EP0670734A4 - Eine subpopulation von mac-1 (cd11b/cd 18) molekülen welche eine neutrophile adhäsion an icam-1 und fibrinogen vermitteln. - Google Patents

Eine subpopulation von mac-1 (cd11b/cd 18) molekülen welche eine neutrophile adhäsion an icam-1 und fibrinogen vermitteln.

Info

Publication number
EP0670734A4
EP0670734A4 EP93924919A EP93924919A EP0670734A4 EP 0670734 A4 EP0670734 A4 EP 0670734A4 EP 93924919 A EP93924919 A EP 93924919A EP 93924919 A EP93924919 A EP 93924919A EP 0670734 A4 EP0670734 A4 EP 0670734A4
Authority
EP
European Patent Office
Prior art keywords
cd11b
subpopulation
icam
fibrinogen
mac
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93924919A
Other languages
English (en)
French (fr)
Other versions
EP0670734A1 (de
Inventor
Michael Diamond
Timothy A Springer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Immune Disease Institute Inc
Original Assignee
Immune Disease Institute Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immune Disease Institute Inc filed Critical Immune Disease Institute Inc
Publication of EP0670734A1 publication Critical patent/EP0670734A1/de
Publication of EP0670734A4 publication Critical patent/EP0670734A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • C07K14/70553—Integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2845—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta2-subunit-containing molecules, e.g. CD11, CD18
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EP93924919A 1992-10-09 1993-10-12 Eine subpopulation von mac-1 (cd11b/cd 18) molekülen welche eine neutrophile adhäsion an icam-1 und fibrinogen vermitteln. Withdrawn EP0670734A4 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95890492A 1992-10-09 1992-10-09
US96415692A 1992-10-22 1992-10-22
US964156 1992-10-22
PCT/US1993/009777 WO1994008620A1 (en) 1992-10-09 1993-10-12 A subpopulation of mac-1 (cd11b/cd18) molecules which mediate neutrophil adhesion to icam-1 and fibrinogen
US958904 1997-10-28

Publications (2)

Publication Number Publication Date
EP0670734A1 EP0670734A1 (de) 1995-09-13
EP0670734A4 true EP0670734A4 (de) 1998-01-14

Family

ID=27130401

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93924919A Withdrawn EP0670734A4 (de) 1992-10-09 1993-10-12 Eine subpopulation von mac-1 (cd11b/cd 18) molekülen welche eine neutrophile adhäsion an icam-1 und fibrinogen vermitteln.

Country Status (5)

Country Link
EP (1) EP0670734A4 (de)
JP (1) JPH08502956A (de)
AU (1) AU674556B2 (de)
CA (1) CA2144738A1 (de)
WO (1) WO1994008620A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2203363A1 (en) * 1994-10-25 1996-05-02 Jean-Yves Marcel Paul Bonnefoy Binding agents to cd23
NL1001380C2 (nl) * 1995-10-09 1997-04-11 Fuji Photo Film Bv Methode voor het dispergeren van een geëmulgeerd materiaal van het olie-druppeltype in een vloeistoftoevoersysteem en bekledingsmethode waarbij van een dergelijke dispergeermethode gebruik wordt gemaakt.
US5914112A (en) * 1996-01-23 1999-06-22 Genentech, Inc. Anti-CD18 antibodies in stroke
US20020081294A1 (en) 1996-01-23 2002-06-27 Genentech, Inc. Co-administration of a thrombolytic and an anti-CD18 antibody in stroke
WO2007048186A1 (en) * 2005-10-25 2007-05-03 Baker Medical Research Institute Leukocyte-binding polypeptides and uses thereof
WO2010017083A1 (en) * 2008-08-04 2010-02-11 Wayne State University Methods of treating cancer with cd11b antibodies
WO2013025944A1 (en) 2011-08-17 2013-02-21 Genentech, Inc. Inhibition of angiogenesis in refractory tumors
US20150337039A1 (en) * 2014-05-22 2015-11-26 Case Western Reserve University Mac-1 antibodies and uses thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988009672A1 (en) * 1987-06-11 1988-12-15 The University Of Michigan Method of reducing tissue damage at an inflammatory site using a monoclonal antibody
WO1989000190A1 (en) * 1987-07-06 1989-01-12 Dana-Farber Cancer Institute Monoclonal antibody specific for the adhesion function domain of a phagocyte cell surface protein
EP0364690A2 (de) * 1988-08-23 1990-04-25 Dana Farber Cancer Institute Alpha-Subeinheit des Mac-1-Leukocyt-Adhäsions-Rezeptors
EP0488061A2 (de) * 1990-11-28 1992-06-03 Center For Blood Research Laboratories, Inc. Die Mac-1-Bindungsstelle von ICAM-1

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990003400A1 (en) * 1988-09-28 1990-04-05 Dana-Farber Cancer Institute Intercellular adhesion molecules, and their binding ligands

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988009672A1 (en) * 1987-06-11 1988-12-15 The University Of Michigan Method of reducing tissue damage at an inflammatory site using a monoclonal antibody
WO1989000190A1 (en) * 1987-07-06 1989-01-12 Dana-Farber Cancer Institute Monoclonal antibody specific for the adhesion function domain of a phagocyte cell surface protein
EP0364690A2 (de) * 1988-08-23 1990-04-25 Dana Farber Cancer Institute Alpha-Subeinheit des Mac-1-Leukocyt-Adhäsions-Rezeptors
EP0488061A2 (de) * 1990-11-28 1992-06-03 Center For Blood Research Laboratories, Inc. Die Mac-1-Bindungsstelle von ICAM-1

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
BROWN E J ET AL: "Mechanism of inhibition of immunoglobulin G-mediated phagocytosis by monoclonal antibodies that recognize the Mac - 1 antigen.", JOURNAL OF CLINICAL INVESTIGATION, (1988 FEB) 81 (2) 365-75. JOURNAL CODE: HS7. ISSN: 0021-9738., United States, XP002094276 *
COLLET B ET AL: "Scintigraphic detection in mice of inflammatory lesions and tumours by an indium-labelled monoclonal antibody directed against Mac - 1 antigen.", CANCER IMMUNOLOGY, IMMUNOTHERAPY, (1988) 26 (3) 237-42. JOURNAL CODE: CN3. ISSN: 0340-7004., GERMANY, WEST: Germany, Federal Republic of, XP002094277 *
DANA N ET AL: "Two functional domains in the phagocyte membrane glycoprotein MO1 identified with monoclonal antibodies", JOURNAL OF IMMUNOLOGY, vol. 137, no. 10, 15 November 1986 (1986-11-15), pages 3259 - 3263, XP000655020 *
DIAMOND M S ET AL: "A Subpopulation of MAC-1 (CD11B/CD18) Molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen", JOURNAL OF CELL BIOLOGY, vol. 120, no. 2, January 1993 (1993-01-01), pages 545 - 556, XP000655147 *
DIAMOND M S ET AL: "The I domain is a major recognition site on the leukocyte integrin Mac-1 (CD11b /CD18) for four distinct adhesion ligands.", JOURNAL OF CELL BIOLOGY, (1993 FEB) 120 (4) 1031-43. JOURNAL CODE: HMV. ISSN: 0021-9525., United States, XP002094281 *
DING A ET AL: "Activation of mouse peritoneal macrophages by monoclonal antibodies to Mac - 1 (complement receptor type 3).", JOURNAL OF EXPERIMENTAL MEDICINE, (1987 MAR 1) 165 (3) 733-49. JOURNAL CODE: I2V. ISSN: 0022-1007., United States, XP002094278 *
ELEMER G ET AL: "Monoclonal antibody 7A10 defines a functional neoepitope of the leukocyte integrin CD11B-CD18 MAC - 1", 1992 MEETING OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY (FASEB), PART II, ANAHEIM, CALIFORNIA, USA, APRIL 5-9, 1992. FASE (FED AM SOC EXP BIOL) J. (1992) 6 (5), A1893. CODEN: FAJOEC. ISSN: 0892-6638., XP002094274 *
KISHIMOTO ET AL.: "The leukocyte integrins", ADVANCES IN IMMUNOLOGY, vol. 46, 1989, pages 149 - 182, XP000655002 *
LUK, JOHN ET AL: "Subunit specificity and epitope mapping of Mac-1 and p150,95 mAb using chimeric CD11b X CD11c transfectants", LEUCOCYTE TYPING V: WHITE CELL DIFFER. ANTIGENS, PROC. INT. WORKSHOP CONF., 5TH (1995), MEETING DATE 1993, VOLUME 2, 1599-1601. EDITOR(S): SCHLOSSMAN, STUART F. PUBLISHER: OXFORD UNIVERSITY PRESS, OXFORD, UK. CODEN: 63WDAC, XP002094280 *
SCHEINBERG D A: "Current applications of monoclonal antibodies for the therapy of hematopoietic cancers.", CURRENT OPINION IN IMMUNOLOGY, (1991 OCT) 3 (5) 679-84. REF: 47 JOURNAL CODE: AH1. ISSN: 0952-7915., ENGLAND: United Kingdom, XP002094279 *
See also references of WO9408620A1 *
SPRINGER T ET AL: "Mac - 1: a macrophage differentiation antigen identified by monoclonal antibody.", EUROPEAN JOURNAL OF IMMUNOLOGY, (1979 APR) 9 (4) 301-6. JOURNAL CODE: EN5. ISSN: 0014-2980., GERMANY, WEST: Germany, Federal Republic of, XP002094275 *

Also Published As

Publication number Publication date
EP0670734A1 (de) 1995-09-13
AU674556B2 (en) 1997-01-02
AU5442394A (en) 1994-05-09
WO1994008620A1 (en) 1994-04-28
JPH08502956A (ja) 1996-04-02
CA2144738A1 (en) 1994-04-28

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