30 Novartis Ag Compositions and methods for treatment of diabetic retinopathy
PE20091024A1 (en) * 2007-11-15 2009-08-12 Chugai Pharmaceutical Co Ltd MONOCLONAL ANTIBODIES BINDING ANEXELEKTO AND ITS USES
WO2009139817A2 (en) 2008-04-15 2009-11-19 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
WO2011050175A1 (en) 2009-10-21 2011-04-28 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
KR102157608B1 (en) 2012-07-25 2020-09-18 에스에이알코드 바이오사이언스 인코포레이티드 Lfa-1 inhibitor and polymorph thereof
EP3717632B1 (en) 2017-11-30 2022-10-26 F. Hoffmann-La Roche AG B-cell cultivation method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE128727T1 (en) * 1987-05-04 1995-10-15 Dana Farber Cancer Inst Inc INTERCELLULAR ADHESION MOLECULES AND THEIR BINDING LIGANDS.
ATE114972T1 (en) * 1987-11-02 1994-12-15 Baylor College Medicine USE OF ICAM-1 OR ITS FUNCTIONAL DERIVATIVES TO TREAT NON-SPECIFIC INFLAMMATION.

Also Published As

Publication number Publication date
DK128990A (en) 1990-07-26
AU679506B2 (en) 1997-07-03
KR900701846A (en) 1990-12-04
HU896074D0 (en) 1990-11-28
AU6319294A (en) 1994-08-25
FI107451B (en) 2001-08-15
HU218904B (en) 2000-12-28
FI102181B (en) 1998-10-30
WO1990003400A1 (en) 1990-04-05
FI981097A (en) 1998-05-18
AU4412889A (en) 1990-04-18
FI102181B1 (en) 1998-10-30
FI902490A0 (en) 1990-05-21
JP2976381B2 (en) 1999-11-10
JPH03501861A (en) 1991-04-25
DK128990D0 (en) 1990-05-25
DK175362B1 (en) 2004-09-13
FI981097A0 (en) 1989-09-28

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