EP0670734A4 - A subpopulation of mac-1 (cd11b/cd18) molecules which mediate neutrophil adhesion to icam-1 and fibrinogen. - Google Patents
A subpopulation of mac-1 (cd11b/cd18) molecules which mediate neutrophil adhesion to icam-1 and fibrinogen.Info
- Publication number
- EP0670734A4 EP0670734A4 EP93924919A EP93924919A EP0670734A4 EP 0670734 A4 EP0670734 A4 EP 0670734A4 EP 93924919 A EP93924919 A EP 93924919A EP 93924919 A EP93924919 A EP 93924919A EP 0670734 A4 EP0670734 A4 EP 0670734A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- cd11b
- subpopulation
- icam
- fibrinogen
- mac
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70546—Integrin superfamily
- C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95890492A | 1992-10-09 | 1992-10-09 | |
US96415692A | 1992-10-22 | 1992-10-22 | |
US964156 | 1992-10-22 | ||
PCT/US1993/009777 WO1994008620A1 (en) | 1992-10-09 | 1993-10-12 | A subpopulation of mac-1 (cd11b/cd18) molecules which mediate neutrophil adhesion to icam-1 and fibrinogen |
US958904 | 1997-10-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
EP0670734A1 EP0670734A1 (en) | 1995-09-13 |
EP0670734A4 true EP0670734A4 (en) | 1998-01-14 |
Family
ID=27130401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP93924919A Withdrawn EP0670734A4 (en) | 1992-10-09 | 1993-10-12 | A subpopulation of mac-1 (cd11b/cd18) molecules which mediate neutrophil adhesion to icam-1 and fibrinogen. |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP0670734A4 (en) |
JP (1) | JPH08502956A (en) |
AU (1) | AU674556B2 (en) |
CA (1) | CA2144738A1 (en) |
WO (1) | WO1994008620A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ295158A (en) * | 1994-10-25 | 1999-09-29 | Glaxo Group Ltd | Binding agents, particularly antibodies, to cd-23, treatment of autoimmune disease |
NL1001380C2 (en) * | 1995-10-09 | 1997-04-11 | Fuji Photo Film Bv | Method of dispersing an oil droplet type emulsified material in a liquid supply system and coating method using such a dispersing method. |
US20020081294A1 (en) | 1996-01-23 | 2002-06-27 | Genentech, Inc. | Co-administration of a thrombolytic and an anti-CD18 antibody in stroke |
US5914112A (en) * | 1996-01-23 | 1999-06-22 | Genentech, Inc. | Anti-CD18 antibodies in stroke |
US20090291048A1 (en) * | 2005-10-25 | 2009-11-26 | Baker Idi Heart And Diabetes Institute Holdings Limited | Leukocyte-binding polypeptides and uses thereof |
WO2010017083A1 (en) * | 2008-08-04 | 2010-02-11 | Wayne State University | Methods of treating cancer with cd11b antibodies |
EP2744825A1 (en) | 2011-08-17 | 2014-06-25 | F.Hoffmann-La Roche Ag | Inhibition of angiogenesis in refractory tumors |
US20150337039A1 (en) * | 2014-05-22 | 2015-11-26 | Case Western Reserve University | Mac-1 antibodies and uses thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988009672A1 (en) * | 1987-06-11 | 1988-12-15 | The University Of Michigan | Method of reducing tissue damage at an inflammatory site using a monoclonal antibody |
WO1989000190A1 (en) * | 1987-07-06 | 1989-01-12 | Dana-Farber Cancer Institute | Monoclonal antibody specific for the adhesion function domain of a phagocyte cell surface protein |
EP0364690A2 (en) * | 1988-08-23 | 1990-04-25 | Dana Farber Cancer Institute | The alpha-subunit of the Mac-1 leukocyte adhesion receptor |
EP0488061A2 (en) * | 1990-11-28 | 1992-06-03 | Center For Blood Research Laboratories, Inc. | The MAC-1 binding site of ICAM-1 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4412889A (en) * | 1988-09-28 | 1990-04-18 | Dana-Farber Cancer Institute | Intercellular adhesion molecules, and their binding ligands |
-
1993
- 1993-10-12 CA CA002144738A patent/CA2144738A1/en not_active Abandoned
- 1993-10-12 WO PCT/US1993/009777 patent/WO1994008620A1/en not_active Application Discontinuation
- 1993-10-12 EP EP93924919A patent/EP0670734A4/en not_active Withdrawn
- 1993-10-12 JP JP6510234A patent/JPH08502956A/en active Pending
- 1993-10-12 AU AU54423/94A patent/AU674556B2/en not_active Ceased
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988009672A1 (en) * | 1987-06-11 | 1988-12-15 | The University Of Michigan | Method of reducing tissue damage at an inflammatory site using a monoclonal antibody |
WO1989000190A1 (en) * | 1987-07-06 | 1989-01-12 | Dana-Farber Cancer Institute | Monoclonal antibody specific for the adhesion function domain of a phagocyte cell surface protein |
EP0364690A2 (en) * | 1988-08-23 | 1990-04-25 | Dana Farber Cancer Institute | The alpha-subunit of the Mac-1 leukocyte adhesion receptor |
EP0488061A2 (en) * | 1990-11-28 | 1992-06-03 | Center For Blood Research Laboratories, Inc. | The MAC-1 binding site of ICAM-1 |
Non-Patent Citations (12)
Title |
---|
BROWN E J ET AL: "Mechanism of inhibition of immunoglobulin G-mediated phagocytosis by monoclonal antibodies that recognize the Mac - 1 antigen.", JOURNAL OF CLINICAL INVESTIGATION, (1988 FEB) 81 (2) 365-75. JOURNAL CODE: HS7. ISSN: 0021-9738., United States, XP002094276 * |
COLLET B ET AL: "Scintigraphic detection in mice of inflammatory lesions and tumours by an indium-labelled monoclonal antibody directed against Mac - 1 antigen.", CANCER IMMUNOLOGY, IMMUNOTHERAPY, (1988) 26 (3) 237-42. JOURNAL CODE: CN3. ISSN: 0340-7004., GERMANY, WEST: Germany, Federal Republic of, XP002094277 * |
DANA N ET AL: "Two functional domains in the phagocyte membrane glycoprotein MO1 identified with monoclonal antibodies", JOURNAL OF IMMUNOLOGY, vol. 137, no. 10, 15 November 1986 (1986-11-15), pages 3259 - 3263, XP000655020 * |
DIAMOND M S ET AL: "A Subpopulation of MAC-1 (CD11B/CD18) Molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen", JOURNAL OF CELL BIOLOGY, vol. 120, no. 2, January 1993 (1993-01-01), pages 545 - 556, XP000655147 * |
DIAMOND M S ET AL: "The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b /CD18) for four distinct adhesion ligands.", JOURNAL OF CELL BIOLOGY, (1993 FEB) 120 (4) 1031-43. JOURNAL CODE: HMV. ISSN: 0021-9525., United States, XP002094281 * |
DING A ET AL: "Activation of mouse peritoneal macrophages by monoclonal antibodies to Mac - 1 (complement receptor type 3).", JOURNAL OF EXPERIMENTAL MEDICINE, (1987 MAR 1) 165 (3) 733-49. JOURNAL CODE: I2V. ISSN: 0022-1007., United States, XP002094278 * |
ELEMER G ET AL: "Monoclonal antibody 7A10 defines a functional neoepitope of the leukocyte integrin CD11B-CD18 MAC - 1", 1992 MEETING OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY (FASEB), PART II, ANAHEIM, CALIFORNIA, USA, APRIL 5-9, 1992. FASE (FED AM SOC EXP BIOL) J. (1992) 6 (5), A1893. CODEN: FAJOEC. ISSN: 0892-6638., XP002094274 * |
KISHIMOTO ET AL.: "The leukocyte integrins", ADVANCES IN IMMUNOLOGY, vol. 46, 1989, pages 149 - 182, XP000655002 * |
LUK, JOHN ET AL: "Subunit specificity and epitope mapping of Mac-1 and p150,95 mAb using chimeric CD11b X CD11c transfectants", LEUCOCYTE TYPING V: WHITE CELL DIFFER. ANTIGENS, PROC. INT. WORKSHOP CONF., 5TH (1995), MEETING DATE 1993, VOLUME 2, 1599-1601. EDITOR(S): SCHLOSSMAN, STUART F. PUBLISHER: OXFORD UNIVERSITY PRESS, OXFORD, UK. CODEN: 63WDAC, XP002094280 * |
SCHEINBERG D A: "Current applications of monoclonal antibodies for the therapy of hematopoietic cancers.", CURRENT OPINION IN IMMUNOLOGY, (1991 OCT) 3 (5) 679-84. REF: 47 JOURNAL CODE: AH1. ISSN: 0952-7915., ENGLAND: United Kingdom, XP002094279 * |
See also references of WO9408620A1 * |
SPRINGER T ET AL: "Mac - 1: a macrophage differentiation antigen identified by monoclonal antibody.", EUROPEAN JOURNAL OF IMMUNOLOGY, (1979 APR) 9 (4) 301-6. JOURNAL CODE: EN5. ISSN: 0014-2980., GERMANY, WEST: Germany, Federal Republic of, XP002094275 * |
Also Published As
Publication number | Publication date |
---|---|
WO1994008620A1 (en) | 1994-04-28 |
EP0670734A1 (en) | 1995-09-13 |
CA2144738A1 (en) | 1994-04-28 |
AU674556B2 (en) | 1997-01-02 |
AU5442394A (en) | 1994-05-09 |
JPH08502956A (en) | 1996-04-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 19950407 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
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A4 | Supplementary search report drawn up and despatched |
Effective date: 19971128 |
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AK | Designated contracting states |
Kind code of ref document: A4 Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LI LU MC NL PT SE |
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DA4 | Supplementary search report drawn up and despatched (deleted) | ||
RA4 | Supplementary search report drawn up and despatched (corrected) |
Effective date: 19990318 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20000501 |