EP0670734A4 - A subpopulation of mac-1 (cd11b/cd18) molecules which mediate neutrophil adhesion to icam-1 and fibrinogen. - Google Patents

A subpopulation of mac-1 (cd11b/cd18) molecules which mediate neutrophil adhesion to icam-1 and fibrinogen.

Info

Publication number
EP0670734A4
EP0670734A4 EP19930924919 EP93924919A EP0670734A4 EP 0670734 A4 EP0670734 A4 EP 0670734A4 EP 19930924919 EP19930924919 EP 19930924919 EP 93924919 A EP93924919 A EP 93924919A EP 0670734 A4 EP0670734 A4 EP 0670734A4
Authority
EP
Grant status
Application
Patent type
Prior art keywords
cd11b
cd18
subpopulation
icam
fibrinogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19930924919
Other languages
German (de)
French (fr)
Other versions
EP0670734A1 (en )
Inventor
Michael Diamond
Timothy A Springer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immune Disease Institute Inc
Original Assignee
Immune Disease Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546Integrin superfamily
    • C07K14/70553Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
EP19930924919 1992-10-09 1993-10-12 A subpopulation of mac-1 (cd11b/cd18) molecules which mediate neutrophil adhesion to icam-1 and fibrinogen. Withdrawn EP0670734A4 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US95890492 true 1992-10-09 1992-10-09
US958904 1992-10-09
US96415692 true 1992-10-22 1992-10-22
US964156 1992-10-22
PCT/US1993/009777 WO1994008620A1 (en) 1992-10-09 1993-10-12 A subpopulation of mac-1 (cd11b/cd18) molecules which mediate neutrophil adhesion to icam-1 and fibrinogen

Publications (2)

Publication Number Publication Date
EP0670734A1 true EP0670734A1 (en) 1995-09-13
EP0670734A4 true true EP0670734A4 (en) 1998-01-14

Family

ID=27130401

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19930924919 Withdrawn EP0670734A4 (en) 1992-10-09 1993-10-12 A subpopulation of mac-1 (cd11b/cd18) molecules which mediate neutrophil adhesion to icam-1 and fibrinogen.

Country Status (4)

Country Link
EP (1) EP0670734A4 (en)
JP (1) JPH08502956A (en)
CA (1) CA2144738A1 (en)
WO (1) WO1994008620A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1018517A3 (en) * 1994-10-25 2000-07-26 Glaxo Group Limited Binding agents to CD23 for treatment of inflammatory, autoimmune or allergic diseases
NL1001380C2 (en) * 1995-10-09 1997-04-11 Fuji Photo Film Bv Method for dispersing an emulsified material of the oil droplet type in a liquid supply system and method in which coating is made of a dispersing method such use.
US20020081294A1 (en) 1996-01-23 2002-06-27 Genentech, Inc. Co-administration of a thrombolytic and an anti-CD18 antibody in stroke
US5914112A (en) * 1996-01-23 1999-06-22 Genentech, Inc. Anti-CD18 antibodies in stroke
US20090291048A1 (en) * 2005-10-25 2009-11-26 Baker Idi Heart And Diabetes Institute Holdings Limited Leukocyte-binding polypeptides and uses thereof
WO2010017083A1 (en) * 2008-08-04 2010-02-11 Wayne State University Methods of treating cancer with cd11b antibodies
CA2842481A1 (en) 2011-08-17 2013-02-21 Genentech, Inc. Inhibition of angiogenesis in refractory tumors
US20150337039A1 (en) * 2014-05-22 2015-11-26 Case Western Reserve University Mac-1 antibodies and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988009672A1 (en) * 1987-06-11 1988-12-15 The University Of Michigan Method of reducing tissue damage at an inflammatory site using a monoclonal antibody
WO1989000190A1 (en) * 1987-07-06 1989-01-12 Dana-Farber Cancer Institute Monoclonal antibody specific for the adhesion function domain of a phagocyte cell surface protein
EP0364690A2 (en) * 1988-08-23 1990-04-25 Dana Farber Cancer Institute The alpha-subunit of the Mac-1 leukocyte adhesion receptor
EP0488061A2 (en) * 1990-11-28 1992-06-03 Center For Blood Research Laboratories, Inc. The MAC-1 binding site of ICAM-1

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2976381B2 (en) * 1988-09-28 1999-11-10 ダナ ファーバー キャンサー インスティテュート Intercellular adhesion molecule and its binding ligand

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988009672A1 (en) * 1987-06-11 1988-12-15 The University Of Michigan Method of reducing tissue damage at an inflammatory site using a monoclonal antibody
WO1989000190A1 (en) * 1987-07-06 1989-01-12 Dana-Farber Cancer Institute Monoclonal antibody specific for the adhesion function domain of a phagocyte cell surface protein
EP0364690A2 (en) * 1988-08-23 1990-04-25 Dana Farber Cancer Institute The alpha-subunit of the Mac-1 leukocyte adhesion receptor
EP0488061A2 (en) * 1990-11-28 1992-06-03 Center For Blood Research Laboratories, Inc. The MAC-1 binding site of ICAM-1

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
BROWN E J ET AL: "Mechanism of inhibition of immunoglobulin G-mediated phagocytosis by monoclonal antibodies that recognize the Mac - 1 antigen.", JOURNAL OF CLINICAL INVESTIGATION, (1988 FEB) 81 (2) 365-75. JOURNAL CODE: HS7. ISSN: 0021-9738., United States, XP002094276 *
COLLET B ET AL: "Scintigraphic detection in mice of inflammatory lesions and tumours by an indium-labelled monoclonal antibody directed against Mac - 1 antigen.", CANCER IMMUNOLOGY, IMMUNOTHERAPY, (1988) 26 (3) 237-42. JOURNAL CODE: CN3. ISSN: 0340-7004., GERMANY, WEST: Germany, Federal Republic of, XP002094277 *
DANA N ET AL: "Two functional domains in the phagocyte membrane glycoprotein MO1 identified with monoclonal antibodies", JOURNAL OF IMMUNOLOGY, vol. 137, no. 10, 15 November 1986 (1986-11-15), pages 3259 - 3263, XP000655020 *
DIAMOND M S ET AL: "A Subpopulation of MAC-1 (CD11B/CD18) Molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen", JOURNAL OF CELL BIOLOGY, vol. 120, no. 2, January 1993 (1993-01-01), pages 545 - 556, XP000655147 *
DIAMOND M S ET AL: "The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b /CD18) for four distinct adhesion ligands.", JOURNAL OF CELL BIOLOGY, (1993 FEB) 120 (4) 1031-43. JOURNAL CODE: HMV. ISSN: 0021-9525., United States, XP002094281 *
DING A ET AL: "Activation of mouse peritoneal macrophages by monoclonal antibodies to Mac - 1 (complement receptor type 3).", JOURNAL OF EXPERIMENTAL MEDICINE, (1987 MAR 1) 165 (3) 733-49. JOURNAL CODE: I2V. ISSN: 0022-1007., United States, XP002094278 *
ELEMER G ET AL: "Monoclonal antibody 7A10 defines a functional neoepitope of the leukocyte integrin CD11B-CD18 MAC - 1", 1992 MEETING OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY (FASEB), PART II, ANAHEIM, CALIFORNIA, USA, APRIL 5-9, 1992. FASE (FED AM SOC EXP BIOL) J. (1992) 6 (5), A1893. CODEN: FAJOEC. ISSN: 0892-6638., XP002094274 *
KISHIMOTO ET AL.: "The leukocyte integrins", ADVANCES IN IMMUNOLOGY, vol. 46, 1989, pages 149 - 182, XP000655002 *
LUK, JOHN ET AL: "Subunit specificity and epitope mapping of Mac-1 and p150,95 mAb using chimeric CD11b X CD11c transfectants", LEUCOCYTE TYPING V: WHITE CELL DIFFER. ANTIGENS, PROC. INT. WORKSHOP CONF., 5TH (1995), MEETING DATE 1993, VOLUME 2, 1599-1601. EDITOR(S): SCHLOSSMAN, STUART F. PUBLISHER: OXFORD UNIVERSITY PRESS, OXFORD, UK. CODEN: 63WDAC, XP002094280 *
SCHEINBERG D A: "Current applications of monoclonal antibodies for the therapy of hematopoietic cancers.", CURRENT OPINION IN IMMUNOLOGY, (1991 OCT) 3 (5) 679-84. REF: 47 JOURNAL CODE: AH1. ISSN: 0952-7915., ENGLAND: United Kingdom, XP002094279 *
See also references of WO9408620A1 *
SPRINGER T ET AL: "Mac - 1: a macrophage differentiation antigen identified by monoclonal antibody.", EUROPEAN JOURNAL OF IMMUNOLOGY, (1979 APR) 9 (4) 301-6. JOURNAL CODE: EN5. ISSN: 0014-2980., GERMANY, WEST: Germany, Federal Republic of, XP002094275 *

Also Published As

Publication number Publication date Type
CA2144738A1 (en) 1994-04-28 application
EP0670734A1 (en) 1995-09-13 application
JPH08502956A (en) 1996-04-02 application
WO1994008620A1 (en) 1994-04-28 application

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