DK128990A - INTERCELLULAR ADHESION MOLECULES AND LIGANDS WHICH MAY BE BINDED - Google Patents

INTERCELLULAR ADHESION MOLECULES AND LIGANDS WHICH MAY BE BINDED Download PDF

Info

Publication number
DK128990A
DK128990A DK128990A DK128990A DK128990A DK 128990 A DK128990 A DK 128990A DK 128990 A DK128990 A DK 128990A DK 128990 A DK128990 A DK 128990A DK 128990 A DK128990 A DK 128990A
Authority
DK
Denmark
Prior art keywords
binded
ligands
adhesion molecules
intercellular adhesion
intercellular
Prior art date
Application number
DK128990A
Other languages
Danish (da)
Other versions
DK175362B1 (en
DK128990D0 (en
Inventor
Timothy A Springer
Robert Rothlein
Steven D Marlin
Michael L Dustin
Original Assignee
Dana Farber Cancer Inst Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dana Farber Cancer Inst Inc filed Critical Dana Farber Cancer Inst Inc
Publication of DK128990D0 publication Critical patent/DK128990D0/en
Publication of DK128990A publication Critical patent/DK128990A/en
Application granted granted Critical
Publication of DK175362B1 publication Critical patent/DK175362B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70525—ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK199001289A 1988-09-28 1990-05-25 Soluble functional derivative of ICAM-1, recombinant DNA molecule and method for preparing said derivative, pharmaceutical composition containing such derivative and the use of the derivative to prepare such preparation, and ... DK175362B1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US25044688A 1988-09-28 1988-09-28
US25044688 1988-09-28
US37388289A 1989-06-30 1989-06-30
US37388289 1989-06-30
PCT/US1989/004242 WO1990003400A1 (en) 1988-09-28 1989-09-28 Intercellular adhesion molecules, and their binding ligands
US8904242 1989-09-28

Publications (3)

Publication Number Publication Date
DK128990D0 DK128990D0 (en) 1990-05-25
DK128990A true DK128990A (en) 1990-07-26
DK175362B1 DK175362B1 (en) 2004-09-13

Family

ID=26940882

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199001289A DK175362B1 (en) 1988-09-28 1990-05-25 Soluble functional derivative of ICAM-1, recombinant DNA molecule and method for preparing said derivative, pharmaceutical composition containing such derivative and the use of the derivative to prepare such preparation, and ...

Country Status (7)

Country Link
JP (1) JP2976381B2 (en)
KR (1) KR900701846A (en)
AU (2) AU4412889A (en)
DK (1) DK175362B1 (en)
FI (2) FI102181B1 (en)
HU (1) HU218904B (en)
WO (1) WO1990003400A1 (en)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA896668B (en) * 1988-09-01 1990-06-27 Molecular Therapeutics Inc A human rhinovirus receptor protein that inhibits virus infectivity
US6143298A (en) * 1988-09-01 2000-11-07 Bayer Corporation Soluble truncated forms of ICAM-1
ES2097748T3 (en) * 1989-03-16 1997-04-16 Blood Res Center USE OF FUNCTIONAL DERIVATIVES OF THE ICAM-1 INTERCELLULAR ADHESION MOLECULA IN ANTIVIRIC THERAPY.
WO1991018010A1 (en) * 1990-05-15 1991-11-28 Swinburne Limited Inhibition of viral infection using intercellular adhesion molecule-1-like peptides and/or analogues thereof
WO1991018011A1 (en) * 1990-05-15 1991-11-28 Swinburne Limited Inhibition of cell adhesion using intercellular adhesion molecule-1-like peptides and/or analogues thereof
DK162890D0 (en) * 1990-07-06 1990-07-06 Novo Nordisk As POLYPEPTIDE
US5686582A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric forms of human rhinovirus receptor protein
US5686581A (en) * 1990-07-20 1997-11-11 Bayer Corporation Multimeric form of human rhinovirus receptor protein
US6107461A (en) * 1990-07-20 2000-08-22 Bayer Corporation Multimeric forms of human rhinovirus receptor and fragments thereof, and method of use
US5283058A (en) 1990-08-30 1994-02-01 The General Hospital Corporation Methods for inhibiting rejection of transplanted tissue
CA2056143A1 (en) * 1990-11-28 1992-05-29 Michael S. Diamond The mac-1 binding site of icam-1
US5932214A (en) 1994-08-11 1999-08-03 Biogen, Inc. Treatment for inflammatory bowel disease with VLA-4 blockers
PT644768E (en) * 1992-06-11 2002-03-28 Scripps Research Inst METHODS AND COMPOSITIONS FOR INHIBITING INFLAMMATION MEDIATED BY ENDOTHELIAL CELLS AND FIBRINOGEN
US5599790A (en) 1992-06-11 1997-02-04 The Scripps Research Institute Fibrinogen γ chain polypeptide and compositions thereof
EP0670734A4 (en) * 1992-10-09 1998-01-14 Blood Res Center A subpopulation of mac-1 (cd11b/cd18) molecules which mediate neutrophil adhesion to icam-1 and fibrinogen.
DE4335273A1 (en) * 1993-10-15 1995-04-20 Univ Ludwigs Albert Peptides for tumor therapy
WO1995028170A1 (en) * 1994-04-19 1995-10-26 The University Of Kansas Icam-1/lfa-1 short-chain peptides and method of using same
WO1997000956A1 (en) * 1995-06-20 1997-01-09 Trustees Of Boston University Hypoxia-responsive adhesion molecules, specific antibodies, and their uses
AU7338500A (en) * 1999-09-01 2001-03-26 Boehringer Ingelheim Pharmaceuticals, Inc. Methods and compositions for treating autoimmune disease
CA2544678C (en) 2003-11-05 2013-12-31 Sunesis Pharmaceuticals, Inc. Modulators of cellular adhesion
SI2444079T1 (en) 2005-05-17 2017-05-31 Sarcode Bioscience Inc. Compositions and Methods for Treatment of Eye Disorders
EP2209371B1 (en) 2007-10-19 2017-01-04 SARcode Bioscience Inc. Compositions and methods for treatment of diabetic retinopathy
JP5554993B2 (en) * 2007-11-15 2014-07-23 中外製薬株式会社 Monoclonal antibody binding to nexelekto and use thereof
US8080562B2 (en) 2008-04-15 2011-12-20 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
WO2011050175A1 (en) 2009-10-21 2011-04-28 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
US9085553B2 (en) 2012-07-25 2015-07-21 SARcode Bioscience, Inc. LFA-1 inhibitor and methods of preparation and polymorph thereof
WO2019105864A1 (en) 2017-11-30 2019-06-06 F. Hoffmann-La Roche Ag B-cell cultivation method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2080044T3 (en) * 1987-05-04 1996-02-01 Dana Farber Cancer Inst Inc INTERCELLULAR ADHESION MOLECULES AND THEIR FIXATION LINKS.
EP0314863B1 (en) * 1987-11-02 1994-12-07 Baylor College Of Medicine Use of ICAM-1 or its functional derivatives for the treatment of non-specific inflammation

Also Published As

Publication number Publication date
FI981097A (en) 1998-05-18
JP2976381B2 (en) 1999-11-10
AU4412889A (en) 1990-04-18
AU6319294A (en) 1994-08-25
JPH03501861A (en) 1991-04-25
DK175362B1 (en) 2004-09-13
FI102181B (en) 1998-10-30
FI107451B (en) 2001-08-15
HU218904B (en) 2000-12-28
WO1990003400A1 (en) 1990-04-05
FI981097A0 (en) 1989-09-28
AU679506B2 (en) 1997-07-03
FI102181B1 (en) 1998-10-30
DK128990D0 (en) 1990-05-25
FI902490A0 (en) 1990-05-21
HUT56120A (en) 1991-07-29
HU896074D0 (en) 1990-11-28
KR900701846A (en) 1990-12-04

Similar Documents

Publication Publication Date Title
DK128990D0 (en) INTERCELLULAR ADHESION MOLECULES AND LIGANDS WHICH MAY BE BINDED
DK0390394T3 (en) Means and uses thereof
NO934491L (en) Intercellular adhesion molecule-3 and its binding ligands
IT8921465A0 (en) RESILIENTLY MOUNTED SPEAKERS.
DK67490A (en) INTERCELLULAR ADHESION MOLECULES AND LIGANDS WHICH MAY BE BINDED
DE68911649D1 (en) Joining metallic surfaces.
NO872045D0 (en) HYDRAULIC FRACTURING PROCESS AND MIXTURES.
NO894350D0 (en) PYRROLOKINOLINE AND PYRROLOPHENOTIAZINE CARBOXAMIDES AND RELATED COMPOUNDS.
IT8920480V0 (en) BRACELET CLAMP.
NO900033L (en) LASBOLT AND CUTTING CLAMPS.
FI896020A0 (en) COORDINATING FACTORS AND STEREOSKOPISK MAETANORDNING.
DK365289A (en) POLYSACCHARIDES, MANUFACTURING AND USING THEREOF
IE960275L (en) Intercellular adhesion molecules, and their binding ligands
NO902311D0 (en) INTRACELLULAR ADHESION MOLECULES AND THEIR BINDING LIGANDS.
ZA897335B (en) Intercellular adhesion molecules and their binding ligands
ES1009855Y (en) PERFECTED STRUCTURAL ARRANGEMENT IN WINDOWS AND SIMILAR.
ES1005638Y (en) PERFECTED BRIEFCASE.
ES1007783Y (en) PERFECTED GRILL.
DK338989D0 (en) THE LIPASEGEN AND ITS USE
IT8840029A0 (en) EQUALIZER
ES1006679Y (en) PERFECTED WALLET.
IT8820185A0 (en) ORNAMENTS WITH ROTATING ELEMENTS.
DK94288D0 (en) SCAFFILIATE AND SCANDBOOK THEREOF
BR6801386U (en) CONFIGURATION APPLIED IN PULOVER AND THE LIKE
NO912313D0 (en) CARBON FIBRILLES AND MANUFACTURING THEREOF.

Legal Events

Date Code Title Description
PUP Patent expired