FI973085A - Förfarande för framställning av 1-(tiometyl)-cyklopropanättikssyra - Google Patents

Förfarande för framställning av 1-(tiometyl)-cyklopropanättikssyra Download PDF

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Publication number
FI973085A
FI973085A FI973085A FI973085A FI973085A FI 973085 A FI973085 A FI 973085A FI 973085 A FI973085 A FI 973085A FI 973085 A FI973085 A FI 973085A FI 973085 A FI973085 A FI 973085A
Authority
FI
Finland
Prior art keywords
thiomethyl
preparation
cyclopropaneacetic acid
cyclopropaneacetic
acid
Prior art date
Application number
FI973085A
Other languages
English (en)
Finnish (fi)
Other versions
FI973085A0 (sv
Inventor
Steven King
Brenda Pipik
David A Conlon
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI973085A0 publication Critical patent/FI973085A0/sv
Publication of FI973085A publication Critical patent/FI973085A/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/20—Esters of monothiocarboxylic acids
    • C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/16—Preparation of carboxylic acid nitriles by reaction of cyanides with lactones or compounds containing hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/10—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms two oxygen atoms and one sulfur atom, e.g. cyclic sulfates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI973085A 1995-01-23 1997-07-22 Förfarande för framställning av 1-(tiometyl)-cyklopropanättikssyra FI973085A (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/376,715 US5523477A (en) 1995-01-23 1995-01-23 Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid
PCT/US1996/000625 WO1996022987A1 (en) 1995-01-23 1996-01-19 Process for the preparation of 1-(thiomethyl)-cyclopropaneacetic acid

Publications (2)

Publication Number Publication Date
FI973085A0 FI973085A0 (sv) 1997-07-22
FI973085A true FI973085A (sv) 1997-07-22

Family

ID=23486169

Family Applications (1)

Application Number Title Priority Date Filing Date
FI973085A FI973085A (sv) 1995-01-23 1997-07-22 Förfarande för framställning av 1-(tiometyl)-cyklopropanättikssyra

Country Status (16)

Country Link
US (1) US5523477A (sv)
EP (1) EP0805808A1 (sv)
CN (1) CN1072218C (sv)
AR (1) AR000772A1 (sv)
AU (1) AU4657396A (sv)
BR (1) BR9607083A (sv)
CZ (1) CZ234897A3 (sv)
EA (2) EA000090B1 (sv)
FI (1) FI973085A (sv)
HR (1) HRP960028A2 (sv)
RO (1) RO118131B1 (sv)
SK (1) SK99897A3 (sv)
TW (1) TW322475B (sv)
UA (1) UA50730C2 (sv)
WO (1) WO1996022987A1 (sv)
YU (1) YU3596A (sv)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5904068A (en) 1996-04-30 1999-05-18 Eaton Corporation Semi-automatic shift implementation with synchronized transmission emulation
WO2003066582A1 (en) * 2002-02-06 2003-08-14 Delmar Chemicals Inc. Process for the preparation of 1-(mercaptomethyl)-cyclopropaneacetic acid
CA2371048C (en) 2002-02-06 2011-01-04 Delmar Chemicals Inc. Process for the preparation of 1-(mercaptomethyl)-cyclopropaneacetic acid
AU2004229507B2 (en) * 2003-04-15 2008-12-18 Merck Frosst Canada & Co. Polymorphic form of montelukast sodium
IL174758A (en) * 2003-10-10 2012-09-24 Synthon Bv Crystalline form of montelukast, pharmaceutical composition comprising it, process for the preparation thereof and uses thereof as a medicament
WO2005074935A1 (en) * 2004-01-30 2005-08-18 Teva Pharmaceutical Industries Ltd. Montelukast free acid polymorphs
EP1760077A1 (en) * 2004-01-30 2007-03-07 Teva Pharmaceutical Industries Ltd. Montelukast free acid polymorphs
WO2005075427A2 (en) * 2004-01-30 2005-08-18 Teva Pharmaceutical Industries Ltd. Montelukast sodium polymorphs
JP2007532686A (ja) * 2004-04-21 2007-11-15 テバ ファーマシューティカル インダストリーズ リミティド モンテルカストナトリウムを調製する方法
US7829716B2 (en) * 2004-04-30 2010-11-09 Synthon Pharmaceuticals, Inc. Process for making montelukast and intermediates therefor
US7501517B2 (en) * 2004-04-30 2009-03-10 Synthon Ip, Inc. Process for making montelukast and intermediates therefor
ATE500225T1 (de) * 2004-07-19 2011-03-15 Matrix Lab Ltd Verfahren zur herstellung von montelukast und salzen davon
CN101213177A (zh) * 2005-07-05 2008-07-02 特瓦制药工业有限公司 孟鲁司特的纯化
KR20080033425A (ko) * 2005-07-20 2008-04-16 닥터 레디스 래보러토리즈, 인코포레이티드 몬테루캐스트의 제조 공정
WO2007059325A2 (en) * 2005-11-16 2007-05-24 Teva Pharmaceutical Industries Ltd. Drying methods of montelukast sodium by azeotropic removal of the solvent
AR056815A1 (es) * 2005-11-18 2007-10-24 Synthon Bv PROCESO PARA PREPARAR MONTELUKAST, INTERMEDIARIOS DEL MISMO Y SUS SALES DE ADICIoN Y PROCEDIMIENTO DE PURIFICACIoN DE ÉSTOS Y DE MONTELUKAST
JP2009529495A (ja) * 2006-02-21 2009-08-20 ケマジス・リミテッド モンテルカストアンモニウム塩の新規な多形体およびその調製方法
IL181607A0 (en) * 2006-02-27 2007-07-04 Chemagis Ltd Novel process for preparing montelukast and salts thereof
CN101432267A (zh) * 2006-03-17 2009-05-13 斯索恩有限公司 孟鲁司特金刚烷胺盐
US20090326232A1 (en) * 2006-06-26 2009-12-31 Uttam Kumar Ray Process for the Preparation of Leukotriene Receptor Antagonist (Montelukast Sodium)
GB0618703D0 (en) * 2006-09-22 2006-11-01 Almac Sciences Ltd Synthesis of leikotriene compounds
US7700776B2 (en) * 2006-10-24 2010-04-20 Formosa Laboratories, Inc. Compounds and preparation for montelukast sodium
US7271268B1 (en) 2006-12-22 2007-09-18 Formosa Laboratories Inc. Process for preparation of [1-(mercaptomethyl)cyclopropyl]acetic acid and related derivatives
US20080188664A1 (en) * 2007-01-15 2008-08-07 Chemagis Ltd. Process for preparing montelukast sodium containing controlled levels of impurities
KR101072896B1 (ko) 2007-10-09 2011-10-17 한미홀딩스 주식회사 이온성 액체 매개체를 이용한 몬테루카스트산의 제조 방법
WO2009130056A1 (en) * 2008-04-25 2009-10-29 Synthon B.V. Process for making montelukast intermediates
EP2288595B1 (en) * 2008-05-26 2016-11-02 Laurus Labs Private Limited An improved process for preparing montelukast and salts thereof
CN101880270B (zh) * 2009-05-07 2012-10-03 上海华升生物科技有限公司 一种制备1,1-环丙烷二甲醇环亚硫酸酯的方法
WO2011004298A1 (en) 2009-07-09 2011-01-13 Alembic Limited Montelukast hexamethylenediamine salt and its use for the preparation of montelukast sodium
US8471030B2 (en) 2010-12-06 2013-06-25 Orochem Technologies Inc. Purification of montelukast using simulated moving bed
KR101431678B1 (ko) * 2012-01-10 2014-08-22 (주)위즈켐 1-(1'-(카복시메틸)시클로프로판메틸디설파닐메틸)시클로프로판아세트산과 그 유도체의 제조방법
CN103058884B (zh) * 2012-12-14 2014-10-29 武汉赛狮药物化学有限公司 1-羟甲基环丙基乙腈的合成方法
CN111170939A (zh) * 2019-12-20 2020-05-19 牡丹江恒远药业股份有限公司 一种高纯度孟鲁司特钠及其中间体的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0172371A1 (de) * 1984-07-27 1986-02-26 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Verfahren zur Herstellung von Dehydroxypantolacton
ES2114882T3 (es) * 1990-10-12 1998-06-16 Merck Frosst Canada Inc Acidos hidroxialquilquinolinos insaturados como antagonistas de leucotrienos.
US5270324A (en) * 1992-04-10 1993-12-14 Merck Frosst Canada, Inc. Fluorinated hydroxyalkylquinoline acids as leukotriene antagonists
CA2111372C (en) * 1992-12-22 2007-01-16 Robert N. Young Diaryl 5,6-fusedheterocyclic acids as leukotriene antagonists
US5438141A (en) * 1993-05-21 1995-08-01 Merck Frosst Canada, Inc. Heteroaryl and haloaryl quinoline derivatives of cyclopropaneacetic acid as leukotriene antagonists
US5350760A (en) * 1993-08-04 1994-09-27 Merck Frosst Canada, Inc. Aza-5,5-fused hetrocyclic acids as leukotriene antagonists
TW416948B (en) * 1993-12-28 2001-01-01 Merck & Co Inc Process for the preparation of leukotriene antagonists

Also Published As

Publication number Publication date
UA50730C2 (uk) 2002-11-15
FI973085A0 (sv) 1997-07-22
WO1996022987A1 (en) 1996-08-01
HRP960028A2 (en) 1997-10-31
CN1172481A (zh) 1998-02-04
RO118131B1 (ro) 2003-02-28
SK99897A3 (en) 1998-04-08
BR9607083A (pt) 1997-11-11
EA199700137A1 (ru) 1997-12-30
YU3596A (sh) 1998-07-10
EP0805808A1 (en) 1997-11-12
EA000090B1 (ru) 1998-06-25
US5523477A (en) 1996-06-04
CZ234897A3 (cs) 1998-02-18
TW322475B (sv) 1997-12-11
AR000772A1 (es) 1997-08-06
CN1072218C (zh) 2001-10-03
AU4657396A (en) 1996-08-14

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